CN107308255A - Treat medicine for oral administration, externally applied drug and the two preparation method of acne - Google Patents

Treat medicine for oral administration, externally applied drug and the two preparation method of acne Download PDF

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CN107308255A
CN107308255A CN201710427098.2A CN201710427098A CN107308255A CN 107308255 A CN107308255 A CN 107308255A CN 201710427098 A CN201710427098 A CN 201710427098A CN 107308255 A CN107308255 A CN 107308255A
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parts
acne
oral administration
medicine
treatment
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CN107308255B (en
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田启旺
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The present invention relates to dermatosis treating medicine field, more particularly to a kind of medicine for oral administration for treating acne, externally applied drug and the two preparation method.The medicine for oral administration for the treatment of acne is mixed by following raw mill：The fruit of summer cypress, indigo naturalis, full worm, oldenlandia diffusa, radix scutellariae, coptis root, the capsule of weeping forsythia, two flowers, chrysanthemum indicum, public English, schizonepeta, the windproof, dried rhizome of rehmannia, Poria cocos, Radix Angelicae Sinensis, Ligusticum wallichii, radix glycyrrhizae, tribulus terrestris and the root of kudzu vine.The externally applied drug for the treatment of acne is formed by following raw material is brewed：Full worm, centipede, kuh-seng, frutus cnidii, honeycomb, Fructus meliae toosendan, snake slough, sulphur and borneol.Medicine for oral administration, the externally applied drug for treating acne are with low cost, and for the acne of puberty men and women, curative effect is obvious, uneasy to recur and has no toxic side effect.Medicine for oral administration, the method for preparing externally applied for treating acne are simple.

Description

Treat medicine for oral administration, externally applied drug and the two preparation method of acne
Technical field
The present invention relates to dermatosis treating medicine field, more particularly to a kind of medicine for oral administration for treating acne, externally applied drug and the two system Preparation Method.
Background technology
Acne is called acne, whelk, is a kind of common skin disease of human body, is more common in adolescence men and women.It is in The men and women of adolescence, because personal lifestyle is irregular, likes eating maror, causes endocrinopathy, stomach unsaturated vapor, skin Skin immunity degradation, so as to cause acne.Clinically acne mainly appears on face, upper limbs, chest hall, neck, and symptom is not system One.Acne is not only damaged to the healthy of puberty men and women, and their health at heart is impacted.
It is presently used for treating that dermopathic Chinese and Western medicine kind is numerous but less to the acne scope of application, and for acne There is also respective shortcoming for therapeutic effect.Generally speaking, Western medicine generally existing side effect, rear easily recurrence, Chinese medicine is then most Curative effect is not obvious.
Therefore, need be a kind of with low cost, for the acne of puberty men and women, curative effect is obvious, uneasy to recur and nontoxic pair Medicine for oral administration, externally applied drug and the two preparation method of the treatment acne of effect.
The content of the invention
(1) technical problem to be solved
In order to solve the above mentioned problem of prior art, the present invention provides a kind of with low cost, for the Cuo of puberty men and women Sore, curative effect is obvious, uneasy to recur and medicine for oral administration, externally applied drug and the two preparation method for the treatment of acne for having no toxic side effect.
(2) technical scheme
In order to achieve the above object, the main technical schemes that the present invention is used include：
The medicine for oral administration for the treatment acne that the present invention is provided, is mixed by the raw mill of following parts by weight：
20-30 parts of the fruit of summer cypress, 10-20 parts of indigo naturalis, full worm 10-20 parts, it is 5-15 parts of oldenlandia diffusa, 10-20 parts of radix scutellariae, yellow It is 10-20 parts of lotus, 10-20 parts of the capsule of weeping forsythia, two 10-20 part of flowers, 15-25 parts of chrysanthemum indicum, 20-30 parts of English of public affairs, 10-20 parts of schizonepeta, windproof 10-20 parts, 10-20 parts of the dried rhizome of rehmannia, 10-20 parts of Poria cocos, 10-20 parts of Radix Angelicae Sinensis, 10-20 parts of Ligusticum wallichii, 10-20 parts of radix glycyrrhizae, tribulus terrestris 20- 30 parts and 20-30 parts of the root of kudzu vine.
