CN107224543A - Treat the medicine of sleep-disorder - Google Patents
Treat the medicine of sleep-disorder Download PDFInfo
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- CN107224543A CN107224543A CN201611146724.2A CN201611146724A CN107224543A CN 107224543 A CN107224543 A CN 107224543A CN 201611146724 A CN201611146724 A CN 201611146724A CN 107224543 A CN107224543 A CN 107224543A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of medicine for treating sleep-disorder, it is made up of the bulk drug of following masses part：10 80 parts of Chinese yam, 10 50 parts of spina date seed, 10 80 parts of the red sage root, 10 50 parts of paniculate swallowwort, 10 60 parts of mountain centipede, block close 10 60 parts, 10 30 parts of Poria cocos, 5 20 parts of gynostemma pentaphylla, 10 40 parts of borneol, 10 50 parts of Semen sesami nigrum, 10 50 parts of the root of herbaceous peony, 10 50 parts of globose phaenosperma herb, 10 30 parts of jatamans valeriana rhizome.The medicine of the present invention is from organic conception, and diagnosis and treatment based on an overall analysis of the illness and the patient's condition, determined curative effect is lasting, and security is good, patient medication compliance is high, the especially adjustment to light moderate patient compliance life style, with treatment by Chinese herbs safely, effectively, it is economical, meet the Treatment need of sleep-disorder patient.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, a kind of medicine for treating sleep-disorder is related in particular to.
Background technology
With the increasingly quickening of Modern Live rhythm, social competition intensifies, life and pressure of competition, frustrated and mistake
Having some setbacks for bitterness, cause and the marriage fallen, has a sleepless night, incidence of depression rises year by year, and sleep-disorder has turned into particularly common
Disease.Show that the people that China has more than 42.5% exists according to the whole world sleep of nearest phase China investigation result statistics
Different degrees of sleep-disorder, the incidence of disease of insomnia is up to 10%~20%.
Sleep-disorder is mainly shown as：Difficulty falling asleep；It can not sleep soundly；Early awakening；It can not be fallen asleep after waking up；Frequently shy from bad dream
Wake up；Sensation is all being had horrible nightmares whole night；Energy does not recover after sleeping；Do not recover from fatigue.Insomnia makes one to have a dizzy spell, palpitation,
Fatigue and asthenia, forgetful, apocleisis, tinnitus, anxious irritability of making an uproar, nauseous bitter taste, pain in low back and legs；Insomnia causes absent minded, work
Learning efficiency declines, and permanent insomnia causes immunity degradation, endocrine disturbance, spirit is fidgety, easily cause cardiovascular unexpected, stomach
Enteropathy, hypertension, hypogona dism and psychological disease etc..Decline quality of life, or even cause sudden death.In addition, patient day
Between it is drowsiness also it occur frequently that production and traffic accident.Sleep-disorder has turned into puzzlement modern, has had a strong impact on human body physical and mental health
A big illness.
Current Western medicine is in terms for the treatment of sleep-disorder and insomnia, in spite of the adverse reaction benzene two light compared with barbiturate
The derivative (stable class medicine) of nitrogen Zhuo class.It is well known that stable class medicine is used in a small amount, short can play certain
Effect, but certain harmfulness of also hiding simultaneously.It is considered that such safety of medicine, will not habituation, but have habituation repeatly in recent years
Case report, it sometimes appear that withrawal symptom, such as anxiety, sleep-disorder；More common is psychological dependence, gives up meeting after medicine
Cause insomnia, thus long-term taking and be difficult to cut off, Recent study also found, such medicine can cause memory disorders, especially
It is to take class medicine in short-term easily to occur.Some other people take rear next day and have incoordination phenomenon, such as indescribable wrestling,
Therefore driving task should not be served as.Simultaneously pregnant woman, nursing women, elderly and infirm, have heart, liver and nephropathy person, sleep
Dormancy respiratory disorder person etc. should not take stable class medicine.It is many adverse reactions of stable class medicine and its tolerance, additive
It greatly limit its market competitiveness.
Traditional Chinese medicine has obvious advantage in terms of sleep quality and treatment sleep-disorder is improved, and Chinese medicine is in terms of action
Though be not as fast as Western medicine, without obvious adverse reaction, it is adapted to patient and takes the long period, the function that can adjust patient is gentle
The operation of blood body fluid, QI invigorating of calming the nerves makes patient possess good sleep, nourishes the brain impaired because of chronic insomnia, recovers people
The self-regeneration function of body, fundamentally releases sufferer, reaches the purpose treated both principal and secondary aspect of disease.Many is had been disclosed in existing literature
Treat the Chinese medicine of insomnia and dreamful sleep.
