CN107261022A - Anti-acne ointment and preparation method thereof - Google Patents

Anti-acne ointment and preparation method thereof Download PDF

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Publication number
CN107261022A
CN107261022A CN201710547724.1A CN201710547724A CN107261022A CN 107261022 A CN107261022 A CN 107261022A CN 201710547724 A CN201710547724 A CN 201710547724A CN 107261022 A CN107261022 A CN 107261022A
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Prior art keywords
parts
acne
weight
filtrate
kuh
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万家林
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Hefei Fengruilong Biological Technology Co Ltd
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Hefei Fengruilong Biological Technology Co Ltd
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Priority to CN201710547724.1A priority Critical patent/CN107261022A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses a kind of anti-acne ointment and preparation method thereof, using honeysuckle, the capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, peppermint, mung bean as raw material, realize and continue oil-control and acne-removing, epidermis bacterium and hair follicle root bacillus can quickly be killed, effective happy pore, cleaning hair follicle, integrate oil suction, anti-inflammatory, sterilization, Bergamot Mint Extract, with good anti-acne, scar eliminating and promotion skin repair effect；And inventive formulation science, dosage is adapted to, each component synergistic application, with oil suction oil-control, tissue repair and antibacterial and bacteriostasis, so as to reach the effect of anti-acne, and cheap, and curative effect is rapid.

Description

Anti-acne ointment and preparation method thereof
Technical field
The present invention relates to anti-acne field, more particularly to a kind of anti-acne ointment and preparation method thereof.
Background technology
Whelk be a kind of hair follicle, sebaceous glands involvement chronic inflammation illness, it is very vast throughout crowd.Feature is shown For the vigorous position of the sebum secretions such as forehead, cheek, nasolabial groove, chest and back and shoulder occur acne, papule, warts, tubercle, The skin lesion such as tumour and scar, is often accompanied by seborrhea.The pathogenic factor of dark sore is more and complicated, influence is alternateed, with something lost Biography, androgen levels rise, pilosebaceous duct dyskeratosis, propionibacterium acnes infection, immune response, mental element, The factor such as normal diet and living environment is relevant.Its treatment method can be divided into oral or external medication and physics is controlled Treat, although current treatment method has certain curative effect, but be difficult to eliminate symptomatology, allow patient to can't bear it and disturb.
The content of the invention
In view of this, it is an object of the invention to provide a kind of anti-acne ointment and preparation method thereof, anti-acne effect is good, cure rate It is high.
To achieve these goals, the present invention provides following technical scheme：
A kind of anti-acne ointment, includes the raw material of following parts by weight：
Preferably, the raw material of following parts by weight is included：
Preferably, in addition to auxiliary material, the parts by weight of the auxiliary material are 150~200 parts.
Preferably, the auxiliary material includes pearl powder, Sodium Hyaluronate, glycerine, beeswax and single stearic acid glycerine lipoprotein.
Present invention also offers a kind of above-mentioned preparation method of anti-acne ointment, comprise the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add water for the first time, after stirring, soak 3~5h；Into the medicine decocting tank Secondary addition water, boils rear slow fire and endures 3~5h, filtering, obtains the first filtrate；Added water for the third time into the filter residue being filtrated to get, Boil rear slow fire and endure 1~2h, filter, obtain the second filtrate；First filtrate and second filtrate are merged, concentrated, is obtained To anti-acne ointment.
Preferably, in addition into the material after concentration auxiliary material is added.
Preferably, the consumption that the first time adds water is the honeysuckle, the capsule of weeping forsythia, the orange peel, the Semen Coicis Benevolence, the borneol, the aloe, the Radix Astragali, the kuh-seng, the Radix Angelicae Sinensis, the wrinkled giant hyssop, the Asiatic plantain, the peppermint, 2~3 times of the mung bean；The consumption added water for the second time is the honeysuckle, the capsule of weeping forsythia, the orange peel, the heart of a lotus seed It is meter Ren, the borneol, the aloe, the Radix Astragali, the kuh-seng, the Radix Angelicae Sinensis, the wrinkled giant hyssop, the Asiatic plantain, described thin Lotus, 4~6 times of the mung bean total amount；The consumption of third time feedwater be the honeysuckle, the capsule of weeping forsythia, the orange peel, The SEMEN COICIS, the borneol, the aloe, the Radix Astragali, the kuh-seng, the Radix Angelicae Sinensis, the wrinkled giant hyssop, the Asiatic plantain, The peppermint, 2~3 times of the mung bean total amount.