Further, the medicine for oral administration for the treatment of acne of the invention, is mixed by the raw mill of following parts by weight：
23-29 parts of the fruit of summer cypress, 13-16 parts of indigo naturalis, full worm 12-18 parts, it is 6-12 parts of oldenlandia diffusa, 12-17 parts of radix scutellariae, yellow It is 11-16 parts of lotus, 13-18 parts of the capsule of weeping forsythia, two 13-19 part of flowers, 19-23 parts of chrysanthemum indicum, 22-28 parts of English of public affairs, 13-19 parts of schizonepeta, windproof 12-17 parts, 14-17 parts of the dried rhizome of rehmannia, 11-17 parts of Poria cocos, 13-16 parts of Radix Angelicae Sinensis, 14-16 parts of Ligusticum wallichii, 12-19 parts of radix glycyrrhizae, tribulus terrestris 23- 26 parts and 23-29 parts of the root of kudzu vine.
Further, the medicine for oral administration for the treatment of acne of the invention, is mixed by the raw mill of following parts by weight：
25 parts of the fruit of summer cypress, 15 parts of indigo naturalis, 15 parts of full worm, 10 parts of oldenlandia diffusa, 15 parts of radix scutellariae, 15 parts of the coptis, the capsule of weeping forsythia 15 Part, two spend 15 parts, 20 parts of chrysanthemum indicum, public 25 parts of English, 15 parts of schizonepeta, windproof 15 parts, 15 parts of the dried rhizome of rehmannia, 15 parts of Poria cocos, 15 parts of Radix Angelicae Sinensis, 25 parts of 15 parts of Ligusticum wallichii, 15 parts of radix glycyrrhizae, 25 parts of tribulus terrestris and the root of kudzu vine.
The externally applied drug for the treatment acne that the present invention is provided, is formed by the raw material of following parts by weight is brewed：
Full 10-20 parts of worm, 10-20 parts of centipede, 30-40 parts of kuh-seng, 30-40 parts of frutus cnidii, 30-40 parts of honeycomb, Fructus meliae toosendan 5-15 parts of 20-30 parts, 10-20 parts of snake slough, 5-15 parts of sulphur and borneol.
Further, the externally applied drug for the treatment of acne of the invention, is formed by the raw material of following parts by weight is brewed：
Complete 15 parts of worm, 15 parts of centipede, 35 parts of kuh-seng, 35 parts of frutus cnidii, 35 parts of honeycomb, 25 parts of Fructus meliae toosendan, 15 parts of snake slough, sulphur 10 parts of 10 parts of sulphur and borneol.
The medicament preparation for oral administration for the treatment acne that the present invention is provided, comprises the following steps：
S1：The raw material of the medicine for oral administration of above-mentioned treatment acne is chosen, mixed grinding forms powdered semi-finished product standby into powder With；
S2：Powdered semi-finished product stirring in above-mentioned S1 is mixed to form the medicine for oral administration that powder shape treats acne, mixing speed Degree is in the range of 120rpm-150rpm, and incorporation time is in the range of 5min-10min.
Further, the medicament preparation for oral administration for the treatment of acne of the invention, in addition to：
S3：The medicine for oral administration of powder shape treatment acne in above-mentioned S2 is filled in capsule, capsule shape treatment acne is formed Medicine for oral administration.
Further, the medicament preparation for oral administration for the treatment of acne of the invention, in addition to：
S3 ＇：The medicine for oral administration and honey mf mass pil shape of powder shape treatment acne in above-mentioned S2 are treated into acne Medicine for oral administration.
The method for preparing externally applied for the treatment acne that the present invention is provided, comprises the following steps：
S1：The raw material of the externally applied drug of above-mentioned treatment acne is chosen, mixture is mixed to form standby；
S2：Mixture in above-mentioned S1 is put into 43%-58% grain wine brewed 55-65 days.
Further, in S2, the mixture in above-mentioned S1 is put into 50% grain wine brewed 60 days.
(3) beneficial effect
The beneficial effects of the invention are as follows：
In the medicine for oral administration of the treatment acne of the present invention, the fruit of summer cypress, indigo naturalis clearing damp and promoting diuresis, clearing heat and detoxicating, blood cooling and ecchymoses removing are altogether Monarch drug in a prescription；
Radix scutellariae, coptis root, the capsule of weeping forsythia, two flowers, chrysanthemum indicum, public English, oldenlandia diffusa, the dried rhizome of rehmannia, Radix Angelicae Sinensis, Poria cocos clearing heat and cooling blood are dispelled It is wet, it is altogether ministerial drug；
Schizonepeta, the windproof, root of kudzu vine, tribulus terrestris expelling wind and eliminating dampness, full worm relieves dizziness, high fever, infantile convulsions, epilepsy, etc. dispersing pathogen accumulation, is altogether adjutant；
Ligusticum wallichii expelling wind and activating blood flow promoting the circulation of qi, the above-mentioned each raw material of radix glycyrrhizae mediation is to make medicine altogether；
Above-mentioned each raw material is common Chinese medicine, on the one hand, with low cost；On the other hand, collective effect there is clearing heat and promoting diuresis, it is cool Effect of blood removing toxic substances, the externally applied drug with treatment acne is used cooperatively, for the acne of puberty men and women, and curative effect is obvious, it is multiple to be difficult Send out and have no toxic side effect.
