CN107192825A - A kind of antiviral antibody detecting system and method - Google Patents
A kind of antiviral antibody detecting system and method Download PDFInfo
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- CN107192825A CN107192825A CN201710643989.1A CN201710643989A CN107192825A CN 107192825 A CN107192825 A CN 107192825A CN 201710643989 A CN201710643989 A CN 201710643989A CN 107192825 A CN107192825 A CN 107192825A
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Abstract
The invention provides a kind of antiviral antibody detecting system and method, a mobile test end is designed first to be acquired the test result of antiviral antibody sample and viral antigen test solution, temperature now is measured simultaneously, relative humidity and air pressure, then by the test result, temperature, relative humidity and pressure information are by being sent to data terminal, data terminal is by the information of reception from testing obtained different temperature in advance, test experience result under varying environment relative humidity and different air pressure conditions is contrasted, obtain the analysis result of antiviral antibody, and the analysis result is sent to mobile test end, solving existing viral antibody test technology needs to carry out in laboratory conditions, the problem of testing result time lag and low detection efficiency, reach and simplified detection method, increase detection device portability and improve the purpose of detection accuracy.
Description
Technical field
The invention belongs to field of measuring technique, it is related to a kind of antiviral antibody detecting system and method.
Background technology
The detection of general antiviral antibody uses immunodetection, and immunodetection is the one kind combined based on Ag-Ab
Specific biochemical substances are carried out the technology of qualitative or quantitative analysis by immunological detection method.The epitope that antibody passes through antigenic surface
Identification correspondence antigen is simultaneously combined, this to recognize the specificity for also making immune detection have height：As aids antibody only can be with Chinese mugwort
Grow sick antigen binding, without with other antigen-reactives.
Existing antibody test be typically by the operating personnel Jing Guo professional training laboratory environment using buy or
Homemade kit simultaneously combines such as fluorescence microscope instrument to complete.Because the necessary condition of antigen and antibody binding is antigen
Come close to or in contact with antibody, there is target antigen in the testing sample covered before dispatching from the factory in existing kit, testing sample leads to
Often need in laboratory by the pretreatment such as centrifugation, in addition, part detection is also needed to buy the antigen crossed of fluorescence labeling and
Into.Test experience result is typically to observe the change of color in kit, or is obtained with fluorescence microscopy fluorescent brightness
Take, achieved finally by manually result is recorded to preserve.Because testing staff needs professional training, testing result and detection people
The experience of member is related, and with certain subjectivity, the detection of antibody is caused indirectly larger systematic error.
To sum up, inventor has found, the problem of current immune detection is present has：Complex operation, the detection of many antibody is all needed
To be carried out in laboratory environment；Need to carry out special training to testing staff simultaneously, testing result has subjectivity；Except this it
Outside, detection cycle length, testing result time lag.
The content of the invention
It is an object of the invention to provide a kind of antiviral antibody detecting system and method, for solving existing antiviral antibody inspection
Need to carry out in laboratory conditions in survey technology and the problem of detection efficiency is low.
In order to achieve the above object, the invention provides a kind of mobile test end, including：Test module, for detecting
Antiviral antibody sample is stated, to obtain the test result that antiviral antibody sample reacts with viral antigen test solution；
Environment detection module, for obtaining mobile test end institute when antiviral antibody sample reacts with viral antigen test solution
Locate the information of environment, the information of mobile test end local environment includes temperature, relative humidity and air pressure；
And the first signal transmitting and receiving module, for by the information of mobile test end local environment and test result hair
A data terminal is delivered to, and receives the antiviral antibody concentration analysis that the data terminal is sent.
Optionally, prepared by the viral antigen test solution is specially：Filtration treatment is carried out to viral antigen test solution, institute is filtered out
State the impurity in viral antigen test solution.
Optionally, the mobile test end is also including being used to record the locating module of test position information, believing for inputting
The input module of breath and the clock module for recording detection time, the locating module, the input module and the clock
Module is connected with the first signal transmitting and receiving module.
