CN104982533A - Formula milk powder for enhancing immunity of infants and preparation method - Google Patents
Formula milk powder for enhancing immunity of infants and preparation method Download PDFInfo
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Abstract
The invention relates to formula milk powder for enhancing immunity of infants and a preparation method. The formula milk powder provided by the invention has the benefits that combined components of whey protein hydrolysates, bifidobacterium and lactoferrin are particularly added into the formula milk powder, so that the components of the formula milk powder are closer to those of breast milk. Compared to common milk powder, the formula milk powder has a function of enhancing the resistance of the infants. The preparation method of the formula milk powder disclosed by the invention is a dry-mixing production process which is different from a conventional wet-method addition method, so that the damage to the nutrients in the formula milk powder is greatly reduced, and the final finished product formula milk powder is higher in nutritional value.
Description
Technical field
The invention belongs to baby formula milk powder field, be specifically related to a kind of formula milk and the preparation method that strengthen infant immunity.
Background technology
As everyone knows, the safest most nourishing food concerning breast milk all babies, can't deny, breast milk enriches perfect nutrition and the first-selection that becomes nascent baby because possess, as the protein containing high-quality, immunoglobulin (Ig) etc. are of value to the nutrition of baby, can promote digesting and assimilating of baby, strengthen passive protective physical fitness, these all illustrate that breast milk is the best nutrition grain of baby.But often there is not enough or other reason of breast milk in reality can not breastfeeding situation, at this moment just can only select formula milk.At present, on market, most of formula milk can meet needed for infant's basic nutrition, but the effect imperfection to infant's develop immunitypty, and after consumption by infants, anti-infection ability is poor, and easily causes indigestion, absorbs bad.
On the other hand, preparing in formula milk, often use wet method additive process, but often need in formula milk to add functional bioactivator, these bioactivator majorities have thermal sensitivity or use limitation, be not suitable for wet method to add, ingress of air as direct in DHA and ARA and moisture very easily oxidation deterioration, DHA and the ARA pulvis of industrial use, all through microencapsulation embedding treatment, certainly will cause encapsulating layer destroyed if wet method is added and cause loss.The composition such as lactoferrin, probio its loss of activity after wet method sterilization even loses activity very greatly.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of formula milk and the preparation method that strengthen infant immunity.The excellent anti-system of HBL is employed in described formula milk.Described HBL is the initial combination of hydrolyzing lactoalbumin (hydrolysates), Bifidobacterium (Bifidobacterium), lactoferrin (lactoferrin) three English name, use the formula milk of three to form closer to breast milk compared with ordinary powdered milk, there is the effect strengthening infant's resistance.
The technical solution adopted in the present invention is: a kind of formula milk strengthening infant immunity, is made up of following raw material: desalted whey powder, whole milk powder, hydrolyzing lactoalbumin powder, PURE WHEY, galactooligosaccharide, FOS, DHA, eicosatetraenoic acid, lactoferrin, Bifidobacterium, B B-complex, composite mineral matter.
Preferably, described formula milk is made up of the raw material of following mass parts: desalted whey powder 600-800 part, whole milk powder 100-200 part, hydrolyzing lactoalbumin powder 3-5 part, PURE WHEY 1-3 part, galactooligosaccharide 2-5 part, FOS 1-3 part, DHA 1-3 part, eicosatetraenoic acid 1-3 part, lactoferrin 0.4-1 part, Bifidobacterium 0.05-0.07 part, B B-complex 3-6 part, composite mineral matter 2-7 part.
Preferably, described desalted whey powder is high oily desalted whey powder, and in the oily desalted whey powder of described height, the mass fraction of edible vegetable oil is 20-30%.
Further, described edible vegetable oil is one or more any combination in corn oil, sunflower oil, soybean oil, rapeseed oil and coconut oil.
Preferably, in formula milk described in 100g, described B B-complex comprises following ingredients: vitamin A 1500-2500IU, Cobastab
6800-1500 μ g, vitamin D 250-500IU, vitamin E 10-50IU, vitamin C 30-100mg, folic acid 200-500 μ g, biotin 4-6 μ g, surplus is maltodextrin.
