CN107198078A - Stage of icterus small peptide growing nutrient element and technique manufacturing method - Google Patents

Stage of icterus small peptide growing nutrient element and technique manufacturing method Download PDF

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Publication number
CN107198078A
CN107198078A CN201710414990.7A CN201710414990A CN107198078A CN 107198078 A CN107198078 A CN 107198078A CN 201710414990 A CN201710414990 A CN 201710414990A CN 107198078 A CN107198078 A CN 107198078A
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vitamin
somebody
icterus
oiling
powder
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王莹
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TIANJIN DEHENG TECHNOLOGY Co Ltd
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TIANJIN DEHENG TECHNOLOGY Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385Concentrates of non-alcoholic beverages
    • A23L2/39Dry compositions
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • A23L33/155Vitamins A or D
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/19Dairy proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to stage of icterus small peptide growing nutrient element and technique manufacturing method, the mass percent that wherein each component accounts for product is:Oiling desalted whey is with feed powder 59.85% 87.27%, depth hydrolysis' albumen 1.40% 7.30%, alpha-lactalbumin 1.00% 5.70%, edible glucose 6.15% 18.37%, nutrition fortifier 1.07% 2.60%, FOS 1.58% 2.63%, galactooligosaccharide 1.30% 2.20%, lactase 0.05% 0.25%, algae oil DHA powder 0.08% 0.40%, ARA powder 0.10% 0.70%.Beneficial effects of the present invention:It is oral by reconstituting, reduce the pain that neonate brings by jaundice.Add nutrition fortifier and ensure that the neonatal development stage obtains comprehensively rational nutrition, the normal need of physiology and life is met, to maintain and improve the neonatal general level of the health.

Description

Stage of icterus small peptide growing nutrient element and technique manufacturing method
Technical field
The invention belongs to protein solid beverage field, more particularly to a kind of is icterus neonatorum and hyperbilirubinemia crowd The stage of icterus small peptide growing nutrient element and technique manufacturing method of nutritional support are provided.
Background technology
Jaundice is common sympton and sign, and it is due to bilirubin metabolism obstacle and causes bilirubin concentration in serum Caused by rise.Clinical signs are that sclera, mucous membrane, skin and its hetero-organization are dyed to yellow.Because sclera contains more elasticity Scleroprotein, has stronger affinity with bilirubin, thus Patients with Jaundice icteric sclera often prior to mucous membrane, skin and be noticeable first. When serum total bilirubin does not see jaundice in 17.1~34.2 μm of ol/L, and naked eyes, claim jaundice occult or subclinical jaundice;When When bloodstain total bilirubin concentration is more than 34.2 μm of ol/L, jaundice, also referred to as clinical jaundice can be clinically found.Medically not The jaundice of full moon (in birth 28 days) baby, referred to as icterus neonatorum, there is point of physiological and pathologic.General symptom is generally Spirit is poor, and yellowing of the skin is shinny, poor, brown urine of sucking the breast.Different type absurdity and corresponding symptom and feature.
After normal neonate's life from 3 days, sclera, mucous membrane, skin and its hetero-organization can start little by little to be dyed to yellow, In the trend aggravated gradually, about to after 7 days, gradually disappear, almost basic by the 10th day to disappear, this is neonate's physiological The process of jaundice.Jaundice occurs in about 60% term infant and 80% premature, and the original of physiologic jaundice occurs for neonate Because being mainly:In intrauterine, the red blood cell of fetus is much higher far beyond the red blood cell of adult, it is raw after neonatal erythrocyte number by Decrescence few, to the erythrocyte number transition of adult, then excessive red blood cell is destroyed, discharges bilirubin, and neonate Shunted bilirubin source is more, and liver function is still immature, and liver excretion bilirubin function is poor, and the function that excretion combines bilirubin is poor.This Outside, normal flora is not yet set up in enteron aisle when neonate is just born, it is impossible to which the bilirubin for entering enteron aisle is converted into UBG excrement Courage is former, neonate is occurred jaundice.Typically, during physiologic jaundice, bilirubin will not be too high, more in 205 μm of below ol/L, to child Son there will not be big influence, but if can not timely and effectively control and prevention is likely to deteriorate that to turn into pathologic yellow Subcutaneous ulcer.But sometimes due to pregnant drug, has such as used the medicine of sulfamido, there is the danger for aggravating jaundice.Individual other icterus neonatorum Heavier, more than 205 μm ol/L, doctor can irradiate blue light to child, or also need plus albumin intravenous injection, to subtract subicteric journey Degree.
When carrying out blue light illumination, the bilirubin in skin shallow-layer is absorbed after light, and structure just changes, by original Fat-soluble to become water-soluble, making bilirubin, metabolic pathway changes in vivo, can be excreted out from bile, urine, so that Mitigate icterus neonatorum.In the visible spectrum, wavelength is most strong in 420~460mm effect of the light to bilirubin, and blue light ripple A length of 425-480mm, therefore as the best light source for the treatment of icterus neonatorum.Blue-light treatment does not have complication substantially, and its is common Adverse reaction have heating, diarrhoea, fash etc..But it is noted that:, must for heavier jaundice, it is impossible to individually using blue-light treatment Must complex treatment, such as combination medicine, nutrient.
The content of the invention
For the above mentioned problem to be solved, the present invention provides stage of icterus small peptide growing nutrient element and technique manufacturing method.
Technical scheme:Stage of icterus small peptide growing nutrient element, including oiling desalted whey match somebody with somebody feed powder, table grapes Sugar, α-lactalbumin, depth hydrolysis' albumen, nutrition fortifier, FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder.
Further, each component accounts for the mass percent of product:Oiling desalted whey matches somebody with somebody feed powder 59.85%-87.27%, Depth hydrolysis albumen 1.40%-7.30%, α-lactalbumin 1.00%-5.70%, edible glucose 6.15%-18.37%, battalion Support hardening agent 1.07%-2.60%, FOS 1.58%-2.63%, galactooligosaccharide 1.30%-2.20%, lactase 0.05%-0.25%, algae oil DHA powder 0.08%-0.40%, ARA powder 0.10%-0.70%.
Further, oiling desalted whey, which is matched somebody with somebody, includes medium chain fatty acid MCT in feed powder.
Further, nutrition fortifier includes calcium carbonate, tricalcium phosphate, ferric pyrophosphate, zinc gluconate, vitamin A, dimension Raw element D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, D-VB5 calcium, vitamin C.
Further, the medium chain fatty acid MCT that oiling desalted whey is matched somebody with somebody in feed powder accounts for the 23.94%- of this product 34.91%.
Further, each component nutrient accounts for the mass percent of total nutrition fortifier:Calcium carbonate 15.96%- 21.04%th, tricalcium phosphate 29.95%-51.09%, ferric pyrophosphate 9.85%-13.76%, zinc gluconate 2.23%- 6.79%th, vitamin A 0.31%-0.71%, vitamin D30.05%-0.09%, vitamin E 2.34%-2.77%, dimension life Plain B10.07%-0.47%, vitamin B21.34%-1.81%, vitamin B60.04%-0.44%, vitamin B12 0.07%-0.47%, nicotinic acid 1.49%-1.91%, folic acid 0.06%-0.11%, D-VB5 calcium 0.18%-0.58%, dimension life Plain C 14.92%-19.10%.