Present invention also offers a kind of data terminal, the data terminal includes：
Experiment sample database, for recording in multiple different temperatures values, multiple different rh values and multiple differences
Viral antigen test solution and antiviral antibody sample response data under the conditions of atmospheric pressure value；
Analysis module, for environmental information and test result and the experiment sample data for sending a mobile terminal
Data in storehouse are compared, to obtain the concentration of antiviral antibody in the antiviral antibody sample；And secondary signal is received
Module is sent out, for receiving environmental information and test result that the mobile test end is sent, and by the analysis knot of analysis module
Fruit feeds back to the mobile test end.
Optionally, the preparation method of the experiment sample database includes：
Keep experiment rh value and experiment atmospheric pressure value it is constant, change experimental temperature value by the antiviral antibody sample with
The viral antigen test solution reaction, obtains temperature experiment sample data；
Keep experimental temperature value and experiment atmospheric pressure value it is constant, change experiment rh value by the antiviral antibody sample with
The viral antigen test solution reaction, obtains humidity experiment sample data；
Keep experimental temperature value and experiment rh value it is constant, change experiment atmospheric pressure value by the antiviral antibody sample with
The viral antigen test solution reaction, obtains air pressure experimental data；
The temperature experimental data, the humidity experimental data and the air pressure fitting experimental data are obtained into the reaction
Experiment sample database.
Optionally, the antiviral antibody sample includes the antiviral antibody sample of different virus antibody concentration, the experiment sample
The preparation method of database is specially：
Keep RH=50% and P=101.325kPa constant, in T=-50 ° of+0.5n1Under conditions of, the virus is anti-
Body sample reacts with the viral antigen test solution, obtains the temperature experimental data, n1For experiment number, n1For 0 to 100 it is whole
Number；
T=20 ° of holding and P=101.325kPa are constant, in RH=(n2- 1) it is under conditions of × 5%, the virus is anti-
Body sample reacts with the viral antigen test solution, obtains the humidity experimental data, n2For humidity experiment number, n2For 1 to 21
Integer；
T=20 ° of holding and RH=50% are constant, in P=(901.325+5n3) under conditions of kPa, by the antiviral antibody
Sample reacts with the viral antigen test solution, obtains the air pressure experimental data, n3For air pressure experiment number, n3For 0 to 40 it is whole
Number；
T is the experimental temperature value, and RH is the experiment rh value, and P is the experiment atmospheric pressure value；
The temperature experimental data, the humidity experimental data and the air pressure fitting experimental data are obtained into the reaction
Experiment sample database.
Preferably, the data terminal also includes the memory module and use for being used to record the analysis module analysis result
In the display module for showing the analysis result, the memory module is connected with the analysis module signal.
Preferably, present invention also offers a kind of antiviral antibody detection method, it includes：
S1：The antiviral antibody sample is detected at the mobile test end, obtains the antiviral antibody sample and the virus
The test result of antigen test solution, and by the mobile test end detect the ambient temperature value, the environmental wet angle value,
The ambient pressure value and the test result are sent to the data terminal；
S2：According to the ambient temperature value, the environmental wet angle value, the ambient pressure value from the experiment sample data
The antiviral antibody sample response data of different antibodies concentration is obtained in storehouse；
S3：The response data is analyzed with the test result, disease in the antiviral antibody sample is obtained
The analysis result of malicious antibody concentration, and the analysis result is sent to the mobile test end.
Optionally, the formula of comparative analysis is in the S3：
Wherein, f0For the analysis result, f (T, RH, P) is the experiment sample database, P0For the ambient pressure
Value, T0For the ambient temperature value, RH0For the envionmental humidity, T1And T2For in the experiment sample database with T0Phase
Two adjacent experimental temperature values, laFor T1And T2Between threshold length, l1And l2Respectively T0Correspond to T1And T2Distance；RH1
And RH2For in the experiment sample database with RH0Two adjacent experiment rh values, lbFor RH1And RH2Between threshold value
Length, l3And l4Respectively RH0Correspond to RH1And RH2Distance；P1And P2For in the experiment sample database with P0Adjacent
Two experiment atmospheric pressure values, lcFor P1And P2Between threshold length, l5And l6Respectively P0Correspond to P1And P2Distance.
