CN107225006A - 基于主动控制液体流动的多通量微流控芯片 - Google Patents
基于主动控制液体流动的多通量微流控芯片 Download PDFInfo
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- CN107225006A CN107225006A CN201710531302.5A CN201710531302A CN107225006A CN 107225006 A CN107225006 A CN 107225006A CN 201710531302 A CN201710531302 A CN 201710531302A CN 107225006 A CN107225006 A CN 107225006A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/082—Active control of flow resistance, e.g. flow controllers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
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- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
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- General Physics & Mathematics (AREA)
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Abstract
Description
Claims (10)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710531302.5A CN107225006B (zh) | 2017-07-03 | 2017-07-03 | 基于主动控制液体流动的多通量微流控芯片 |
SG11201913816TA SG11201913816TA (en) | 2017-07-03 | 2017-12-06 | Multi-flux micro-fluidic chip based on active fluid flow control |
PCT/CN2017/114690 WO2019006977A1 (zh) | 2017-07-03 | 2017-12-06 | 基于主动控制液体流动的多通量微流控芯片 |
EP17896326.0A EP3470143B1 (en) | 2017-07-03 | 2017-12-06 | Multiflux microfluidic chip based on active control on liquid flowing |
US16/079,516 US10761092B2 (en) | 2017-07-03 | 2017-12-06 | Multi-flux micro-fluidic chip based on active fluid flow control |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710531302.5A CN107225006B (zh) | 2017-07-03 | 2017-07-03 | 基于主动控制液体流动的多通量微流控芯片 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107225006A true CN107225006A (zh) | 2017-10-03 |
CN107225006B CN107225006B (zh) | 2018-04-03 |
Family
ID=59956852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710531302.5A Active CN107225006B (zh) | 2017-07-03 | 2017-07-03 | 基于主动控制液体流动的多通量微流控芯片 |
Country Status (5)
Country | Link |
---|---|
US (1) | US10761092B2 (zh) |
EP (1) | EP3470143B1 (zh) |
CN (1) | CN107225006B (zh) |
SG (1) | SG11201913816TA (zh) |
WO (1) | WO2019006977A1 (zh) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108169301A (zh) * | 2018-03-15 | 2018-06-15 | 宁波雪弗尔生物科技有限公司 | 一种高通量定量检测核酸反应密闭实验系统装置 |
CN108371961A (zh) * | 2018-04-04 | 2018-08-07 | 南京岚煜生物科技有限公司 | 具有显色本底检测功能的微流控芯片及其检测方法 |
CN109100525A (zh) * | 2018-09-08 | 2018-12-28 | 重庆科技学院 | 一种多通道检测用纸基微流控芯片的使用方法 |
WO2019006977A1 (zh) * | 2017-07-03 | 2019-01-10 | 南京岚煜生物科技有限公司 | 基于主动控制液体流动的多通量微流控芯片 |
CN109453826A (zh) * | 2018-12-06 | 2019-03-12 | 昆明市儿童医院 | 一种利用Semaphorin 4D诊断急性白血病的微流控芯片 |
CN109738632A (zh) * | 2019-01-09 | 2019-05-10 | 南京岚煜生物科技有限公司 | 多指标微流控芯片及其使用方法 |
CN110124758A (zh) * | 2019-05-12 | 2019-08-16 | 南京岚煜生物科技有限公司 | 微流控芯片的进样腔及单指标微流控芯片 |
CN110320353A (zh) * | 2019-07-20 | 2019-10-11 | 中国人民解放军总医院 | 一种应用于高原环境的荧光免疫分析仪及样本检测方法 |
CN110684656A (zh) * | 2019-06-29 | 2020-01-14 | 东南大学 | 一种基于sers技术的集成微流控芯片平台 |