A kind of anti-acne ointment that the present invention is provided and preparation method thereof, with honeysuckle, the capsule of weeping forsythia, orange peel, SEMEN COICIS, ice Piece, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, peppermint, mung bean are raw material, realize and continue oil-control and acne-removing, energy It is quick to kill epidermis bacterium and hair follicle root bacillus, effective happy pore, cleaning hair follicle, collection oil suction, anti-inflammatory, sterilization, equilibrium oil Fat is secreted in one, with good anti-acne, scar eliminating and promotion skin repair effect；And inventive formulation science, dosage fit Close, each component synergistic application, with oil suction oil-control, tissue repair and antibacterial and bacteriostasis, so as to reach the effect of anti-acne, and is made Valency is cheap, and curative effect is rapid.
Embodiment
In order to further appreciate that the present invention, the preferred embodiments of the invention are described with reference to embodiment, but It is it should be appreciated that these descriptions are simply to further illustrate the features and advantages of the present invention rather than to patent requirements of the present invention Limitation.
The invention provides a kind of anti-acne ointment, include the raw material of following parts by weight：
Above-mentioned technical proposal, with honeysuckle, the capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, the leaves of pulse plants Perfume, Asiatic plantain, peppermint, mung bean are raw material, realize and continue oil-control and acne-removing, can quickly kill epidermis bacterium and hair follicle root Bacillus, effective happy pore, cleaning hair follicle, integrates oil suction, anti-inflammatory, sterilization, Bergamot Mint Extract, with good anti-acne, Scar eliminating and promotion skin repair effect；And inventive formulation science, dosage be adapted to, each component synergistic application, with oil suction Oil-control, tissue repair and antibacterial and bacteriostasis, so that the effect of anti-acne is reached, and it is cheap, curative effect is rapid.
Honeysuckle has clearing heat and detoxicating, clearing and activating the channels and collaterals effect.In the present invention, the parts by weight of honeysuckle are 4~8 Part；In an embodiment of the present invention, the parts by weight of honeysuckle are 5~7 parts；In other embodiments, the parts by weight of honeysuckle Number is 5.5~6.5 parts.
The capsule of weeping forsythia has the effect of restraining and sterilizing bacteria.In the present invention, the parts by weight of the capsule of weeping forsythia are 3~6 parts；In the reality of the present invention Apply in example, the parts by weight of the capsule of weeping forsythia are 3.5~5.5 parts；In other embodiments, the parts by weight of the capsule of weeping forsythia are 4~5 parts.
Orange peel has effects that greasy skin and removes wrinkle.In the present invention, the parts by weight of orange peel are 8~15 Part；In an embodiment of the present invention, the parts by weight of orange peel are 10~13 parts；In other embodiments, the weight of orange peel Number is 11~12 parts.
SEMEN COICIS, which has, controls the flat acne of wart, light speckles, beautification and white, the effect of moisturizing smoothing wrinkle.In the present invention, the parts by weight of SEMEN COICIS Number is 3~5 parts；In an embodiment of the present invention, the parts by weight of SEMEN COICIS are 3.3~4.7 parts；In other embodiments, the heart of a lotus seed Meter Ren parts by weight are 3.7~4.2 parts.
Borneol has clearing heat for detumescence, wards off the effect of dirty deodorization.In the present invention, the parts by weight of borneol are 2~5 parts； In embodiments of the invention, the parts by weight of borneol are 2.5~4.5 parts；In other embodiments, the parts by weight of borneol are 3 ~4 parts.