In the medicament preparation for oral administration of the treatment acne of the present invention, by the fruit of summer cypress, indigo naturalis, full worm, oldenlandia diffusa, Huang A kind of reed mentioned in ancient books, coptis root, the capsule of weeping forsythia, two flowers, chrysanthemum indicum, public English, schizonepeta, the windproof, dried rhizome of rehmannia, Poria cocos, Radix Angelicae Sinensis, Ligusticum wallichii, radix glycyrrhizae, tribulus terrestris and the root of kudzu vine Ground and mixed is made, and preparation method is simple.
In the externally applied drug of the treatment acne of the present invention, full worm, the removing toxic substances of centipede ceases wind, dissipating bind dredging collateral, are altogether monarch drug in a prescription；
Kuh-seng, frutus cnidii, Fructus meliae toosendan heat-clearing and damp-drying drug, wind-dispelling removing toxic substances, are altogether ministerial drug；
It is snake slough, honeycomb wind dispelling insecticide, antipruritic, it is altogether adjutant；
Sulphur, borneol desinsection treat sore, swelling and pain relieving, heat-clearing dissipates poison, are to make medicine altogether；
Above-mentioned each raw material is common Chinese medicine, on the one hand, with low cost, on the other hand, and collective effect has heat-clearing and damp-drying drug, solution Effect of malicious dissipating bind, is used cooperatively with the medicine for oral administration of above-mentioned treatment acne, for the acne of puberty men and women, and curative effect is substantially, no Easily recur and have no toxic side effect.
In the method for preparing externally applied of the treatment acne of the present invention, by full worm, centipede, kuh-seng, frutus cnidii, honeycomb, melia toosendan Son, snake slough, sulphur and borneol is brewed forms, preparation method is simple.
To sum up, the medicine for oral administration for the treatment of acne of the invention, externally applied drug are with low cost, for the acne of puberty men and women, treat Effect is obvious, uneasy to recur and has no toxic side effect.Medicine for oral administration, the method for preparing externally applied of the treatment acne of the present invention are simple.
Embodiment
In order to preferably explain the present invention, in order to understand, by embodiment, the present invention is described in detail.
Embodiment 1
Choose the raw material of following quality：Fruit of summer cypress 25g, indigo naturalis 15g, full worm 15g, oldenlandia diffusa 10g, radix scutellariae 15g, Huang Even 15g, capsule of weeping forsythia 15g, two spend 15g, chrysanthemum indicum 20g, public English 25g, schizonepeta 15g, windproof 15g, dried rhizome of rehmannia 15g, Poria cocos 15g, Radix Angelicae Sinensis 15g, Ligusticum wallichii 15g, radix glycyrrhizae 15g, tribulus terrestris 25g and root of kudzu vine 25g.
Specifically, the medicament preparation for oral administration of the treatment acne of the present embodiment, comprises the following steps：
S1：Choose the raw material of the medicine for oral administration of the treatment acne of above-mentioned quality, mixed grinding into powder, formed powdered half into Product are standby；
S2：Powdered semi-finished product stirring in above-mentioned S1 is mixed to form the medicine for oral administration that powder shape treats acne, mixing speed Spend 135rpm, incorporation time 8min.
More specifically, the medicine for oral administration of the treatment acne of the present embodiment can also comprise the following steps：
S3：The medicine for oral administration of powder shape treatment acne in above-mentioned S2 is filled in capsule, capsule shape treatment acne is formed Medicine for oral administration.
Or, the medicine for oral administration of the treatment acne of the present embodiment can also comprise the following steps：
S3 ＇：The medicine for oral administration and honey mf mass pil shape of powder shape treatment acne in above-mentioned S2 are treated into acne Medicine for oral administration.