A kind of process for manufacturing stage of icterus small peptide growing nutrient element, it is characterised in that comprise the following steps:
Step one:Determine to need the nutrition fortifier pre-processed in advance to have tricalcium phosphate, calcium carbonate, vitamin C, Jiao first Ferric phosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2, vitamin B6, dimension Raw element D3, folic acid, vitamin B12, processing method is as follows:
(1) vitamin B2, folic acid, vitamin B12Gradient dilution is needed to handle, according to the dilution ratio of different material, accurately Calculate raw material and oiling desalted whey matches somebody with somebody the consumption of feed powder, carry out after gradient mixing, sieve respectively, then enter mixing tank respectively respectively It is well mixed, tank sieving, standard compliant raw material after being handled are gone out respectively;
(2) tricalcium phosphate, calcium carbonate, vitamin C, ferric pyrophosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B6, vitamin D3Need first to sieve, extracting screen underflow, then oversize is again by crushing, grinding Honed sieve, obtains the standard compliant raw material of institute.
Step 2:Hardening agent component is supported into according to prescription quality percentage precise by each processing rear batallion, specifically:
1) tricalcium phosphate, calcium carbonate, ferric pyrophosphate, zinc gluconate are added into mixing tank successively in order first to be filled Divide mixing sieving, obtain mineral-supplemented dose of bag;
2) and then in order successively by vitamin C, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, dimension life Plain B2, vitamin B6, vitamin D3, folic acid, vitamin B12Add mixing tank to carry out being sufficiently mixed sieving, obtain vitamin enrichment Agent bag;
Step 3:According to formula each component mass percent precise and by oiling desalted whey with feed powder, edible Portugal Grape sugar, α-lactalbumin, depth hydrolysis' albumen, FOS, galactooligosaccharide, lactase are thrown into mixing tank successively in order Material is fully mixed, and sieve to obtain aniseed bag;
Step 4:The mineral-supplemented dose of bag and vitamin enrichment bag that step 2 is mixed put into aniseed bag and filled successively Divide mixing, sieving produces product.
Further, vitamin B2, folic acid, vitamin B12Gradient dilution processing is needed to specifically refer to:
Vitamin B2Before processing content of monomer 100%, adds auxiliary material oiling desalted whey and matches somebody with somebody feed powder content of monomer 10%;
Folic acid before processing content of monomer 98%, adds auxiliary material oiling desalted whey and matches somebody with somebody feed powder content of monomer 0.1%;
Vitamin B12Before processing content of monomer 98%, adds auxiliary material oiling desalted whey and matches somebody with somebody feed powder content of monomer 10%.
Further, sieving is 60 mesh sieves in the step one;Sieving is 60 mesh sieves in the step 2.
Further, sieving is 40 mesh sieves in the step 3.
Present invention has the advantages that:Formula sets reasonable, and α-lactalbumin can be coupled with unconjugated bilirubin, so as to hinder Only bilirubin passes through pellicle such as cell membrane, placenta, gall-bladder, blood-brain barrier;Edible monomeric glucose can change into Portugal in vivo Grape uronic acid, glucuronic acid can combine to form combination under the catalytic action of glucuronyl transferase with unconjugated bilirubin Bilirubin is external so as to discharge it, and has very great help to the treatment for promoting icterus neonatorum.In addition, depth hydrolysis' albumen is reduced The possibility of neonate's milk protein allergy, lactase can prevent premature or neonate's lactose intolerance again, help baby to exist In stage of icterus, while alleviating and shorten the jaundice course of disease, evade milk protein allergy and lactose intolerance problem, body is can ensure that again The sufficient nutrition for meeting demand of growing is obtained by reconstituting orally, the pain that neonate brings by jaundice is reduced.Addition battalion Support hardening agent and ensure that the neonatal development stage obtains comprehensively rational nutrition, the normal need of physiology and life is met, to tie up The neonatal general level of the health is held and improves, the technique manufacturing method of stage of icterus small peptide growing nutrient element is reasonable in design, it is easy to raw Production, is easy to control.
Brief description of the drawings
Fig. 1 is a kind of process schematic flow sheet for manufacturing stage of icterus small peptide growing nutrient element of the present invention.
Embodiment
A kind of embodiment to the present invention is explained below in conjunction with the accompanying drawings.
The present invention relates to stage of icterus small peptide growing nutrient element and technique manufacturing method.
Stage of icterus small peptide growing nutrient element, including oiling desalted whey match somebody with somebody feed powder, edible glucose, α-lactalbumin, depth Spend protein hydrolysate, nutrition fortifier, FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder.
α-lactalbumin can be coupled with unconjugated bilirubin, so as to prevent bilirubin from passing through pellicle such as cell membrane, tire Disk, gall-bladder, blood-brain barrier;Edible monomeric glucose can change into glucuronic acid in vivo, and glucuronic acid is in grape alditol It can be combined to form under the catalytic action of sour transferase with unconjugated bilirubin with reference to bilirubin so as to discharge it in vitro, to promoting The treatment of icterus neonatorum has very great help.In addition, depth hydrolysis' albumen reduces the possibility of neonate's milk protein allergy, breast Carbohydrase can prevent premature or neonate's lactose intolerance again, help baby in stage of icterus, alleviate and shorten the jaundice course of disease Meanwhile, evade milk protein allergy and lactose intolerance problem, can ensure that body obtains the sufficient battalion for meeting demand of growing again Support.
Each component accounts for the mass percent of product:Oiling desalted whey matches somebody with somebody feed powder 59.85%-87.27%, depth hydrolysis' egg White 1.40%-7.30%, α-lactalbumin 1.00%-5.70%, edible glucose 6.15%-18.37%, nutrition fortifier 1.07%-2.60%, FOS 1.58%-2.63%, galactooligosaccharide 1.30%-2.20%, lactase 0.05%- 0.25%, algae oil DHA powder 0.08%-0.40%, ARA powder 0.10%-0.70%.
Oiling desalted whey, which is matched somebody with somebody, includes medium chain fatty acid MCT in feed powder.Oiling desalted whey mainly provides product with feed powder Fat and protein.Desalted whey powder is to slough the mineral salt in whey powder.For infant, content of mineral substances mistake Height can increase the kidney burden of baby, therefore whey powder typically can all slough mineral matter.Oiling desalted whey is in this base with feed powder Increase grease on plinth to meet requirement of the infant to fat.
Nutrition fortifier includes calcium carbonate, tricalcium phosphate, ferric pyrophosphate, zinc gluconate, vitamin A, vitamin D3, dimension Raw element E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, D-VB5 calcium, vitamin C.
The medium chain fatty acid MCT that oiling desalted whey is matched somebody with somebody in feed powder accounts for the application stage of icterus small peptide growing nutrient element 23.94%-34.91%.
Each component nutrient accounts for the mass percent of total nutrition fortifier:Calcium carbonate 15.96%-21.04%, tricalcium phosphate 29.95%-51.09%, ferric pyrophosphate 9.85%-13.76%, zinc gluconate 2.23%-6.79%, vitamin A 0.31%- 0.71%th, vitamin D30.05%-0.09%, vitamin E 2.34%-2.77%, vitamin B10.07%-0.47%, dimension Raw element B21.34%-1.81%, vitamin B60.04%-0.44%, vitamin B120.07%-0.47%, nicotinic acid 1.49%-1.91%, folic acid 0.06%-0.11%, D-VB5 calcium 0.18%-0.58%, vitamin C 14.92%- 19.10%.
Contrast groups data:
Index bilirubin before stage of icterus small peptide nutrient element of the present invention is taken, averagely at 268 micromoles per liters (μm ol/L), to take Stage of icterus small peptide nutrient element is after three days, and bilirubin declines obvious in average 231 micromoles per liters (μm ol/L), bilirubin.
It is average in 273 micromoles per liters (μm ol/L), clothes that control group 1 takes index bilirubin before " comfortable jaundice nutrient " With after " comfortable jaundice nutrient " three days, bilirubin still remains high, and with spitting blood and situation about having blood in stool.