Preferably, in formula milk described in 100g, described composite mineral matter comprises following ingredients: ferrous lactate 10-15mg, zinc lactate 10-16mg, magnesium carbonate 100-200mg, manganese sulfate 500-1200 μ g, surplus is maltodextrin.
Below the raw material in the present invention is further elaborated:
Desalted whey powder, English name: demineralised whey powder, refers to the whey product of the mineral matter that removing is dissolved and moisture.Whey powder main component is lactalbumin and lactose.Desalted whey powder is sloughed by the mineral salt in whey powder.For infant, the high kidney burden that can increase baby of content of mineral substances, therefore must slough mineral matter.And can protein ratio be adjusted, close to breast milk level.Certainly, these all belong to prior art, and industry technical staff can easily obtain, and just repeats no more at this.
In order to balanced in nutrition, the desalted whey powder in the present invention is high oily desalted whey powder, and that is, in the oily desalted whey powder of described height, the mass fraction of edible vegetable oil is 15-30%; The edible vegetable oil added is one in corn oil, sunflower oil, soybean oil, rapeseed oil or coconut oil or any combination.The edible vegetable oil added is more conducive to the balanced in nutrition of infant.
Whole milk powder, English by name: whole milk powder, be that fresh milk is made through sterilization, dehydration, spraying dry.Because of spray-dried process, protein curd is tiny, soft, and comparatively fresh milk is easy to digestion, is one of raw material that babies ' formula milk powder is conventional.The present invention uses whole milk powder as one of raw material, is to be that final product formula milk powder more easily absorbs.
PURE WHEY, the many advantages such as whey protein powder adopts advanced technologies from milk separation and Extraction precious protein out, high with its purity, absorptivity is high, amino acid composition is the most reasonable are pushed away as " king of albumen ".All essential amino acids containing needed by human body, the amino acid compositional model in its amino acid compositional model and skeletal muscle is almost completely the same, extremely easily absorb by human body.The present invention uses PURE WHEY, is to be that final product formula milk powder more easily absorbs.
Further, hydrolyzing lactoalbumin powder (hydrolysates) is a kind of high-protein food fortifier, and the PURE WHEY compared without hydrolysis is more easily absorbed; Hydrolyzed protein loses the ability causing human allergy, and appeal to all ages crowd, can be used for hypoallergenic infant formula milk powder.With the addition of described hydrolyzing lactoalbumin powder in formula milk in the present invention, is to be that final product formula milk powder more easily absorbs.
Galactooligosaccharide, English by name: Galactooligosaccharides, it is a kind of functional oligose with natural attribute, galactooligosaccharide is the nutrient source and effective MF that in human body intestinal canal, the beneficial bacterium such as Bifidobacterium, Lactobacillus acidophilus is fabulous, can improve the digestion and absorption function of human body intestinal canal.Neonatal digestive function is weaker, so with the addition of galactooligosaccharide in formula milk in the present invention.
FOS, also known as fructooligosaccharide, is the mixture of ketose, Nystose and GF4 etc.FOS is to the proliferation function as selective in Bifidobacterium Bifidum, Bacillus acidi lactici etc. of profitable strain in enteron aisle; profitable strain is taken advantage in enteron aisle; suppress the growth of harmful bacteria; reduce the formation of noxious material; to intestinal mucosa cells and liver, there is protective effect; thus prevent the generation of pathology intestinal cancer, strengthen immunity of organisms.
DHA, English by name: Docosahexaenoic Acid, i.e. DHA, it is the necessary a kind of polyunsaturated fatty acid of human body, DHA is the important composition composition of brain cell film, participates in the formation of brain cell and growth, is formed with important function to the extension of nerve cell axons and new projection, the normal physiological activity of nerve cell can be maintained, participate in human thinking and memory forming process.
Eicosatetraenoic acid, also known as arachidonic acid, i.e. ARA, belongs to Omega6 clan elder's chain polybasic unsaturated fatty acid.Belong to essential fatty acid at child's eicosatetraenoic acid in period, the shortage of eicosatetraenoic acid is for the growth of human tissue organ, and especially brain and nervous system development may produce serious harmful effect.