Using in the medicine for oral administration of capsule shape treatment acne made from above-mentioned steps S3 or S3 ＇ or pill shape treatment acne Medication, with the medicine for oral administration using powder shape treatment acne made from above-mentioned S2 in the curative effect for the treatment of acne without essential distinction.
In the medicine for oral administration of the treatment acne of the present invention, fruit of summer cypress clearing heat and promoting diuresis, dispelling wind and arresting itching, for rubella, eczema, skin The treatment of itch；
Indigo naturalis clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body；
Full worm ceases wind antispastic, dispersing pathogen accumulation, remove obstruction in channels to relieve pain, cure mainly rheumatoid arthritis stubborn, sore, scrofula；
Oldenlandia diffusa is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness, outstanding kind treatment all kinds inflammation；
Radix scutellariae heat-clearing and damp-drying drug, cool blood are antiabortive, removing toxic substances, cure mainly the diseases such as warm heat disease, cough with lung heat, neonatal jaundice caused by dampness-heat, carbuncle swells furuncle sore；
Coptis heat-clearing and damp-drying drug, purging intense heat and detonicating, it is wet for damp and hot feeling of fullness, heart-fire hyperactivity, dysphoria and insomnia, carbuncle swells furunculosis, eczema Sore；
The capsule of weeping forsythia is clearing heat and detoxicating, dispersing swelling and dissipating binds, for ulcer, scrofula；
Two flower dispelling wind-heats, removing summer-heat blood poison, for various febrile diseases, such as body heat, dermexanthesis, hair spot, heat toxin sore carbuncle disease；
Chrysanthemum indicum dispelling wind and heat from the body, subdhing swelling and detoxicating, can treat the diseases such as furunculosis carbuncle swells；
Public English diuresis, laxative；
Schizonepeta town phlegm, wind-dispelling, cool blood, inducing diaphoresis dissipate wind, promoting eruption, the sore that disappears, hemostasis, for measles without adequate eruption；
Windproof diseases caused by external factors exterior syndrome, for rubella itch, arthralgia pain due to rheumatism；
Dried rhizome of rehmannia clearing heat and cooling blood, ying blood, blood-heat and toxin exuberance, atropurpureus macula are entered for warm heat disease heat；
Poria cocos dampness removing can control difficult urination, oedema turgor, phlegm and retained fluid and cough the diseases such as inverse, vomiting during early pregnancy without hindering healthy tendency；
Chinese angelica blood supplementing, promoting blood circulation, moisturize laxation, cure mainly ulcer sores；
Ligusticum wallichii expelling wind and activating blood flow promoting the circulation of qi, treatment ulcer sores etc.；
Radix glycyrrhizae is clearing heat and detoxicating, expelling phlegm and arresting coughing；
Tribulus terrestris flat liver solution strongly fragrant, dispelling pathogenic wind for improving eyesight, for diseases such as pruituses；
The heating of root of kudzu vine exterior syndrome, stiff nape and back, measles without adequate eruption, for pyreticosis to be thirsty, the deficiency of Yin is quenched one's thirst, splenasthenic diarrhea.
To sum up, in the medicine for oral administration for the treatment of acne of the invention, the fruit of summer cypress, indigo naturalis clearing damp and promoting diuresis, clearing heat and detoxicating, cool blood disappear Spot, is altogether monarch drug in a prescription；
Radix scutellariae, coptis root, the capsule of weeping forsythia, two flowers, chrysanthemum indicum, public English, oldenlandia diffusa, the dried rhizome of rehmannia, Radix Angelicae Sinensis, Poria cocos clearing heat and cooling blood are dispelled It is wet, it is altogether ministerial drug；
Schizonepeta, the windproof, root of kudzu vine, tribulus terrestris expelling wind and eliminating dampness, full worm relieves dizziness, high fever, infantile convulsions, epilepsy, etc. dispersing pathogen accumulation, is altogether adjutant；
Ligusticum wallichii expelling wind and activating blood flow promoting the circulation of qi, the above-mentioned each raw material of radix glycyrrhizae mediation is to make medicine altogether；
Above-mentioned each raw material is common Chinese medicine, on the one hand, with low cost；On the other hand, collective effect there is clearing heat and promoting diuresis, it is cool Effect of blood removing toxic substances, the externally applied drug with treatment acne is used cooperatively, for the acne of puberty men and women, and curative effect is obvious, it is multiple to be difficult Send out and have no toxic side effect.
The medicament preparation for oral administration of the treatment acne of the present invention is simple.