Aloe has effects that bactericidal antiphlogistic, the effect for removing free radical, improves blood circulation, acne-removing, skin-nourishing.In this hair In bright, the parts by weight of aloe are 10~20 parts；In an embodiment of the present invention, the volume parts by weight of aloe are 12~18 parts； In other embodiments, the parts by weight of aloe are 14~16 parts.
The Radix Astragali has the conditioning deficiency of vital energy, the effect of beautifying face and moistering lotion.In the present invention, the parts by weight of the Radix Astragali are 1~3 part； In embodiments of the invention, the parts by weight of the Radix Astragali are 1.4~2.6 parts；In other embodiments, the parts by weight of the Radix Astragali are 1.7~2.2 parts.
Kuh-seng has heat-clearing and damp-drying drug, the effect of wind-dispelling removing toxic substances.In the present invention, the parts by weight of kuh-seng are 1~2 part； In embodiments of the invention, the parts by weight of kuh-seng are 1.2~1.8 parts；In other embodiments, the parts by weight of kuh-seng are 1.4~1.6 parts.
Radix Angelicae Sinensis has the effect of promoting blood circulation.In the present invention, the parts by weight of Radix Angelicae Sinensis are 4~7 parts；In embodiments of the invention In, the parts by weight of Radix Angelicae Sinensis are 4.5~6.5 parts；In other embodiments, the parts by weight of Radix Angelicae Sinensis are 5~6 parts.
Wrinkled giant hyssop have remove dampness by means of aromatics, deliver relieving summer-heat, inducing diaphoresis dissipate evil, dampness removing except wind, relieving heat and thirst, anti-vomiting, fast gas and In, stomach invigorating clearing damp the effects such as.In the present invention, the parts by weight of wrinkled giant hyssop are 1~3 part；In an embodiment of the present invention, wrinkled giant hyssop Parts by weight are 1.3~2.7 parts；In other embodiments, the parts by weight of wrinkled giant hyssop are 1.7~2.2 parts.
Asiatic plantain has the effect of antibacterial bacteriostatic.In the present invention, the parts by weight of Asiatic plantain are 4~7 parts；In the present invention Embodiment in, the parts by weight of Asiatic plantain are 4.5~6.5 parts；In other embodiments, the parts by weight of Asiatic plantain are 5~6 Part.
Peppermint have bactericidal, activate blood circulation and disperse blood clots, the work of relieving mood.In the present invention, the parts by weight of peppermint be 7~ 13 parts；In an embodiment of the present invention, the parts by weight of peppermint are 8.8~11.5 parts；In other embodiments, the weight of peppermint Number is 10~11 parts.
Mung bean has antibacterial bacteriostatic, prevents the effect of clogging of pores.In the present invention, the parts by weight of mung bean are 10~16 Part；In an embodiment of the present invention, the parts by weight of mung bean are 11~15 parts；In other embodiments, the parts by weight of mung bean For 12~14 parts.
In an embodiment of the present invention, in addition to auxiliary material, the parts by weight of auxiliary material are 150~200 parts.
In an embodiment of the present invention, auxiliary material includes pearl powder, Sodium Hyaluronate, glycerine, beeswax, glycerol monostearate Fat.In an embodiment of the present invention, pearl powder, Sodium Hyaluronate, glycerine, beeswax, the mass ratio of single stearic acid glycerine lipoprotein are (0.4~0.7)：(0.5~0.8)：(1~2)：(0.1~0.3)：(0.3~0.5).
Above-mentioned auxiliary material can improve the percutaneous abilities of medicine, and skin to the absorbability of ointment, give full play to each raw material Effect, dispel small pox and acne print.
Present invention also offers a kind of above-mentioned preparation method of anti-acne ointment, comprise the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add water for the first time, after stirring, soak 3~5h；Into the medicine decocting tank Secondary addition water, boils rear slow fire and endures 3~5h, filtering, obtains the first filtrate；Added water for the third time into the filter residue being filtrated to get, Boil rear slow fire and endure 1~2h, filter, obtain the second filtrate；First filtrate and second filtrate are merged, concentrated, is obtained To anti-acne ointment.
Wherein, honeysuckle, the capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, Peppermint, mung bean are same as above, will not be repeated here.