Lactoferrin, formal name used at school is: lactoferrin, LF, is that in milk, a kind of important nonheme iron, in conjunction with glycoprotein, has the monomeric glycoprotein of bactericidal activity in neutrophil leucocyte particle.Lactoferrin not only participates in the transhipment of iron, and has the powerful biological functions such as broad-spectrum antiseptic, anti-oxidant, anticancer, immunity moderation system,
Bifidobacterium, English by name: Bifidobacterium, be a kind of Gram-positive bacillus of anaerobism, end is bifurcated usually, therefore named Bifidobacterium.Bifidobacterium can produce lactic acid and acetic acid after fermenting in human body intestines, can improve the utilization rate of calcium, phosphorus, iron, promotes the absorption of iron and vitamin D.Bifidobacterium fermentation lactose produces galactolipin, is to form cerebronic composition in cerebral nervous system, has substantial connection with the ramp of baby due hindbrain.Bifidobacterium can produce the nutriment of the needed by human such as vitamin B1, B2, B6, B12 and alanine, valine, aspartic acid and threonine, human body is had to the important trophism that can not be ignored.
In formula milk in the present invention, creationaryly add galactooligosaccharide and FOS, the two all plays huge facilitation to the growth and breeding of Bifidobacterium in human body intestinal canal, can improve the digestion and absorption function of human body intestinal canal.Because the digestive function of newborn infants is weaker, this is concerning newborn infants, and tool is of great significance; In addition, described galactooligosaccharide and FOS make the profitable strain in enteron aisle take advantage, and suppress the growth of harmful bacteria; reduce the formation of noxious material; to intestinal mucosa cells and liver, there is protective effect, thus prevent the generation of pathology intestinal cancer, enhance the immunity of organisms of infant.
Add B B-complex in the present invention, be infant's replenishing vitamins, wherein, vitamin A vitamin, vitamin D, vitamin E, vitamin C, folic acid, biotin are the indispensable trace element of vital movement, just repeat no more at this.
In addition, the iron that described composite mineral matter provides, zinc, magnesium, manganese are also the indispensable trace element of vital movement, also repeat no more at this.
Present invention also offers a kind of preparation method of described formula milk, comprise the following steps:
1) hydrolyzing lactoalbumin powder, galactooligosaccharide, FOS, DHA, eicosatetraenoic acid, lactoferrin, B B-complex, composite mineral matter and a part of desalted whey powder are poured in agitator mix, as premixing flour;
2) whole milk powder, PURE WHEY, Bifidobacterium and remaining desalted whey powder are poured in described premixing flour, mix in agitator, obtain formula milk in bulk;
3) by filling for described formula milk in bulk, product formula milk powder is obtained.
Preferably, step 1) in the desalted whey powder that adds account for the 4-10% of whole desalted whey powder quality.
Preferably, described agitator is three-dimensional mixer, and step 1) in mixing time be 5-10 minute, speed of agitator is 35-45 rev/min; Step 2) in speed of agitator be 35-45 rev/min, mixing time is 80-100 second; Step 3) described in fill operations carry out filling for vacuumizing filling inert gas.
Preferably, step 2) described in before whole milk powder, PURE WHEY, Bifidobacterium and remaining desalted whey powder pour described premixing flour into, after first crossing 30-40 mesh sieve, then add described premixing flour.
Beneficial effect of the present invention is:
1, add hydrolyzing lactoalbumin, Bifidobacterium and lactoferrin three kinds of compositions in formula milk disclosed by the invention especially, make the composition of described formula milk closer to breast milk, there is the function strengthening infant's resistance compared with ordinary powdered milk.
2, the preparation method of formula milk disclosed by the invention adopts and is dry mixed production technology, is different from traditional wet method additive process, greatly reduce in formula milk to the destruction of nutriment, be that final product formula milk powder nutritive value is higher.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated.
Embodiment 1
Strengthen a formula milk for infant immunity, described formula milk is made up of the raw material of following quality: desalted whey powder 600g, whole milk powder 100g, hydrolyzing lactoalbumin powder 3g, PURE WHEY 1g, galactooligosaccharide 2g, FOS 1g, DHA 1g, eicosatetraenoic acid 1g, lactoferrin 0.4g, Bifidobacterium 0.05g, B B-complex 3g, composite mineral matter 2g.