The preparation process of be the same as Example 1 is similar, embodiment 2-9 be by adjust the quality of each raw material in preparation process, The incorporation time in mixing velocity and S2 in S2 prepares the medicine for oral administration for the treatment of acne.Embodiment 2-9 is to treatment acne Medicine for oral administration preparation situation it is specifically as shown in table 1.
Table 1：Preparation situations of the embodiment 2-9 to the medicine for oral administration for the treatment of acne
The medicine for oral administration for the treatment of acne prepared by above-described embodiment 1-9 coordinates the externally applied drug of the treatment acne of same composition, right Treatment acne is respectively provided with obvious curative effects.Wherein, in above-described embodiment 1-9, the medicine for oral administration for the treatment of acne prepared by embodiment 1 is matched somebody with somebody The externally applied drug of the treatment acne of the composition of contract one, it is best to treatment acne curative effect.
Embodiment 10
Choose the raw material of following quality：Full worm 15g, centipede 15g, kuh-seng 35g, frutus cnidii 35g, honeycomb 35g, Fructus meliae toosendan 25g, snake slough 15g, sulphur 10g and borneol 10g.
Specifically, the method for preparing externally applied of the treatment acne of the present embodiment, comprises the following steps：
S1：The raw material of the externally applied drug of the treatment acne of above-mentioned quality is chosen, mixture is mixed to form standby；
S2：Mixture in above-mentioned S1 is put into 50% grain wine brewed 60 days.
In the externally applied drug of the treatment acne of the present invention, full worm ceases wind antispastic, dispersing pathogen accumulation, remove obstruction in channels to relieve pain, treatment of ulcer, scrofula Scrofula；
Centipede ceases wind antispastic, dispersing pathogen accumulation, remove obstruction in channels to relieve pain, for sore, scrofula；
Kuh-seng heat-clearing and damp-drying drug, wind-dispelling removing toxic substances, for eczema, wet sore, pruitus, mange leprosy；
Frutus cnidii eliminating dampness, wind-dispelling, desinsection；
Honeycomb detoxicating and destroying parasites, wind-expelling pain-stopping, for sore swollen toxin, scrofula, skin stubborn dermatitis；
Fructus meliae toosendan relaxes liver, promoting qi circulation and relieving pain, expelling parasite；
Snake slough wind-dispelling, calm the frightened, detoxify, moving back screen, for pruitus；
Sulphur external application energy desinsection is antipruritic, disinfection, kill scabies；
Borneol leads to all keys, dissipates stagnated fire, swelling and pain relieving.
To sum up, in the externally applied drug for the treatment of acne of the invention, full worm, the removing toxic substances of centipede ceases wind, dissipating bind dredging collateral, are altogether monarch drug in a prescription；
Kuh-seng, frutus cnidii, Fructus meliae toosendan heat-clearing and damp-drying drug, wind-dispelling removing toxic substances, are altogether ministerial drug；
It is snake slough, honeycomb wind dispelling insecticide, antipruritic, it is altogether adjutant；
Sulphur, borneol desinsection treat sore, swelling and pain relieving, heat-clearing dissipates poison, are to make medicine altogether；
Above-mentioned each raw material is common Chinese medicine, on the one hand, with low cost, on the other hand, and collective effect has heat-clearing and damp-drying drug, solution Effect of malicious dissipating bind, is used cooperatively with the medicine for oral administration of above-mentioned treatment acne, for the acne of puberty men and women, and curative effect is substantially, no Easily recur and have no toxic side effect.
The method for preparing externally applied of the treatment acne of the present invention is simple.
The preparation process of be the same as Example 10 is similar, and embodiment 11-18 is the matter by adjusting each raw material in preparation process Amount, the brew time in S2 in the number of degrees and S2 of grain wine prepare the externally applied drug for the treatment of acne.Embodiment 11-18 is to controlling The preparation situation for treating the externally applied drug of acne is specifically as shown in table 2.
Table 2：Preparation situations of the embodiment 11-18 to the externally applied drug for the treatment of acne
The externally applied drug for the treatment of acne prepared by above-described embodiment 10-18 coordinates the medicine for oral administration of the treatment acne of same composition, Obvious curative effects are respectively provided with to treatment acne, wherein, in above-described embodiment 10-18, outside treatment acne prepared by embodiment 10 Medication coordinates the medicine for oral administration of the treatment acne of same composition, best to treatment acne curative effect.
