CN107249743B - 数字微流控稀释设备、系统及相关方法 - Google Patents

数字微流控稀释设备、系统及相关方法 Download PDF

Info

Publication number
CN107249743B
CN107249743B CN201580077138.4A CN201580077138A CN107249743B CN 107249743 B CN107249743 B CN 107249743B CN 201580077138 A CN201580077138 A CN 201580077138A CN 107249743 B CN107249743 B CN 107249743B
Authority
CN
China
Prior art keywords
electrode
area
electrodes
droplet
droplets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580077138.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN107249743A (zh
Inventor
A.费希尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to CN201911326727.8A priority Critical patent/CN110935496A/zh
Publication of CN107249743A publication Critical patent/CN107249743A/zh
Application granted granted Critical
Publication of CN107249743B publication Critical patent/CN107249743B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Accessories For Mixers (AREA)
CN201580077138.4A 2014-12-31 2015-12-21 数字微流控稀释设备、系统及相关方法 Active CN107249743B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911326727.8A CN110935496A (zh) 2014-12-31 2015-12-21 数字微流控稀释设备、系统及相关方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098679P 2014-12-31 2014-12-31
US62/098679 2014-12-31
PCT/US2015/067021 WO2016109279A1 (en) 2014-12-31 2015-12-21 Digital microfluidic dilution apparatus, systems, and related methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201911326727.8A Division CN110935496A (zh) 2014-12-31 2015-12-21 数字微流控稀释设备、系统及相关方法

Publications (2)

Publication Number Publication Date
CN107249743A CN107249743A (zh) 2017-10-13
CN107249743B true CN107249743B (zh) 2020-01-10

Family

ID=55273514

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580077138.4A Active CN107249743B (zh) 2014-12-31 2015-12-21 数字微流控稀释设备、系统及相关方法
CN201911326727.8A Pending CN110935496A (zh) 2014-12-31 2015-12-21 数字微流控稀释设备、系统及相关方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201911326727.8A Pending CN110935496A (zh) 2014-12-31 2015-12-21 数字微流控稀释设备、系统及相关方法

Country Status (6)

Country Link
US (2) US10369565B2 (https=)
EP (1) EP3240634A1 (https=)
JP (2) JP6622811B2 (https=)
CN (2) CN107249743B (https=)
CA (1) CA2972577A1 (https=)
WO (1) WO2016109279A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6622811B2 (ja) 2014-12-31 2019-12-18 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ デジタルマイクロ流体希釈装置、システムおよび関連方法
US12364538B2 (en) * 2018-11-05 2025-07-22 Biosense Webster (Israel) Ltd. Indifferent electrode with selectable area
CN109652287B (zh) * 2019-01-03 2021-04-30 京东方科技集团股份有限公司 一种微控基板及其制作方法和微流控芯片
WO2020154642A1 (en) * 2019-01-24 2020-07-30 Fluxergy, Llc Microfluidic device with constant heater uniformity
CN112295616B (zh) * 2020-09-11 2022-03-18 东南大学 一种微液滴混合强化微流控装置
CN114166615A (zh) * 2021-11-22 2022-03-11 南方科技大学 一种数字微流控液滴的稀释方法
CN114534805B (zh) * 2022-02-09 2024-08-06 上海天马微电子有限公司 微流控装置及其驱动方法、制作方法
WO2024050639A1 (en) * 2022-09-09 2024-03-14 Nicoya Lifesciences Inc. Microfluidics device including ganged reservoir configurations and methods of using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019875A2 (en) * 2003-08-22 2005-03-03 Stratos Biosystems, Llc Electrowetting sample presentation device
CN101945767A (zh) * 2007-12-23 2011-01-12 先进液体逻辑公司 液滴致动器配置以及引导液滴操作的方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927377D0 (en) 1989-12-04 1990-01-31 Univ Edinburgh Improvements in and relating to amperometric assays
US5104480A (en) 1990-10-12 1992-04-14 General Electric Company Direct patterning of metals over a thermally inefficient surface using a laser
GB9221099D0 (en) 1992-10-07 1992-11-18 Ecossensors Ltd Improvements in and relating to gas permeable membranes for amperometric gas electrodes
AU1517999A (en) 1997-10-15 1999-05-03 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6662439B1 (en) 1999-10-04 2003-12-16 Roche Diagnostics Corporation Laser defined features for patterned laminates and electrodes
TWI286629B (en) 2000-07-20 2007-09-11 Samsung Electronics Co Ltd Liquid crystal display device and flexible circuit board
DE10212639A1 (de) 2002-03-21 2003-10-16 Siemens Ag Vorrichtung und Verfahren zur Laserstrukturierung von Funktionspolymeren und Verwendungen
JP3492350B2 (ja) 2002-04-12 2004-02-03 新藤電子工業株式会社 回路基板および回路基板の製造方法
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
FR2871076A1 (fr) 2004-06-04 2005-12-09 Univ Lille Sciences Tech Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique
WO2008027090A2 (en) * 2006-05-17 2008-03-06 The Regents Of The University Of California Control of materials and porous magnetic particles
JP4185904B2 (ja) * 2004-10-27 2008-11-26 株式会社日立ハイテクノロジーズ 液体搬送基板、分析システム、分析方法
JP4500733B2 (ja) 2005-05-30 2010-07-14 株式会社日立ハイテクノロジーズ 化学分析装置
US8802214B2 (en) 2005-06-13 2014-08-12 Trillion Science, Inc. Non-random array anisotropic conductive film (ACF) and manufacturing processes
US20060280912A1 (en) 2005-06-13 2006-12-14 Rong-Chang Liang Non-random array anisotropic conductive film (ACF) and manufacturing processes
US9266076B2 (en) 2006-11-02 2016-02-23 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
US8178028B2 (en) 2006-11-06 2012-05-15 Samsung Electronics Co., Ltd. Laser patterning of nanostructure-films
US8685344B2 (en) 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
EP2148838B1 (en) * 2007-05-24 2017-03-01 Digital Biosystems Electrowetting based digital microfluidics
BRPI0815698A2 (pt) 2007-08-24 2017-06-13 Advanced Liquid Logic Inc manipulação de contas em um atuador de gotículas.
WO2009076414A2 (en) 2007-12-10 2009-06-18 Advanced Liquid Logic, Inc. Droplet actuator configurations and methods
ES2438989T3 (es) 2008-05-13 2014-01-21 Advanced Liquid Logic, Inc. Dispositivos, sistemas y métodos accionadores de gotitas
CN101294971A (zh) * 2008-06-05 2008-10-29 复旦大学 基于介质上电润湿效应的数字微流控器件及其控制方法
WO2010108050A2 (en) * 2009-03-19 2010-09-23 Figure 8 Surgical, Inc. Systems and methods for sternum repair
US8448530B2 (en) 2009-03-27 2013-05-28 CSEM Centre Suisee d'Electronique et de Microtechnique SA-Recherche et Developpement Roll-to-roll compatible pressure sensitive event sensing label
WO2011002957A2 (en) 2009-07-01 2011-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
CN101773814B (zh) * 2010-01-21 2012-03-14 高婧 多稳态微流控器件
US8815070B2 (en) * 2010-03-09 2014-08-26 Sparkle Power, Inc. Microelectrode array architecture
EP2553473A4 (en) * 2010-03-30 2016-08-10 Advanced Liquid Logic Inc DROPLET OPERATION PLATFORM
US20110266151A1 (en) 2010-04-23 2011-11-03 Fredrik Jansson Microfluidic systems with electronic wettability switches
EP2588322B1 (en) 2010-06-30 2015-06-17 Advanced Liquid Logic, Inc. Droplet actuator assemblies and methods of making same
US20130018611A1 (en) 2011-07-11 2013-01-17 Advanced Liquid Logic Inc Systems and Methods of Measuring Gap Height
EP2867645B1 (en) * 2012-06-27 2019-06-05 Advanced Liquid Logic, Inc. Techniques and droplet actuator designs for reducing bubble formation
US8847078B2 (en) 2012-09-27 2014-09-30 Ibiden Co., Ltd. Printed wiring board and method for manufacturing printed wiring board
CN103170384B (zh) * 2013-05-06 2015-03-04 复旦大学 一种基于大小液滴操控的数字微流芯片
EP3131758B1 (en) 2014-04-16 2021-11-24 Abbott Laboratories Droplet actuator fabrication apparatus, systems, and related methods
JP6622811B2 (ja) 2014-12-31 2019-12-18 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ デジタルマイクロ流体希釈装置、システムおよび関連方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019875A2 (en) * 2003-08-22 2005-03-03 Stratos Biosystems, Llc Electrowetting sample presentation device
CN101945767A (zh) * 2007-12-23 2011-01-12 先进液体逻辑公司 液滴致动器配置以及引导液滴操作的方法