Above-mentioned technical proposal, preparation method is simple, and the work of each raw material can be fully extracted using first soaking to be cooked by slow fire again Property composition, so as to effectively eliminate small pox, and curative effect is stable, has no side effect, and cure rate is high.
In an embodiment of the present invention, in addition into the material after concentration auxiliary material is added.
In an embodiment of the present invention, the consumption added water for the first time be honeysuckle, the capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, Aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, peppermint, 2~3 times of institute's beans；The consumption added water for the second time is gold and silver Flower, the capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, peppermint, institute's beans total amount 4~ 6 times；The consumption of third time feedwater is institute honeysuckle, the capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, the leaves of pulse plants Perfume, Asiatic plantain, peppermint, 2~3 times of institute's beans total amount.
In order to further illustrate the present invention, anti-acne ointment provided with reference to embodiment the present invention and preparation method thereof It is described in detail, but they can not be interpreted as limiting the scope of the present invention.
Raw material used is commercially available in following examples.
Embodiment 1
Anti-acne ointment includes the raw material of following parts by weight：
5.5 portions of honeysuckles, 4 parts of capsules of weeping forsythia, 10 parts of orange peels, 3.7 parts of SEMEN COICISs, 2 parts of borneols, 14 portions of aloes, 3 parts of Radixs Astragali, 1.8 parts of kuh-sengs, 4.5 parts of Radix Angelicae Sinensis, 1.7 parts of wrinkled giant hyssops, 4 parts of Asiatic plantains, 11 parts of peppermints, 12 parts of mung beans, 39.67 parts of pearl powders, 28.33 Part Sodium Hyaluronate, 56.67 parts of glycerine, 17 parts of beeswaxs and 28.33 parts of single stearic acid glycerine lipoproteins.
The preparation method of anti-acne ointment comprises the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add 154.4 parts of water, after stirring, and soak 3h；Added into the medicine decocting tank 463.2 parts of water, boil rear slow fire and endure 5h, filtering, obtain the first filtrate；Add 154.4 parts of water into the filter residue being filtrated to get, boil Slow fire endures 1h afterwards, filtering, obtains the second filtrate；First filtrate and second filtrate are merged, concentration, and to after concentration Material in add auxiliary material, obtain anti-acne ointment.
Embodiment 2
Anti-acne ointment includes the raw material of following parts by weight：
6.5 portions of honeysuckles, 5 parts of capsules of weeping forsythia, 13 parts of orange peels, 3.3 parts of SEMEN COICISs, 5 parts of borneols, 16 portions of aloes, 1 part of Radix Astragali, 1.4 parts of kuh-sengs, 4 parts of Radix Angelicae Sinensis, 2.7 portions of wrinkled giant hyssops, 5 portions of Asiatic plantains, 10 portions of peppermints, 11 portions of mung beans, 30.51 parts of pearl powders, 30.51 parts Sodium Hyaluronate, 61.02 parts of glycerine, 12.71 parts of beeswaxs and 15.25 parts of single stearic acid glycerine lipoproteins.
The preparation method of anti-acne ointment comprises the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add 184.58 parts of water, after stirring, and soak 5h；Added into the medicine decocting tank 461.45 parts of water, boil rear slow fire and endure 3h, filtering, obtain the first filtrate；Into the filter residue being filtrated to get plus 184.58 parts of water, Boil rear slow fire and endure 2h, filter, obtain the second filtrate；First filtrate and second filtrate are merged, concentration, and to dense Auxiliary material is added in material after contracting, anti-acne ointment is obtained.
Embodiment 3
Anti-acne ointment includes the raw material of following parts by weight：
5 parts of honeysuckles, 5.5 parts of capsules of weeping forsythia, 8 parts of orange peels, 4.7 parts of SEMEN COICISs, 2.5 parts of borneols, 12 parts of aloes, 1.4 parts of Huangs Stilbene, 1.2 parts of kuh-sengs, 7 parts of Radix Angelicae Sinensis, 1.3 portions of wrinkled giant hyssops, 6 portions of Asiatic plantains, 11.5 portions of peppermints, 15 portions of mung beans, 28.12 parts of pearl powders, 39.38 parts of Sodium Hyaluronates, 78.75 parts of glycerine, 8.44 parts of beeswaxs and 25.31 parts of single stearic acid glycerine lipoproteins.