The instructions of taking of the medicine for oral administration of the treatment acne of the present invention：3 times a day, one after each meal, each taking containing in dosage The common 3-6g of raw material；The lighter patient of the state of an illness and initial patient need to take one to two course for the treatment of, disease long and patient with severe symptoms need to take three to Six courses for the treatment of a, course for the treatment of is 30 days.
The application method of the externally applied drug of the treatment acne of the present invention：Two stages are divided into, the first stage smeared one every 1 day Secondary, second stage was smeared once every 3 days, and the time of first stage and second stage is equal；The lighter patient of the state of an illness and initial patient need One to two course for the treatment of is used in conjunction, disease is long and three to six courses for the treatment of need to be used in conjunction in patient with severe symptoms, and a course for the treatment of is 30 days.
The externally applied drug of the treatment acne of the present invention and the medicine for oral administration for the treatment of acne are used simultaneously, and during medication, avoid tea, Cigarette, wine and spicy food.
The externally applied drug of the medicine for oral administration and treatment acne of the treatment acne of the present invention is used cooperatively, treatment acne, Lung Qi deficiency, spleen It is damp and hot contain, the symptom such as skin resistance is weak, have preferable curative effect.
The clinical trial results being shown below, are the non-public property clinical trials that applicant is carried out in specific region, at this Not to anyone open drug ingedient and preparation method before applying for date of filing.
Clinical trial one
126 patients with acne, take the medicine for oral administration of the treatment acne of the present invention orally, while coordinating the outer treatment Cuo for smearing the present invention The externally applied drug of sore, the concrete condition of clinical trial treatment acne is as follows：
(1) basic condition of patients with acne：
Male 61, women 65, age 15-30 Sui, the one full year of life of average age 22.5, the course of disease most short number day is most long 10 years.
(2) diagnostic criteria：
The cardinal symptom of acne is the skin damageds such as acne, papule, warts, the tumour at face, upper chest, back etc..Wherein,
Acne：From the beginning of for grain grain or aperture size papule, there is white translucent of embolism, head black matrix in hair follicle aperture, It can go out during extruding；
Papule：Sebaceous glands mouthful entirely shuts, and forms papule, there is blackhead in center, can form inflammatory or non-inflammation Papule；
Warts：Infected on the basis of papule, occur at the top of papule, have and sticky yellow purulence is flowed out after warts, ulceration；
Tumour：The sebaceous cyst that skin lesions circumferece formation is differed in size, normal color of the leather or kermesinus, can there is courage and uprightness during pressing Or gluey secretion discharge；
Tubercle：When inflammation is deeper, the wall of warts thickeies, and forms light red or purplish red tubercle, or protuberance is in hemisphere or circular cone Shape, can exist for a long time, also can gradually absorb, and also have routed purulence to scab or into sinus person.
Any of the above skin damaged, can with it is several and meanwhile in the presence of, it is also possible to mutual inversion of phases, most of patients is with seborrhea, nothing Subjective symptoms, if inflammation can cause pain and tenderness when obvious.
(3) medicine application method：
Used according to patient's actual conditions.
The medicine for oral administration of the treatment acne of the present invention, 3 times a day, one after each meal, each taking the common 3-6g containing raw material in dosage； The lighter patient of the state of an illness and initial patient need to take one to two course for the treatment of, and disease is long and patient with severe symptoms need to take three to six courses for the treatment of, one The individual course for the treatment of is 30 days.
The externally applied drug of the treatment acne of the present invention, is divided into two stages, the first stage smeared once every 1 day, second stage Smeared once every 3 days, the time of first stage and second stage is equal；One to two need to be used in conjunction in the lighter patient of the state of an illness and initial patient The course for the treatment of, disease is long and three to six courses for the treatment of need to be used in conjunction in patient with severe symptoms, and a course for the treatment of is 30 days (points for attention：Treat the external application of acne Medicine takes orally poisonous, it is impossible to oral, can only external application).
During the medicine for oral administration for taking treatment acne, all patients cut out other drugs, and advise patient avoid tea, cigarette, Wine and spicy food.
(4) efficacy assessment standard is as shown in table 3：
Table 3：Treat medicine for oral administration, the efficacy assessment standard of externally applied drug of acne
Cure Symptom all disappears
It is effective Symptom substantially mitigates
Effectively Symptom has been alleviated, mitigated, but not obvious enough
It is invalid It is continuous to use six months, do not reach effective standard
In table 3, all patients are both needed to use blood test, further make a definite diagnosis.