In formula milk described in 100g, described B B-complex contains following material: vitamin A 1500IU, Cobastab
6800 μ g, vitamin D 250IU, vitamin E 10IU, vitamin C 30mg, folic acid 200 μ g, biotin 4 μ g, surplus is maltodextrin.
In formula milk described in 100g, described composite mineral matter contains following material: ferrous lactate 10mg, zinc lactate 10mg, magnesium carbonate 100mg, manganese sulfate 500 μ g, surplus is maltodextrin.
Embodiment 2
Strengthen a formula milk for infant immunity, described formula milk is made up of the raw material of following quality: high oily desalted whey powder 600g, whole milk powder 100g, hydrolyzing lactoalbumin powder 3g, PURE WHEY 1g, galactooligosaccharide 2g, FOS 1g, DHA 1g, eicosatetraenoic acid 1g, lactoferrin 0.4g, Bifidobacterium 0.05g, B B-complex 3g, composite mineral matter 2g.
In the oily desalted whey powder of described height, the mass fraction of edible vegetable oil is 20%; Described edible vegetable oil be corn oil and rapeseed oil etc. mass mixing thing.
In formula milk described in 100g, described B B-complex contains following material: vitamin A 1500IU, vitamin B6 800 μ g, vitamin D 250IU, vitamin E 10IU, vitamin C 30mg, folic acid 200 μ g, biotin 4 μ g.
In formula milk described in 100g, described composite mineral matter contains following material: ferrous lactate 10mg, zinc lactate 10mg, magnesium carbonate 100mg, manganese sulfate 500 μ g.
Embodiment 3
Strengthen a formula milk for infant immunity, described formula milk is made up of the raw material of following quality: high oily desalted whey powder 800g, whole milk powder 200g, hydrolyzing lactoalbumin powder 5g, PURE WHEY 3g, galactooligosaccharide 5g, FOS 3g, DHA 3g, eicosatetraenoic acid 3g, lactoferrin 1g, Bifidobacterium 0.07g, B B-complex 6g, composite mineral matter 7g.
In the oily desalted whey powder of described height, the mass fraction of edible vegetable oil is 30%; Described edible vegetable oil be sunflower oil and soybean oil etc. mass mixing thing.
In formula milk described in 100g, described B B-complex contains following material: vitamin A 2500IU, Cobastab
61500 μ g, vitamin D 500IU, vitamin E 50IU, vitamin C 100mg, folic acid 500 μ g, biotin 6 μ g.
In formula milk described in 100g, described composite mineral matter contains following material: ferrous lactate 15mg, zinc lactate 16mg, magnesium carbonate 200mg, manganese sulfate 1200 μ g.
Embodiment 4
Strengthen a formula milk for infant immunity, described formula milk is made up of the raw material of following quality: high oily desalted whey powder 700g, whole milk powder 150g, hydrolyzing lactoalbumin powder 4g, PURE WHEY 2g, galactooligosaccharide 3g, FOS 2g, DHA 2g, eicosatetraenoic acid 2g, lactoferrin 0.7g, Bifidobacterium 0.06g, B B-complex 4g, composite mineral matter 4g.
In the oily desalted whey powder of described height, the mass fraction of edible vegetable oil is 25%; Described edible vegetable oil be corn oil, sunflower oil, soybean oil, rapeseed oil and coconut oil etc. mass mixing thing.
In formula milk described in 100g, described B B-complex contains following material: vitamin A 2000IU, Cobastab
61100 μ g, vitamin D 375IU, vitamin E 30IU, vitamin C 65mg, folic acid 350 μ g, biotin 5 μ g.
In formula milk described in 100g, described composite mineral matter contains following material: ferrous lactate 12mg, zinc lactate 13mg, magnesium carbonate 150mg, manganese sulfate 850 μ g.
Embodiment 5
According to a preparation method for the arbitrary described formula milk of embodiment 1-4, comprise the following steps:
1) hydrolyzing lactoalbumin powder, galactooligosaccharide, FOS, DHA, eicosatetraenoic acid, lactoferrin, B B-complex, composite mineral matter and a part of desalted whey powder are poured in three-dimensional mixer, speed of agitator is 35 revs/min, stir 5 minutes, after mixing, as premixing flour; Wherein, the desalted whey powder added accounts for 4% of whole desalted whey powder quality;
2), after whole milk powder, PURE WHEY, Bifidobacterium and remaining desalted whey powder first being crossed 30 mesh sieves, pour in described premixing flour, under the rotating speed of 35 revs/min, stir 80 seconds, after being uniformly mixed, obtain formula milk in bulk;
3) described formula milk in bulk being vacuumized filling inert gas carries out filling, obtains product formula milk powder.
