CN107233508A - Treat the medicine of anorexia nervosa - Google Patents

Treat the medicine of anorexia nervosa Download PDF

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Publication number
CN107233508A
CN107233508A CN201611145915.7A CN201611145915A CN107233508A CN 107233508 A CN107233508 A CN 107233508A CN 201611145915 A CN201611145915 A CN 201611145915A CN 107233508 A CN107233508 A CN 107233508A
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parts
root
asarum
borneol
centipede
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于晓宇
李丽娜
任宏伟
甘泽
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North China University of Science and Technology
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North China University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of medicine for treating anorexia nervosa, the medicine for treating anorexia nervosa is prepared from by the bulk drug of following masses part：10 80 parts of Chinese yam, 10 50 parts of Ligusticum wallichii, 10 80 parts of broom top, 10 50 parts of radix bupleuri, 10 60 parts of mountain centipede, block close 10 60 parts, 10 30 parts of Poria cocos, 5 20 parts of asarum, 10 40 parts of borneol, 10 50 parts of Semen sesami nigrum, 10 50 parts of the root of herbaceous peony, 10 50 parts of globose phaenosperma herb, 10 30 parts of the root of Dahurain angelica.The medicine of the present invention is from organic conception, and diagnosis and treatment based on an overall analysis of the illness and the patient's condition, determined curative effect is lasting, and security is good, patient medication compliance is high, the especially adjustment to light moderate patient compliance life style, with treatment by Chinese herbs safely, effectively, it is economical, meet the Treatment need of patients with anorexia nervosa.

Description

Treat the medicine of anorexia nervosa
Technical field
The invention belongs to technical field of traditional Chinese medicines, a kind of medicine for treating anorexia nervosa is related in particular to.
Background technology
Anorexia nervosa, also known as apositia, are that the body weight that patient oneself causes intentionally is decreased obviously to normal physiological Below standard weight, and strongly maintain a kind of psychophysiological disorders of this state.Due to long-term control feed, or even also constantly Ground stimulates pharyngeal with finger, the food eaten is spued again and comes, and has so artificially upset normal nervous physiology reflection, has caused It is no longer excited that brain " sees " food signal, and digestive juice secretion is reduced, and gastrointestinal peristalsis slows down, in face of food there is no hunger, But really detest from sensation at heart, keck, last psychology, physiological reaction reach unanimity, formation pathologic neural reflex.Nerve Property apocleisis refer to individual by the means such as go on a diet, cause intentionally and maintain body weight significantly lower than a kind of feed that arm's length standard is characterized Obstacle, belongs in psychiatric department field " physiological barrier related to psychological factor " class.It is mainly characterized by fearing body strongly Paying close attention to body weight and the extreme of build with the characteristics of increasing and get fat again, blindly pursues slender, body weight significantly mitigates, often nutritious There is amenorrhoea in bad, metabolism and endocrine disturbance, such as women.Severe patient cachexia shape can occur because extreme is malnutritive State, body exhaustion are so as to threat to life, and 5%~15% patient finally dies from cardiac complication, MOF, secondary Infection, suicide etc..
At present, the therapeutic modality of anorexia nervosa is divided into：Psychological education, supportive treatment, nutrition treatment, drug therapy and Psychotherapy.But current therapeutic modality prognosis is poor, is extremely difficult to normal type, there is chronic, recurrent exerbation, need to live repeatedly Institute is treated, and huge spirit and financial burden are brought to patient.Therefore, we are badly in need of developing during a kind of safety has no side effect Medicine sits the hardship that anorexia nervosa is brought to help patient to break away from.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of medicine for treating anorexia nervosa.
The purpose of the present invention is achieved by following technical proposals.
A kind of Chinese medicine composition, the Chinese medicine composition is made up of the bulk drug of following masses part：
10-80 parts of Chinese yam, 10-50 parts of Ligusticum wallichii, 10-80 parts of broom top, 10-50 parts of radix bupleuri, centipede 10-60 parts of mountain is blocked close 10-60 parts, 10-30 parts of Poria cocos, 5-20 parts of asarum, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony, globose phaenosperma herb 10-50 parts, 10-30 parts of the root of Dahurain angelica.