(5) medicine is as shown in table 4 using result：
Table 4：Treat medicine for oral administration, the use result of externally applied drug of acne
It is total
Patient's number of cases before treatment 126
Cure patient's number of cases 116
Effective patient's number of cases 6
Effective patient's number of cases 4
Refractory patient's number of cases 0
Total effective rate 100%
Table 4 illustrates：In this clinical trial one, above-mentioned 126 patients with acne take for oral administration of the treatment acne of the present invention Medicine, and coordinate simultaneously after the externally applied drug of the outer treatment acne for smearing the present invention, the skin symptom of all patients is all effectively treated, Total effective rate up to 100%, wherein, cure 116, effective 6, in effective 4, and the follow-up of above-mentioned healing patient after one year Do not occur Relapse rate phenomenon.
Above-mentioned clinical trial one illustrates：The medicine for oral administration of the treatment acne of the present invention is taken, while smearing the present invention's outside coordinating The externally applied drug of acne is treated, the acne curative effect to puberty men and women is obvious, uneasy to recur and has no toxic side effect.
Clinical trial model case：
Certain man, 18 years old, suffers from face acnes 2 years, takes the medicine for oral administration that capsule shape of the present invention treats acne, and smear this outside simultaneously The externally applied drug of the treatment acne of invention, 4 courses for the treatment of altogether, symptom all disappears.
Certain female, 19 years old, suffers from face acnes more than a year, takes the medicine for oral administration that capsule shape of the present invention treats acne, and simultaneously outer The externally applied drug of the treatment acne of the present invention is smeared, altogether 3 courses for the treatment of, symptom all disappears.
Certain female, 30 years old, suffers from face acnes blackspot 10 years, takes the medicine for oral administration that capsule shape of the present invention treats acne, and simultaneously The externally applied drug of the treatment acne of the present invention is smeared outside, altogether 6 courses for the treatment of, symptom all disappears.
Certain female, 29 years old, suffers from face acnes 2 years, takes the medicine for oral administration that capsule shape of the present invention treats acne, and smear this outside simultaneously The externally applied drug of the treatment acne of invention, 3 courses for the treatment of altogether, symptom all disappears.
Certain man, 24 years old, suffers from face acnes 5 years, takes the medicine for oral administration that capsule shape of the present invention treats acne, and smear this outside simultaneously The externally applied drug of the treatment acne of invention, 5 courses for the treatment of altogether, symptom all disappears.
Certain man, 15 years old, suffers from facial thoracic dorsal acne 2 years, takes the medicine for oral administration that capsule shape of the present invention treats acne, and simultaneously outer The externally applied drug of the treatment acne of the present invention is smeared, altogether 6 courses for the treatment of, symptom all disappears.
Certain female, 24 years old, suffers from face acnes 3 years, takes the medicine for oral administration that capsule shape of the present invention treats acne, and smear this outside simultaneously The externally applied drug of the treatment acne of invention, 4 courses for the treatment of altogether, symptom all disappears.
Certain man, 19 years old, suffers from face acnes 2 years, takes the medicine for oral administration that capsule shape of the present invention treats acne, and smear this outside simultaneously The externally applied drug of the treatment acne of invention, 4 courses for the treatment of altogether, symptom all disappears.
Above-mentioned clinical trial model case is further illustrated：The medicine for oral administration of the treatment acne of the present invention is taken, is coordinated simultaneously The externally applied drug of the outer treatment acne for smearing the present invention, the acne curative effect to puberty men and women is obvious.
To sum up, the medicine for oral administration for the treatment of acne of the invention, externally applied drug are with low cost, for the acne of puberty men and women, treat Effect is obvious, uneasy to recur and has no toxic side effect.Medicine for oral administration, the method for preparing externally applied of the treatment acne of the present invention are simple.
Above content is only presently preferred embodiments of the present invention, for one of ordinary skill in the art, according to the present invention's Thought, will change in specific embodiments and applications, and this specification content should not be construed as to the present invention Limitation.

Claims (10)

1. a kind of medicine for oral administration for treating acne, it is characterised in that be mixed by the raw mill of following parts by weight：
20-30 parts of the fruit of summer cypress, 10-20 parts of indigo naturalis, full worm 10-20 parts, 5-15 parts of oldenlandia diffusa, 10-20 parts of radix scutellariae, coptis root 10-20 parts, 10-20 parts of the capsule of weeping forsythia, two flower 10-20 part, 15-25 parts of chrysanthemum indicum, public affairs 20-30 parts of English, 10-20 parts of schizonepeta, windproof 10- 20 parts, 10-20 parts of the dried rhizome of rehmannia, 10-20 parts of Poria cocos, 10-20 parts of Radix Angelicae Sinensis, 10-20 parts of Ligusticum wallichii, 10-20 parts of radix glycyrrhizae, tribulus terrestris 20-30 20-30 parts of part and the root of kudzu vine.
