CN107213351A - A kind of stem of noble dendrobium lozenge and preparation method thereof - Google Patents
A kind of stem of noble dendrobium lozenge and preparation method thereof Download PDFInfo
- Publication number
- CN107213351A CN107213351A CN201710442464.1A CN201710442464A CN107213351A CN 107213351 A CN107213351 A CN 107213351A CN 201710442464 A CN201710442464 A CN 201710442464A CN 107213351 A CN107213351 A CN 107213351A
- Authority
- CN
- China
- Prior art keywords
- parts
- stem
- noble dendrobium
- lozenge
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to medicine processing technique field, and in particular to a kind of stem of noble dendrobium lozenge and preparation method thereof.The stem of noble dendrobium lozenge is made up of the raw material of following parts by weight：180 235 parts of the stem of noble dendrobium, 12 26 parts of menthol, 18 28 parts of sealwort, 17 22 parts of honeysuckle, 57 parts of sorbierite, 12 15 parts of chitosan, 26 parts of glycerine, 8 12 parts of maltodextrin, 23 40 parts of magnesium stearate.The present invention provides a kind of stem of noble dendrobium lozenge, by rational compatibility, keeps the appropriate sweet taste of medicine, color and luster, smell, with clearing heat and detoxicating, anti-inflammation, the effect such as wet one's whistle of promoting the production of body fluid, has significant effect in terms for the treatment of sphagitis and canker sore；The preparation method of stem of noble dendrobium lozenge of the present invention can preserve the active ingredient in raw material, and production technology rationally, is adapted to industrialized production.
Description
Technical field
The present invention relates to medicine processing technique field, more particularly to a kind of stem of noble dendrobium lozenge and preparation method thereof.
Background technology
Buccal tablet refers to the compressed tablets for being contained in slow mechanism dissolved in oral cavity, and oral cavity and the lasting drug effect of pharyngeal generation can be used for
Local anti-inflammatory, sterilization, detumescence, stimulation mucosal secretions etc., are the common drugs for treating oral cavity and pharyngolaryngitis.Buccal tablet is because of it
Excellent mouthfeel and convenient instructions of taking and welcome by many patients.But there is also problems with for Chinese medicine buccal tablet：1、
Drug matching is unreasonable, and drug effect is not good；2nd, the figuration composition such as carbohydrate, essence pigment is more, causes patient particularly children by mistake will
Lozenge is eaten as " sugar ", and over administration causes adverse reaction；3 preparation methods are not enough refined, it is impossible to play drug effect completely.
The content of the invention
For in place of above the deficiencies in the prior art, the present invention provides a kind of stem of noble dendrobium lozenge and preparation method thereof, by closing
The compatibility of reason, keeps the appropriate sweet taste of medicine, color and luster, smell, with clearing heat and detoxicating, anti-inflammation, the effect such as wet one's whistle of promoting the production of body fluid,
There is significant effect in terms for the treatment of sphagitis and canker sore.The preparation method of stem of noble dendrobium lozenge of the present invention can preserve raw material
In active ingredient, production technology rationally, be adapted to industrialized production.To solve above technical problem, the technology that the present invention takes
Scheme is as follows：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：180-235 parts of the stem of noble dendrobium, 12-26 parts of menthol, sealwort
18-28 parts, it is 17-22 parts of honeysuckle, 5-7 parts of sorbierite, 12-15 parts of chitosan, 2-6 parts of glycerine, 8-12 parts of maltodextrin, stearic
Sour magnesium 23-40 parts.
It is preferred that, a kind of stem of noble dendrobium lozenge of the present invention is made up of (parts by weight) following component：200 parts of the stem of noble dendrobium, peppermint
26 parts of brain, 20 parts of sealwort, 22 parts of honeysuckle, 5 parts of sorbierite, 15 parts of chitosan, 6 parts of glycerine, 8 parts of maltodextrin, magnesium stearate
30 parts.