Wherein, the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of Ligusticum wallichii, 10-30 parts of broom top, 10-15 parts of radix bupleuri, centipede 10-20 parts of mountain, card It is close 10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of asarum, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony, globose phaenosperma herb 10-20 parts, 10-15 parts of the root of Dahurain angelica；
(2) Chinese yam 30-50 parts, 20-30 parts of Ligusticum wallichii, 30-50 parts of broom top, 15-25 parts of radix bupleuri, centipede 20-35 parts of mountain, card Close 20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of asarum, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony shows son It is careless 20-30 parts, 15-20 parts of the root of Dahurain angelica；
(3) Chinese yam 50-70 parts, 30-40 parts of Ligusticum wallichii, 50-70 parts of broom top, 25-35 parts of radix bupleuri, centipede 35-45 parts of mountain, card Close 30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of asarum, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony shows son It is careless 30-40 parts, 20-25 parts of the root of Dahurain angelica；
(4) Chinese yam 70-80 parts, 40-50 parts of Ligusticum wallichii, 70-80 parts of broom top, 35-50 parts of radix bupleuri, centipede 45-60 parts of mountain, card Close 40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of asarum, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony shows son It is careless 40-50 parts, 25-30 parts of the root of Dahurain angelica.
In the above-mentioned Chinese medicine composition of the present invention, selectivity is low by Chinese yam, Ligusticum wallichii, broom top, radix bupleuri, mountain centipede, card Close, Poria cocos, asarum, borneol, Semen sesami nigrum, the root of herbaceous peony, globose phaenosperma herb and the root of Dahurain angelica are combined, and these drug regimens are caused into each medicine Effect produces synergy, so as to effectively treatment anorexia nervosa.Wherein it is from Chinese yam because Chinese yam, which has, controls all Void hundred damages, treat general debility, relieving restlessness heat, bushing unsaturated vapor, reaches heart hole, many accounts, kidney-nourishing gas, strengthening the spleen and stomach, antidiarrheal dysentery, moisten hair Skin, it is raw to smash the swollen effect that controlled with hard poison of patch.Wherein it is that, because Ligusticum wallichii promote breath and open depression, method wind-dryness is wet from Ligusticum wallichii.Wherein select Broom top is because broom top has effects that enriching yin and blood and invigorating the spleen.Wherein it is from radix bupleuri because radix bupleuri inducing diaphoresis is brought down a fever；Dredge Liver solution is strongly fragrant, rises and lifts yang-energy.It is wherein because the strongly fragrant scattered stasis of blood of mountain centipede solution from mountain centipede.It is because blocking close invigorating the spleen wherein from blocking close Stomach, replenishing qi and blood.It is wherein because Poria cocos calming heart from Poria cocos.Wherein it is that, because asarum wind-dispelling, water-filling is had one's ideas straightened out from asarum.Its Middle selection Semen sesami nigrum is because Semen sesami nigrum has nourishing liver and kidney, effect of beneficial blood ease constipation.Wherein it is from the root of herbaceous peony because the root of herbaceous peony is supported Blood holds back the moon, soft liver analgesic, Pinggan Yang.Wherein it is from globose phaenosperma herb because globose phaenosperma herb has effects that qi-restoratives invigorating the spleen.Wherein select The root of Dahurain angelica is because root of Dahurain angelica wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving.Above-mentioned 13 taste medicine is cooperateed with each other to be acted, and it is made jointly Produce the therapeutic effect for anorexia nervosa.
