CN107184849A - It is a kind of to be used to treat ointment of onychomycosis and preparation method thereof - Google Patents

It is a kind of to be used to treat ointment of onychomycosis and preparation method thereof Download PDF

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Publication number
CN107184849A
CN107184849A CN201710469190.5A CN201710469190A CN107184849A CN 107184849 A CN107184849 A CN 107184849A CN 201710469190 A CN201710469190 A CN 201710469190A CN 107184849 A CN107184849 A CN 107184849A
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parts
ointment
onychomycosis
root bark
treat
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李建华
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Suzhou Li Liangji Health Industry Co Ltd
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Suzhou Li Liangji Health Industry Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract

The invention discloses a kind of ointment for being used to treat onychomycosis and preparation method thereof.The ointment is made up of the raw material of following weight：20 25 parts of rhizoma imperatae, windproof 20 24 parts, 20 25 parts of schizonepeta, 12 16 parts of the root bark of tree peony, 11 16 parts of the root bark of Chinese wolf-berry, 18 22 parts of pipewort, 13 17 parts of Sculellaria barbata, 10 18 parts of felwort, 10 15 parts of eucommia vine, 10 15 parts of saururus chinensis, 20 26 parts of spina gleditsiae, 10 15 parts of dark plum, 16 20 parts of Poria cocos, 12 16 parts of thizoma curculiginis, 150 400 parts of minium, 500 1100 parts of salad oil.Chinese medicine ointment of the present invention have swelling and pain relieving, channels sootheing and network vessel quickening, dissipate wind dampness removing, it is promoting blood circulation and removing blood stasis the effect of, have good killing action to the mushroom for causing onychomycosis, fundamentally effect a radical cure onychomycosis；Selected medicinal material compatibility is suitable, meets traditional Chinese medicine and pharmacy and modern medical theory, and safe without toxic side effect is evident in efficacy, and quick result is with low cost, and non-relapse after healing is treated both principal and secondary aspect of disease, and should be widely promoted application.

