CN107303280A - Okra chews tablet composition and preparation method thereof - Google Patents

Okra chews tablet composition and preparation method thereof Download PDF

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Publication number
CN107303280A
CN107303280A CN201610244104.6A CN201610244104A CN107303280A CN 107303280 A CN107303280 A CN 107303280A CN 201610244104 A CN201610244104 A CN 201610244104A CN 107303280 A CN107303280 A CN 107303280A
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okra
chews
tablet composition
preparation
powder
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岳进
徐国斌
邓云
贺鑫
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Shanghai Jiaotong University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
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Abstract

Tablet composition and preparation method thereof is chewed the invention provides a kind of okra, the chewable tablets includes the following component matched by constant weight percentage:Okra powder, sweetener, vitamin C, pregelatinized starch, microcrystalline cellulose, lubricant.The preparation method comprises the following steps:After sweetener, vitamin C, pregelatinized starch, microcrystalline cellulose are crushed respectively, sieving is well mixed with okra powder, adds water and be modulated into softwood;The softwood is pelletized, and drying to moisture content is not higher than 7%;Lubricant is added, tabletting and sterilizing are carried out successively after being well mixed, the okra is obtained and chews tablet composition.The present invention is solved the problem of Various Seasonal edible gumbo, and it can fully supplement a variety of trophic function factors contained in gumbo, utilize wet granulation, so that major ingredient and auxiliary material mixing it is more uniform, obtained mobility of particle is caused to greatly enhance simultaneously so that particle is easier to make for tabletting.