Compared with prior art, the present invention is provided a kind of antiviral antibody detecting system and method, with following beneficial effect
Really：
1st, without by the outdoor extraction antiviral antibody sample of experiment and in laboratory conditions to the antiviral antibody sample
This progress is detected, portability is increased by using mobile test end, while improving detection efficiency, slow down testing result
Time lag；
2nd, testing result is obtained by data analysis, more artificial subjective judgement accuracy is high, substitution manual record is achieved, drop
Low systematic error, prevents the cheating occurred during manual record, improves the accuracy of antiviral antibody detection；
3rd, according to temperature, relative humidity and the pneumatic parameter of influence testing result, the broad experiment sample number of threshold value is formulated
According to storehouse, the detection to antiviral antibody under the conditions of different geographical natural environment and climates is well adapted for, disclosure satisfy that in remote districts
With the use requirement in the severe area of natural conditions；
4th, the personnel without specialty are operable, it is not necessary to carrying out professional technique training using crowd, reduced using behaviour
Make difficulty, be easy to promote the use of；
5th, mobile test end structure is simple, is easy to carry；
6th, mobile test end detection antiviral antibody, by mobile communication transmission to data terminal, and then obtains different regions
Antiviral antibody and its concentration data information, to disease treatment, medical resource are delivered, prevention from suffering from the diseases and scientific research have necessarily
Meaning.
Brief description of the drawings
Fig. 1 is mobile test end provided in an embodiment of the present invention and data terminal structure schematic diagram；
Fig. 2 is experiment sample database preparation method provided in an embodiment of the present invention；
Fig. 3 is antiviral antibody detection method flow chart provided in an embodiment of the present invention；
Wherein, 1- test tubes, 21- temperature sensors, 22- relative humidity sensors, 23- baroceptors, 3- signal acquisitions
Module, 4- the first signal transmitting and receiving modules, 5- pumping signal modules, 6- secondary signal transceiver modules, 7- analysis modules, 8- experiment samples
Database, 9- mobile communication, 10- locating modules, 11- clock modules, 12- input modules, 13- memory modules.
Embodiment
The embodiment of the present invention is described in more detail below in conjunction with schematic diagram.According to description below and
Claims, advantages and features of the invention will become apparent from.It should be noted that, accompanying drawing uses very simplified form and equal
Using non-accurately ratio, only for the purpose of facilitating and clarifying the purpose of the embodiments of the invention.
Referring to Fig. 1, the embodiments of the invention provide a kind of mobile test end A, it is sick in antiviral antibody sample for detecting
Malicious antibody concentration, including：
Test module, it is anti-to obtain antiviral antibody sample and viral antigen test solution for detecting the antiviral antibody sample
The test result answered；
Environment detection module, for obtaining mobile test end institute when antiviral antibody sample reacts with viral antigen test solution
Locate the information of environment, the information of mobile test end local environment includes temperature, humidity and air pressure；
And the first signal transmitting and receiving module, for by the information of mobile test end local environment and test result hair
A data terminal is delivered to, and receives the antiviral antibody concentration analysis that the data terminal is sent.
The test module includes the test tube 1 and signal acquisition module 3 for being used to deposit the viral antigen test solution, the disease
Malicious antigen test solution is used for the antiviral antibody concentration for demarcating the antiviral antibody sample, and signal acquisition module 3 is used to gather institute
State the test result that antiviral antibody sample reacts with the viral antigen test solution；
The environment detection module include be used for measure the mobile test end A ambient temperature values temperature sensor 21,
For measuring the humidity sensor 22 of the mobile test end A envionmental humidity values and for measuring the mobile test end A
The baroceptor 23 of ambient pressure value；
The test result that first signal transmitting and receiving module 4 gathers signal acquisition module 3, temperature sensor 21 are measured
The atmospheric pressure value that the envionmental humidity and baroceptor 23 that environment temperature, relative humidity sensor 22 are measured are measured is sent to number
According to end B, and receive the antiviral antibody concentration analysis that data terminal B sends and come.