But, the Chinese medicine sedation of disclosed many treatment insomnia and dreamful sleeps is not obvious, and the curative effect to insomnia is not also notable,
And need to add multiple auxiliary materials in the production process of preparation, add the dosage and use cost of patient.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of medicine for treating sleep-disorder.
The purpose of the present invention is achieved by following technical proposals.
A kind of Chinese medicine composition, the Chinese medicine composition is made up of the bulk drug of following masses part：
10-80 parts of Chinese yam, 10-50 parts of spina date seed, 10-80 parts of the red sage root, 10-50 parts of paniculate swallowwort, centipede 10-60 parts of mountain, card
Close 10-60 parts, 10-30 parts of Poria cocos, 5-20 parts of gynostemma pentaphylla, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony shows son
It is careless 10-50 parts, 10-30 parts of jatamans valeriana rhizome.
Wherein, the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of spina date seed, 10-30 parts of the red sage root, 10-15 parts of paniculate swallowwort, centipede 10-20 parts of mountain,
Block close 10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of gynostemma pentaphylla, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony shows
Sub- 10-20 parts of grass, 10-15 parts of jatamans valeriana rhizome；
(2) Chinese yam 30-50 parts, 20-30 parts of spina date seed, 30-50 parts of the red sage root, 15-25 parts of paniculate swallowwort, centipede 20-35 parts of mountain,
Block close 20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of gynostemma pentaphylla, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony,
20-30 parts of globose phaenosperma herb, 15-20 parts of jatamans valeriana rhizome；
(3) Chinese yam 50-70 parts, 30-40 parts of spina date seed, 50-70 parts of the red sage root, 25-35 parts of paniculate swallowwort, centipede 35-45 parts of mountain,
Block close 30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of gynostemma pentaphylla, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony,
30-40 parts of globose phaenosperma herb, 20-25 parts of jatamans valeriana rhizome；
(4) Chinese yam 70-80 parts, 40-50 parts of spina date seed, 70-80 parts of the red sage root, 35-50 parts of paniculate swallowwort, centipede 45-60 parts of mountain,
Block close 40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of gynostemma pentaphylla, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony,
40-50 parts of globose phaenosperma herb, 25-30 parts of jatamans valeriana rhizome.
The present invention above-mentioned Chinese medicine composition in, selectivity it is low by Chinese yam, spina date seed, the red sage root, paniculate swallowwort, mountain centipede,
Block close, Poria cocos, gynostemma pentaphylla, borneol, Semen sesami nigrum, the root of herbaceous peony, globose phaenosperma herb and jatamans valeriana rhizome to be combined, these drug regimens are caused respectively
Individual efficacy of drugs produces synergy, so as to effectively treatment sleep-disorder.Wherein it is to be controlled because Chinese yam has from Chinese yam
Weakness, general debility, relieving restlessness heat are treated, bushing unsaturated vapor, heart hole, many accounts is reached, kidney-nourishing gas, strengthening the spleen and stomach, antidiarrheal dysentery, moistens
Fur, it is raw to smash the swollen effect that controlled with hard poison of patch.It is because of spina date seed calming heart wherein from spina date seed, calms the nerves.Wherein from pellet
Ginseng is because the red sage root has effects that relieving restlessness that clears away heart-fire.It is wherein because paniculate swallowwort QI invigorating from paniculate swallowwort.Wherein select mountain centipede
It is because the strongly fragrant scattered stasis of blood of mountain centipede solution.It is because blocking close strengthening the spleen and stomach, replenishing qi and blood wherein from blocking close.It is wherein because Fu from Poria cocos
Siberian cocklebur calming heart.It is wherein because gynostemma pentaphylla eliminating inflammation and expelling toxin from gynostemma pentaphylla.Wherein it is from Semen sesami nigrum because Semen sesami nigrum has nourishing
Liver kidney, effect of beneficial blood ease constipation.Wherein it is because the moon, soft liver analgesic, Pinggan Yang are held back in root of herbaceous peony blood-nourishing from the root of herbaceous peony.Wherein from aobvious
Sub- grass is because globose phaenosperma herb has effects that qi-restoratives invigorating the spleen.Wherein it is, because jatamans valeriana rhizome regulating qi-flowing for relieving pain, to help digestion only from jatamans valeriana rhizome
Rush down, dispelling wind and eliminating dampness, tranquillizing the mind by relieving convulsion.Above-mentioned 13 taste medicine is cooperateed with each other to be acted, and it is produced for sleep-disorder jointly
Therapeutic effect.