Control group 2 is only with blue light, and index bilirubin is average in 259 micromoles per liters (μm ol/L), blue-light treatment before treatment Bilirubin is average at 224 micromoles per liters (μm ol/L) after three days.
Using stage of icterus small peptide nutrient element auxiliary blue-light treatment, before treatment, index bilirubin is average micro- is rubbed 250 for control group 3 You/liter (μm ol/L), treatment two days later bilirubin in average 206 micromoles per liters (μm ol/L).Show stage of icterus small peptide nutrient element Auxiliary blue light illumination is coordinated to be relieved jaundice and shorten the jaundice course of disease.
By control group data, show that the stage of icterus small peptide growing nutrient element of the application is used alone, bilirubin declines bright Aobvious, control group 3 coordinates auxiliary blue light illumination energy using stage of icterus small peptide nutrient element auxiliary blue-light treatment, stage of icterus small peptide nutrient element It is relieved jaundice and shortens the jaundice course of disease.
Compared with prior art, formula sets reasonable, it is easy to absorb, α-lactalbumin can join with unconjugated bilirubin Knot, so as to prevent bilirubin from passing through pellicle such as cell membrane, placenta, gall-bladder, blood-brain barrier;Edible monomeric glucose in vivo may be used Glucuronic acid is changed into, glucuronic acid can be combined under the catalytic action of glucuronyl transferase with unconjugated bilirubin Formed and combine bilirubin so as to discharge it in vitro, had very great help to the treatment for promoting icterus neonatorum.In addition, depth hydrolysis Albumen reduces the possibility of neonate's milk protein allergy, and lactase can prevent premature or neonate's lactose intolerance again, helps Baby is helped in stage of icterus, while alleviating and shorten the jaundice course of disease, evades milk protein allergy and lactose intolerance problem, and energy Ensure that body obtains the sufficient nutrition for meeting demand of growing by reconstituting orally, reduce the pain that neonate brings by jaundice It is bitter;Add nutrition fortifier and ensure that the neonatal development stage obtains comprehensively rational nutrition, meet the normal of physiology and life Need, to maintain and improve the neonatal general level of the health.
A kind of process for manufacturing stage of icterus small peptide growing nutrient element, it is characterised in that comprise the following steps:
Step one:Determine to need the nutrition fortifier pre-processed in advance to have tricalcium phosphate, calcium carbonate, vitamin C, Jiao first Ferric phosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2, vitamin B6, dimension Raw element D3, folic acid, vitamin B12, processing method is as follows:
(1) vitamin B2, folic acid, vitamin B12Gradient dilution is needed to handle, according to the dilution ratio of different material, accurately Calculate raw material and oiling desalted whey matches somebody with somebody the consumption of feed powder, carry out respectively after gradient mixing, sieve 60 mesh sieves respectively, then enters respectively Mixing tank is well mixed, and tank sieving is gone out respectively, and standard compliant raw material after being handled, specific raw material dilution ratio is shown in Table:
(2) tricalcium phosphate, calcium carbonate, vitamin C, ferric pyrophosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B6, vitamin D3Need to cross 60 mesh sieves respectively, take respective screenings, then will each sieve Upper thing again by crushing, it is ground sieve respectively, obtain the standard compliant raw material of institute, specifically used equipment is permanent with reference to Tianjin moral The patent application of Science and Technology Ltd.:The entitled rotary sealing device of rotating shaft of Application No. 200920096540.9, application number Device is pulverized and mixed for 200920096539.6 entitled one kind.
Step 2:Hardening agent component is supported into according to prescription quality percentage precise by each processing rear batallion, specifically:
Each component nutrient accounts for the mass percent of total nutrition fortifier in formula:Calcium carbonate 15.96%-21.04%, Tricalcium phosphate 29.95%-51.09%, ferric pyrophosphate 9.85%-13.76%, zinc gluconate 2.23%-6.79%, vitamin A0.31%-0.71%, vitamin D30.05%-0.09%, vitamin E 2.34%-2.77%, vitamin B10.07%- 0.47%th, vitamin B21.34%-1.81%, vitamin B60.04%-0.44%, vitamin B120.07%-0.47%, Nicotinic acid 1.49%-1.91%, folic acid 0.06%-0.11%, D-VB5 calcium 0.18%-0.58%, vitamin C 14.92%- 19.10%;
1) tricalcium phosphate, calcium carbonate, ferric pyrophosphate, zinc gluconate are added into mixing tank successively in order first to be filled Divide mixing sieving, obtain mineral-supplemented dose of bag;
2) and then in order successively by vitamin C, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, dimension life Plain B2, vitamin B6, vitamin D3, folic acid, vitamin B12Add mixing tank to carry out being sufficiently mixed sieving, obtain vitamin enrichment Agent bag;
Step 3:According to each component mass percent precise is formulated, specifically:
Each component accounts for the mass percent of product:Oiling desalted whey matches somebody with somebody feed powder 87.27%-59.85%, depth hydrolysis' egg White 1.40%-7.30%, α-lactalbumin 1.00%-5.70%, edible glucose 6.15%-18.37%, nutrition fortifier 1.07%-2.60%, FOS 1.58%-2.63%, galactooligosaccharide 1.30%-2.20%, lactase 0.05%- 0.25%, algae oil DHA powder 0.08%-0.40%, ARA powder 0.10%-0.70%;
Except nutrition fortifier weighs mixing in step 2, other components process step is as follows:And the desalted whey that will refuel With feed powder, edible glucose, α-lactalbumin, depth hydrolysis' albumen, FOS, galactooligosaccharide, lactase according to formula Each component mass percent precise feed intake successively into mixing tank in order it is abundant mix, sieve to obtain aniseed bag;
Step 4:The mineral-supplemented dose of bag and vitamin enrichment bag that step 2 is mixed put into aniseed bag and filled successively Divide mixing, sieving produces product.
Wherein, sieving is 60 mesh sieves in the step one;Sieving is mistake in 60 mesh sieves, the step 3 in the step 2 Sieve as 40 mesh sieves.
The process of manufacture stage of icterus small peptide growing nutrient element in the present invention, it is reasonable in design, it is easy to accomplish and production, It is easy to control product quality.
Embodiment 1:
Stage of icterus small peptide growing nutrient element, including oiling desalted whey match somebody with somebody feed powder, edible glucose, α-lactalbumin, depth Protein hydrolysate, nutrition fortifier, FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are spent, each component accounts for product Mass percent:Oiling desalted whey matches somebody with somebody feed powder 59.85-87.27%%, depth hydrolysis albumen 1.40%-7.30%, α-breast Albumin 1.00%-5.70%, edible glucose 6.15%-18.37%, nutrition fortifier 1.07%-2.60%, FOS 1.58%-2.63%, galactooligosaccharide 1.30%-2.20%, lactase 0.05%-0.25%, algae oil DHA powder 0.08%- 0.40%, ARA powder 0.10%-0.70%, wherein oiling desalted whey, which match somebody with somebody, includes medium chain fatty acid MCT, oiling desalination in feed powder The medium chain fatty acid MCT that whey is matched somebody with somebody in feed powder accounts for the 23.94%-34.91% of this product;Nutrition fortifier includes calcium carbonate, phosphorus Sour DFP, ferric pyrophosphate, zinc gluconate, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, D-VB5 calcium, vitamin C.Each component nutrient accounts for the quality percentage of total nutrition fortifier Than:Calcium carbonate 15.96%-21.04%, tricalcium phosphate 51.09%-29.95%, ferric pyrophosphate 9.85%-13.76%, grape Saccharic acid zinc 2.23%-6.79%, vitamin A 0.31%-0.71%, vitamin D30.05%-0.09%, vitamin E 2.34%-2.77%, vitamin B10.07%-0.47%, vitamin B21.34%-1.81%, vitamin B60.04%- 0.44%th, vitamin B120.07%-0.47%, nicotinic acid 1.49%-1.91%, folic acid 0.06%-0.11%, D-VB5 calcium 0.18%-0.58%, vitamin C 14.92%-19.10%.