Inventor has found that existing antiviral antibody detection technique, typically by gathering antiviral antibody sample, is then protected
Hide, then the antibody sample collected is transported in laboratory, the antiviral antibody sample is carried out in laboratory environment
Detection, using this protocol step is various, testing result time lag, detection efficiency it is low, and need to carry out personnel special
Industry training is required with meeting detection.Inventor has found that：The environmental factor of influence antiviral antibody detection is mainly detection
When temperature, envionmental humidity and air pressure, therefore inventors herein propose in non-laboratory condition (i.e. in different temperature, environment
Under relative humidity and air pressure conditions) antiviral antibody sample is detected, then by the way that it is obtained into different gas from experiment in advance
Test experience result under temperature, envionmental humidity and air pressure conditions is contrasted, and obtains the technology of antiviral antibody testing result
Scheme.In order to realize above-mentioned technical proposal, a mobile test end A is designed first to the institute in antiviral antibody sample and test tube 1
The test result for stating viral antigen test solution is acquired, while measuring temperature now, by relative by temperature sensor 21
Humidity sensor 22 measures relative humidity now and measures air pressure now by baroceptor 23, then will test knot
Really, temperature, relative humidity and pressure information are sent to data terminal B by the first signal transmitting and receiving module, and the transmission is with movement
The mode of communication 9 is carried out, and the mobile communication 9 is, for example, GSM, GPRS, 4G, 5G and/or wifi.
Preferably, prepared by the viral antigen test solution is specially：The viral antigen test solution is filtered and purification at
Reason, filters out the impurity in the viral antigen test solution, and then improves the concentration of viral antigen in the viral antigen test solution, with
Reduce influence of the unrelated impurity to testing result in viral antigen test solution., can be by the virus in test tube 1 in practical operation
Antigen test solution is prepared according to fixed standard, and the test tube 1 is using being detachably connected on the A of mobile test end, under progress
During one antiviral antibody pattern detection, change the outfit the new test tube 1 equipped with the viral antigen test solution, and then realizes to multiple diseases
The detection of malicious antibody sample.
Preferably, mobile test end A is also including being used to record the locating module 10 of test position information, being detected for recording
The clock module 11 of time and the input module 12 for inputting information, it is the locating module 10, the clock module 11, described
Input module 12 is connected with the first signal transmitting and receiving module 4 and can realize data transfer.Carrying out antiviral antibody detection
While, positional information, temporal information during to detection record and are transferred to data terminal B by the first signal transmitting and receiving module 4.
The time and positional information of antiviral antibody are recorded, contributes to data terminal B to understand and surveys detection site and detection time, enter
And contribute to the area for understanding antiviral antibody distribution to need to detect the Annual distribution of antiviral antibody with tester, disease is prevented
Control, the input of medical resource and scientific research have positive meaning.Input module 12 can be defeated using input through keyboard, fingerprint
Enter and/or handwriting input mode, the detection information marked is needed during to detection as detected the species of object, age, sex, the people
Race, health status etc. are inputted and illustrated, help to understand the further information of the antiviral antibody, if measurement object is
During people, the visitor of testing result can be improved with the signature data and/or finger print information of handwriting input tester and detected person
Sight, fairness.
Preferably, the mobile test end A also includes being used to encourage the viral antigen test solution and the institute in the test tube 1
The pumping signal module 5 of antiviral antibody sample reaction is stated, the pumping signal module 5 is connected with the test tube 1, the test tube
The viral antigen test solution and the antiviral antibody sample mixing reaction of formation test solution, the work of the pumping signal module 5 in 1
Working frequency is 10Hz to 10MHz.When the viral antigen in the viral antigen test solution and antibody in the antiviral antibody sample are anti-
During raw immune response, the change of voltage and/or electric current and signal phase can occur for the output signal of the pumping signal in test tube 1
Change, this change turns to the test result, signal acquisition module 3 is used to gather the voltage and/or electric current and letter occurred in test tube 1
The change of number phase, signal acquisition module 3 is connected with the signal of the first signal transmitting and receiving module 4, and the first signal transmitting and receiving module 4 is used for will
The test result is sent to the data terminal.