The preparation method of anti-acne ointment comprises the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add 194.64 parts of water, after stirring, and soak 4h；Added into the medicine decocting tank 324.4 parts of water, boil rear slow fire and endure 5h, filtering, obtain the first filtrate；Add 243.3 parts of water into the filter residue being filtrated to get, boil Slow fire endures 1h afterwards, filtering, obtains the second filtrate；First filtrate and second filtrate are merged, concentration, and to after concentration Material in add auxiliary material, obtain anti-acne ointment.
Embodiment 4
Anti-acne ointment includes the raw material of following parts by weight：
7 parts of honeysuckles, 3.5 parts of capsules of weeping forsythia, 15 parts of orange peels, 3 parts of SEMEN COICISs, 4.5 parts of borneols, 18 parts of aloes, 2.6 parts of Huangs Stilbene, 1.6 parts of kuh-sengs, 6.5 parts of Radix Angelicae Sinensis, 1 portion of wrinkled giant hyssop, 7 portions of Asiatic plantains, 8.8 portions of peppermints, 14 portions of mung beans, 19.69 parts of pearl powders, 39.38 parts of Sodium Hyaluronates, 78.77 parts of glycerine, 4.93 parts of beeswaxs and 17.23 parts of single stearic acid glycerine lipoproteins.
The preparation method of anti-acne ointment comprises the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add 240.5 parts of water, after stirring, and soak 4h；Added into the medicine decocting tank 416.25 parts of water, boil rear slow fire and endure 4h, filtering, obtain the first filtrate；Add 240.5 parts of water into the filter residue being filtrated to get, boil Slow fire endures 2h after boiling, filtering, obtains the second filtrate；First filtrate and second filtrate are merged, concentration, and to concentration Auxiliary material is added in material afterwards, anti-acne ointment is obtained.
Embodiment 5
Anti-acne ointment includes the raw material of following parts by weight：
4 portions of honeysuckles, 6 parts of capsules of weeping forsythia, 11 parts of orange peels, 5 parts of SEMEN COICISs, 3 parts of borneols, 10 portions of aloes, 1.7 parts of Radixs Astragali, 1 part Kuh-seng, 5 parts of Radix Angelicae Sinensis, 3 parts of wrinkled giant hyssops, 6.5 parts of Asiatic plantains, 7 parts of peppermints, 10 parts of mung beans, 34.4 parts of pearl powders, 29.11 parts of hyalomitomes Sour sodium, 95.26 parts of glycerine, 14.29 parts of beeswaxs and 16.94 parts of single stearic acid glycerine lipoproteins.
The preparation method of anti-acne ointment comprises the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add 201.96 parts of water, after stirring, and soak 3h；Added into the medicine decocting tank 307.44 parts of water, boil rear slow fire and endure 5h, filtering, obtain the first filtrate；Add 201.96 parts of water into the filter residue being filtrated to get, boil Slow fire endures 1h after boiling, filtering, obtains the second filtrate；First filtrate and second filtrate are merged, concentration, and to concentration Auxiliary material is added in material afterwards, anti-acne ointment is obtained.
Embodiment 6
Anti-acne ointment includes the raw material of following parts by weight：
8 parts of honeysuckles, 3 parts of capsules of weeping forsythia, 12 parts of orange peels, 4.2 parts of SEMEN COICISs, 4 parts of borneols, 20 parts of aloes, 2.2 parts of Radixs Astragali, 2 Part kuh-seng, 6 parts of Radix Angelicae Sinensis, 2.2 portions of wrinkled giant hyssops, 4.5 portions of Asiatic plantains, 13 portions of peppermints, 16 portions of mung beans, 23.68 parts of pearl powders, 39.47 parts Sodium Hyaluronate, 105.26 parts of glycerine, 6.85 parts of beeswaxs and 24.74 parts of single stearic acid glycerine lipoproteins.