Each component is acted on:Oiling desalted whey mainly provides the fat and protein of product with feed powder.Desalted whey powder is Mineral salt in whey powder is sloughed.For infant, content of mineral substances is too high to increase the kidney burden of baby, therefore breast Clear powder typically can all slough mineral matter.It is to increase grease on this basis to meet infant to fat that oiling desalted whey, which matches somebody with somebody feed powder, The requirement of fat.
α-lactalbumin can be coupled with unconjugated bilirubin, so as to prevent bilirubin from passing through pellicle such as cell membrane, tire Disk, gall-bladder, blood-brain barrier;
Edible monomeric glucose can change into glucuronic acid in vivo, and glucuronic acid is in glucuronyl transferase It can be combined to form under catalytic action with unconjugated bilirubin with reference to bilirubin so as to discharge it in vitro, to promoting icterus neonatorum Treatment have very great help;
Depth hydrolysis' albumen reduces the possibility of neonate's milk protein allergy, and lactase can prevent premature or new life again Youngster's lactose intolerance, helps baby in stage of icterus, while alleviating and shorten the jaundice course of disease, evades milk protein allergy and breast Sugar can ensure that body obtains the sufficient nutrition for meeting demand of growing again intolerant to problem.
Compound nutrition fortifier, it is therefore intended that improve food nutrition density, make up the mesotrophic loss of Dairy Processing, more Close to breast milk composition, the nutritional need of infant's normal growth is met.In addition, can especially be supplemented using food enrichment Some nutriments, reach the purpose of special diet and health.Nutrition fortifier not only improves the nutritional quality of food, can be with Reduce and prevent many deficiency diseases and other caused complication of nutritional deficiency, some nutrition fortifiers also have raising food concurrently The aesthetic quality of product and the effect of keeping property.
FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are association area usual ingredients, are act as often See function.
A kind of process for manufacturing stage of icterus small peptide growing nutrient element, it is characterised in that comprise the following steps:
Step one:Determine to need the nutrition fortifier pre-processed in advance to have tricalcium phosphate, calcium carbonate, vitamin C, Jiao first Ferric phosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2, vitamin B6, dimension Raw element D3, folic acid, vitamin B12, processing method is as follows:
(1) vitamin B2, folic acid, vitamin B12Gradient dilution is needed to handle, according to the dilution ratio of different material, accurately Calculate raw material and oiling desalted whey matches somebody with somebody the consumption of feed powder, carry out respectively after gradient mixing, sieve 60 mesh sieves respectively, then enters respectively Mixing tank is well mixed, and tank is gone out respectively and crosses 60 mesh sieves, standard compliant raw material after being handled, specific raw material dilution ratio is shown in Table:
Material name Before processing content of monomer Add auxiliary material Content of monomer after processing
Vitamin B2 100% Oiling desalted whey matches somebody with somebody feed powder 10%
Vitamin B12 98% Oiling desalted whey matches somebody with somebody feed powder 0.1%
Folic acid 98% Oiling desalted whey matches somebody with somebody feed powder 10%
(2) tricalcium phosphate, calcium carbonate, vitamin C, ferric pyrophosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B6, vitamin D3Need to cross 60 mesh sieves respectively, take respective screenings, then will each sieve Upper thing crosses 60 mesh sieves respectively by crushing, grinding again, obtains the standard compliant raw material of institute, and specifically used equipment refers to Tianjin moral The patent application of permanent Science and Technology Ltd.:The entitled rotary sealing device of rotating shaft of Application No. 200920096540.9, application Number device is pulverized and mixed for 200920096539.6 entitled one kind.
Step 2:Hardening agent component is supported into according to prescription quality percentage precise by each processing rear batallion, specifically:
Each component nutrient accounts for the mass percent of total nutrition fortifier in formula:Calcium carbonate 15.96%-21.04%, Tricalcium phosphate 29.95%-51.09%, ferric pyrophosphate 9.85%-13.76%, zinc gluconate 2.23%-6.79%, vitamin A0.31%-0.71%, vitamin D30.05%-0.09%, vitamin E 2.34%-2.77%, vitamin B10.07%- 0.47%th, vitamin B21.34%-1.81%, vitamin B60.04%-0.44%, vitamin B120.07%-0.47%, Nicotinic acid 1.49%-1.91%, folic acid 0.06%-0.11%, D-VB5 calcium 0.18%-0.58%, vitamin C 14.92%- 19.10%;
1) tricalcium phosphate, calcium carbonate, ferric pyrophosphate, zinc gluconate are added into mixing tank successively in order first to be filled Divide and mixed 60 mesh sieves, obtain mineral-supplemented dose of bag;
2) and then in order successively by vitamin C, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, dimension life Plain B2, vitamin B6, vitamin D3, folic acid, vitamin B12Add mixing tank to carry out being sufficiently mixed 60 mesh sieves, obtain vitamin Hardening agent bag;
Step 3:According to each component mass percent precise is formulated, specifically:
Each component accounts for the mass percent of product:Oiling desalted whey matches somebody with somebody feed powder 59.85%-87.27%, depth hydrolysis' egg White 1.40%-7.30%, α-lactalbumin 1.00%-5.70%, edible glucose 6.15%-18.37%, nutrition fortifier 1.07%-2.60%, FOS 1.58%-2.63%, galactooligosaccharide 1.30%-2.20%, lactase 0.05%- 0.25%, algae oil DHA powder 0.08%-0.40%, ARA powder 0.10%-0.70%;
Except nutrition fortifier weighs mixing in step 2, other components process step is as follows:And the desalted whey that will refuel With feed powder, edible glucose, α-lactalbumin, depth hydrolysis' albumen, FOS, galactooligosaccharide, lactase according to formula Each component mass percent precise feed intake successively into mixing tank in order it is abundant mix, obtain aniseed bag;
Step 4:The mineral-supplemented dose of bag and vitamin enrichment bag that step 2 is mixed put into aniseed bag and filled successively Divide mixing, cross 40 mesh sieves and produce product.
The process of manufacture stage of icterus small peptide growing nutrient element in the present invention, it is reasonable in design, it is easy to accomplish and production, It is easy to control product quality.
Embodiment 2:
Stage of icterus small peptide growing nutrient element, including oiling desalted whey match somebody with somebody feed powder, edible glucose, α-lactalbumin, depth Protein hydrolysate, nutrition fortifier, FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are spent, each component accounts for product Mass percent:Oiling desalted whey matches somebody with somebody feed powder 78.92%, depth hydrolysis' albumen 3.14%, α-lactalbumin 4.79%, food With glucose 6.89%, nutrition fortifier 1.17%, FOS 2.53%, galactooligosaccharide 2.11%, lactase 0.15%, Algae oil DHA powder 0.10%, ARA powder 0.20%, wherein oiling desalted whey, which are matched somebody with somebody, includes medium chain fatty acid MCT in feed powder, refuel de- The medium chain fatty acid MCT that salt whey is matched somebody with somebody in feed powder accounts for the 31.57% of product;Nutrition fortifier includes calcium carbonate, tricalcium phosphate, Jiao Ferric phosphate, zinc gluconate, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, D-VB5 calcium, vitamin C.Each component nutrient accounts for the mass percent of total nutrition fortifier:Calcium carbonate 17.96%th, tricalcium phosphate 39.73%, ferric pyrophosphate 12.99%, zinc gluconate 4.79%, vitamin A 0.51%, dimension life Plain D30.07%th, vitamin E 2.57%, vitamin B10.17%th, vitamin B21.58%th, vitamin B60.15%th, tie up Raw element B120.17%th, nicotinic acid 1.71%, folic acid 0.09%, D-VB5 calcium 0.38%, vitamin C 17.13%.