Traditional detection method is typically combined by the Brownian movement between antibody and antigen molecule, due to Blang's fortune
Dynamic speed causes testing result time lag more slowly, and the reaction test solution is persistently swashed using signal driving frequency
Encourage, increase the motion liveness of antibody and antigen molecule, it is possible to increase the reaction speed of the reaction test solution, and then reduce
Detection time, improves detection efficiency.
The embodiment of the present invention additionally provides a kind of data terminal B, for receiving, analyzing the virus from mobile test end A
The signal that antigen test solution reacts with antiviral antibody sample, and analysis result is sent to mobile test end A, the data terminal bag
Include：
Experiment sample database 8, the experiment sample database 8 is used to record in multiple different temperatures values, multiple differences
Viral antigen test solution and antiviral antibody sample response data under the conditions of rh value and different atmospheric pressure values；
Analysis module 7, the analysis module 7 is used for the environmental information and test result for sending a mobile test end A
It is compared with the data in the experiment sample database 8, to obtain antiviral antibody in the antiviral antibody sample
Concentration；
And secondary signal transceiver module 6, the secondary signal transceiver module 6 is for receiving the mobile test end A hairs
The environmental information and test result sent, and the analysis result of analysis module 6 is fed back into the mobile test end A.
Referring to Fig. 2, the preparation method of the experiment sample database is：
Keep experiment rh value and experiment atmospheric pressure value it is constant, change experimental temperature value by the antiviral antibody sample with
The viral antigen test solution reaction, obtains temperature experiment sample data；
Keep experimental temperature value and experiment atmospheric pressure value it is constant, change experiment rh value by the antiviral antibody sample with
The viral antigen test solution reaction, obtains humidity experiment sample data；
Keep experimental temperature value and experiment rh value it is constant, change experiment atmospheric pressure value by the antiviral antibody sample with
The viral antigen test solution reaction, obtains air pressure experimental data；
The temperature experimental data, the humidity experimental data and the air pressure fitting experimental data are obtained into the reaction
Experiment sample database.
Preferably, the antiviral antibody sample includes the antiviral antibody sample of different virus antibody concentration, the experiment sample
The preparation of database is specially：
Keep RH=50% and P=101.325kPa constant, in T=-50 ° of+0.5n1Under conditions of, the virus is anti-
Body sample reacts with the viral antigen test solution, obtains the temperature experimental data, n1For experiment number, n1For 0 to 100 it is whole
Number, temperature is different between each sample in temperature experimental data, and the measurement tolerance between each sample is 0.5 degree Celsius,
This measurement tolerance is taken to be based on temperature sensor resolution ratio, economic serviceability, experiment number and sample data volume for inventor
Consideration, preferred value is drawn by experimental verification, in a practical situation with the susceptibility of antiviral antibody and viral antigen to temperature
Consider, more or less temperature experimental data samples, i.e. measurement tolerance between each sample can be gathered and taken the photograph for 1
Family name's degree ..., 0.4 degree Celsius, 0.3 degree Celsius, 0.2 degree Celsius, 0.1 degree Celsius ....It is note to take the purpose so tested
Record controls temperature change, observation temperature change is to the antiviral antibody sample and institute under certain relative humidity and air pressure conditions
State the situation of viral antigen test solution reaction；
T=20 ° of holding and P=101.325kPa are constant, in RH=(n2- 1) it is under conditions of × 5%, the virus is anti-
Body sample reacts with the viral antigen test solution, obtains the humidity experimental data, n2For humidity experiment number, n2For 1 to 21
Integer, relative humidity is different between each sample in relative humidity experimental data, and the relative humidity between each sample is public
Difference is 1%, takes this relative humidity tolerance to be based on relative humidity sensor resolution ratio, economic serviceability, experiment for inventor
The consideration of number of times and sample data volume, preferred value is drawn by experimental verification, anti-with antiviral antibody and virus in a practical situation