The preparation method of anti-acne ointment comprises the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add 291.3 parts of water, after stirring, and soak 5h；Added into the medicine decocting tank 553.47 parts of water, boil rear slow fire and endure 4h, filtering, obtain the first filtrate；Add 233.04 parts of water into the filter residue being filtrated to get, boil Slow fire endures 1h after boiling, filtering, obtains the second filtrate；First filtrate and second filtrate are merged, concentration, and to concentration Auxiliary material is added in material afterwards, anti-acne ointment is obtained.
Embodiment 7
Anti-acne ointment includes the raw material of following parts by weight：
6 parts of honeysuckles, 4.5 parts of capsules of weeping forsythia, 11.5 parts of orange peels, 4 parts of SEMEN COICISs, 3.5 parts of borneols, 15 parts of aloes, 2 parts of Huangs Stilbene, 1.5 parts of kuh-sengs, 5.5 parts of Radix Angelicae Sinensis, 2 portions of wrinkled giant hyssops, 5.5 portions of Asiatic plantains, 10.5 portions of peppermints, 13 portions of mung beans, 29.17 parts of pearl powders, 34.47 parts of Sodium Hyaluronates, 79.54 parts of glycerine, 10.61 parts of beeswaxs and 21.21 parts of single stearic acid glycerine lipoproteins.
The preparation method of anti-acne ointment comprises the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, thin Lotus, mung bean add medicine decocting tank after crushing, and add 211.25 parts of water, after stirring, and soak 4h；Added into the medicine decocting tank 422.5 parts of water, boil rear slow fire and endure 4h, filtering, obtain the first filtrate；Add 211.25 parts of water into the filter residue being filtrated to get, boil Slow fire endures 1.5h after boiling, filtering, obtains the second filtrate；First filtrate and second filtrate are merged, concentration, and to dense Auxiliary material is added in material after contracting, anti-acne ointment is obtained.
First, safety testing：
The product mix of Example 1~5, obtains hybrid medicine.
It is dynamic by experiment of the small white mouse of body weight 18-20g male and female half and half using the hybrid medicine of above-mentioned gained as trial drug Thing, is divided into 5 groups by totally 150, respectively the medicine of gavage various concentrations, concentration be respectively 10mg/ml, 40mg/ml, 60mg/ml, 80mg/ml, 100mg/ml, administered volume are 40ml/kg, to gastric infusion in mouse one day 3 times, accumulation gastric infusion volume For 100ml/kg.Observation 7 days, has no overt toxicity reaction and the reaction of pawpaw enteron aisle.Through visually observing after dissection, main organs Non Apparent Abnormality.
The small white mouse of body weight 18-20g male and female half and half is experimental animal, totally 80, is divided into two groups, carries out long term toxicity examination Test, one group of administration concentration is 60mg/ml, and administered volume is 40ml/kg；Another group is isometric distilled water, continuously gavages 3 Individual month, carry out long term toxicity test.Long term toxicity test result shows that the general behavior activity of experimental animal and body weight increase are just Often, to hematological indices, the organ coefficient of hepatic and renal function and main organs is had no significant effect, and main organs are damaged without obvious pathology Wound, shows that medicine is non-toxic.
2nd, the anti-acne ointment for obtaining embodiment 1~5 carries out clinical test, as a result as follows：
1st, subject selects：The whelk patient totally 800 in March, 2011~certain hospital accepts for medical treatment so far is selected, wherein man Property patient 385, female patient 415.
2nd, packet design：All patients are randomly divided into eight groups, respectively experimental group 1, experimental group 2, experimental group 3, experimental group 4th, experimental group 5, experimental group 6, experimental group 7 and control group, each 100, eight groups of patients are in terms of age, the state of an illness without significance difference It is different, with comparativity.The anti-acne ointment that wherein experimental group 1~7 is prepared using embodiment 1~7 respectively.
3rd, instructions of taking：Experimental group 1~7 directly smears ointment to face, twice daily, continuously smears 15d.Control group makes With moral hall Chinese medicine Whelk-eliminating paste is accumulate, twice daily, 15d is continuously smeared.Smearing standard is all defined by ointment covering small pox.