Each component is acted on:Oiling desalted whey mainly provides the fat and protein of product with feed powder.Desalted whey powder is Mineral salt in whey powder is sloughed.For infant, content of mineral substances is too high to increase the kidney burden of baby, therefore breast Clear powder typically can all slough mineral matter.It is to increase grease on this basis to meet infant to fat that oiling desalted whey, which matches somebody with somebody feed powder, The requirement of fat.
α-lactalbumin can be coupled with unconjugated bilirubin, so as to prevent bilirubin from passing through pellicle such as cell membrane, tire Disk, gall-bladder, blood-brain barrier;
Edible monomeric glucose can change into glucuronic acid in vivo, and glucuronic acid is in glucuronyl transferase It can be combined to form under catalytic action with unconjugated bilirubin with reference to bilirubin so as to discharge it in vitro, to promoting icterus neonatorum Treatment have very great help;
Depth hydrolysis' albumen reduces the possibility of neonate's milk protein allergy, and lactase can prevent premature or new life again Youngster's lactose intolerance, helps baby in stage of icterus, while alleviating and shorten the jaundice course of disease, evades milk protein allergy and breast Sugar can ensure that body obtains the sufficient nutrition for meeting demand of growing again intolerant to problem.
Nutrition fortifier is using compounding nutrition fortifier, it is therefore intended that improves food nutrition density, makes up in Dairy Processing The loss of nutrition, is more nearly breast milk composition, meets the nutritional need of infant's normal growth.In addition, strong using food nutrition Agent can especially supplement some nutriments, reach the purpose of special diet and health.Nutrition fortifier not only improves food Nutritional quality, can also reduce and prevent many deficiency diseases and nutritional deficiency caused by other complication, some nutrition Hardening agent also has the effect of the aesthetic quality for improving food and keeping property concurrently.
FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are association area usual ingredients, are act as often See function.
A kind of process for manufacturing stage of icterus small peptide growing nutrient element, it is characterised in that comprise the following steps:
Step one:Determine to need the nutrition fortifier pre-processed in advance to have tricalcium phosphate, calcium carbonate, vitamin C, Jiao first Ferric phosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2, vitamin B6, dimension Raw element D3, folic acid, vitamin B12, processing method is as follows:
(1) vitamin B2, folic acid, vitamin B12Gradient dilution is needed to handle, according to the dilution ratio of different material, accurately Calculate raw material and oiling desalted whey matches somebody with somebody the consumption of feed powder, carry out respectively after gradient mixing, sieve 60 mesh sieves respectively, then enters respectively Mixing tank is well mixed, and tank is gone out respectively and crosses 60 mesh sieves, standard compliant raw material after being handled, specific raw material dilution ratio is shown in Table:
Material name Before processing content of monomer Add auxiliary material Content of monomer after processing
Vitamin B2 100% Oiling desalted whey matches somebody with somebody feed powder 10%
Vitamin B12 98% Oiling desalted whey matches somebody with somebody feed powder 0.1%
Folic acid 98% Oiling desalted whey matches somebody with somebody feed powder 10%
(2) tricalcium phosphate, calcium carbonate, vitamin C, ferric pyrophosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B6, vitamin D3Need to cross 60 mesh sieves respectively, take respective screenings, then will each sieve Upper thing again by crushing, it is ground cross 60 mesh sieves respectively, obtain the standard compliant raw material of institute, specifically used equipment refers to Tianjin The patent application of De Heng Science and Technology Ltd.s:The entitled rotary sealing device of rotating shaft of Application No. 200920096540.9, Shen Number device please be pulverized and mixed for 200920096539.6 entitled one kind.
Step 2:Hardening agent component is supported into according to prescription quality percentage precise by each processing rear batallion, specifically:
Each component nutrient accounts for the mass percent of total nutrition fortifier in formula:Calcium carbonate 17.96%, tricalcium phosphate 39.73%th, ferric pyrophosphate 12.99%, zinc gluconate 4.79%, vitamin A 0.51%, vitamin D30.07%th, dimension life Plain E 2.57%, vitamin B10.17%th, vitamin B21.58%th, vitamin B60.15%th, vitamin B120.17%th, nicotinic acid 1.71%th, folic acid 0.09%, D-VB5 calcium 0.38%, vitamin C 17.13%, processing method is such as
1) tricalcium phosphate, calcium carbonate, ferric pyrophosphate, zinc gluconate are added into mixing tank successively in order first to be filled Divide and mixed 60 mesh sieves, obtain mineral-supplemented dose of bag;
2) and then in order successively by vitamin C, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, dimension life Plain B2, vitamin B6, vitamin D3, folic acid, vitamin B12Add mixing tank to carry out being sufficiently mixed 60 mesh sieves, obtain vitamin Hardening agent bag;
Step 3:According to each component mass percent precise is formulated, specifically:
Each component accounts for the mass percent of product:Oiling desalted whey matches somebody with somebody feed powder 78.92%, depth hydrolysis' albumen 3.14%, α-lactalbumin 4.79%, edible glucose 6.89%, nutrition fortifier 1.17%, FOS 2.53% is oligomeric Galactolipin 2.11%, lactase 0.15%, algae oil DHA powder 0.10%, wherein ARA powder 0.20%, oiling desalted whey match somebody with somebody feed powder In include medium chain fatty acid MCT, oiling desalted whey match somebody with somebody feed powder in medium chain fatty acid MCT account for the 31.57% of this product;
It is mixed into except nutrition fortifier is weighed in step 2, other components process step is as follows:And oiling desalination is newborn Clearly with feed powder, edible glucose, α-lactalbumin, depth hydrolysis' albumen, FOS, galactooligosaccharide, lactase according to matching somebody with somebody Square each component mass percent precise feed intake successively into mixing tank in order it is abundant mix, obtain aniseed bag;
Step 4:The mineral-supplemented dose of bag and vitamin enrichment bag that step 2 is mixed put into aniseed bag and filled successively Divide mixing, cross 40 mesh sieves and produce product.
The process of manufacture stage of icterus small peptide growing nutrient element in the present invention, it is reasonable in design, it is easy to accomplish and production, It is easy to control product quality.
Embodiment 3:
Stage of icterus small peptide growing nutrient element, including oiling desalted whey match somebody with somebody feed powder, edible glucose, α-lactalbumin, depth Protein hydrolysate, nutrition fortifier, FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are spent, each component accounts for product Mass percent:Oiling desalted whey matches somebody with somebody feed powder 64.49%, depth hydrolysis' albumen 6.32%, α-lactalbumin 5.45%, food With glucose 18.37%, nutrition fortifier 1.18%, FOS 1.71%, galactooligosaccharide 1.43%, lactase 0.15%, algae oil DHA powder 0.30%, ARA powder 0.60%, wherein oiling desalted whey, which are matched somebody with somebody, includes medium chain fatty acid MCT in feed powder, The medium chain fatty acid MCT that oiling desalted whey is matched somebody with somebody in feed powder accounts for the 25.80% of product;Nutrition fortifier includes calcium carbonate, phosphoric acid DFP, ferric pyrophosphate, zinc gluconate, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6、 Vitamin B12, nicotinic acid, folic acid, D-VB5 calcium, vitamin C.Each component nutrient accounts for the mass percent of total nutrition fortifier: Calcium carbonate 16.04%, tricalcium phosphate 43.53%, ferric pyrophosphate 11.89%, zinc gluconate 4.23%, vitamin A 0.51%th, vitamin D30.07%th, vitamin E 2.56%, vitamin B10.17%th, vitamin B21.61%th, vitamin B6 0.15%th, vitamin B120.17%th, nicotinic acid 1.69%, folic acid 0.08%, D-VB5 calcium 0.38%, vitamin C 16.92%.