Accordingly, present invention also offers a kind of preparation method of stem of noble dendrobium lozenge, its preparation method is comprised the steps of：
(1) a, the stem of noble dendrobium for weighing recipe quantity, sealwort and honeysuckle, crush, and cross 400-500 mesh sieves, obtain ultra-micro powder, use
40%-45% ethanol waters are extracted, and extract solution decompression boils off ethanol, the dregs of a decoction after obtaining extract solution and extracting；B, by a steps
Macroporous resin column on extract solution, is eluted with distilled water, alkali lye successively；Wherein, distillation water elution is efflux A；Alkali lye is eluted
Obtain efflux B；Efflux B is neutralized to neutrality with acid, and 1.5-3h is extracted with 40%-50% ethanol waters, and evaporated under reduced pressure obtains powder
End is 1.；C, in mass ratio 1:5 mix the dregs of a decoction described in a steps with water, keep 40 DEG C of -60 DEG C of water-bath 4-6h, are walked after cooling with b
Rapid described efflux A merges, concentration, adds absolute ethyl alcohol and produces precipitation, filter, dries, obtain powder 2.；By powder 1. with powder
2. end is well mixed, and obtains Traditional Chinese drug mixture, standby；
(2) Traditional Chinese drug mixture of step (1) is well mixed with the menthol of recipe quantity, sorbierite, chitosan, glycerine,
It is standby；
(3) magnesium stearate, the maltodextrin of recipe quantity, well mixed, dry, mistake are added in the compound of step (2)
Sieve, obtains composition, tabletting obtains stem of noble dendrobium lozenge.
It is preferred that, the stem of noble dendrobium in stem of noble dendrobium lozenge of the present invention includes HERBA DENDROBII, dendrobium candidum, Dendrobidium huoshanness, horsewhip
One or more in the stem of noble dendrobium.
A kind of proportioning mechanism of each component of stem of noble dendrobium lozenge of the present invention is as follows：
The stem of noble dendrobium (scientific name：Dendrobium nobile Lindl), also known as lofty or bottomless palpus, bracketplant, Lin Lan, prohibition of life, nobile flower
Deng.The main active of the stem of noble dendrobium is：Dendrobine, dendrobium polysaccharide, dendramine, nobilonine, research show the stem of noble dendrobium have antibacterial,
Effect that is anti-oxidant, antitumor, improving immunity and protection nerve.
Honeysuckle：Containing pharmacological components such as chlorogenic acid, cyanidenon glycosides, to hemolytic streptococcus, golden yellow grape ball
The various pathogens such as bacterium and infection of the upper respiratory tract Causative virus etc. have stronger restraint, in addition can also strengthen immunity, anti-morning
Pregnant, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis (blood coagulation), suppression intestinal absorption cholesterol etc..
Sealwort：It is hypoglycemic with hypotensive, reducing blood lipid, atherosclerosis, the effect such as anti-aging and antibacterial,
Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.
Menthol：Menthol is extracted in the leaf and stem of peppermint, is the main component in peppermint and lavender essential oil.
Peppermint brain-capacity optionally stimulates the frigidoreceptor of human body skin or mucous membrane, produces sense of cold reflection and creeping chill, causes skin to stick
Film vessel retraction (actually skin keeps normal)；Contraction can also be caused to the blood vessel of deep tissue in addition, and produce treatment and make
With.It is for oral administration to alleviate local inflammation (sphagitis) and treatment flu, and have stomach invigorating, wind dispelling effect.
Sorbierite：Conditioning agent, fixer, antioxidant as food or medicine.
Chitosan：Chitosan has preferable antibacterial activity, can suppress the growth and breeding of fungi, bacterium and virus.Meanwhile,
Chitosan is used as thickener, fruit glaze agent in field of food.
Glycerine：NMF, lubricant as food or medicine.
Maltodextrin：For increasing viscosity, enhancing product dispersiveness and dissolubility, maltodextrin has preferably emulsification to make
With and thickening effect.
Magnesium stearate：Lubricant is mainly used as, makes the medicinal powder being made that there is good mobility and compressibility.
Compared with prior art, the beneficial effects of the invention are as follows：Product of the present invention keeps medicine to fit by rational compatibility
When sweet taste, color and luster, smell, with clearing heat and detoxicating, anti-inflammation, the effect of wetting one's whistle etc. of promoting the production of body fluid, burst in treatment sphagitis and oral cavity
There is significant effect in terms of ulcer；The preparation method of stem of noble dendrobium lozenge of the present invention can preserve the active ingredient in raw material, production
Rational technology, is adapted to industrialized production.
Embodiment
The invention will now be further described with reference to specific embodiments, advantages of the present invention and feature will be with description and
It is apparent, but protection scope of the present invention is not limited to following examples.
Embodiment 1：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：200 parts of dendrobium candidum, 26 parts of menthol, sealwort 20
Part, 22 parts of honeysuckle, 5 parts of sorbierite, 15 parts of chitosan, 6 parts of glycerine, 8 parts of maltodextrin, 30 parts of magnesium stearate.
Preparation method is as follows：
(1) a, the stem of noble dendrobium for weighing recipe quantity, sealwort and honeysuckle, crush, and cross 400 mesh sieves, ultra-micro powder are obtained, using 40%
Ethanol water is extracted, and extract solution decompression boils off ethanol, the dregs of a decoction after obtaining extract solution and extracting；B, by the extract solution of a steps
Macroporous resin column, is eluted with distilled water, alkali lye successively；Wherein, distillation water elution is efflux A；Alkali lye elutes to obtain efflux
B；Efflux B is neutralized to neutrality with acid, and 3h is extracted with 40% ethanol water, and 1. evaporated under reduced pressure obtains powder；In mass ratio 1:5 will
The dregs of a decoction described in a steps are mixed with water, are kept 60 DEG C of water-bath 6h, are merged after cooling with the efflux A described in b step, are concentrated, plus
Enter absolute ethyl alcohol and produce precipitation, filter, dry, obtain powder 2.；2. 1. powder is well mixed with powder, Traditional Chinese drug mixture is obtained,
It is standby；
(2) Traditional Chinese drug mixture of step (1) is well mixed with the menthol of recipe quantity, sorbierite, chitosan, glycerine,
It is standby；
(3) magnesium stearate, the maltodextrin of recipe quantity, well mixed, dry, mistake are added in the compound of step (2)
Sieve, obtains composition, tabletting obtains stem of noble dendrobium lozenge.
Embodiment 2：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：180 parts of HERBA DENDROBII, 12 parts of menthol, sealwort 18
Part, 17 parts of honeysuckle, 5 parts of sorbierite, 12 parts of chitosan, 2 parts of glycerine, 8 parts of maltodextrin, 23 parts of magnesium stearate.
Preparation method is as follows：
(1) a, the stem of noble dendrobium for weighing recipe quantity, sealwort and honeysuckle, crush, and cross 500 mesh sieves, ultra-micro powder are obtained, using 45%
Ethanol water is extracted, and extract solution decompression boils off ethanol, the dregs of a decoction after obtaining extract solution and extracting；B, by the extract solution of a steps
Macroporous resin column, is eluted with distilled water, alkali lye successively；Wherein, distillation water elution is efflux A；Alkali lye elutes to obtain efflux
B；Efflux B is neutralized to neutrality with acid, and 1.5h is extracted with 50% ethanol water, and 1. evaporated under reduced pressure obtains powder；In mass ratio 1:5
The dregs of a decoction described in a steps are mixed with water, 50 DEG C of water-bath 4h is kept, merges after cooling with the efflux A described in b step, are concentrated,
Add absolute ethyl alcohol and produce precipitation, filter, dry, obtain powder 2.；2. 1. powder is well mixed with powder, Chinese medicine mixing is obtained
Thing, it is standby；
(2) Traditional Chinese drug mixture of step (1) is well mixed with the menthol of recipe quantity, sorbierite, chitosan, glycerine,
It is standby；
(3) magnesium stearate, the maltodextrin of recipe quantity, well mixed, dry, mistake are added in the compound of step (2)
Sieve, obtains composition, tabletting obtains stem of noble dendrobium lozenge.
Embodiment 3：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：235 parts of Dendrobidium huoshanness, 26 parts of menthol, sealwort 28
Part, 22 parts of honeysuckle, 7 parts of sorbierite, 15 parts of chitosan, 6 parts of glycerine, 12 parts of maltodextrin, 40 parts of magnesium stearate.
Preparation method is as follows：
(1) a, the stem of noble dendrobium for weighing recipe quantity, sealwort and honeysuckle, crush, and cross 450 mesh sieves, ultra-micro powder are obtained, using 45%
Ethanol water is extracted, and extract solution decompression boils off ethanol, the dregs of a decoction after obtaining extract solution and extracting；B, by the extract solution of a steps
Macroporous resin column, is eluted with distilled water, alkali lye successively；Wherein, distillation water elution is efflux A；Alkali lye elutes to obtain efflux
B；Efflux B is neutralized to neutrality with acid, and 2h is extracted with 45% ethanol water, and 1. evaporated under reduced pressure obtains powder；C, in mass ratio 1:5
The dregs of a decoction described in a steps are mixed with water, 40 DEG C of DEG C of water-bath 5h is kept, merges after cooling with the efflux A described in b step, it is dense
Contracting, adds absolute ethyl alcohol and produces precipitation, filter, dry, obtain powder 2.；2. 1. powder is well mixed with powder, Chinese medicine is obtained and mixes
Compound, it is standby；
(2) Traditional Chinese drug mixture of step (1) is well mixed with the menthol of recipe quantity, sorbierite, chitosan, glycerine,
It is standby；
(3) magnesium stearate, the maltodextrin of recipe quantity, well mixed, dry, mistake are added in the compound of step (2)
Sieve, obtains composition, tabletting obtains stem of noble dendrobium lozenge.
Embodiment 4：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：200 parts of Dendrobidium huoshanness, 20 parts of menthol, sealwort 20
Part, 20 parts of honeysuckle, 5 parts of sorbierite, 12 parts of chitosan, 6 parts of glycerine, 10 parts of maltodextrin, 30 parts of magnesium stearate.
Preparation method：
(1) a, the stem of noble dendrobium for weighing recipe quantity, sealwort and honeysuckle, crush, and cross 500 mesh sieves, ultra-micro powder are obtained, using 40%
Ethanol water is extracted, and extract solution decompression boils off ethanol, the dregs of a decoction after obtaining extract solution and extracting；B, by the extract solution of a steps
Macroporous resin column, is eluted with distilled water, alkali lye successively；Wherein, distillation water elution is efflux A；Alkali lye elutes to obtain efflux
B；Efflux B is neutralized to neutrality with acid, and 2h is extracted with 45% ethanol water, and 1. evaporated under reduced pressure obtains powder；C, in mass ratio 1:5
The dregs of a decoction described in a steps are mixed with water, 40 DEG C of water-bath 6h is kept, merges after cooling with the efflux A described in b step, are concentrated,
Add absolute ethyl alcohol and produce precipitation, filter, dry, obtain powder 2.；2. 1. powder is well mixed with powder, Chinese medicine mixing is obtained
Thing, it is standby；
(2) Traditional Chinese drug mixture of step (1) is well mixed with the menthol of recipe quantity, sorbierite, chitosan, glycerine,
It is standby；
(3) magnesium stearate, the maltodextrin of recipe quantity, well mixed, dry, mistake are added in the compound of step (2)
Sieve, obtains composition, tabletting obtains stem of noble dendrobium lozenge.
Comparative example 1：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：100 parts of dendrobium candidum, 5 parts of menthol, 7 parts of sealwort,
10 parts of honeysuckle, 1 part of sorbierite, 4 parts of chitosan, 1 part of glycerine, 3 parts of maltodextrin, 10 parts of magnesium stearate.
Preparation method：It is same as Example 1.
Comparative example 2：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：400 parts of dendrobium candidum, 30 parts of menthol, sealwort 35
Part, 40 parts of honeysuckle, 20 parts of sorbierite, 20 parts of chitosan, 15 parts of glycerine, 40 parts of maltodextrin, 70 parts of magnesium stearate.
Preparation method：It is same as Example 1.
Comparative example 3：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：It is same as Example 1.
Preparation method：
(1) take the dendrobium candidum, sealwort, honeysuckle of recipe quantity to be smashed after fully drying, cross 75 mesh sieves standby；
(2) powder smashed obtained by step (1) is thoroughly mixed, obtains compound standby；
(3) menthol of addition recipe quantity, sorbierite, chitosan, glycerine, malt paste in compound obtained by step (2)
Essence, magnesium stearate, mixing, sieving obtain composition, and stem of noble dendrobium lozenge is processed on tablet press machine.
Comparative example 4：
A kind of stem of noble dendrobium lozenge, is made up of (parts by weight) following component：
(cordate houttuynia replacement sealwort, sucrose replacement chitosan and sorbierite) 200 parts of HERBA DENDROBII, 26 parts of menthol, fish raw meat
20 parts of grass, 22 parts of honeysuckle, 15 parts of sucrose, 6 parts of glycerine, 8 parts of maltodextrin, 30 parts of magnesium stearate
Preparation method：It is same as Example 1.
Experimental example 1：Organoleptic indicator determines
Experimental method：Take above-described embodiment 1 to embodiment 4, comparative example 1 to the sample of comparative example 4, investigate respectively outside it
Sight, mouthfeel, disintegration.Experimental result is shown in Table 1：
Table 1：Organoleptic indicator's measurement result
Test result indicates that：Embodiment 1 to the sample of embodiment 4 shows excellent organoleptic indicator；The sample of comparative example 1
The clouding and slightly bitter taste in mouthfeel, the sample of comparative example 2 is slightly salubrious in mouthfeel and slightly sweet tea, it may be possible to because the place of the two
Caused by square consumption proportion is unreasonable；The sample surfaces of comparative example 3 are slightly coarse, and this is due to that its processing technology is relatively simple, component
Process is not enough refined；Substantial amounts of sweetener is with the addition of in the sample of comparative example 4, causes sweet taste weight.
Experimental example 2：Antibacterial experiment in vitro
MIC is determined：Example 1 to the sample of embodiment 4, comparative example 1 to comparative example 4 is diluted with nutrient broth respectively
(doubling dilution) is configured to the experiment liquid of each concentration, is respectively placed in test tube (1.0ml/ pipes), and often pipe adds 1.0ml bacterium solution
(1.5×106CFU/ml), mix, at the same design blank control (containing only meat soup), it is positive control (be not added with test liquid), negative right
According to (being not added with bacterium solution), 24h is cultivated in the biochemical cultivation case for being placed in 35 ± 1 DEG C, bacterial growth situation is visually observed.Upper liquid is clarified
For asepsis growth, upper liquid muddiness is has bacteria growing, and the minimum drug concentration without bacterial growth is MIC using in test tube.Experiment knot
Fruit is shown in Table 2.
MBC is determined：On the basis of the MIC of measure, each pipe content is inoculated in culture dish with 0.01ml oese
In, 24h is cultivated in the biochemical cultivation case for being placed in 35 ± 1 DEG C, bacterial growth situation is observed, original bacterium can be added by 99.9%
The lowest concentration of drug of kill is MBC.Experimental result is shown in Table 3.
Table 2：Antibacterial experiment in vitro result (MIC) unit mg/ml
Table 2：Antibacterial experiment in vitro result (MBC) unit mg/ml
Test result indicates that：The experimental result of comparative example 1~4 is poor compared with embodiment 1~4.Embodiment 1 is to implementation
There is the sample of example 4 antibacterial well and sterilization to imitate to staphylococcus aureus, streptococcus pneumonia, Pseudomonas aeruginosa and Escherichia coli bacterium
Really, minimum inhibitory concentration (MIC) is between 0.0625-0.125mg/ml, and minimum bactericidal concentration (MBC) is in 0.125-0.25mg/
Between ml, illustrate that product of the present invention has good fungistatic effect.
A kind of stem of noble dendrobium lozenge is obtained by the prescription compatibility of medicines and preparation technology of the present invention, the lozenge is round sheet, surface
Bright and clean, consolidation, clean taste is not sweet, keeps the appropriate sweet taste of medicine, color and luster, smell, with clearing heat and detoxicating, anti-inflammation,
Promote the production of body fluid the effect of wetting one's whistle etc., for staphylococcus aureus, streptococcus pneumonia, Pseudomonas aeruginosa, alpha-Hemolytic streptococcus, beta hemolysis
Streptococcus, haemophilus influenzae, Escherichia coli etc. have to be suppressed and killing action well, in treatment sphagitis and canker sore
In terms of have significant effect.Stem of noble dendrobium lozenge of the present invention can fully extract Chinese medicinal component using refined preparation technology
Active ingredient, the effect of each component active ingredient formation Synergistic, plays the maximum therapeutic efficiency of medicine, and production technology is closed
Reason, is adapted to industrialized production.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God is with principle, and any modification, equivalent substitution and improvements done etc. should be included within the scope of protection of the invention.
Claims (4)
1. a kind of stem of noble dendrobium lozenge, it is characterised in that be made up of (parts by weight) following component：180-235 parts of the stem of noble dendrobium, menthol 12-
26 parts, 18-28 parts of sealwort, 17-22 parts of honeysuckle, 5-7 parts of sorbierite, 12-15 parts of chitosan, 2-6 parts of glycerine, maltodextrin 8-
12 parts, 23-40 parts of magnesium stearate.
2. a kind of stem of noble dendrobium lozenge according to claim 1, it is characterised in that be made up of (parts by weight) following component：The stem of noble dendrobium
200 parts, 26 parts of menthol, 20 parts of sealwort, 22 parts of honeysuckle, 5 parts of sorbierite, 15 parts of chitosan, 6 parts of glycerine, maltodextrin 8
Part, 30 parts of magnesium stearate.
3. a kind of stem of noble dendrobium lozenge according to claim any one of 1-2, it is characterised in that its preparation method includes following step
Suddenly：
(1) a, the stem of noble dendrobium for weighing recipe quantity, sealwort and honeysuckle, crush, and cross 400-500 mesh sieves, obtain ultra-micro powder, use
40%-45% ethanol waters are extracted, and extract solution decompression boils off ethanol, the dregs of a decoction after obtaining extract solution and extracting；B, by a steps
Macroporous resin column on extract solution, is eluted with distilled water, alkali lye successively；Wherein, distillation water elution is efflux A；Alkali lye is eluted
Obtain efflux B；Efflux B is neutralized to neutrality with acid, and 1.5-3h is extracted with 40%-50% ethanol waters, and evaporated under reduced pressure obtains powder
End is 1.；C, in mass ratio 1:5 mix the dregs of a decoction described in a steps with water, keep 40 DEG C of -60 DEG C of water-bath 4-6h, are walked after cooling with b
Rapid described efflux A merges, concentration, adds absolute ethyl alcohol and produces precipitation, filter, dries, obtain powder 2.；By powder 1. with powder
2. end is well mixed, and obtains Traditional Chinese drug mixture, standby；
(2) Traditional Chinese drug mixture of step (1) is well mixed with the menthol of recipe quantity, sorbierite, chitosan, glycerine, it is standby；
(3) magnesium stearate, the maltodextrin of recipe quantity are added in the compound of step (2), is well mixed, dries, sieves, obtain
To composition, tabletting obtains stem of noble dendrobium lozenge.
4. a kind of stem of noble dendrobium lozenge according to claim any one of 1-3, it is characterised in that the stem of noble dendrobium includes golden hairpin stone
One or more in dry measure used in former times, dendrobium candidum, Dendrobidium huoshanness, stem of Eyeshaped Dendrobium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710442464.1A CN107213351B (en) | 2017-06-13 | 2017-06-13 | Dendrobium nobile buccal tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710442464.1A CN107213351B (en) | 2017-06-13 | 2017-06-13 | Dendrobium nobile buccal tablet and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107213351A true CN107213351A (en) | 2017-09-29 |
| CN107213351B CN107213351B (en) | 2020-11-13 |
Family
ID=59948724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710442464.1A Active CN107213351B (en) | 2017-06-13 | 2017-06-13 | Dendrobium nobile buccal tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107213351B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113331296A (en) * | 2021-06-22 | 2021-09-03 | 安徽斛生记生物科技有限公司 | Dendrobium candy buccal tablet and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406833A (en) * | 2010-12-01 | 2012-04-11 | 成都中医药大学 | Comprehensive extraction and utilization technology for creeping liriope |
| CN103263588A (en) * | 2013-05-23 | 2013-08-28 | 重庆市中药研究院 | Compound buccal tablet containing dendrobium nobile and honeysuckle and preparation method thereof |
-
2017
- 2017-06-13 CN CN201710442464.1A patent/CN107213351B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406833A (en) * | 2010-12-01 | 2012-04-11 | 成都中医药大学 | Comprehensive extraction and utilization technology for creeping liriope |
| CN103263588A (en) * | 2013-05-23 | 2013-08-28 | 重庆市中药研究院 | Compound buccal tablet containing dendrobium nobile and honeysuckle and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| （美）卡斯坦森著，钟玉绪译: "《现代药用粉体微粒学》", 31 October 2004, 中国医药科技出版社 * |
| 元英进主编: "《现代制药工艺学 下册》", 31 January 2006, 化学工业出版社 * |
| 广西卫生学校药学教研组编: "《药剂学》", 31 December 1975 * |
| 房学贤等主编: "《中西医结合眼耳鼻喉齿科临床手册》", 31 January 2014, 安徽科学技术出版社 * |
| 胡雅军等: ""浅谈如何解决中药片剂生产中的常见问题"", 《中国中医药现代远程教育》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113331296A (en) * | 2021-06-22 | 2021-09-03 | 安徽斛生记生物科技有限公司 | Dendrobium candy buccal tablet and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107213351B (en) | 2020-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101467316B1 (en) | Oral cleansing composition fermented taraxacum extract-containing complex herbal extract | |
| CN108606939B (en) | Composition with oral health care function and application and preparation method thereof | |
| CN104382786A (en) | Hair loss prevention hair-blacking agent and preparation method thereof | |
| CN104435379B (en) | A kind of plant extract complex with antibacterial anti-inflammatory, hemostasis and pain relieving and application thereof | |
| CN112263606A (en) | Traditional Chinese medicine gargle and preparation method thereof | |
| CN102919439B (en) | Honeysuckle-olive tea and method for making same | |
| CN101181208B (en) | Gargle containing natural antibiotics and preparation method thereof | |
| CN105106894A (en) | Chinese herbal medicine preparation for treating white head-mouth disease of xiphophorus helleri and preparation method thereof | |
| CN104434690A (en) | Mouthwash and preparation method thereof | |
| KR101790034B1 (en) | Oral composition for preventing cavity and halitosis | |
| CN104013846A (en) | Traditional Chinese medicine composition for treating dental ulcer and application thereof | |
| KR20140131409A (en) | Composition comprising complex extract of Astragalus membranaceus BUNGE, Saposhnikovia divaricata Schiskin, Ostericum koreanum Maximowicz, Scutellaria baicalensis Georgi and Atractylodes japonica Koidz for preventing or treating asthma, bronchitis or pneumonia | |
| CN105613853A (en) | Preparation method of five-flower honey tea capable of removing summer-heat | |
| CN107213351A (en) | A kind of stem of noble dendrobium lozenge and preparation method thereof | |
| CN105638780A (en) | TCM (traditional Chinese medicine) antibacterial disinfectant and preparation method thereof | |
| CN105832619A (en) | Sterilization and deodorization foot bath salt and preparation method | |
| KR101910013B1 (en) | A composition for improving, preventing and treating of pain comprising herb extract | |
| CN103520287B (en) | Forsythia suspense leaves refreshing sugar | |
| CN106038334A (en) | Bacterium-inhibiting and odor-removing toothpaste containing ilex latifolia thunb extract | |
| CN109464540A (en) | A kind of alleviation oral cavity and the spray of throat discomfort and preparation method thereof | |
| CN108935525A (en) | A kind of environmental protection disinfectant suitable for cattle farm | |
| CN101313960A (en) | Lozenge for preventing and controlling whelk | |
| CN106615512A (en) | Eggplant and honey throat-soothing candies and preparation method thereof | |
| CN105343840A (en) | Traditional Chinese medicine for treating pneumonia for traditional Chinese medicine internal medicine department | |
| CN109224037A (en) | A kind of antibacterial cream of erysipelas and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder |
Address after: 570100 No.111, Changdao village, Shishan town, Xiuying District, Haikou City, Hainan Province Patentee after: HAINAN SHIBOLI BIOTECHNOLOGY Co.,Ltd. Patentee after: INSTITUTE OF TROPICAL BIOSCIENCE AND BIOTECHNOLOGY, CHINESE ACADEMY OF TROPICAL AGRICULTURAL SCIENCES Address before: 570203 2nd floor, Haichuang space, data Valley, Hainan building, No.5 Guoxing Avenue, Meilan District, Haikou City, Hainan Province Patentee before: HAINAN SHIBOLI BIOTECHNOLOGY Co.,Ltd. Patentee before: INSTITUTE OF TROPICAL BIOSCIENCE AND BIOTECHNOLOGY, CHINESE ACADEMY OF TROPICAL AGRICULTURAL SCIENCES |
|
| CP02 | Change in the address of a patent holder |