The medicine for the sleep-disorder that can further be obtained medical treatment using above-mentioned Chinese medicine composition, by the raw material of following masses part
Medicine is made：
10-80 parts of Chinese yam, 10-50 parts of spina date seed, 10-80 parts of the red sage root, 10-50 parts of paniculate swallowwort, centipede 10-60 parts of mountain, card
Close 10-60 parts, 10-30 parts of Poria cocos, 5-20 parts of gynostemma pentaphylla, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony shows son
It is careless 10-50 parts, 10-30 parts of jatamans valeriana rhizome.
Wherein, the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of spina date seed, 10-30 parts of the red sage root, 10-15 parts of paniculate swallowwort, centipede 10-20 parts of mountain,
Block close 10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of gynostemma pentaphylla, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony shows
Sub- 10-20 parts of grass, 10-15 parts of jatamans valeriana rhizome；
(2) Chinese yam 30-50 parts, 20-30 parts of spina date seed, 30-50 parts of the red sage root, 15-25 parts of paniculate swallowwort, centipede 20-35 parts of mountain,
Block close 20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of gynostemma pentaphylla, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony,
20-30 parts of globose phaenosperma herb, 15-20 parts of jatamans valeriana rhizome；
(3) Chinese yam 50-70 parts, 30-40 parts of spina date seed, 50-70 parts of the red sage root, 25-35 parts of paniculate swallowwort, centipede 35-45 parts of mountain,
Block close 30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of gynostemma pentaphylla, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony,
30-40 parts of globose phaenosperma herb, 20-25 parts of jatamans valeriana rhizome；
(4) Chinese yam 70-80 parts, 40-50 parts of spina date seed, 70-80 parts of the red sage root, 35-50 parts of paniculate swallowwort, centipede 45-60 parts of mountain,
Block close 40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of gynostemma pentaphylla, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony,
40-50 parts of globose phaenosperma herb, 25-30 parts of jatamans valeriana rhizome.
Medicament selection of the present invention is prepared into any conventional oral preparations using the conventional method of Chinese medicine preparation, for example will be above-mentioned
Bulk drug is ground into after powder and is well mixed, and add water decoction；Above-mentioned raw materials medicine is added water together and concentrated after decocting, to obtain this
The active component of invention medicine, adds various customary adjuvants required when preparing different dosage forms, such as disintegrant, adhesive
Deng (starch, dextrin, sodium carboxymethylcellulose etc.), any traditional oral agent is prepared into conventional method of Chinese medicinal
Type, such as tablet, capsule, pill, oral liquid.
Preferably, the preparation method of medicine activity component of the present invention is as follows：
1) each bulk drug is weighed according to the proportion by weight, adds each bulk drug quality and 6~9 times of water, adjusted
After the PH to 8~9 for saving whole system, boiling is heated to, flows back at least 2 hours, is filtrated to get extract solution A and residue；
2) each bulk drug quality and 3~8 times of water are added in the residue, the PH to 8~9 of whole system is adjusted
Afterwards, it is again heated to after boiling, flows back at least 5 hours, extract solution B is obtained after filtering；
3) pH to 7~7.5 is adjusted after extract solution A and extract solution B is merged, it is 1~1.2 to be concentrated under reduced pressure into density.
In the step 1) in, each bulk drug is weighed, 40-80 mesh sieves are crossed after crushing.
In the step 1) in, the time of backflow is 3~6 hours.
In the step 2) in, the time of backflow is 6~10 hours.
In the step 3) in, adjust pH to 7 after extract solution A and extract solution B is merged.
The application of Chinese medicine composition, medicine and preparation method of the invention in treatment sleep disorder remedies as described above.
Advantages of the present invention and beneficial effect are：
The medicine of the present invention is from organic conception, and diagnosis and treatment based on an overall analysis of the illness and the patient's condition, determined curative effect is lasting, and security is good, patient medication
Compliance is high, the especially adjustment to light moderate patient compliance life style, with treatment by Chinese herbs safely, effectively, it is economical, meet and sleep
The Treatment need of dormancy impaired patients.The medicine of the present invention has the effect of mental-tranquilization, and the active ingredient of medicine can go directly focus,
Have the advantages that instant effect, cure rate are high for treatment sleep-disorder, have no toxic side effect, safe ready and curative effect it is lasting.
