CN107206007B - 用于治疗肺高血压的方法 - Google Patents

用于治疗肺高血压的方法 Download PDF

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Publication number
CN107206007B
CN107206007B CN201680010141.9A CN201680010141A CN107206007B CN 107206007 B CN107206007 B CN 107206007B CN 201680010141 A CN201680010141 A CN 201680010141A CN 107206007 B CN107206007 B CN 107206007B
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China
Prior art keywords
group
compound
och
pulmonary hypertension
acid
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CN201680010141.9A
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English (en)
Chinese (zh)
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CN107206007A (zh
Inventor
L·巴特
M·坎廷棱
E·M·瓦里斯
S·R·巴特
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Reviva Pharmaceuticals Inc
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Reviva Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680010141.9A 2015-01-12 2016-01-11 用于治疗肺高血压的方法 Active CN107206007B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562102470P 2015-01-12 2015-01-12
US62/102,470 2015-01-12
PCT/US2016/012873 WO2016115039A1 (en) 2015-01-12 2016-01-11 Methods for treating pulmonary hypertension

Publications (2)

Publication Number Publication Date
CN107206007A CN107206007A (zh) 2017-09-26
CN107206007B true CN107206007B (zh) 2021-08-10

Family

ID=56406257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680010141.9A Active CN107206007B (zh) 2015-01-12 2016-01-11 用于治疗肺高血压的方法

Country Status (5)

Country Link
US (1) US10441590B2 (enExample)
EP (1) EP3244896B1 (enExample)
JP (1) JP6787926B2 (enExample)
CN (1) CN107206007B (enExample)
WO (1) WO2016115039A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019133901A1 (en) 2017-12-28 2019-07-04 Reviva Pharmaceuticals, Inc. Methods for treating pulmonary fibrosis
WO2021108303A1 (en) * 2019-11-25 2021-06-03 PHPrecisionMed, LLC Pharmaceutical compositions for the treatment of pulmonary hypertension
KR20240161147A (ko) 2022-03-14 2024-11-12 슬랩 파마슈티컬스 엘엘씨 다중 사이클릭 화합물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102413830A (zh) * 2009-02-26 2012-04-11 雷维瓦药品公司 利用芳基哌嗪衍生物的组合物、合成及方法

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US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
GB0227240D0 (en) 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
US20090238761A1 (en) * 2005-01-03 2009-09-24 Universita Degli Studi Di Siena Novel Aryl Piperazine Derivatives With Medical Utility
AR063302A1 (es) 2006-10-13 2009-01-21 Otsuka Pharma Co Ltd Derivados de 4-benzo[b]tiofen-4-il-piperazin-1-il con accion antagonista del receptor 5-ht2a de serotonina y receptor de adrenalina alfa1 y agonista parcial del receptor d2, una composicion farmaceutica que lo comprende y un proceso para producirla.
JP5466147B2 (ja) 2007-05-21 2014-04-09 レビバ ファーマシューティカルズ，インコーポレーテッド キノリノン系非定型抗精神病薬剤の組成物、合成、及び使用方法
TWI373336B (en) * 2007-06-15 2012-10-01 Univ Kaohsiung Medical Kmup-1 capable of treating hypertension
US8207163B2 (en) * 2008-05-27 2012-06-26 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using piperazine based antipsychotic agents
JP2012506434A (ja) * 2008-10-22 2012-03-15 サム アマー アンド カンパニー インコーポレーテッド 肺動脈高血圧症の治療方法
CN104892589A (zh) * 2014-03-07 2015-09-09 中国科学院上海药物研究所 一类杂环化合物、其制备方法和用途
WO2015157451A1 (en) 2014-04-08 2015-10-15 Reviva Pharmaceuticals, Inc. Methods for treating attention deficit hyperactivity disorder

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102413830A (zh) * 2009-02-26 2012-04-11 雷维瓦药品公司 利用芳基哌嗪衍生物的组合物、合成及方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats;Eiji Hironaka等;《Cardiovascular Research》;20031231;第60卷;第692–699页 *

Also Published As

Publication number Publication date
HK1244448A1 (zh) 2018-08-10
US10441590B2 (en) 2019-10-15
JP2018502156A (ja) 2018-01-25
EP3244896A1 (en) 2017-11-22
EP3244896C0 (en) 2024-06-12
EP3244896B1 (en) 2024-06-12
JP6787926B2 (ja) 2020-11-18
EP3244896A4 (en) 2018-08-29
WO2016115039A1 (en) 2016-07-21
US20180125851A1 (en) 2018-05-10
CN107206007A (zh) 2017-09-26

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