Can further be obtained medical treatment the medicine of anorexia nervosa using above-mentioned Chinese medicine composition, by following masses part Bulk drug is made：
10-80 parts of Chinese yam, 10-50 parts of Ligusticum wallichii, 10-80 parts of broom top, 10-50 parts of radix bupleuri, centipede 10-60 parts of mountain is blocked close 10-60 parts, 10-30 parts of Poria cocos, 5-20 parts of asarum, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony, globose phaenosperma herb 10-50 parts, 10-30 parts of the root of Dahurain angelica.
Wherein, the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of Ligusticum wallichii, 10-30 parts of broom top, 10-15 parts of radix bupleuri, centipede 10-20 parts of mountain, card It is close 10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of asarum, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony, globose phaenosperma herb 10-20 parts, 10-15 parts of the root of Dahurain angelica；
(2) Chinese yam 30-50 parts, 20-30 parts of Ligusticum wallichii, 30-50 parts of broom top, 15-25 parts of radix bupleuri, centipede 20-35 parts of mountain, card Close 20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of asarum, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony shows son It is careless 20-30 parts, 15-20 parts of the root of Dahurain angelica；
(3) Chinese yam 50-70 parts, 30-40 parts of Ligusticum wallichii, 50-70 parts of broom top, 25-35 parts of radix bupleuri, centipede 35-45 parts of mountain, card Close 30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of asarum, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony shows son It is careless 30-40 parts, 20-25 parts of the root of Dahurain angelica；
(4) Chinese yam 70-80 parts, 40-50 parts of Ligusticum wallichii, 70-80 parts of broom top, 35-50 parts of radix bupleuri, centipede 45-60 parts of mountain, card Close 40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of asarum, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony shows son It is careless 40-50 parts, 25-30 parts of the root of Dahurain angelica.
Medicament selection of the present invention is prepared into any conventional oral preparations using the conventional method of Chinese medicine preparation, for example will be above-mentioned Bulk drug is ground into after powder and is well mixed, and add water decoction；Above-mentioned raw materials medicine is added water together and concentrated after decocting, to obtain this The active component of invention medicine, adds various customary adjuvants required when preparing different dosage forms, such as disintegrant, adhesive Deng (starch, dextrin, sodium carboxymethylcellulose etc.), any traditional oral agent is prepared into conventional method of Chinese medicinal Type, such as tablet, capsule, pill, oral liquid.
Preferably, the preparation method of medicine activity component of the present invention is as follows：
1) each bulk drug is weighed according to the proportion by weight, adds each bulk drug quality and 6~9 times of water, adjusted After the PH to 8~9 for saving whole system, boiling is heated to, flows back at least 2 hours, is filtrated to get extract solution A and residue；
2) each bulk drug quality and 3~8 times of water are added in the residue, the PH to 8~9 of whole system is adjusted Afterwards, it is again heated to after boiling, flows back at least 5 hours, extract solution B is obtained after filtering；
3) pH to 7~7.5 is adjusted after extract solution A and extract solution B is merged, it is 1~1.2 to be concentrated under reduced pressure into density.
In the step 1) in, each bulk drug is weighed, 40-80 mesh sieves are crossed after crushing.
In the step 1) in, the time of backflow is 3~6 hours.
In the step 2) in, the time of backflow is 6~10 hours.
In the step 3) in, adjust pH to 7 after extract solution A and extract solution B is merged.
As described above of the invention Chinese medicine composition, medicine and preparation method in treatment anorexia nervosa disease drug should With.
Advantages of the present invention and beneficial effect are：
The medicine of the present invention is from organic conception, and diagnosis and treatment based on an overall analysis of the illness and the patient's condition, determined curative effect is lasting, and security is good, patient medication Compliance is high, the especially adjustment to light moderate patient compliance life style, with treatment by Chinese herbs safely, effectively, it is economical, meet god Treatment need through property apositia patient.The medicine of the present invention has mental-tranquilization, reducing fever and causing diuresis, the effect of dampness elimination disperse accumulations, and The active ingredient of medicine can go directly focus, have that instant effect, cure rate are high for treatment anorexia nervosa, have no toxic side effect, Safe ready and the lasting advantage of curative effect.