Description

It is a kind of to be used to treat ointment of onychomycosis and preparation method thereof
Technical field
The invention belongs to tcm field, more particularly to a kind of it is used to treat ointment of onychomycosis and preparation method thereof.
Background technology
Onychomycosis, is commonly called as " onychomycosis ", refers to that dermatophytes invades disease caused under deck or first.Onychomycosis is often by red hair The various fungies such as tinea bacterium, alpha fungus, acrothesium floccosum cause.Minority is by other filamentous fungis, yeast-like fungus and yeast Bacterium causes, and can also be caused once in a while by pityrosporion ovale, sickle-like bacteria and ashen aspergillus etc., underfed first is more common in greatly.It as the saying goes： " hand is second face of people ".The makings attractive in appearance for directly affecting a people of hand.And the aesthetic feeling of hand, significant portion is in nail.Hand Portion hinders attractive in appearance really with onychomycosis, and patient and people shake hands and felt unworthy, and feel awkward.Onychomycosis can cause pain and discomfort, Easily trigger the complication such as paronychia, onychia, finger pyoderma, the deep tissues such as erysipelas or cellulitis can occur when serious The serious disease with the constitutional symptom of organ infection, or even life threatening.Feminine half, which suffers from onychomycosis, can infect private parts, form mould Property vaginitis and candida albicans vaginitis etc. are difficult to the gynaecological disease cured.Onychomycosis readily becomes mycotic infection Source.Patient, other positions of fungal infection to body, can produce new tinea disease with scratching, and household can be also transmitted to when serious And friend.Kith and kin Chang Yin changes footwear, trick contact and shares daily necessities and infect, once it is infected, be easy for being formed tinea of feet and hands, The severe skin diseases such as tinea pedis and manus, erysipelas.According to statistics, the country there are about three one-tenth of onychomycosis family numbers of patients, also have in various degree Foot mycotic infection phenomenon.People often ignore the seriousness of onychomycosis, the mould at other positions of treat-and-release body During infection, it can just find that trick suffers from onychomycosis, the source of infection of the patient of many of which comes from the household of oneself.Treatment should When sick, for instant effect, doctor can be treated mostly using Western medicine but Western medicine principle of curing the disease be directed to one of illness or Several performances, are targetedly treated, and the otherwise factor of human body is not considered, so wound can be caused other aspects to human body Evil, is that one kind only controls target treatment method, it is impossible to eliminate focus, reach the purpose of healing；Secondly Western medicine, which can be used, largely uses Hormone and biological agent, its treatment cost are high, and medicine toxic side effect is more, is unfavorable for health.And Chinese medicine is particular about reinvigoration, lead to Resistance of enhancing human body itself is crossed to cure, therefore originally therapeutic effect is still less obvious, treatment cycle is long, also needs auxiliary Enter other medicines treatment, and it is larger to there is the recurrent of interruption.Through research, traditional Chinese medicine for oral administration thing is coordinated to have by using external therapy Effect ground improves curative effect, and wherein plaster belongs to using a kind of most usages in external therapy, and Chinese medicine surgical plaster is returned with Chinese medicine Through principle, coordinate mutually with medicine for efficiency, the big compound of many herbal medicines is constituted, to play the good result of medicine. Plaster external application, can receive the profit of soup, and without its disadvantage, medicine can be promoted to go deep into skin deep, play drug effect；And contain in plaster The strong medicine of excitant, strong stimulation can adjust body function and promote antibody to be formed, improve human immunity by neural reflex Power.Plaster is cured the disease as can be seen here, convenient material drawing, simple to operate, low-cost, safe no pain, and its disease curing range is extensive in addition, Easily received by people.Therefore, traditional Chinese medicine for oral administration can be coordinated to treat in the urgent need to finding one kind, and improves curative effect, promotes recovery, nothing The plaster for the onychomycosis that poison has no side effect.
The content of the invention
It is an object of the invention to provide a kind of ointment for being used to treat onychomycosis and preparation method thereof.
To achieve these goals, the invention provides a kind of ointment for being used to treat onychomycosis, by following weight Raw material be made：20-25 parts of rhizoma imperatae, windproof 20-24 parts, 20-25 parts of schizonepeta, 12-16 parts of the root bark of tree peony, 11-16 parts of the root bark of Chinese wolf-berry, paddy Smart 18-22 parts of grass, 13-17 parts of Sculellaria barbata, 10-18 parts of felwort, 10-15 parts of eucommia vine, 10-15 parts of saururus chinensis, spina gleditsiae 20- 26 parts, 10-15 parts of dark plum, 16-20 parts of Poria cocos, 12-16 parts of thizoma curculiginis, 150-400 parts of minium, 500-1100 parts of salad oil.