Description

Okra chews tablet composition and preparation method thereof
Technical field
Tablet composition and preparation method thereof is chewed the present invention relates to a kind of okra, belongs to natural health technical field of pharmaceuticals.
Background technology
Gumbo (scientific name:Abelmoschus esculentusL.Moench):Also known as okra.Originate in Africa, 20 generation Record and China is just introduced by India, be more common in southern china.Its edible portion is Fruit pod, is divided to green and red two kinds, mouth Feel tender and crisp succulence, lubricious oiliness, fragrance is unique, and seed can extract oil.
Okra it is nutritious, in young fruit contain substantial amounts of stick-slip juice, with special fragrance.It is mixed with its juice Pectin, cow's milk glycan and my glycan etc..Its pectin is Soluble Fiber, is extremely paid attention in the new idea of modern health. It is all often to eat the effect of it has stomach invigorating intestines, nourishing negative and positive.According to surveying and determination containing 2.5 grams of protein, fat in every hectogram okra fruit 0.1 gram, 2.7 grams of carbohydrate, the international units of cellulose A 660.Raw B20.06 milligrams of the speed of .2 milligrams of vitaminB10, dimension, 44 milligrams of vitamin, 81 milligrams of calcium, 63 milligrams of phosphorus, 0.8 milligram of iron, are that a kind of new century, preferably high-grade green was sought Support health-care vegetable.
Vitamin A in okra can effectively protect retina, it is ensured that good eyesight, prevent cataract from producing;Really The stickum of the composition such as glue and polysaccharide, has to human body and promotes enterogastric peristalsis, prevents the health-care effects such as constipation, appropriate food With can enhancing sexual function, the endurance of human body can also be strengthened;And okra low-sugar low-fat, diet food can be used as;Due to It contains zinc and selenium and other trace elements, can strengthen human body cancer-resisting ability, it can also prevention of cardiovascular rich in vitamin C Disease occurs.
Okra is unique because of its local flavor and nutrition, and deep to be doted on by consumer, not only market demand expands day by day, to the yellow autumn The nutrient functional demand of certain herbaceous plants with big flowers also gradually increases, but at present, the application for gumbo only rests on cooking dish, fresh The edible of gumbo is seriously limited by region and time, lacks the deep process technology to gumbo, effective utilization of okra It cannot ensure.In the prior art for okra processing method such as Chinese patent (CN103636746), Chinese patent (CN104543835), Chinese patent (CN104544103) describes the drying processing method to okra respectively, yellow Compacting is simply mixed with honey in simple mixing compacting after gumbo and fruit drying and crushing, okra powder, okra pollen Technique, technique is comparatively simple, but can not realize effective utilization to the medical value of okra.
The content of the invention
The invention aims to solve the problem of okra utilization rate is low, it is convenient for carrying while providing one kind, medicine High, the good mouthfeel with value, the okra of convenient digestion dilution chews tablet composition and preparation method thereof.
The present invention is achieved by the following technical solutions:
In a first aspect, the invention provides a kind of okra chew tablet composition, it include percentage as Lower component:
Okra powder content is between 30~50%, too high okra powder content, and chewable tablets chewiness can be caused to be deteriorated, Mouthfeel is not good.If okra powder content is too low, the color of okra chewable tablets can be caused bad.Vitamin C is used as acid Taste agent, the ratio with sweetener is 1:15~1:It is the key for the okra chewable tablets for producing sweet and sour taste between 17. Binder content is too low to cause chewable tablets to be difficult to be molded, and hardness and friability are difficult to reach Standard.If too high levels, The mouthfeel of chewable tablets can then be largely effected on.
Preferably, the sweetener includes at least one of xylitol and mannitol.
Preferably, the sweetener is the mixture of xylitol and mannitol, and xylitol and mannitol Weight ratio is 8:9.
Preferably, the lubricant is magnesium stearate.
Second aspect, present invention also offers the preparation method that a kind of okra as the aforementioned chews tablet composition, its Comprise the following steps:
After sweetener, vitamin C, pregelatinized starch, microcrystalline cellulose are crushed respectively, sieving, with okra Powder is well mixed,
Add water and be modulated into softwood;
The softwood is pelletized, and drying to moisture content is not higher than 7%;
Lubricant is added, tabletting and sterilizing are carried out successively after being well mixed, the okra is obtained and chews tablet composition.
Preferably, the preparation method of the okra powder is:
The fresh okra of freezing is thawed, after vacuum microwave drying, is crushed, is crossed 100 mesh sieves, obtain Huang Gumbo powder.
Preferably, the moisture content of the okra powder is not higher than 8%.
Preferably, the condition of the vacuum microwave drying is:Microwave power 500W, drying temperature is 50~60 DEG C, vacuum is 0.06Mpa, and drying time is 135min.
Preferably, a diameter of 1cm for the compression mold that the tabletting is selected, thickness is 3~4mm.
Chewable tablets is after a class direct oral cavity is chewed, the tablet that can swallow, easy to carry with good taste, steady quality, The longer advantage of shelf life, can promote nutritional ingredient to dissolve, absorb in vivo after chewing, and bioavilability is high. For the medicine of hardly possible disintegration, chewable tablets, which is made, to accelerate it to be disintegrated, and improve drug effect.Chewable tablets is convenient to take, even in scarce Under conditions of water can also medication on time, be particularly suitable for use in children, old man, dysphagia or the poor patient of gastrointestinal function, Burden of the medicine to intestines and stomach can be reduced.