Embodiment 6
According to a preparation method for the arbitrary described formula milk of embodiment 1-4, comprise the following steps:
1) hydrolyzing lactoalbumin powder, galactooligosaccharide, FOS, DHA, eicosatetraenoic acid, lactoferrin, B B-complex, composite mineral matter and a part of desalted whey powder are poured in three-dimensional mixer, speed of agitator is 45 revs/min, stir 10 minutes, after mixing, as premixing flour; Wherein, the desalted whey powder added accounts for 10% of whole desalted whey powder quality;
2), after whole milk powder, PURE WHEY, Bifidobacterium and remaining desalted whey powder first being crossed 40 mesh sieves, pour in described premixing flour, under the rotating speed of 45 revs/min, stir 100 seconds, after being uniformly mixed, obtain formula milk in bulk;
3) described formula milk in bulk being vacuumized filling inert gas carries out filling, obtains product formula milk powder.
Embodiment 7
According to a preparation method for the arbitrary described formula milk of embodiment 1-4, comprise the following steps:
1) hydrolyzing lactoalbumin powder, galactooligosaccharide, FOS, DHA, eicosatetraenoic acid, lactoferrin, B B-complex, composite mineral matter and a part of desalted whey powder are poured in three-dimensional mixer, speed of agitator is 40 revs/min, stir 7 minutes, after mixing, as premixing flour; Wherein, the desalted whey powder added accounts for 7% of whole desalted whey powder quality;
2), after whole milk powder, PURE WHEY, Bifidobacterium and remaining desalted whey powder first being crossed 35 mesh sieves, pour in described premixing flour, under the rotating speed of 40 revs/min, stir 90 seconds, after being uniformly mixed, obtain formula milk in bulk;
3) described formula milk in bulk being vacuumized filling inert gas carries out filling, obtains product formula milk powder.
Embodiment 8
The present embodiment is the clinical testing of effect formula milk in the present invention being improved to immunity.
Get the small white mouse in 90 45 ~ 60 day ages, be divided into control group at random, test 1 group and test 2 groups of three groups, often organize 30, gavage physiological saline, ordinary powdered milk, formula milk (concentration is 1g/ml) described in embodiment 4 respectively, once a day, each 4mL/ only, gavage 10 days continuously, after 10 days, control group, all small white mouses vertebra dislocation method of testing in 1 group and experiment 2 groups are put to death, weigh in respectively, take out spleen and weigh.Using the ratio of spleen weight and body weight as index and spleen index.Wherein, the unit of spleen is mg, and the unit of small white mouse body weight is g; The mouse spleen index of different group is as shown in table 1.
Table 1: the mouse spleen index of different group
Group | Size of animal | Index and spleen index (mg/g) |
Control group | 30 | 4.65±0.83 |
Test 1 group | 30 | 5.62±0.49 |
Test 2 groups | 30 | 6.98±0.28 |
As shown in table 1, find through data analysis, the index and spleen index difference between control group and test 2 groups extremely significantly (p < 0.01); Index and spleen index between control group and test 1 group has significant difference (p < 0.05).From above experiment, gavage the formula milk in ordinary powdered milk and the present invention, all can significantly improve the index and spleen index of mouse, but the small white mouse index and spleen index increase adding the formula milk in the present invention is more, illustrate formula milk in the present invention comparatively ordinary powdered milk more can improve immunity.
The present invention is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; no matter but any change is done in its shape or structure; every have identical with the application or akin technical scheme, all drops within protection scope of the present invention.
Claims (10)
1. one kind strengthens the formula milk of infant immunity, it is characterized in that, be made up of following raw material: desalted whey powder, whole milk powder, hydrolyzing lactoalbumin powder, PURE WHEY, galactooligosaccharide, FOS, DHA, eicosatetraenoic acid, lactoferrin, Bifidobacterium, B B-complex, composite mineral matter.