Embodiment
Technical scheme is further illustrated with reference to specific embodiment.
It is first according to the bulk drug mass ratio described in following table to be weighed, crushing (crossing 60 mesh sieves) is well mixed afterwards.
According to above-described embodiment 1-9, decoction is carried out according to following method：
1) each bulk drug quality and 7 times of water are added, after the PH to 9 for adjusting whole system, boiling, backflow 4 is heated to Hour, it is filtrated to get extract solution A and residue；
2) each bulk drug quality and 6 times of water are added in residue, after the PH to 9 for adjusting whole system, is heated again To after seething with excitement, flow back 6 hours, extract solution B is obtained after filtering；
3) pH to 7 is adjusted after extract solution A and extract solution B is merged, it is 1 to be concentrated under reduced pressure into density.
According to a daily dose 30g, three parts are divided into, in the morning, afternoon and evening three times oral () at 8 points, 12 points and 20 points.
The concentrate 1-9 prepared according to above-mentioned preparation method and bulk drug proportioning, carries out specific clinical test, When taking, different patients are selected to take the test that concentrate carries out parameters after two months, specific clinical test knot respectively Fruit is as follows：
200 patients with anorexia nervosa, wherein, man is 20, and woman is 180, takes the medicine two of the present invention After individual month, the difficulty falling asleep symptom of 190 patients is disappeared, and sleep quality is improved, and the anorexia nervosa symptom such as appetite increase is bright It is aobvious to disappear.
Exemplary description is done to the present invention above, it should explanation, in the situation for the core for not departing from the present invention Under, any simple deformation, modification or other skilled in the art can not spend the equivalent substitution of creative work equal Fall into protection scope of the present invention.

Claims (10)

1. a kind of pharmaceutical composition, it is characterised in that described pharmaceutical composition is made up of the bulk drug of following masses part：
10-80 parts of Chinese yam, 10-50 parts of Ligusticum wallichii, 10-80 parts of broom top, 10-50 parts of radix bupleuri, close 10-60 is blocked on centipede 10-60 parts of mountain Part, 10-30 parts of Poria cocos, 5-20 parts of asarum, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony, globose phaenosperma herb 10-50 Part, 10-30 parts of the root of Dahurain angelica.
2. pharmaceutical composition according to claim 1, it is characterised in that the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of Ligusticum wallichii, 10-30 parts of broom top, 10-15 parts of radix bupleuri, centipede 10-20 parts of mountain is blocked close 10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of asarum, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony, globose phaenosperma herb 10-20 parts, 10-15 parts of the root of Dahurain angelica；
(2) Chinese yam 30-50 parts, 20-30 parts of Ligusticum wallichii, 30-50 parts of broom top, 15-25 parts of radix bupleuri, centipede 20-35 parts of mountain is blocked close 20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of asarum, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony, globose phaenosperma herb 20-30 parts, 15-20 parts of the root of Dahurain angelica；
(3) Chinese yam 50-70 parts, 30-40 parts of Ligusticum wallichii, 50-70 parts of broom top, 25-35 parts of radix bupleuri, centipede 35-45 parts of mountain is blocked close 30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of asarum, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony, globose phaenosperma herb 30-40 parts, 20-25 parts of the root of Dahurain angelica；
(4) Chinese yam 70-80 parts, 40-50 parts of Ligusticum wallichii, 70-80 parts of broom top, 35-50 parts of radix bupleuri, centipede 45-60 parts of mountain is blocked close 40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of asarum, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony, globose phaenosperma herb 40-50 parts, 25-30 parts of the root of Dahurain angelica.
3. a kind of medicine for treating anorexia nervosa, it is characterised in that be made up of the bulk drug of following masses part：
10-80 parts of Chinese yam, 10-50 parts of Ligusticum wallichii, 10-80 parts of broom top, 10-50 parts of radix bupleuri, close 10-60 is blocked on centipede 10-60 parts of mountain Part, 10-30 parts of Poria cocos, 5-20 parts of asarum, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony, globose phaenosperma herb 10-50 Part, 10-30 parts of the root of Dahurain angelica.