Chewable tablets prepared by present invention selection xylitol, mannitol, starch, microcrystalline cellulose (MCC), vitamin C, Magnesium stearate etc. is used as auxiliary material.Wherein, mannitol, xylitol not only effectively improves okra nozzle as sweetener The taste of piece is chewed, simultaneously because the rise of blood glucose will not be caused, it is adaptable to which the patient with diabetes takes.Chewable tablets Auxiliary material does not have particular/special requirement, and mouthfeel is crucial.Chewable tablets has been widely used in food and health products research field, this kind of Novel foodstuff tablet has alimentary health-care function, is good casual health food.
Therefore, compared with prior art, the present invention has following beneficial effect:
The preparation technology of okra chewable tablets among the present invention, is solved the problem of Various Seasonal edible gumbo, and And a variety of trophic function factors contained in gumbo can be fully supplemented, utilize wet granulation so that major ingredient and auxiliary material mixing It is more uniform, while so that obtained mobility of particle is greatly enhanced so that particle is easier to make for tabletting.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to those skilled in the art Member further understands the present invention, but the invention is not limited in any way.It should be pointed out that to the common skill of this area For art personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These are belonged to Protection scope of the present invention.
Embodiment 1
A kind of okra chewable tablets that the present embodiment is provided, major ingredient and ratio of adjuvant are as follows:Okra powder 40%;Xylitol 14.4%;Mannitol 13%;Vitamin C 1.6%;Pregelatinized starch 15.5%;MCC15%;Magnesium stearate 0.5%; Pure water 12% (another to add).
The okra chewable tablets preparation technology that the present invention is provided is as follows:
1st, okra powder is prepared:The fresh okra of freezing is thawed, after vacuum microwave drying, crushed, mistake 100 mesh sieves, are made okra powder used (moisture content is about 8% or so);
2nd, raw material is mixed:100 are crossed after in advance crushing xylitol, mannitol, vitamin C, pregelatinized starch, MCC Mesh sieve, then according to okra powder 40%;Xylitol 14.4%;Mannitol 13%;Vitamin C 1.6%;Pregelatinated forms sediment Powder 15.5%;MCC15% ratio, okra powder and each auxiliary material are well mixed;
3rd, softwood processed:After treating that material is well mixed, 12% pure water is slowly added to using watering can, humidity of materials is adjusted, Softwood is made, its soft or hard degree pinches agglomerating with hand, light pressure, which dissipates, to be defined;
4th, granulation is with drying:By ready-made softwood, pelletized with 20 eye mesh screens, be placed in baking oven and dry to moisture content 7%;
5th, tabletting and sterilizing:To the magnesium stearate of the particle addition 0.5% after whole grain as lubricant, after being well mixed, Tabletting machine is dosed into, and is irradiated 20~30 minutes under ultraviolet light, is packed in time.
Embodiment 2:
A kind of okra chewable tablets that the present invention is provided, major ingredient and ratio of adjuvant are as follows:Okra powder 50%;Xylitol 12.5%;Mannitol 11%;Vitamin C 1.5%;Pregelatinized starch 12.5%;MCC 12%;Magnesium stearate 0.5%; Pure water 12% (another to add).
The okra chewable tablets preparation technology that the present invention is provided is as follows:
1st, okra powder is prepared:The fresh okra of freezing is thawed, after vacuum microwave drying, crushed, mistake 100 mesh sieves, are made okra powder used (moisture content is about 8% or so);
2nd, raw material is mixed:100 are crossed after in advance crushing xylitol, mannitol, vitamin C, pregelatinized starch, MCC Mesh sieve, then according to okra powder 50%;Xylitol 12.5%;Mannitol 11%;Vitamin C 1.5%;Pregelatinated forms sediment Powder 12.5%;MCC 12% ratio, okra powder and each auxiliary material are well mixed;
3rd, softwood processed:After treating that material is well mixed, 12% pure water is slowly added to using watering can, humidity of materials is adjusted, Softwood is made, its soft or hard degree pinches agglomerating with hand, light pressure, which dissipates, to be defined;
4th, granulation is with drying:By ready-made softwood, pelletized with 20 eye mesh screens, be placed in baking oven and dry to moisture content 7%;
5th, tabletting and sterilizing:To the magnesium stearate of the particle addition 0.5% after whole grain as lubricant, after being well mixed, Tabletting machine is dosed into, and is irradiated 20~30 minutes under ultraviolet light, is packed in time.
Embodiment 3:
A kind of okra chewable tablets that the present invention is provided, major ingredient and ratio of adjuvant are as follows:Okra powder 40%;Xylitol 14%;Mannitol 14.3%;Vitamin C 1.2%;Pregelatinized starch 13%;MCC 17%;Magnesium stearate 0.5%; Pure water 11% (another to add).
The okra chewable tablets preparation technology that the present invention is provided is as follows:
1st, okra powder is prepared:The fresh okra of freezing is thawed, after vacuum microwave drying, crushed, mistake 100 mesh sieves, are made okra powder used (moisture content is about 8% or so);
2nd, raw material is mixed:100 are crossed after in advance crushing xylitol, mannitol, vitamin C, pregelatinized starch, MCC Mesh sieve, then according to okra powder 40%;Xylitol 14%;Mannitol 14.3%;Vitamin C 1.2%;Pregelatinated forms sediment Powder 13%;MCC 17% ratio, okra powder and each auxiliary material are well mixed;