2. the medicine for oral administration of acne is treated as claimed in claim 1, it is characterised in that mixed by the raw mill of following parts by weight It is made：
23-29 parts of the fruit of summer cypress, 13-16 parts of indigo naturalis, full worm 12-18 parts, 6-12 parts of oldenlandia diffusa, 12-17 parts of radix scutellariae, coptis root 11-16 parts, 13-18 parts of the capsule of weeping forsythia, two flower 13-19 part, 19-23 parts of chrysanthemum indicum, public affairs 22-28 parts of English, 13-19 parts of schizonepeta, windproof 12- 17 parts, 14-17 parts of the dried rhizome of rehmannia, 11-17 parts of Poria cocos, 13-16 parts of Radix Angelicae Sinensis, 14-16 parts of Ligusticum wallichii, 12-19 parts of radix glycyrrhizae, tribulus terrestris 23-26 23-29 parts of part and the root of kudzu vine.
3. the medicine for oral administration of acne is treated as claimed in claim 2, it is characterised in that mixed by the raw mill of following parts by weight It is made：
25 parts of the fruit of summer cypress, 15 parts of indigo naturalis, 15 parts of full worm, 10 parts of oldenlandia diffusa, 15 parts of radix scutellariae, 15 parts of the coptis, 15 parts of the capsule of weeping forsythia, two Spend 15 parts, 20 parts of chrysanthemum indicum, public 25 parts of English, 15 parts of schizonepeta, windproof 15 parts, 15 parts of the dried rhizome of rehmannia, 15 parts of Poria cocos, 15 parts of Radix Angelicae Sinensis, Ligusticum wallichii 25 parts of 15 parts, 15 parts of radix glycyrrhizae, 25 parts of tribulus terrestris and the root of kudzu vine.
4. a kind of externally applied drug for treating acne, it is characterised in that formed by the raw material of following parts by weight is brewed：
Full 10-20 parts of worm, 10-20 parts of centipede, 30-40 parts of kuh-seng, 30-40 parts of frutus cnidii, 30-40 parts of honeycomb, Fructus meliae toosendan 20-30 Part, 10-20 parts of snake slough, 5-15 parts of sulphur and 5-15 parts of borneol.
5. as claimed in claim 4 treatment acne externally applied drug, it is characterised in that by the raw material of following parts by weight it is brewed and Into：
Complete 15 parts of worm, 15 parts of centipede, 35 parts of kuh-seng, 35 parts of frutus cnidii, 35 parts of honeycomb, 25 parts of Fructus meliae toosendan, 15 parts of snake slough, sulphur 10 10 parts of part and borneol.
6. a kind of medicament preparation for oral administration for treating acne, it is characterised in that comprise the following steps：
S1：Choose the raw material of the medicine for oral administration for the treatment of acne any one of claim 1-3, mixed grinding is into powder, shape Into powdered semi-finished product for standby；
S2：Powdered semi-finished product stirring in above-mentioned S1 is mixed to form the medicine for oral administration that powder shape treats acne, mixing velocity exists In the range of 120rpm-150rpm, incorporation time is in the range of 5min-10min.
7. the medicament preparation for oral administration of acne is treated as claimed in claim 6, it is characterised in that also included：
S3：The medicine for oral administration of powder shape treatment acne in above-mentioned S2 is filled in capsule, the interior of capsule shape treatment acne is formed Medication.
8. the medicament preparation for oral administration of acne is treated as claimed in claim 6, it is characterised in that also included：
S3 ＇：By the medicine for oral administration of powder shape treatment acne in above-mentioned S2 and taking orally for honey mf mass pil shape treatment acne Medicine.
9. a kind of method for preparing externally applied for treating acne, it is characterised in that comprise the following steps：
S1：The raw material of the externally applied drug for the treatment of acne any one of selection claim 4-5, is mixed to form mixture standby With；
S2：Mixture in above-mentioned S1 is put into 43%-58% grain wine brewed 55-65 days.
10. the method for preparing externally applied of acne is treated as claimed in claim 9, it is characterised in that
In S2, the mixture in above-mentioned S1 is put into 50% grain wine brewed 60 days.
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