SG11201913816TA - Multi-flux micro-fluidic chip based on active fluid flow control - Google Patents

Multi-flux micro-fluidic chip based on active fluid flow control

Info

Publication number
SG11201913816TA
SG11201913816TA SG11201913816TA SG11201913816TA SG11201913816TA SG 11201913816T A SG11201913816T A SG 11201913816TA SG 11201913816T A SG11201913816T A SG 11201913816TA SG 11201913816T A SG11201913816T A SG 11201913816TA SG 11201913816T A SG11201913816T A SG 11201913816TA
Authority
SG
Singapore
Prior art keywords
fluid flow
flow control
fluidic chip
chip based
active fluid
Prior art date
Application number
SG11201913816TA
Other languages
English (en)
Inventor
Xingshang Xu
Jeffery Chen
Long Wang
Weiyan Sun
Qilu Wan
Shen Yang
Original Assignee
Nanjing Lansion Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Lansion Biotechnology Co Ltd filed Critical Nanjing Lansion Biotechnology Co Ltd
Publication of SG11201913816TA publication Critical patent/SG11201913816TA/en

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16KVALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00Subject matter not provided for in other groups of this subclass
    • F16K99/0001Microvalves
    • F16K99/0034Operating means specially adapted for microvalves
    • F16K99/0042Electric operating means therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/069Absorbents; Gels to retain a fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874Three dimensional network
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/082Active control of flow resistance, e.g. flow controllers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
SG11201913816TA 2017-07-03 2017-12-06 Multi-flux micro-fluidic chip based on active fluid flow control SG11201913816TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710531302.5A CN107225006B (zh) 2017-07-03 2017-07-03 基于主动控制液体流动的多通量微流控芯片
PCT/CN2017/114690 WO2019006977A1 (zh) 2017-07-03 2017-12-06 基于主动控制液体流动的多通量微流控芯片

Publications (1)

Publication Number Publication Date
SG11201913816TA true SG11201913816TA (en) 2020-01-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201913816TA SG11201913816TA (en) 2017-07-03 2017-12-06 Multi-flux micro-fluidic chip based on active fluid flow control

Country Status (5)

Country Link
US (1) US10761092B2 (zh)
EP (1) EP3470143B1 (zh)
CN (1) CN107225006B (zh)
SG (1) SG11201913816TA (zh)
WO (1) WO2019006977A1 (zh)

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CN107219360B (zh) 2017-07-03 2018-04-03 南京岚煜生物科技有限公司 单通道化学发光微流控芯片及其检测方法
CN107739706B (zh) * 2017-09-26 2020-04-14 南京岚煜生物科技有限公司 主动控制流路的多通量微流控核酸检测芯片及其使用方法
CN108169301A (zh) * 2018-03-15 2018-06-15 宁波雪弗尔生物科技有限公司 一种高通量定量检测核酸反应密闭实验系统装置
CN108371961B (zh) * 2018-04-04 2019-03-29 南京岚煜生物科技有限公司 具有显色本底检测功能的微流控芯片及其检测方法
CN109100525B (zh) * 2018-09-08 2023-07-28 重庆科技学院 一种多通道检测用纸基微流控芯片的使用方法
CN109453826B (zh) * 2018-12-06 2021-03-26 昆明市儿童医院 一种利用Semaphorin 4D诊断急性白血病的微流控芯片
CN109738632B (zh) * 2019-01-09 2022-04-29 南京岚煜生物科技有限公司 多指标微流控芯片及其使用方法
CN110124758B (zh) * 2019-05-12 2024-03-19 南京岚煜生物科技有限公司 微流控芯片的进样腔及单指标微流控芯片
CN110684656A (zh) * 2019-06-29 2020-01-14 东南大学 一种基于sers技术的集成微流控芯片平台
CN110320353B (zh) * 2019-07-20 2020-09-22 中国人民解放军总医院 一种应用于高原环境的荧光免疫分析仪及样本检测方法
CN113804658B (zh) * 2020-06-11 2023-06-06 京东方科技集团股份有限公司 微流控流道结构、检测系统及其使用方法
CN111841669B (zh) * 2020-06-19 2023-10-20 华中科技大学同济医学院附属同济医院 一种用于微生物检测的pcr芯片及基于该pcr芯片的液滴分配方法
CN111715149B (zh) * 2020-07-11 2023-02-14 深圳市和来生物技术有限公司 基于时序控制的定量加液装置、方法以及微流控芯片
CN111804355A (zh) * 2020-07-15 2020-10-23 上海理工大学 一种用于电渗流传输的微通道结构及装置
CN111812085A (zh) * 2020-07-27 2020-10-23 重庆大学 一种发酵黄水检测装置
CN111929460B (zh) * 2020-08-19 2024-03-01 河南科技大学 一种适用于微流控自动检测用取样、芯片及进液控制装置
WO2022125071A1 (en) * 2020-12-08 2022-06-16 Hp Health Solutions Inc. Input port seals
CN113234571B (zh) * 2021-04-29 2023-08-25 杭州霆科生物科技有限公司 一种高通量酶筛选芯片
TWI786896B (zh) * 2021-10-21 2022-12-11 醫流體股份有限公司 指壓式電晶體微流道晶片及其操作方法
CN114062632B (zh) * 2021-11-17 2023-12-29 扬州大学 一种基于纳米颗粒酶联增敏的镉离子微流控检测方法
CN114152606B (zh) * 2021-12-02 2023-02-21 武汉新烽光电股份有限公司 一种基于微流控盘芯片水质监测设备及监测系统
CN114308163B (zh) * 2021-12-31 2024-01-09 北京京东方技术开发有限公司 微流控芯片检测卡盒
CN114507593B (zh) * 2022-01-29 2023-10-17 扬州大学 一种集成便携式药敏检测芯片
CN115069316B (zh) * 2022-06-21 2023-08-04 扬州大学 一种能同时检测多种体液的芯片
CN115074229B (zh) * 2022-07-21 2023-08-11 北京泰豪生物科技有限公司 套式生化反应芯片以及生物检测装置
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CN116532175B (zh) * 2023-07-06 2023-10-13 北京中医药大学 辊压式微流控芯片及控制方法

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CN107225006B (zh) * 2017-07-03 2018-04-03 南京岚煜生物科技有限公司 基于主动控制液体流动的多通量微流控芯片

Also Published As

Publication number Publication date
US10761092B2 (en) 2020-09-01
EP3470143B1 (en) 2021-08-04
CN107225006B (zh) 2018-04-03
EP3470143A4 (en) 2019-05-22
EP3470143A1 (en) 2019-04-17
US20190137488A1 (en) 2019-05-09
WO2019006977A1 (zh) 2019-01-10
CN107225006A (zh) 2017-10-03

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