Embodiment
Technical scheme is further illustrated with reference to specific embodiment.
It is first according to the bulk drug mass ratio described in following table to be weighed, crushing (crossing 60 mesh sieves) is well mixed afterwards.
According to above-described embodiment 1-9, decoction is carried out according to following method：
1) each bulk drug quality and 7 times of water are added, after the PH to 9 for adjusting whole system, boiling, backflow 4 is heated to
Hour, it is filtrated to get extract solution A and residue；
2) each bulk drug quality and 6 times of water are added in residue, after the PH to 9 for adjusting whole system, is heated again
To after seething with excitement, flow back 6 hours, extract solution B is obtained after filtering；
3) pH to 7 is adjusted after extract solution A and extract solution B is merged, it is 1 to be concentrated under reduced pressure into density.
According to a daily dose 30g, three parts are divided into, in the morning, afternoon and evening three times oral () at 8 points, 12 points and 20 points.
The concentrate 1-9 prepared according to above-mentioned preparation method and bulk drug proportioning, carries out specific clinical test,
When taking, different patients are selected to take the test that concentrate carries out parameters after two months, specific clinical test knot respectively
Fruit is as follows：
200 sleep-disorder patients, wherein, man is 20, and woman is 180, takes the medicine of the present invention two months
Afterwards, the sleep quality of 190 patients is improved, and the sleep-disorder symptom such as difficulty falling asleep substantially disappears.
Exemplary description is done to the present invention above, it should explanation, in the situation for the core for not departing from the present invention
Under, any simple deformation, modification or other skilled in the art can not spend the equivalent substitution of creative work equal
Fall into protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that the Chinese medicine composition is made up of the bulk drug of following masses part：
10-80 parts of Chinese yam, 10-50 parts of spina date seed, 10-80 parts of the red sage root, 10-50 parts of paniculate swallowwort, close 10- is blocked on centipede 10-60 parts of mountain
60 parts, 10-30 parts of Poria cocos, 5-20 parts of gynostemma pentaphylla, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony, globose phaenosperma herb 10-
50 parts, 10-30 parts of jatamans valeriana rhizome.
2. Chinese medicine composition according to claim 1, it is characterised in that the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of spina date seed, 10-30 parts of the red sage root, 10-15 parts of paniculate swallowwort, centipede 10-20 parts of mountain is blocked close
10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of gynostemma pentaphylla, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony, globose phaenosperma herb
10-20 parts, 10-15 parts of jatamans valeriana rhizome；
(2) Chinese yam 30-50 parts, 20-30 parts of spina date seed, 30-50 parts of the red sage root, 15-25 parts of paniculate swallowwort, centipede 20-35 parts of mountain is blocked close
20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of gynostemma pentaphylla, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony shows son
It is careless 20-30 parts, 15-20 parts of jatamans valeriana rhizome；
(3) Chinese yam 50-70 parts, 30-40 parts of spina date seed, 50-70 parts of the red sage root, 25-35 parts of paniculate swallowwort, centipede 35-45 parts of mountain is blocked close
30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of gynostemma pentaphylla, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony shows son
It is careless 30-40 parts, 20-25 parts of jatamans valeriana rhizome；
(4) Chinese yam 70-80 parts, 40-50 parts of spina date seed, 70-80 parts of the red sage root, 35-50 parts of paniculate swallowwort, centipede 45-60 parts of mountain is blocked close
40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of gynostemma pentaphylla, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony shows son
It is careless 40-50 parts, 25-30 parts of jatamans valeriana rhizome.
3. a kind of medicine for treating sleep-disorder, it is characterised in that be made up of the bulk drug of following masses part：
10-80 parts of Chinese yam, 10-50 parts of spina date seed, 10-80 parts of the red sage root, 10-50 parts of paniculate swallowwort, close 10- is blocked on centipede 10-60 parts of mountain
60 parts, 10-30 parts of Poria cocos, 5-20 parts of gynostemma pentaphylla, 10-40 parts of borneol, 10-50 parts of Semen sesami nigrum, 10-50 parts of the root of herbaceous peony, globose phaenosperma herb 10-
50 parts, 10-30 parts of jatamans valeriana rhizome.