The former susceptibility to envionmental humidity considers, and can gather more or less humidity experimental data samples, i.e., each
Relative humidity tolerance between individual sample is 10% ..., 4%, 3%, 2%, 1% ....Taking the purpose so tested is
Record controls relative humidity variations, observation relative humidity variations are to the antiviral antibody sample under certain temperature and air pressure conditions
This situation about being reacted with the viral antigen test solution；
T=20 ° of holding and RH=50% are constant, in P=(901.325+5n3) under conditions of kPa, by the antiviral antibody
Sample reacts with the viral antigen test solution, obtains the air pressure experimental data, n3For air pressure experiment number, n3For 0 to 40 it is whole
Number, air pressure is different between each sample in air pressure experimental data, and the air pressure tolerance between each sample is 5kPa, takes this
Individual air pressure tolerance is consideration of the inventor based on baroceptor resolution ratio, economic serviceability, experiment number and sample data volume,
Preferred value is drawn by experimental verification, the susceptibility of air pressure is integrated with antiviral antibody and viral antigen examined in a practical situation
Consider, can gather more or less air pressure experimental data samples, i.e. air pressure tolerance between each sample is
10kPa、……、4kPa、3kPa、2kPa、1kPa、…….Take the purpose so tested be recorded on certain relative humidity and
Under temperature conditionss, air pressure change is controlled, observation air pressure change is reacted the antiviral antibody sample and the viral antigen test solution
Situation；
T is the experimental temperature value, and RH is the experiment rh value, and P is the experiment atmospheric pressure value；By the temperature
Experimental data, the humidity experimental data and the air pressure fitting experimental data obtain the reaction experiment sample database.
Preferably, the data terminal B also include be used for record the memory module 13 of the analysis result of analysis module 7 with
And for showing the display module (not marked in figure) of the analysis result, the memory module 13 respectively with the analysis module
7 are connected, due to mobile test end A gather antiviral antibody sample from viral antigen test solution from different areas, Ran Houyi
Dynamic test lead A will collect information and be sent to data terminal B by telecommunication 9, therefore memory module 13 has different regions, no
Same geographical environment, different nationalities, Various Seasonal, the big data of all ages and classes antiviral antibody sample, this is for disease treatment, medical treatment
Resource is delivered, prevention from suffering from the diseases and scientific research have certain meaning, while testing result is transferred to data terminal B, prevents artificial
The cheating occurred in recording process.
Fig. 3 is refer to, present invention also offers a kind of antiviral antibody detection method, it includes：
S1：The mobile test end A detects the antiviral antibody sample, obtains the antiviral antibody sample and the virus
The test result of antigen test solution, and by the mobile test end A detect the ambient temperature value, the ambient humidity
Value, the ambient pressure value and the test result are sent to the data terminal B；
S2：According to the ambient temperature value, the environmental wet angle value, the ambient pressure value from the experiment sample data
The antiviral antibody sample response data of different antibodies concentration is obtained in storehouse 8；
S3：The response data is analyzed with the test result, the disease of the antiviral antibody sample is obtained
Malicious antibody concentration, and analysis result is sent to the mobile test end A.
Preferably, the formula of comparative analysis is in the S3：
Wherein, f0For the analysis result, f (T, RH, P) is the experiment sample database, P0For the ambient pressure
Value, T0For the ambient temperature value, RH0For the envionmental humidity, T1And T2For in the experiment sample database with T0Phase
Two adjacent experimental temperature values, laFor T1And T2Between threshold length, l1And l2Respectively T0Correspond to T1And T2Distance；RH1
And RH2For in the experiment sample database with RH0Two adjacent experiment rh values, lbFor RH1And RH2Between threshold value
Length, l3And l4Respectively RH0Correspond to RH1And RH2Distance；P1And P2For in the experiment sample database with P0Adjacent
Two experiment atmospheric pressure values, lcFor P1And P2Between threshold length, l5And l6Respectively P0Correspond to P1And P2Distance, using adding
Weight average algorithm, further increases the accuracy of testing result.