Also Published As

Publication number Publication date
JP6622811B2 (ja) 2019-12-18
JP2018500573A (ja) 2018-01-11
WO2016109279A1 (en) 2016-07-07
EP3240634A1 (en) 2017-11-08
CA2972577A1 (en) 2016-07-07
US20160184823A1 (en) 2016-06-30
JP2020024206A (ja) 2020-02-13
US10369565B2 (en) 2019-08-06
US20190351411A1 (en) 2019-11-21
CN107249743A (zh) 2017-10-13
US11213817B2 (en) 2022-01-04
CN110935496A (zh) 2020-03-31
JP6917425B2 (ja) 2021-08-11

Similar Documents

Publication Publication Date Title
CN107249743B (zh) 数字微流控稀释设备、系统及相关方法
US20210060549A1 (en) Droplet actuator fabrication apparatus, systems, and related methods
Luo et al. Error recovery in cyberphysical digital microfluidic biochips
US9201042B2 (en) Architectural layout for dilution with reduced wastage in digital microfluidic based lab-on-a-chip
JP2006058031A (ja) 化学分析装置
CN101679078A (zh) 基于电湿润的数字微流体
EP1595598A1 (en) Confinement of fluids on surfaces
TWI603836B (zh) 圖案化的層沉積
CN117599876A (zh) 一种基于光学虚拟电湿润通道的液体选择性驱动方法
Luo et al. Biochemistry synthesis on a cyberphysical digital microfluidics platform under completion-time uncertainties in fluidic operations
Cheng et al. Simultaneous multiple-droplet generation with meniscus filling on digital microfluidics chip
Poddar et al. Error-tolerant biochemical sample preparation with microfluidic lab-on-chip
US20200086316A1 (en) Cassettes with a proud die
Jagannathan Organic and printed electronics for biological microfluidic applications
Henning et al. An all-at-once factorial method to optimize dip-pen deposition of liquid protein inks
Nichols et al. MALDI-TOF Mass Spectrometry and Digital Microfluidics for the Investigation of Pre-steady State Enzyme Kinetics
US20170068757A1 (en) Simulation device for semiconductor device, and short-circuit determination method for semiconductor device

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant