CN107208132A - 用于诊断胃肠胰神经内分泌瘤的组合物、方法和试剂盒 - Google Patents

用于诊断胃肠胰神经内分泌瘤的组合物、方法和试剂盒 Download PDF

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CN107208132A
CN107208132A CN201580061761.0A CN201580061761A CN107208132A CN 107208132 A CN107208132 A CN 107208132A CN 201580061761 A CN201580061761 A CN 201580061761A CN 107208132 A CN107208132 A CN 107208132A
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biomarkers
value
nen
gep
expression
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I.M.莫林
M.基德
I.德罗斯多夫
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Clifton Life Sciences LLC
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201580061761.0A 2014-09-15 2015-09-15 用于诊断胃肠胰神经内分泌瘤的组合物、方法和试剂盒 Pending CN107208132A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462050465P 2014-09-15 2014-09-15
US62/050465 2014-09-15
PCT/US2015/050274 WO2016044330A1 (en) 2014-09-15 2015-09-15 Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm

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CN107208132A true CN107208132A (zh) 2017-09-26

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US (3) US10407730B2 (enExample)
EP (2) EP3194618B1 (enExample)
JP (2) JP6782700B2 (enExample)
KR (2) KR102762958B1 (enExample)
CN (1) CN107208132A (enExample)
AU (3) AU2015317893B2 (enExample)
CA (1) CA2959670C (enExample)
DK (2) DK3194618T3 (enExample)
ES (2) ES2881474T3 (enExample)
IL (2) IL250867B (enExample)
MX (2) MX386919B (enExample)
PL (2) PL3194618T3 (enExample)
WO (1) WO2016044330A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108048564A (zh) * 2018-02-09 2018-05-18 中国科学院昆明动物研究所 人glt8d1基因的新用途
CN111479931A (zh) * 2017-11-30 2020-07-31 液体活检研究有限责任公司 使用基因表达测定预测肽受体放射治疗
CN112514001A (zh) * 2018-07-30 2021-03-16 新加坡科技研究局 评价组织样本纤维化的方法和系统
CN113215255A (zh) * 2021-04-26 2021-08-06 山东天川精准医疗科技有限公司 用于肝癌早期诊断或预后的生物标记物及其用途
CN113993475A (zh) * 2020-05-20 2022-01-28 康坦手术股份有限公司 通过图像分析来预测病变复发的方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015317893B2 (en) 2014-09-15 2021-05-20 Clifton Life Sciences LLC Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm
CN111315897B (zh) * 2017-05-25 2024-10-22 液体活检研究有限责任公司 用于黑素瘤检测的方法
AU2020363786A1 (en) 2019-10-10 2022-05-12 Liquid Biopsy Research LLC Compositions, methods and kits for biological sample and RNA stabilization
EP4555094A2 (en) * 2022-07-15 2025-05-21 Emendobio Inc. Strategies for knock-ins at aplp2 safe harbor sites
EP4594532A1 (en) 2022-09-30 2025-08-06 Liquid Biopsy Research LLC Methods for neuroendocrine cancer detection in saliva
CN117292755A (zh) * 2023-08-09 2023-12-26 郑州大学 多模态临界边生物标志物识别方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005020795A2 (en) * 2003-08-25 2005-03-10 The Johns Hopkins University Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differntial gene expression analysis
CN102112145A (zh) * 2008-06-12 2011-06-29 辛它可辛有限公司 神经内分泌病的抑制
CN103502473A (zh) * 2011-03-01 2014-01-08 耶鲁大学 胃肠胰神经内分泌肿瘤(gep-nen)的预测

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015317893B2 (en) 2014-09-15 2021-05-20 Clifton Life Sciences LLC Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005020795A2 (en) * 2003-08-25 2005-03-10 The Johns Hopkins University Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differntial gene expression analysis
CN102112145A (zh) * 2008-06-12 2011-06-29 辛它可辛有限公司 神经内分泌病的抑制
CN103502473A (zh) * 2011-03-01 2014-01-08 耶鲁大学 胃肠胰神经内分泌肿瘤(gep-nen)的预测

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IRVIN M. MODLIN等: "The Identification of Gut Neuroendocrine Tumor Disease by Multiple Synchronous Transcript Analysis in Blood", 《PLOS ONE》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111479931A (zh) * 2017-11-30 2020-07-31 液体活检研究有限责任公司 使用基因表达测定预测肽受体放射治疗
CN111479931B (zh) * 2017-11-30 2024-08-16 液体活检研究有限责任公司 使用基因表达测定预测肽受体放射治疗
CN108048564A (zh) * 2018-02-09 2018-05-18 中国科学院昆明动物研究所 人glt8d1基因的新用途
CN108048564B (zh) * 2018-02-09 2021-03-05 中国科学院昆明动物研究所 人glt8d1基因的新用途
CN112514001A (zh) * 2018-07-30 2021-03-16 新加坡科技研究局 评价组织样本纤维化的方法和系统
CN113993475A (zh) * 2020-05-20 2022-01-28 康坦手术股份有限公司 通过图像分析来预测病变复发的方法
US12357232B2 (en) 2020-05-20 2025-07-15 Quantum Surgical Method for predicting the recurrence of a lesion by image analysis
CN113215255A (zh) * 2021-04-26 2021-08-06 山东天川精准医疗科技有限公司 用于肝癌早期诊断或预后的生物标记物及其用途
CN113215255B (zh) * 2021-04-26 2022-04-05 山东天川精准医疗科技有限公司 用于肝癌早期诊断或预后的生物标记物及其用途

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US10407730B2 (en) 2019-09-10
BR112017005279A2 (pt) 2017-12-12
CA2959670A1 (en) 2016-03-24
IL250867A0 (en) 2017-04-30
DK3194618T3 (da) 2021-07-12
AU2015317893A1 (en) 2017-03-23
EP3194618B1 (en) 2021-04-21
KR20250021631A (ko) 2025-02-13
EP3194618A1 (en) 2017-07-26
JP2017528164A (ja) 2017-09-28
AU2021212151B2 (en) 2023-08-03
US20220325351A1 (en) 2022-10-13
PL3194618T3 (pl) 2021-12-13
CA2959670C (en) 2024-02-20
AU2023258444A1 (en) 2023-11-23
ES2881474T3 (es) 2021-11-29
MX2021012347A (es) 2021-10-22
MX386919B (es) 2025-03-19
AU2021212151A1 (en) 2021-08-26
US11168372B2 (en) 2021-11-09
US12258633B2 (en) 2025-03-25
PL3929303T3 (pl) 2025-04-28
DK3929303T3 (da) 2025-03-03
MX2017003370A (es) 2017-11-22
JP2021019618A (ja) 2021-02-18
IL250867B (en) 2021-03-25
AU2015317893B2 (en) 2021-05-20
JP7157788B2 (ja) 2022-10-20
EP3929303A1 (en) 2021-12-29
US20160076106A1 (en) 2016-03-17
KR20170045365A (ko) 2017-04-26
US20190345568A1 (en) 2019-11-14
WO2016044330A1 (en) 2016-03-24
EP3929303B1 (en) 2024-12-04
JP6782700B2 (ja) 2020-11-11
IL281355B (en) 2022-02-01
IL281355A (en) 2021-04-29
KR102762958B1 (ko) 2025-02-04
ES3013599T3 (en) 2025-04-14

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