Each component is acted on:Oiling desalted whey mainly provides the fat and protein of product with feed powder.Desalted whey powder is Mineral salt in whey powder is sloughed.For infant, content of mineral substances is too high to increase the kidney burden of baby, therefore breast Clear powder typically can all slough mineral matter.It is to increase grease on this basis to meet infant to fat that oiling desalted whey, which matches somebody with somebody feed powder, The requirement of fat.
α-lactalbumin can be coupled with unconjugated bilirubin, so as to prevent bilirubin from passing through pellicle such as cell membrane, tire Disk, gall-bladder, blood-brain barrier;
Edible monomeric glucose can change into glucuronic acid in vivo, and glucuronic acid is in glucuronyl transferase It can be combined to form under catalytic action with unconjugated bilirubin with reference to bilirubin so as to discharge it in vitro, to promoting icterus neonatorum Treatment have very great help;
Depth hydrolysis' albumen reduces the possibility of neonate's milk protein allergy, and lactase can prevent premature or new life again Youngster's lactose intolerance, helps baby in stage of icterus, while alleviating and shorten the jaundice course of disease, evades milk protein allergy and breast Sugar can ensure that body obtains the sufficient nutrition for meeting demand of growing again intolerant to problem.
Nutrition fortifier is using compounding nutrition fortifier, it is therefore intended that improves food nutrition density, makes up in Dairy Processing The loss of nutrition, is more nearly breast milk composition, meets the nutritional need of infant's normal growth.In addition, strong using food nutrition Agent can especially supplement some nutriments, reach the purpose of special diet and health.Nutrition fortifier not only improves food Nutritional quality, can also reduce and prevent many deficiency diseases and nutritional deficiency caused by other complication, some nutrition Hardening agent also has the effect of the aesthetic quality for improving food and keeping property concurrently.
FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are association area usual ingredients, are act as often See function.
A kind of process for manufacturing stage of icterus small peptide growing nutrient element, it is characterised in that comprise the following steps:
Step one:Determine to need the nutrition fortifier pre-processed in advance to have tricalcium phosphate, calcium carbonate, vitamin C, Jiao first Ferric phosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2, vitamin B6, dimension Raw element D3, folic acid, vitamin B12, processing method is as follows:
(1) vitamin B2, folic acid, vitamin B12Gradient dilution is needed to handle, according to the dilution ratio of different material, accurately Calculate raw material and oiling desalted whey matches somebody with somebody the consumption of feed powder, carry out respectively after gradient mixing, sieve 60 mesh sieves respectively, then enters respectively Mixing tank is well mixed, and tank is gone out respectively and crosses 60 mesh sieves, standard compliant raw material after being handled, specific raw material dilution ratio is shown in Table:
Material name Before processing content of monomer Add auxiliary material Content of monomer after processing
Vitamin B2 100% Oiling desalted whey matches somebody with somebody feed powder 10%
Vitamin B12 98% Oiling desalted whey matches somebody with somebody feed powder 0.1%
Folic acid 98% Oiling desalted whey matches somebody with somebody feed powder 10%
(2) tricalcium phosphate, calcium carbonate, vitamin C, ferric pyrophosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B6, vitamin D3Need to cross 60 mesh sieves respectively, take respective screenings, then will each sieve Upper thing again by crushing, it is ground cross 60 mesh sieves respectively, obtain the standard compliant raw material of institute, specifically used equipment refers to Tianjin The patent application of De Heng Science and Technology Ltd.s:The entitled rotary sealing device of rotating shaft of Application No. 200920096540.9, Shen Number device please be pulverized and mixed for 200920096539.6 entitled one kind.
Step 2:Hardening agent component is supported into according to prescription quality percentage precise by each processing rear batallion, specifically:
Each component nutrient accounts for the mass percent of total nutrition fortifier in formula:Calcium carbonate 16.04%, tricalcium phosphate 43.53%th, ferric pyrophosphate 11.89%, zinc gluconate 4.23%, vitamin A 0.51%, vitamin D30.07%th, dimension life Plain E2.56%, vitamin B10.17%th, vitamin B21.61%th, vitamin B60.15%th, vitamin B120.17%th, nicotinic acid 1.69%th, folic acid 0.08%, D-VB5 calcium 0.38%, vitamin C 16.92%;
1) tricalcium phosphate, calcium carbonate, ferric pyrophosphate, zinc gluconate are added into mixing tank successively in order first to be filled Divide and mixed 60 mesh sieves, obtain mineral-supplemented dose of bag;
2) and then in order successively by vitamin C, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, dimension life Plain B2, vitamin B6, vitamin D3, folic acid, vitamin B12Add mixing tank to carry out being sufficiently mixed 60 mesh sieves, obtain vitamin Hardening agent bag;
Step 3:According to each component mass percent precise is formulated, specifically:
Each component accounts for the mass percent of product:Oiling desalted whey matches somebody with somebody feed powder 64.49%, depth hydrolysis' albumen 6.32%, α-lactalbumin 5.45%, edible glucose 18.37%, nutrition fortifier 1.18%, FOS 1.71% is low Poly- galactolipin 1.43%, lactase 0.15%, algae oil DHA powder 0.30%, wherein ARA powder 0.60%, oiling desalted whey dispensing Medium chain fatty acid MCT is included in powder, the medium chain fatty acid MCT that oiling desalted whey is matched somebody with somebody in feed powder accounts for the 25.80% of product;
It is mixed into except nutrition fortifier is weighed in step 2, other components process step is as follows:And oiling desalination is newborn Clearly with feed powder, edible glucose, α-lactalbumin, depth hydrolysis' albumen, FOS, galactooligosaccharide, lactase according to matching somebody with somebody Square each component mass percent precise feed intake successively into mixing tank in order it is abundant mix, obtain aniseed bag;
Step 4:The mineral-supplemented dose of bag and vitamin enrichment bag that step 2 is mixed put into aniseed bag and filled successively Divide mixing, cross 40 mesh sieves and produce product.
The process of manufacture stage of icterus small peptide growing nutrient element in the present invention, it is reasonable in design, it is easy to accomplish and production, It is easy to control product quality.
Embodiment 4:
Stage of icterus small peptide growing nutrient element, including oiling desalted whey match somebody with somebody feed powder, edible glucose, α-lactalbumin, depth Protein hydrolysate, nutrition fortifier, FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are spent, each component accounts for product Mass percent:Oiling desalted whey matches somebody with somebody feed powder 72.12%, depth hydrolysis' albumen 3.06%, α-lactalbumin 4.71%, food With glucose 15.08%, nutrition fortifier 1.17%, FOS 1.68%, galactooligosaccharide 1.43%, lactase 0.15%, algae oil DHA powder 0.20%, ARA powder 0.40%.Wherein oiling desalted whey, which is matched somebody with somebody, includes medium chain fatty acid MCT in feed powder, The medium chain fatty acid MCT that oiling desalted whey is matched somebody with somebody in feed powder accounts for the 28.85% of product;Nutrition fortifier includes calcium carbonate, phosphoric acid DFP, ferric pyrophosphate, zinc gluconate, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6、 Vitamin B12, nicotinic acid, folic acid, D-VB5 calcium, vitamin C.Each component nutrient accounts for the mass percent of total nutrition fortifier: Calcium carbonate 15.57%, tricalcium phosphate 46.95%, ferric pyrophosphate 10.75%, zinc gluconate 3.97%, vitamin A 0.51%th, vitamin D30.07%th, vitamin E 2.57%, vitamin B10.17%th, vitamin B21.54%th, vitamin B6 0.12%th, vitamin B120.17%th, nicotinic acid 1.13%, folic acid 0.09%, D-VB5 calcium 0.38%, vitamin C 16.01%.