US10648975B2 (en) | 2017-07-03 | 2020-05-12 | Lansion Biotechnology Co., Ltd. | Single channel chemiluminescent micro-fluidic chip and detection method thereof |
CN111715149A (zh) * | 2020-07-11 | 2020-09-29 | 深圳市和来生物技术有限公司 | 基于时序控制的定量加液装置、方法以及微流控芯片 |
CN111812085A (zh) * | 2020-07-27 | 2020-10-23 | 重庆大学 | 一种发酵黄水检测装置 |
CN111929460A (zh) * | 2020-08-19 | 2020-11-13 | 河南科技大学 | 一种适用于微流控自动检测用取样、芯片及进液控制装置 |
CN114062632A (zh) * | 2021-11-17 | 2022-02-18 | 扬州大学 | 一种基于纳米颗粒酶联增敏的镉离子微流控检测方法及其检测装置 |
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CN107739706B (zh) * | 2017-09-26 | 2020-04-14 | 南京岚煜生物科技有限公司 | 主动控制流路的多通量微流控核酸检测芯片及其使用方法 |
CN113804658B (zh) * | 2020-06-11 | 2023-06-06 | 京东方科技集团股份有限公司 | 微流控流道结构、检测系统及其使用方法 |
CN111841669B (zh) * | 2020-06-19 | 2023-10-20 | 华中科技大学同济医学院附属同济医院 | 一种用于微生物检测的pcr芯片及基于该pcr芯片的液滴分配方法 |
CN111804355A (zh) * | 2020-07-15 | 2020-10-23 | 上海理工大学 | 一种用于电渗流传输的微通道结构及装置 |
WO2022125071A1 (en) * | 2020-12-08 | 2022-06-16 | Hp Health Solutions Inc. | Input port seals |
CN113234571B (zh) * | 2021-04-29 | 2023-08-25 | 杭州霆科生物科技有限公司 | 一种高通量酶筛选芯片 |
TWI786896B (zh) * | 2021-10-21 | 2022-12-11 | 醫流體股份有限公司 | 指壓式電晶體微流道晶片及其操作方法 |
CN114152606B (zh) * | 2021-12-02 | 2023-02-21 | 武汉新烽光电股份有限公司 | 一种基于微流控盘芯片水质监测设备及监测系统 |
CN114308163B (zh) * | 2021-12-31 | 2024-01-09 | 北京京东方技术开发有限公司 | 微流控芯片检测卡盒 |
CN114507593B (zh) * | 2022-01-29 | 2023-10-17 | 扬州大学 | 一种集成便携式药敏检测芯片 |
CN115069316B (zh) * | 2022-06-21 | 2023-08-04 | 扬州大学 | 一种能同时检测多种体液的芯片 |
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CN205797240U (zh) * | 2016-05-18 | 2016-12-14 | 博奥生物集团有限公司 | 一种集成化微流控芯片 |
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CN106353491A (zh) | 2016-09-14 | 2017-01-25 | 苏州康容生物医疗科技有限公司 | 微流控床旁边快速诊断试剂盒 |
CN106902905B (zh) | 2017-04-01 | 2018-04-03 | 南京岚煜生物科技有限公司 | 用于微流控芯片液体控制防回流装置及其微流控芯片 |
CN106902904B (zh) | 2017-04-01 | 2018-07-03 | 南京岚煜生物科技有限公司 | 用于微流控芯片的液体控制阀门装置及其微流控芯片 |
CN107219360B (zh) * | 2017-07-03 | 2018-04-03 | 南京岚煜生物科技有限公司 | 单通道化学发光微流控芯片及其检测方法 |
CN107225006B (zh) * | 2017-07-03 | 2018-04-03 | 南京岚煜生物科技有限公司 | 基于主动控制液体流动的多通量微流控芯片 |
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2017
- 2017-07-03 CN CN201710531302.5A patent/CN107225006B/zh active Active
- 2017-12-06 EP EP17896326.0A patent/EP3470143B1/en active Active
- 2017-12-06 US US16/079,516 patent/US10761092B2/en active Active
- 2017-12-06 SG SG11201913816TA patent/SG11201913816TA/en unknown
- 2017-12-06 WO PCT/CN2017/114690 patent/WO2019006977A1/zh unknown
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Also Published As
Publication number | Publication date |
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SG11201913816TA (en) | 2020-01-30 |
US10761092B2 (en) | 2020-09-01 |
EP3470143B1 (en) | 2021-08-04 |
CN107225006B (zh) | 2018-04-03 |
EP3470143A4 (en) | 2019-05-22 |
EP3470143A1 (en) | 2019-04-17 |
US20190137488A1 (en) | 2019-05-09 |
WO2019006977A1 (zh) | 2019-01-10 |
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