4. medicine according to claim 3, it is characterised in that the mass parts of each component are preferably as follows：
(1) Chinese yam 10-30 parts, 10-20 parts of spina date seed, 10-30 parts of the red sage root, 10-15 parts of paniculate swallowwort, centipede 10-20 parts of mountain is blocked close
10-20 parts, 10-15 parts of Poria cocos, 5-10 parts of gynostemma pentaphylla, 10-20 parts of borneol, 10-20 parts of Semen sesami nigrum, 10-20 parts of the root of herbaceous peony, globose phaenosperma herb
10-20 parts, 10-15 parts of jatamans valeriana rhizome；
(2) Chinese yam 30-50 parts, 20-30 parts of spina date seed, 30-50 parts of the red sage root, 15-25 parts of paniculate swallowwort, centipede 20-35 parts of mountain is blocked close
20-30 parts, 15-20 parts of Poria cocos, 10-15 parts of gynostemma pentaphylla, 20-30 parts of borneol, 20-30 parts of Semen sesami nigrum, 20-30 parts of the root of herbaceous peony shows son
It is careless 20-30 parts, 15-20 parts of jatamans valeriana rhizome；
(3) Chinese yam 50-70 parts, 30-40 parts of spina date seed, 50-70 parts of the red sage root, 25-35 parts of paniculate swallowwort, centipede 35-45 parts of mountain is blocked close
30-40 parts, 20-25 parts of Poria cocos, 15-18 parts of gynostemma pentaphylla, 30-35 parts of borneol, 30-40 parts of Semen sesami nigrum, 30-40 parts of the root of herbaceous peony shows son
It is careless 30-40 parts, 20-25 parts of jatamans valeriana rhizome；
(4) Chinese yam 70-80 parts, 40-50 parts of spina date seed, 70-80 parts of the red sage root, 35-50 parts of paniculate swallowwort, centipede 45-60 parts of mountain is blocked close
40-60 parts, 25-30 parts of Poria cocos, 18-20 parts of gynostemma pentaphylla, 35-40 parts of borneol, 40-50 parts of Semen sesami nigrum, 40-50 parts of the root of herbaceous peony shows son
It is careless 40-50 parts, 25-30 parts of jatamans valeriana rhizome.
5. a kind of preparation method of the medicine as described in claim 3 or 4, it is characterised in that comprise the following steps：
1) each bulk drug is weighed according to the proportion by weight, adds each bulk drug quality and 6~9 times of water, adjusted whole
After the PH of individual system to 8~9, boiling is heated to, flows back at least 2 hours, is filtrated to get extract solution A and residue；
2) each bulk drug quality and 3~8 times of water are added in the residue, after the PH to 8~9 for adjusting whole system, then
It is secondary to be heated to after boiling, flow back at least 5 hours, extract solution B is obtained after filtering；
3) pH to 7~7.5 is adjusted after extract solution A and extract solution B is merged, it is 1~1.2 to be concentrated under reduced pressure into density.
6. preparation method according to claim 5, it is characterised in that in the step 1) in, weigh each bulk drug, powder
40-80 mesh sieves are crossed after broken.
7. preparation method according to claim 5, it is characterised in that in the step 1) in, the time of backflow is 3~6
Hour.
8. preparation method according to claim 5, it is characterised in that in the step 2) in, the time of backflow is 6~10
Hour.
9. preparation method according to claim 5, it is characterised in that in the step 3) in, by extract solution A and extract solution
B adjusts pH to 7 after merging.
10. preparation method described in medicine described in Chinese medicine composition as claimed in claim 1, claim 3 and claim 5 is being controlled
Treat the application in sleep disorder remedies.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611146724.2A CN107224543A (en) | 2016-12-13 | 2016-12-13 | Treat the medicine of sleep-disorder |
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| CN201611146724.2A CN107224543A (en) | 2016-12-13 | 2016-12-13 | Treat the medicine of sleep-disorder |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101032560A (en) * | 2006-07-15 | 2007-09-12 | 广西玉林制药有限责任公司 | Chinese medicine composition for treating somnipathy and preparing method thereof |
| CN105168541A (en) * | 2015-09-23 | 2015-12-23 | 山西远扬医药科技有限公司 | Traditional Chinese medicine composition with function of improving sleep and preparation method and application thereof |
-
2016
- 2016-12-13 CN CN201611146724.2A patent/CN107224543A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101032560A (en) * | 2006-07-15 | 2007-09-12 | 广西玉林制药有限责任公司 | Chinese medicine composition for treating somnipathy and preparing method thereof |
| CN105168541A (en) * | 2015-09-23 | 2015-12-23 | 山西远扬医药科技有限公司 | Traditional Chinese medicine composition with function of improving sleep and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘华等: ""酸枣仁合剂对失眠症夜间慢波睡眠影响的研究"", 《宁夏医学杂志》 * |
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