CN107266529A - 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途 - Google Patents

一类抑制丙肝病毒的大环状杂环化合物及其制备和用途 Download PDF

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Publication number
CN107266529A
CN107266529A CN201610219170.8A CN201610219170A CN107266529A CN 107266529 A CN107266529 A CN 107266529A CN 201610219170 A CN201610219170 A CN 201610219170A CN 107266529 A CN107266529 A CN 107266529A
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CN
China
Prior art keywords
compound
amino
alkyl
group
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610219170.8A
Other languages
English (en)
Chinese (zh)
Inventor
王喆
王栋
陈俊杰
许曼
徐海涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tianjin Chang Sen Pharmaceutcal Corp Ltd
Shanghai Longwood Pharmaceutical Co Ltd
Original Assignee
Tianjin Chang Sen Pharmaceutcal Corp Ltd
Shanghai Longwood Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin Chang Sen Pharmaceutcal Corp Ltd, Shanghai Longwood Pharmaceutical Co Ltd filed Critical Tianjin Chang Sen Pharmaceutcal Corp Ltd
Priority to CN201610219170.8A priority Critical patent/CN107266529A/zh
Priority to CN201780000221.0A priority patent/CN107074876B/zh
Priority to PCT/CN2017/079087 priority patent/WO2017173960A1/fr
Publication of CN107266529A publication Critical patent/CN107266529A/zh
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201610219170.8A 2016-04-08 2016-04-08 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途 Withdrawn CN107266529A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201610219170.8A CN107266529A (zh) 2016-04-08 2016-04-08 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途
CN201780000221.0A CN107074876B (zh) 2016-04-08 2017-03-31 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途
PCT/CN2017/079087 WO2017173960A1 (fr) 2016-04-08 2017-03-31 Macro-hétérocycle utilisé pour supprimer le virus de l'hépatite c, sa préparation et son application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610219170.8A CN107266529A (zh) 2016-04-08 2016-04-08 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途

Publications (1)

Publication Number Publication Date
CN107266529A true CN107266529A (zh) 2017-10-20

Family

ID=60000836

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610219170.8A Withdrawn CN107266529A (zh) 2016-04-08 2016-04-08 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途

Country Status (2)

Country Link
CN (1) CN107266529A (fr)
WO (1) WO2017173960A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074876A (zh) * 2016-04-08 2017-08-18 天津长森药业有限公司 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101909446A (zh) * 2007-11-14 2010-12-08 益安药业 作为丙型肝炎病毒抑制剂的含喹喔啉的化合物
CN102140100A (zh) * 2010-01-27 2011-08-03 爱博新药研发(上海)有限公司 高效抑制丙型肝炎病毒的多环化合物及其制备方法和用途
CN102458444A (zh) * 2009-05-13 2012-05-16 英安塔制药有限公司 用作丙型肝炎病毒抑制剂的大环化合物
CN104230946A (zh) * 2013-06-06 2014-12-24 爱博新药研发(上海)有限公司 抑制丙肝病毒的化合物、药物组合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211891B2 (en) * 2008-04-30 2012-07-03 Enanta Pharmaceuticals, Inc. Difluoromethyl-containing macrocyclic compounds as hepatitis C virus inhibitors
US9193740B2 (en) * 2009-10-19 2015-11-24 Enanta Pharmaceuticals, Inc. Bismacrocyclic compounds as hepatitis C virus inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101909446A (zh) * 2007-11-14 2010-12-08 益安药业 作为丙型肝炎病毒抑制剂的含喹喔啉的化合物
CN102458444A (zh) * 2009-05-13 2012-05-16 英安塔制药有限公司 用作丙型肝炎病毒抑制剂的大环化合物
CN102140100A (zh) * 2010-01-27 2011-08-03 爱博新药研发(上海)有限公司 高效抑制丙型肝炎病毒的多环化合物及其制备方法和用途
CN104230946A (zh) * 2013-06-06 2014-12-24 爱博新药研发(上海)有限公司 抑制丙肝病毒的化合物、药物组合物及其应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074876A (zh) * 2016-04-08 2017-08-18 天津长森药业有限公司 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途
CN107074876B (zh) * 2016-04-08 2019-12-20 上海长森药业有限公司 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途

Also Published As

Publication number Publication date
WO2017173960A1 (fr) 2017-10-12

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Application publication date: 20171020

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