4. medicine according to claim 3, it is characterised in that the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of Ligusticum wallichii, 10-30 parts of broom top, 10-15 parts of radix bupleuri, centipede 10-20 parts of mountain is blocked close 10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of asarum, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony, globose phaenosperma herb 10-20 parts, 10-15 parts of the root of Dahurain angelica；
(2) Chinese yam 30-50 parts, 20-30 parts of Ligusticum wallichii, 30-50 parts of broom top, 15-25 parts of radix bupleuri, centipede 20-35 parts of mountain is blocked close 20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of asarum, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony, globose phaenosperma herb 20-30 parts, 15-20 parts of the root of Dahurain angelica；
(3) Chinese yam 50-70 parts, 30-40 parts of Ligusticum wallichii, 50-70 parts of broom top, 25-35 parts of radix bupleuri, centipede 35-45 parts of mountain is blocked close 30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of asarum, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony, globose phaenosperma herb 30-40 parts, 20-25 parts of the root of Dahurain angelica；
(4) Chinese yam 70-80 parts, 40-50 parts of Ligusticum wallichii, 70-80 parts of broom top, 35-50 parts of radix bupleuri, centipede 45-60 parts of mountain is blocked close 40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of asarum, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony, globose phaenosperma herb 40-50 parts, 25-30 parts of the root of Dahurain angelica.
5. a kind of preparation method of the medicine as described in claim 3 or 4, it is characterised in that comprise the following steps：
1) each bulk drug is weighed according to the proportion by weight, adds each bulk drug quality and 6~9 times of water, adjusted whole After the pH of individual system to 8~9, boiling is heated to, flows back at least 2 hours, is filtrated to get extract solution A and residue；
2) each bulk drug quality and 3~8 times of water are added in the residue, after the pH to 8~9 for adjusting whole system, then It is secondary to be heated to after boiling, flow back at least 5 hours, extract solution B is obtained after filtering；
3) pH to 7~7.5 is adjusted after extract solution A and extract solution B is merged, it is 1~1.2 to be concentrated under reduced pressure into density.
6. preparation method according to claim 5, it is characterised in that in the step 1) in, weigh each bulk drug, powder 40-80 mesh sieves are crossed after broken.
7. preparation method according to claim 5, it is characterised in that in the step 1) in, the time of backflow is 3~6 Hour.
8. preparation method according to claim 5, it is characterised in that in the step 2) in, the time of backflow is 6~10 Hour.
9. preparation method according to claim 5, it is characterised in that in the step 3) in, by extract solution A and extract solution B adjusts pH to 7 after merging.
10. the preparation side described in medicine and claim 5 described in Chinese medicine composition as claimed in claim 1, claim 3 Application of the method in the medicine for the treatment of anorexia nervosa.
CN201611145915.7A 2016-12-13 2016-12-13 Treat the medicine of anorexia nervosa Pending CN107233508A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103735936A (en) * 2012-10-17 2014-04-23 青岛信立德中药技术研究开发有限公司 A traditional Chinese medicine used for trading anorexia nervosa
CN103768452A (en) * 2012-10-24 2014-05-07 青岛信立德中药技术研究开发有限公司 Chinese medicinal composition for treating anorexia nervosa
CN104524277A (en) * 2014-12-19 2015-04-22 济宁学院 Traditional Chinese medicine mixture for treating anorexia nervosa

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103735936A (en) * 2012-10-17 2014-04-23 青岛信立德中药技术研究开发有限公司 A traditional Chinese medicine used for trading anorexia nervosa
CN103768452A (en) * 2012-10-24 2014-05-07 青岛信立德中药技术研究开发有限公司 Chinese medicinal composition for treating anorexia nervosa
CN104524277A (en) * 2014-12-19 2015-04-22 济宁学院 Traditional Chinese medicine mixture for treating anorexia nervosa

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