3rd, softwood processed:After treating that material is well mixed, 11% pure water is slowly added to using watering can, humidity of materials is adjusted, Softwood is made, its soft or hard degree pinches agglomerating with hand, light pressure, which dissipates, to be defined;
4th, granulation is with drying:By ready-made softwood, pelletized with 20 eye mesh screens, be placed in baking oven and dry to moisture content 7%;
5th, tabletting and sterilizing:To the magnesium stearate of the particle addition 0.5% after whole grain as lubricant, after being well mixed, Tabletting machine is dosed into, and is irradiated 20~30 minutes under ultraviolet light, is packed in time.
Embodiment 4:
A kind of okra chewable tablets that the present invention is provided, major ingredient and ratio of adjuvant are as follows:Okra powder 40%;Xylitol 14%;Mannitol 15.9%;Vitamin C 1.6%;Pregelatinized starch 13%;MCC 15%;Magnesium stearate 0.5%; Pure water 11% (another to add).
The okra chewable tablets preparation technology that the present invention is provided is as follows:
1st, okra powder is prepared:The fresh okra of freezing is thawed, after vacuum microwave drying, crushed, mistake 100 mesh sieves, are made okra powder used (moisture content is about 8% or so);
2nd, raw material is mixed:100 are crossed after in advance crushing xylitol, mannitol, vitamin C, pregelatinized starch, MCC Mesh sieve, then according to okra powder 40%;Xylitol 14%;Mannitol 15.9%;Vitamin C 1.6%;Pregelatinated forms sediment Powder 13%;MCC 15% ratio, okra powder and each auxiliary material are well mixed;
3rd, softwood processed:After treating that material is well mixed, 11% pure water is slowly added to using watering can, humidity of materials is adjusted, Softwood is made, its soft or hard degree pinches agglomerating with hand, light pressure, which dissipates, to be defined;
4th, granulation is with drying:By ready-made softwood, pelletized with 20 eye mesh screens, be placed in baking oven and dry to moisture content 7%;
5th, tabletting and sterilizing:To the magnesium stearate of the particle addition 0.5% after whole grain as lubricant, after being well mixed, Tabletting machine is dosed into, and is irradiated 20~30 minutes under ultraviolet light, is packed in time.
Embodiment 5:
A kind of okra chewable tablets that the present invention is provided, major ingredient and ratio of adjuvant are as follows:Okra powder 40%;Xylitol 16%;Mannitol 12.3%;Vitamin C 1.2%;Pregelatinized starch 13%;MCC 17%;Magnesium stearate 0.5%; Pure water 11.5% (another to add).
The okra chewable tablets preparation technology that the present invention is provided is as follows:
1st, okra powder is prepared:The fresh okra of freezing is thawed, after vacuum microwave drying, crushed, mistake 100 mesh sieves, are made okra powder used (moisture content is about 8% or so);
2nd, raw material is mixed:100 are crossed after in advance crushing xylitol, mannitol, vitamin C, pregelatinized starch, MCC Mesh sieve, then according to okra powder 40%;Xylitol 16%;Mannitol 12.3%;Vitamin C 1.2%;Pregelatinated forms sediment Powder 13%;MCC 17% ratio, okra powder and each auxiliary material are well mixed;
3rd, softwood processed:After treating that material is well mixed, 11.5% pure water is slowly added to using watering can, humidity of materials is adjusted, Softwood is made, its soft or hard degree pinches agglomerating with hand, light pressure, which dissipates, to be defined;
4th, granulation is with drying:By ready-made softwood, pelletized with 20 eye mesh screens, be placed in baking oven and dry to moisture content 7%;
5th, tabletting and sterilizing:To the magnesium stearate of the particle addition 0.5% after whole grain as lubricant, after being well mixed, Tabletting machine is dosed into, and is irradiated 20~30 minutes under ultraviolet light, is packed in time.
Embodiment 6:
A kind of okra chewable tablets that the present invention is provided, major ingredient and ratio of adjuvant are as follows:Okra powder 36.5%;Xylitol 16%;Mannitol 12.3%;Vitamin C 1.2%;Pregelatinized starch 13%;MCC 17%;Magnesium stearate 4%;It is pure Water purification 11.5% (another to add).
The okra chewable tablets preparation technology that the present invention is provided is as follows:
1st, okra powder is prepared:The fresh okra of freezing is thawed, after vacuum microwave drying, crushed, mistake 100 mesh sieves, are made okra powder used (moisture content is about 8% or so);
2nd, raw material is mixed:100 are crossed after in advance crushing xylitol, mannitol, vitamin C, pregelatinized starch, MCC Mesh sieve, then according to okra powder 36.5%;Xylitol 16%;Mannitol 12.3%;Vitamin C 1.2%;Pregelatinated Starch 13%;MCC 17% ratio, okra powder and each auxiliary material are well mixed;
3rd, softwood processed:After treating that material is well mixed, 11.5% pure water is slowly added to using watering can, humidity of materials is adjusted, Softwood is made, its soft or hard degree pinches agglomerating with hand, light pressure, which dissipates, to be defined;
4th, granulation is with drying:By ready-made softwood, pelletized with 20 eye mesh screens, be placed in baking oven and dry to moisture content 7%;
5th, tabletting and sterilizing:To the magnesium stearate of the particle addition 4% after whole grain as lubricant, after being well mixed, throw Expect tabletting machine, and irradiate 20~30 minutes under ultraviolet light, pack in time.
In summary, this okra chewable tablets completes by using rational sugar-acid ratio and the taste of okra chewable tablets is changed Kind, the ratio using appropriate gelling starch and MCC enables okra powder to carry out wet granulation and tabletting, finally Obtain easy to carry, taste is good, nutritious okra chewable tablets.
The specific embodiment of the present invention is described above.It is to be appreciated that the invention is not limited in upper Particular implementation is stated, those skilled in the art can make various deformations or amendments within the scope of the claims, This has no effect on the substantive content of the present invention.