2. formula milk according to claim 1, it is characterized in that, be made up of the raw material of following mass parts: desalted whey powder 600-800 part, whole milk powder 100-200 part, hydrolyzing lactoalbumin powder 3-5 part, PURE WHEY 1-3 part, galactooligosaccharide 2-5 part, FOS 1-3 part, DHA 1-3 part, eicosatetraenoic acid 1-3 part, lactoferrin 0.4-1 part, Bifidobacterium 0.05-0.07 part, B B-complex 3-6 part, composite mineral matter 2-7 part.
3. formula milk according to claim 1 and 2, is characterized in that, described desalted whey powder is high oily desalted whey powder, and in the oily desalted whey powder of described height, the mass fraction of edible vegetable oil is 15-30%.
4. formula milk according to claim 3, is characterized in that, described edible vegetable oil is one or more any combination in corn oil, sunflower oil, soybean oil, rapeseed oil and coconut oil.
5. formula milk according to claim 1 and 2, is characterized in that, in formula milk described in 100g, described B B-complex comprises following ingredients: vitamin A 1500-2500IU, Cobastab
6800-1500 μ g, vitamin D 250-500IU, vitamin E 10-50IU, vitamin C 30-100mg, folic acid 200-500 μ g, biotin 4-6 μ g.
6. formula milk according to claim 1 and 2, it is characterized in that, in formula milk described in 100g, described composite mineral matter comprises following ingredients: ferrous lactate 10-15mg, zinc lactate 10-16mg, magnesium carbonate 100-200mg, manganese sulfate 500-1200 μ g.
7. a preparation method for formula milk described in claim 1,2 or 4, is characterized in that, comprise the following steps:
1) hydrolyzing lactoalbumin powder, galactooligosaccharide, FOS, DHA, eicosatetraenoic acid, lactoferrin, B B-complex, composite mineral matter and a part of desalted whey powder are poured in agitator mix, as premixing flour;
2) whole milk powder, PURE WHEY, Bifidobacterium and remaining desalted whey powder are poured in described premixing flour, mix in agitator, obtain formula milk in bulk;
3) by filling for described formula milk in bulk, product formula milk powder is obtained.
8. preparation method according to claim 7, is characterized in that, step 1) in the desalted whey powder that adds account for the 4-10% of whole desalted whey powder quality.
9. preparation method according to claim 7, is characterized in that, described agitator is three-dimensional mixer, and step 1) in mixing time be 5-10 minute, speed of agitator is 35-45 rev/min; Step 2) in speed of agitator be 35-45 rev/min, mixing time is 80-100 second; Step 3) described in fill operations carry out filling for vacuumizing filling inert gas.
10. preparation method according to claim 7, is characterized in that, step 2) described in before whole milk powder, PURE WHEY, Bifidobacterium and remaining desalted whey powder pour described premixing flour into, after first crossing 30-40 mesh sieve, then add described premixing flour.
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CN105230811A (en) * | 2015-11-11 | 2016-01-13 | 嘉必优生物工程(武汉)有限公司 | High oil whey powder containing polyunsaturated fatty acid fat |
CN106359613A (en) * | 2016-08-31 | 2017-02-01 | 郑州轻工业学院 | Formula milk powder for enhancing immunity of infants and preparation method thereof |
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CN105230811A (en) * | 2015-11-11 | 2016-01-13 | 嘉必优生物工程(武汉)有限公司 | High oil whey powder containing polyunsaturated fatty acid fat |
CN106359613A (en) * | 2016-08-31 | 2017-02-01 | 郑州轻工业学院 | Formula milk powder for enhancing immunity of infants and preparation method thereof |
CN107198078A (en) * | 2017-06-05 | 2017-09-26 | 天津市德恒科技有限公司 | Stage of icterus small peptide growing nutrient element and technique manufacturing method |
WO2019109009A1 (en) * | 2017-12-01 | 2019-06-06 | Second Science, Inc. | Formulations for nutritional support in subjects in need thereof |
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CN109007037A (en) * | 2018-10-16 | 2018-12-18 | 北京斯利安药业有限公司 | A kind of composition and products thereof enhancing infant immunity and application |
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Application publication date: 20151021 |