4th, curative effect judging standard
Cure：Patient's whelk symptom disappears；
Effectively：Patient's whelk symptom gradually mitigates or symptom disappears；
It is invalid：Whelk symptom is without improvement；
Total effective rate=(curing number of cases+effective number of cases)/case load.
5th, result is as shown in table 1
The treatment results of the experimental group 1~7 of table 1 and control group
Additionally by viewing it can be found that patient skin is fine and smooth, without acne print, therefore the anti-acne ointment of experimental group 1~7 is not only With acne-removal function, also have effects that to eliminate acne print；And the patient of control group is the whelk of face without and acne print Still exist.
A kind of anti-acne ointment and preparation method provided above the present invention is described in detail, used herein Specific case is set forth to the principle and embodiment of the present invention, and the explanation of above example is only intended to help and understands this The method and its core concept of invention, it is noted that for those skilled in the art, is not departing from this hair On the premise of bright principle, some improvement and modification can also be carried out to the present invention, these are improved and modification also falls into power of the present invention In the protection domain that profit is required.

Claims (7)

1. a kind of anti-acne ointment, it is characterised in that include the raw material of following parts by weight：
2. anti-acne ointment as claimed in claim 1, it is characterised in that include the raw material of following parts by weight：
3. anti-acne ointment as claimed in claim 1 or 2, it is characterised in that also including auxiliary material, the parts by weight of the auxiliary material are 150~200 parts.
4. anti-acne ointment as claimed in claim 3, it is characterised in that the auxiliary material includes pearl powder, Sodium Hyaluronate, sweet Oil, beeswax and single stearic acid glycerine lipoprotein.
5. a kind of preparation method of anti-acne ointment as claimed in claim 1, it is characterised in that comprise the following steps：
By the honeysuckle, capsule of weeping forsythia, orange peel, SEMEN COICIS, borneol, aloe, the Radix Astragali, kuh-seng, Radix Angelicae Sinensis, wrinkled giant hyssop, Asiatic plantain, peppermint, green Medicine decocting tank is added after bean powder is broken, and adds water for the first time, after stirring, 3~5h is soaked；Add for the second time into the medicine decocting tank Enter water, boil rear slow fire and endure 3~5h, filter, obtain the first filtrate；Added water for the third time into the filter residue being filtrated to get, after boiling Slow fire endures 1~2h, filtering, obtains the second filtrate；First filtrate and second filtrate are merged, concentrated, anti-acne is obtained Ointment.
6. preparation method as claimed in claim 5, it is characterised in that also including adding auxiliary material into the material after concentration.
7. preparation method as claimed in claim 5, it is characterised in that the consumption that the first time adds water be the honeysuckle, The capsule of weeping forsythia, the orange peel, the SEMEN COICIS, the borneol, the aloe, the Radix Astragali, the kuh-seng, the Radix Angelicae Sinensis, The wrinkled giant hyssop, the Asiatic plantain, the peppermint, 2~3 times of the mung bean；The consumption added water for the second time is the gold and silver Colored, the described capsule of weeping forsythia, the orange peel, the SEMEN COICIS, the borneol, the aloe, the Radix Astragali, the kuh-seng, it is described work as Return, the wrinkled giant hyssop, the Asiatic plantain, the peppermint, 4~6 times of the mung bean total amount；The consumption of the third time feedwater is institute State honeysuckle, the capsule of weeping forsythia, the orange peel, the SEMEN COICIS, the borneol, the aloe, the Radix Astragali, the kuh-seng, The Radix Angelicae Sinensis, the wrinkled giant hyssop, the Asiatic plantain, the peppermint, 2~3 times of the mung bean total amount.
CN201710547724.1A 2017-07-06 2017-07-06 Anti-acne ointment and preparation method thereof Pending CN107261022A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1319390A (en) * 2001-02-28 2001-10-31 郝艳霞 Body-refreshing bath lotion and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1319390A (en) * 2001-02-28 2001-10-31 郝艳霞 Body-refreshing bath lotion and preparation method thereof

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Application publication date: 20171020