To sum up, in a kind of antiviral antibody detecting system and method provided in an embodiment of the present invention, a shifting is designed first
Dynamic test lead is acquired to the test result of antiviral antibody sample and viral antigen test solution, while temperature, the phase of measurement now
It is then that test result, temperature, relative humidity and pressure information is whole by being sent to data terminal, data to humidity and air pressure
The information of reception is obtained the test experience result under different temperature, envionmental humidity and air pressure conditions from experiment in advance and entered by end
Row contrast, obtains antiviral antibody testing result, and testing result is sent into mobile test end, solves existing antiviral antibody inspection
Need to carry out in laboratory conditions in survey technology, testing result time lag and the problem of low detection efficiency, reached essence
Simple detection method, increase detection device portability and the purpose for improving detection accuracy.
The preferred embodiments of the present invention are above are only, any restriction effect is not played to the present invention.Belonging to any
Those skilled in the art, in the range of technical scheme is not departed from, to the invention discloses technical scheme and
Technology contents make the variation such as any type of equivalent substitution or modification, belong to the content without departing from technical scheme, still
Belong within protection scope of the present invention.
Claims (10)
1. a kind of mobile test end, for detecting the antiviral antibody concentration in antiviral antibody sample, it is characterised in that the movement
Test lead includes：
Test module, for detecting the antiviral antibody sample, to obtain antiviral antibody sample and the reaction of viral antigen test solution
Test result；
Environment detection module, for obtaining ring residing for mobile test end when antiviral antibody sample reacts with viral antigen test solution
The information in border, the information of mobile test end local environment includes temperature, relative humidity and air pressure；
And the first signal transmitting and receiving module, for by the information and test result of mobile test end local environment send to
One data terminal, and receive the antiviral antibody concentration analysis that the data terminal is sent.
2. mobile test end as claimed in claim 1, it is characterised in that the viral antigen test solution is prepared and specifically included：
Filtration treatment and purification processes are carried out to the viral antigen test solution, it is miscellaneous in the viral antigen test solution to filter out
Matter.
3. mobile test end as claimed in claim 1, it is characterised in that the mobile test end also includes：
Locating module for recording test position information；
Clock module for recording detection time；
And for inputting the input module of information.
4. a kind of data terminal, it is characterised in that the data terminal includes：
Experiment sample database, for recording in multiple different temperatures values, multiple different rh values and multiple different air pressure
Viral antigen test solution and antiviral antibody sample response data under the conditions of value；
Analysis module, for environmental information and test result and the experiment sample database for sending a mobile test end
In data be compared, to obtain the concentration of antiviral antibody in the antiviral antibody sample；
And secondary signal transceiver module, for receiving environmental information and test result that the mobile test end is sent, and
The analysis result of analysis module is fed back into the mobile test end.
5. data terminal as claimed in claim 4, it is characterised in that the preparation method of the experiment sample database includes：
Keep experiment rh value and experiment atmospheric pressure value it is constant, change experimental temperature value by the antiviral antibody sample with it is described
Viral antigen test solution reacts, and obtains temperature experiment sample data；
Keep experimental temperature value and experiment atmospheric pressure value it is constant, change experiment rh value by the antiviral antibody sample with it is described
Viral antigen test solution reacts, and obtains humidity experiment sample data；
Keep experimental temperature value and experiment rh value it is constant, change experiment atmospheric pressure value by the antiviral antibody sample with it is described
Viral antigen test solution reacts, and obtains air pressure experimental data；And
The temperature experimental data, the humidity experimental data and the air pressure fitting experimental data are obtained into the reaction experiment
Sample database.