Claims (9)

1. a kind of okra chews tablet composition, it is characterised in that the following component including percentage:
2. okra as claimed in claim 1 chews tablet composition, it is characterised in that the sweetener includes At least one of xylitol and mannitol.
3. okra as claimed in claim 2 chews tablet composition, it is characterised in that the sweetener is wood The mixture of sugar alcohol and mannitol, and the weight ratio of xylitol and mannitol is 1:1.
4. okra as claimed in claim 1 chews tablet composition, it is characterised in that the lubricant is hard Fatty acid magnesium.
5. a kind of okra as described in any one in Claims 1 to 4 chews the preparation method of tablet composition, It is characterised in that it includes following steps:
After sweetener, vitamin C, pregelatinized starch, microcrystalline cellulose are crushed respectively, sieving, with okra Powder is well mixed,
Add water and be modulated into softwood;
The softwood is pelletized, and drying to moisture content is not higher than 7%;
Lubricant is added, tabletting and sterilizing are carried out successively after being well mixed, the okra is obtained and chews tablet composition.
6. okra as claimed in claim 5 chews the preparation method of tablet composition, it is characterised in that described The preparation method of okra powder is:
The fresh okra of freezing is thawed, after vacuum microwave drying, is crushed, is crossed 100 mesh sieves, obtain Huang Gumbo powder.
7. okra as claimed in claim 6 chews the preparation method of tablet composition, it is characterised in that described The moisture content of okra powder is not higher than 8%.
8. okra as claimed in claim 6 chews the preparation method of tablet composition, it is characterised in that described The condition of vacuum microwave drying is:Microwave power 500W, drying temperature is 50~60 DEG C, and vacuum is 0.06Mpa, Drying time is 135min.
9. okra as claimed in claim 5 chews the preparation method of tablet composition, it is characterised in that described The a diameter of 1cm for the compression mold that tabletting is selected, thickness is 3~4mm.
CN201610244104.6A 2016-04-19 2016-04-19 Okra chews tablet composition and preparation method thereof Pending CN107303280A (en)

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
CN110463904A (en) * 2019-09-05 2019-11-19 沈阳师范大学 A kind of wheat bran compound nutritional chewable tablets and its processing method
CN110522022A (en) * 2019-09-20 2019-12-03 浙江大学 Okra powder of relax bowel and defecation and preparation method thereof
CN112715878A (en) * 2020-12-25 2021-04-30 武汉轻工大学 Okra and turmeric chewable tablet and preparation method thereof
CN112715932A (en) * 2020-12-25 2021-04-30 紫阳中地大硒科技有限公司 Abelmoschus manihot selenium-rich chewable tablet and preparation method thereof
CN112715877A (en) * 2020-12-25 2021-04-30 武汉轻工大学 Okra and turmeric orally disintegrating tablet and preparation method thereof
CN114128854A (en) * 2021-10-19 2022-03-04 乾翔农业科技有限公司 Selenium-rich okra food slices and preparation method thereof

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110463904A (en) * 2019-09-05 2019-11-19 沈阳师范大学 A kind of wheat bran compound nutritional chewable tablets and its processing method
CN110522022A (en) * 2019-09-20 2019-12-03 浙江大学 Okra powder of relax bowel and defecation and preparation method thereof
CN110522022B (en) * 2019-09-20 2023-01-06 浙江大学 Okra powder capable of relaxing bowels and preparation method of okra powder
CN112715878A (en) * 2020-12-25 2021-04-30 武汉轻工大学 Okra and turmeric chewable tablet and preparation method thereof
CN112715932A (en) * 2020-12-25 2021-04-30 紫阳中地大硒科技有限公司 Abelmoschus manihot selenium-rich chewable tablet and preparation method thereof
CN112715877A (en) * 2020-12-25 2021-04-30 武汉轻工大学 Okra and turmeric orally disintegrating tablet and preparation method thereof
CN114128854A (en) * 2021-10-19 2022-03-04 乾翔农业科技有限公司 Selenium-rich okra food slices and preparation method thereof

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Application publication date: 20171031