Each component is acted on:Oiling desalted whey mainly provides the fat and protein of product with feed powder.Desalted whey powder is Mineral salt in whey powder is sloughed.For infant, content of mineral substances is too high to increase the kidney burden of baby, therefore breast Clear powder typically can all slough mineral matter.It is to increase grease on this basis to meet infant to fat that oiling desalted whey, which matches somebody with somebody feed powder, The requirement of fat.
α-lactalbumin can be coupled with unconjugated bilirubin, so as to prevent bilirubin from passing through pellicle such as cell membrane, tire Disk, gall-bladder, blood-brain barrier;
Edible monomeric glucose can change into glucuronic acid in vivo, and glucuronic acid is in glucuronyl transferase It can be combined to form under catalytic action with unconjugated bilirubin with reference to bilirubin so as to discharge it in vitro, to promoting icterus neonatorum Treatment have very great help.;
Depth hydrolysis' albumen reduces the possibility of neonate's milk protein allergy, and lactase can prevent premature or new life again Youngster's lactose intolerance, helps baby in stage of icterus, while alleviating and shorten the jaundice course of disease, evades milk protein allergy and breast Sugar can ensure that body obtains the sufficient nutrition for meeting demand of growing again intolerant to problem.
Compound nutrition fortifier, it is therefore intended that improve food nutrition density, make up the mesotrophic loss of Dairy Processing, more Close to breast milk composition, the nutritional need of infant's normal growth is met.Nutrition fortifier not only improves the nutritional quality of food, also It can reduce and prevent many deficiency diseases and other caused complication of nutritional deficiency, some nutrition fortifiers, which also have concurrently, to be carried The aesthetic quality of high food and the effect of keeping property.
FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder are association area usual ingredients, are act as often See function.
A kind of process for manufacturing stage of icterus small peptide growing nutrient element, it is characterised in that comprise the following steps:
Step one:Determine to need the nutrition fortifier pre-processed in advance to have tricalcium phosphate, calcium carbonate, vitamin C, Jiao first Ferric phosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2, vitamin B6, dimension Raw element D3, folic acid, vitamin B12, processing method is as follows:
(1) vitamin B2, folic acid, vitamin B12Gradient dilution is needed to handle, according to the dilution ratio of different material, accurately Calculate raw material and oiling desalted whey matches somebody with somebody the consumption of feed powder, carry out respectively after gradient mixing, sieve 60 mesh sieves respectively, then enters respectively Mixing tank is well mixed, and tank is gone out respectively and crosses 60 mesh sieves, standard compliant raw material after being handled, specific raw material dilution ratio is shown in Table:
Material name Before processing content of monomer Add auxiliary material Content of monomer after processing
Vitamin B2 100% Oiling desalted whey matches somebody with somebody feed powder 10%
Vitamin B12 98% Oiling desalted whey matches somebody with somebody feed powder 0.1%
Folic acid 98% Oiling desalted whey matches somebody with somebody feed powder 10%
(2) tricalcium phosphate, calcium carbonate, vitamin C, ferric pyrophosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B6, vitamin D3Need to cross 60 mesh sieves respectively, take respective screenings, then will each sieve Upper thing again by crushing, it is ground cross 60 mesh sieves respectively, obtain the standard compliant raw material of institute, specifically used equipment refers to Tianjin The patent application of De Heng Science and Technology Ltd.s:The entitled rotary sealing device of rotating shaft of Application No. 200920096540.9, Shen Number device please be pulverized and mixed for 200920096539.6 entitled one kind.
Step 2:Hardening agent component is supported into according to prescription quality percentage precise by each processing rear batallion, specifically:
Each component nutrient accounts for the mass percent of total nutrition fortifier in formula:Calcium carbonate 15.57%, tricalcium phosphate 46.95%th, ferric pyrophosphate 10.75%, zinc gluconate 3.97%, vitamin A 0.51%, vitamin D30.07%th, dimension life Plain E 2.57%, vitamin B10.17%th, vitamin B21.54%th, vitamin B60.12%th, vitamin B120.17%th, cigarette Acid 1.13%, folic acid 0.09%, D-VB5 calcium 0.38%, vitamin C 16.01%, processing method is such as
1) tricalcium phosphate, calcium carbonate, ferric pyrophosphate, zinc gluconate are added into mixing tank successively in order first to be filled Divide and mixed 60 mesh sieves, obtain mineral-supplemented dose of bag;
2) and then in order successively by vitamin C, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, dimension life Plain B2, vitamin B6, vitamin D3, folic acid, vitamin B12Add mixing tank to carry out being sufficiently mixed 60 mesh sieves, obtain vitamin Hardening agent bag;
Step 3:According to each component mass percent precise is formulated, specifically:
Each component accounts for the mass percent of product:Oiling desalted whey matches somebody with somebody feed powder 72.12%, depth hydrolysis' albumen 3.06%, α-lactalbumin 4.71%, edible glucose 15.08%, nutrition fortifier 1.17%, FOS 1.68% is low Poly- galactolipin 1.43%, lactase 0.15%, algae oil DHA powder 0.20%, ARA powder 0.40%, wherein oiling desalted whey dispensing Medium chain fatty acid MCT is included in powder, the medium chain fatty acid MCT that oiling desalted whey is matched somebody with somebody in feed powder accounts for the 28.85% of this product;
It is mixed into except nutrition fortifier is weighed in step 2, other components process step is as follows:And oiling desalination is newborn Clearly basis is pressed with feed powder, edible glucose, α-lactalbumin, depth hydrolysis' albumen, FOS, galactooligosaccharide, lactase Formula each component mass percent precise order fed intake successively into mixing tank it is abundant mix, obtain aniseed bag;
Step 4:The mineral-supplemented dose of bag and vitamin enrichment bag that step 2 is mixed put into aniseed bag and filled successively Divide mixing, cross 40 mesh sieves and produce product.
The process of manufacture stage of icterus small peptide growing nutrient element in the present invention, it is reasonable in design, it is easy to accomplish and production, It is easy to control product quality.
Contrast groups data:
Embodiment 1,2,3,4 is 4 kinds of factory formulas citing of the stage of icterus small peptide nutrient element of the present invention, selects any, takes With stage of icterus small peptide nutrient of the present invention element, with taking " comfortable jaundice nutrient ", and only with blue-light treatment, with using stage of icterus Small peptide nutrient element auxiliary three kinds of contrasts of blue-light treatment, front and rear bilirubin change indicator situation (see specification P5).
By control group data, when showing to use each component mass percent in embodiment 4, the Huang of the application is used alone Subcutaneous ulcer phase small peptide growing nutrient element, bilirubin declines obvious.Using stage of icterus small peptide nutrient element auxiliary blue-light treatment, stage of icterus small peptide Nutrient coordinates auxiliary blue light illumination to be relieved jaundice and effectively shortens the jaundice course of disease, compared to other embodiment, embodiment 4 It is better.