6. data terminal as claimed in claim 5, it is characterised in that it is dense that the antiviral antibody sample includes different virus antibody
The antiviral antibody sample of degree, the preparation method of the experiment sample database is specially：
Keep RH=50% and P=101.325kPa constant, in T=-50 ° of+0.5n1Under conditions of, by the antiviral antibody sample
This reacts with the viral antigen test solution, obtains the temperature experimental data, n1For experiment number, n1For 0 to 100 integer；
T=20 ° of holding and P=101.325kPa are constant, in RH=(n2- 1) under conditions of × 5%, by the antiviral antibody sample
This reacts with the viral antigen test solution, obtains the humidity experimental data, n2For humidity experiment number, n2For 1 to 21 it is whole
Number；
T=20 ° of holding and RH=50% are constant, in P=(901.325+5n3) under conditions of kPa, by the antiviral antibody sample
Reacted with the viral antigen test solution, obtain the air pressure experimental data, n3For air pressure experiment number, n3For 0 to 40 integer；
T is the experimental temperature value, and RH is the experiment rh value, and P is the experiment atmospheric pressure value；
The temperature experimental data, the humidity experimental data and the air pressure fitting experimental data are obtained into the reaction experiment
Sample database.
7. data terminal as claimed in claim 4, it is characterised in that the data terminal also includes：
For recording the memory module of the analysis module analysis result and display module for showing the analysis result,
The memory module is connected with the analysis module signal.
8. a kind of antiviral antibody concentration detection system, it is characterised in that the antiviral antibody detecting system includes：
Mobile test end described in claim any one of 1-3；And any described data terminals of claim 4-7.
9. a kind of antiviral antibody detection method, it is characterised in that the antiviral antibody detection method includes：
S1：The antiviral antibody sample is detected at mobile test end, obtains the survey that antiviral antibody sample reacts with viral antigen test solution
Test result, and the information and the test result of mobile test end local environment are sent to a data terminal；
S2：Different antibodies concentration is obtained from the experiment sample database according to the information of mobile test end local environment
Antiviral antibody sample response data；
S3：The antiviral antibody sample response data of the different antibodies concentration and the test result are analyzed, obtained
The analysis result of antiviral antibody concentration in the antiviral antibody sample is obtained, and the analysis result is sent to the mobile test
End.
10. a kind of antiviral antibody detection method as claimed in claim 9, it is characterised in that the public affairs of comparative analysis in the S3
Formula is：
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<mn>1</mn>
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</msub>
</mrow>
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<mi>f</mi>
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<mrow>
<msub>
<mi>T</mi>
<mn>2</mn>
</msub>
<mo>,</mo>
<msub>
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<mn>2</mn>
</msub>
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<msub>
<mi>P</mi>
<mn>2</mn>
</msub>
</mrow>
<mo>)</mo>
<mo>+</mo>
<mi>f</mi>
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<mrow>
<msub>
<mi>T</mi>
<mn>1</mn>
</msub>
<mo>,</mo>
<msub>
<mi>RH</mi>
<mn>1</mn>
</msub>
<mo>,</mo>
<msub>
<mi>P</mi>
<mn>2</mn>
</msub>
</mrow>
<mo>)</mo>
<mo>+</mo>
<mi>f</mi>
<mo>(</mo>
<mrow>
<msub>
<mi>T</mi>
<mn>2</mn>
</msub>
<mo>,</mo>
<msub>
<mi>RH</mi>
<mn>1</mn>
</msub>
<mo>,</mo>
<msub>
<mi>P</mi>
<mn>2</mn>
</msub>
</mrow>
<mo>)</mo>
<mo>)</mo>
</mrow>
</mrow>
Wherein, f0For the analysis result, f (T, RH, P) is the experiment sample database, P0For the ambient pressure value, T0
For the ambient temperature value, RH0For the envionmental humidity, T1And T2For in the experiment sample database with T0Adjacent
Two experimental temperature values, laFor T1And T2Between threshold length, l1And l2Respectively T0Correspond to T1And T2Distance；RH1With
RH2For in the experiment sample database with RH0Two adjacent experiment rh values, lbFor RH1And RH2Between threshold value it is long
Degree, l3And l4Respectively RH0Correspond to RH1And RH2Distance；P1And P2For in the experiment sample database with P0Adjacent two
Individual experiment atmospheric pressure value, lcFor P1And P2Between threshold length, l5And l6Respectively P0Correspond to P1And P2Distance.
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| WO2022041233A1 (en) * | 2020-08-31 | 2022-03-03 | 余伟华 | Pathogen and antibody detection system for mobile terminal |
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