CA2959670C - Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm - Google Patents

Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm Download PDF

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Publication number
CA2959670C
CA2959670C CA2959670A CA2959670A CA2959670C CA 2959670 C CA2959670 C CA 2959670C CA 2959670 A CA2959670 A CA 2959670A CA 2959670 A CA2959670 A CA 2959670A CA 2959670 C CA2959670 C CA 2959670C
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nen
expression level
gep
biomarkers
test sample
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French (fr)
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CA2959670A1 (en
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Irvin Mark MODLIN
Mark Kidd
Ignat Drozdov
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Clifton Life Sciences LLC
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Clifton Life Sciences LLC
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2959670A 2014-09-15 2015-09-15 Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm Active CA2959670C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462050465P 2014-09-15 2014-09-15
US62/050,465 2014-09-15
PCT/US2015/050274 WO2016044330A1 (en) 2014-09-15 2015-09-15 Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm

Publications (2)

Publication Number Publication Date
CA2959670A1 CA2959670A1 (en) 2016-03-24
CA2959670C true CA2959670C (en) 2024-02-20

Family

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Family Applications (1)

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CA2959670A Active CA2959670C (en) 2014-09-15 2015-09-15 Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm

Country Status (13)

Country Link
US (3) US10407730B2 (enExample)
EP (2) EP3194618B1 (enExample)
JP (2) JP6782700B2 (enExample)
KR (2) KR20250021631A (enExample)
CN (1) CN107208132A (enExample)
AU (3) AU2015317893B2 (enExample)
CA (1) CA2959670C (enExample)
DK (2) DK3194618T3 (enExample)
ES (2) ES3013599T3 (enExample)
IL (2) IL250867B (enExample)
MX (2) MX386919B (enExample)
PL (2) PL3929303T3 (enExample)
WO (1) WO2016044330A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015317893B2 (en) 2014-09-15 2021-05-20 Clifton Life Sciences LLC Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm
BR112019024481A2 (pt) * 2017-05-25 2020-07-14 Liquid Biopsy Research LLC métodos para detecção de melanoma
IL317236A (en) * 2017-11-30 2025-01-01 Liquid Biopsy Res Llc Predicting peptide receptor radiotherapy using gene expression testing
CN108048564B (zh) * 2018-02-09 2021-03-05 中国科学院昆明动物研究所 人glt8d1基因的新用途
SG11202100047YA (en) * 2018-07-30 2021-02-25 Agency Science Tech & Res Method and system for assessing fibrosis in a tissue sample
US20210108259A1 (en) 2019-10-10 2021-04-15 Liquid Biopsy Research LLC Compositions, methods and kits for biological sample and rna stabilization
FR3110764B1 (fr) 2020-05-20 2024-05-10 Quantum Surgical Méthode de prédiction de la récidive d’une lésion par analyse d’images
CN113215255B (zh) * 2021-04-26 2022-04-05 山东天川精准医疗科技有限公司 用于肝癌早期诊断或预后的生物标记物及其用途
WO2024015968A2 (en) * 2022-07-15 2024-01-18 Emendobio Inc. Strategies for knock-ins at aplp2 safe harbor sites
JP2025532965A (ja) * 2022-09-30 2025-10-03 リキッド バイオプシー リサーチ リミティド ライアビリティ カンパニー 唾液での神経内分泌がん検出方法
CN117292755A (zh) * 2023-08-09 2023-12-26 郑州大学 多模态临界边生物标志物识别方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050084883A1 (en) * 2003-08-25 2005-04-21 The Johns Hopkins University School Of Medicine Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differential gene expression analysis
EP3590956A1 (en) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Suppression of neuroendocrine diseases
ES2656487T3 (es) * 2011-03-01 2018-02-27 Yale University Evaluación de la respuesta a la terapia de neoplasmas neuroendocrinos gastroenteropancreáticas (GEP-NEN)
AU2015317893B2 (en) 2014-09-15 2021-05-20 Clifton Life Sciences LLC Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm

Also Published As

Publication number Publication date
BR112017005279A2 (pt) 2017-12-12
CA2959670A1 (en) 2016-03-24
DK3929303T3 (da) 2025-03-03
KR20250021631A (ko) 2025-02-13
ES2881474T3 (es) 2021-11-29
AU2015317893B2 (en) 2021-05-20
JP7157788B2 (ja) 2022-10-20
US20190345568A1 (en) 2019-11-14
WO2016044330A1 (en) 2016-03-24
MX386919B (es) 2025-03-19
JP6782700B2 (ja) 2020-11-11
DK3194618T3 (da) 2021-07-12
US20160076106A1 (en) 2016-03-17
CN107208132A (zh) 2017-09-26
ES3013599T3 (en) 2025-04-14
AU2021212151A1 (en) 2021-08-26
EP3194618A1 (en) 2017-07-26
MX2021012347A (es) 2021-10-22
PL3194618T3 (pl) 2021-12-13
IL250867A0 (en) 2017-04-30
US20220325351A1 (en) 2022-10-13
EP3929303A1 (en) 2021-12-29
IL281355A (en) 2021-04-29
PL3929303T3 (pl) 2025-04-28
EP3194618B1 (en) 2021-04-21
US12258633B2 (en) 2025-03-25
AU2023258444A1 (en) 2023-11-23
US10407730B2 (en) 2019-09-10
MX2017003370A (es) 2017-11-22
KR20170045365A (ko) 2017-04-26
JP2017528164A (ja) 2017-09-28
EP3929303B1 (en) 2024-12-04
KR102762958B1 (ko) 2025-02-04
AU2021212151B2 (en) 2023-08-03
JP2021019618A (ja) 2021-02-18
AU2015317893A1 (en) 2017-03-23
US11168372B2 (en) 2021-11-09
IL250867B (en) 2021-03-25
IL281355B (en) 2022-02-01

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