An example of the present invention is described in detail above, but content is only presently preferred embodiments of the present invention, no The practical range for limiting the present invention can be considered as.Any changes and modifications in accordance with the scope of the present application, Within the patent covering scope that the present invention should still be belonged to.

Claims (10)

1. stage of icterus small peptide growing nutrient is plain, including oiling desalted whey matches somebody with somebody feed powder, edible glucose, α-lactalbumin, depth Protein hydrolysate, nutrition fortifier, FOS, galactooligosaccharide, lactase, algae oil DHA powder, ARA powder.
2. stage of icterus small peptide growing nutrient element according to claim 1, it is characterised in that each component accounts for the quality hundred of product Divide ratio:Oiling desalted whey matches somebody with somebody feed powder 59.85%-87.27%, depth hydrolysis albumen 1.40%-7.30%, α-lactalbumin 1.00%-5.70%, edible glucose 6.15%-18.37%, nutrition fortifier 1.07%-2.60%, FOS 1.58%-2.63%, galactooligosaccharide 1.30%-2.20%, lactase 0.05%-0.25%, algae oil DHA powder 0.08%- 0.40%, ARA powder 0.10%-0.70%.
3. stage of icterus small peptide growing nutrient element according to claim 2, it is characterised in that oiling desalted whey is matched somebody with somebody in feed powder Include medium chain fatty acid MCT.
4. the stage of icterus small peptide growing nutrient element according to Claims 2 or 3, it is characterised in that nutrition fortifier includes carbonic acid Calcium, tricalcium phosphate, ferric pyrophosphate, zinc gluconate, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, dimension Raw element B6, vitamin B12, nicotinic acid, folic acid, D-VB5 calcium, vitamin C.
5. the stage of icterus small peptide growing nutrient element according to claim 3 or 4, it is characterised in that oiling desalted whey matches somebody with somebody feed powder In medium chain fatty acid MCT account for the 23.94%-34.91% of this product.
6. stage of icterus small peptide growing nutrient element according to claim 5, it is characterised in that each component nutrient accounts for Zong Ying Support the mass percent of hardening agent:Calcium carbonate 15.96%-21.04%, tricalcium phosphate 29.95%-51.09%, ferric pyrophosphate 9.85%-13.76%, zinc gluconate 2.23%-6.79%, vitamin A 0.31%-0.71%, vitamin D30.05%- 0.09%th, vitamin E 2.34%-2.77%, vitamin B10.07%-0.47%, vitamin B21.34%-1.81%, dimension Raw element B60.04%-0.44%, vitamin B120.07%-0.47%, nicotinic acid 1.49%-1.91%, folic acid 0.06%- 0.11%th, D-VB5 calcium 0.18%-0.58%, vitamin C 14.92%-19.10%.
7. a kind of process for manufacturing the stage of icterus small peptide growing nutrient element as described in claim 1-6 is any, it is characterised in that Comprise the following steps:
Step one:Determine to need the nutrition fortifier pre-processed in advance to have tricalcium phosphate, calcium carbonate, vitamin C, pyrophosphoric acid first Iron, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2, vitamin B6, vitamin D3, folic acid, vitamin B12, processing method is as follows:
(1) vitamin B2, folic acid, vitamin B12Gradient dilution is needed to handle, it is accurate to calculate according to the dilution ratio of different material Raw material and oiling desalted whey match somebody with somebody the consumption of feed powder, carry out after gradient mixing, sieve respectively respectively, then enter mixing tank mixing respectively Uniformly, tank sieving, standard compliant raw material after being handled are gone out respectively;
(2) tricalcium phosphate, calcium carbonate, vitamin C, ferric pyrophosphate, zinc gluconate, vitamin E, nicotinic acid, vitamin A, D- are general Sour calcium, vitamin B1, vitamin B6, vitamin D3Need first to sieve, extracting screen underflow, then oversize again through crushing, it is ground Sieve, obtains the standard compliant raw material of institute.
Step 2:Hardening agent component is supported into according to prescription quality percentage precise by each processing rear batallion, specifically:
1) tricalcium phosphate, calcium carbonate, ferric pyrophosphate, zinc gluconate are added into mixing tank successively in order first fully mix Sieving is closed, mineral-supplemented dose of bag is obtained;
2) and then in order successively by vitamin C, vitamin E, nicotinic acid, vitamin A, D-VB5 calcium, vitamin B1, vitamin B2、 Vitamin B6, vitamin D3, folic acid, vitamin B12Add mixing tank to carry out being sufficiently mixed sieving, obtain vitamin enrichment agent bag;
Step 3:According to formula each component mass percent precise and by oiling desalted whey with feed powder, edible glucose, α-lactalbumin, depth hydrolysis' albumen, FOS, galactooligosaccharide, lactase feed intake into mixing tank fill in order successively Divide and mix, sieve to obtain aniseed bag;
Step 4:The mineral-supplemented dose of bag and vitamin enrichment bag that step 2 is mixed are put into aniseed bag successively fully to be mixed Close, sieving produces product.
8. a kind of process for manufacturing stage of icterus small peptide growing nutrient element according to claim 7, it is characterised in that institute State vitamin B in step one2, folic acid, vitamin B12Gradient dilution processing is needed to specifically refer to:
Vitamin B2Before processing content of monomer 100%, adds auxiliary material oiling desalted whey and matches somebody with somebody feed powder content of monomer 10%;
Folic acid before processing content of monomer 98%, adds auxiliary material oiling desalted whey and matches somebody with somebody feed powder content of monomer 0.1%;
Vitamin B12, before processing content of monomer 98%, addition auxiliary material oiling desalted whey is with feed powder content of monomer 10%.
9. a kind of process of manufacture stage of icterus small peptide growing nutrient element according to claim 7 or 8, it is characterised in that Sieving is 60 mesh sieves in the step one;Sieving is 60 mesh sieves in the step 2.
10. a kind of process of manufacture stage of icterus small peptide growing nutrient element according to claim 7 or 8, its feature exists Sieving is 40 mesh sieves in the step 3.
CN201710414990.7A 2017-06-05 2017-06-05 Stage of icterus small peptide growing nutrient element and technique manufacturing method Pending CN107198078A (en)

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CN110037115A (en) * 2019-05-14 2019-07-23 宁波特壹食品有限公司 A kind of partially hydrolysed protein formula powder and preparation method thereof
CN110037114A (en) * 2019-05-14 2019-07-23 宁波特壹食品有限公司 A kind of depth hydrolysis' protein prescription powder and preparation method thereof

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CN104982533A (en) * 2015-07-17 2015-10-21 多加多乳业(天津)有限公司 Formula milk powder for enhancing immunity of infants and preparation method
CN106668040A (en) * 2015-11-06 2017-05-17 合肥华方医药科技有限公司 Medicinal composition for preventing and treating neonatal jaundice and preparation method and application thereof

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CN1429113A (en) * 2000-05-08 2003-07-09 努特里奇亚有限公司 Nutritional preparation comprising ribose and folic acid and medical use thereof
CN104585327A (en) * 2015-01-16 2015-05-06 陕西欢恩宝乳业股份有限公司 Infant formula goat milk powder and production method thereof
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Publication number Priority date Publication date Assignee Title
CN107712874A (en) * 2017-10-17 2018-02-23 天津市德恒科技有限公司 Depth hydrolysis' protein prescription powder and technique manufacturing method
CN110037115A (en) * 2019-05-14 2019-07-23 宁波特壹食品有限公司 A kind of partially hydrolysed protein formula powder and preparation method thereof
CN110037114A (en) * 2019-05-14 2019-07-23 宁波特壹食品有限公司 A kind of depth hydrolysis' protein prescription powder and preparation method thereof

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Application publication date: 20170926