A kind of ointment for being used to treat onychomycosis, is made up of the raw material of following weight：23 parts of rhizoma imperatae, windproof 22 Part, 23 parts of schizonepeta, 14 parts of the root bark of tree peony, 14 parts of the root bark of Chinese wolf-berry, 20 parts of pipewort, 15 parts of Sculellaria barbata, 10-18 parts of felwort, eucommia vine 13 Part, 13 parts of saururus chinensis, 23 parts of spina gleditsiae, 13 parts of dark plum, 18 parts of Poria cocos, 14 parts of thizoma curculiginis, 300 parts of minium, 800 parts of salad oil.
A kind of preparation method for being used to treat the ointment of onychomycosis, comprises the following steps：First by windproof, schizonepeta, the root bark of tree peony, bone Skin, eucommia vine, saururus chinensis, spina gleditsiae removal of impurities, net system, mixing；Carried out with salad oil behind frying, frying Wai Hei Neihuang County, remove the dregs of a decoction Medicine oil is stayed, is refined oil 2-5 hours at 240-260 DEG C, minium is added and receives cream, release fire-toxin；Then remaining hybrid medicine is ground into Coarse powder, is extracted 1-4 times, every time dipping 12-24 hours with 5-20 times of weight 30-90% alcohol dipping, is collected, is merged dipping Extract solution at a temperature of 55-85 DEG C, is condensed into the concentrate that relative density is 1.0-1.5 by liquid, filtration；It will finally release fire-toxin The heating fusing of plaster water proof, add obtained concentrate, remove vapor, add ointment bases and be sufficiently stirred for, mix, fill Dress, is produced
Refined oil 3 hours at 250 DEG C, add minium and receive cream, release fire-toxin.
At a temperature of 65-75 DEG C, extract solution is condensed into the concentrate that relative density is 1.2-1.3.
Beneficial effects of the present invention：Chinese medicine ointment of the present invention has swelling and pain relieving, channels sootheing and network vessel quickening, dissipates wind dampness removing, promoting blood circulationization The effect of stasis of blood, there is good killing action to the mushroom for causing onychomycosis, fundamentally effect a radical cure onychomycosis；Selected medicinal material compatibility is suitable, Meet traditional Chinese medicine and pharmacy and modern medical theory, safe without toxic side effect is evident in efficacy, and quick result is with low cost, after healing Do not recur, treat both principal and secondary aspect of disease, should be widely promoted application.
Embodiment
Embodiment 1
A kind of ointment for being used to treat onychomycosis, is made up of the raw material of following weight：20 parts of rhizoma imperatae, windproof 20 parts, chaste tree 20 parts of mustard, 12 parts of the root bark of tree peony, 11-16 parts of the root bark of Chinese wolf-berry, 18 parts of pipewort, 13 parts of Sculellaria barbata, 10 parts of felwort, 10 parts of eucommia vine, three White 10 parts of grass, 20 parts of spina gleditsiae, 10 parts of dark plum, 16 parts of Poria cocos, 12 parts of thizoma curculiginis, 150 parts of minium, 500 parts of salad oil.It is prepared Method, comprises the following steps：First by windproof, schizonepeta, the root bark of tree peony, the root bark of Chinese wolf-berry, eucommia vine, saururus chinensis, spina gleditsiae removal of impurities, net system is mixed Close；Carried out with salad oil behind frying, frying Wai Hei Neihuang County, go the dregs of a decoction to stay medicine oil, refined oil 2-5 hours at 240-260 DEG C, added Minium receives cream, releases fire-toxin；Then remaining hybrid medicine is ground into coarse powder, carried with 5-20 times of weight 30-90% alcohol dipping Take 1-4 times, every time dipping 12-24 hours, collect, merge maceration extract, at a temperature of 55-85 DEG C, extract solution is condensed into for filtration Relative density is 1.0-1.5 concentrate；Finally the plaster water proof released fire-toxin is heated and melted, obtained concentrate is added, goes Water purification steam, adds ointment bases and is sufficiently stirred for, and mixes, filling, produces.
Embodiment 2
A kind of ointment for being used to treat onychomycosis, is made up of the raw material of following weight：25 parts of rhizoma imperatae, windproof 24 parts, chaste tree 25 parts of mustard, 16 parts of the root bark of tree peony, 16 parts of the root bark of Chinese wolf-berry, 22 parts of pipewort, 17 parts of Sculellaria barbata, 18 parts of felwort, 15 parts of eucommia vine, saururus chinensis 15 parts, 26 parts of spina gleditsiae, 15 parts of dark plum, 20 parts of Poria cocos, 16 parts of thizoma curculiginis, 400 parts of minium, 1100 parts of salad oil.Its preparation side Method, comprises the following steps：First by windproof, schizonepeta, the root bark of tree peony, the root bark of Chinese wolf-berry, eucommia vine, saururus chinensis, spina gleditsiae removal of impurities, net system, mixing； Carried out with salad oil behind frying, frying Wai Hei Neihuang County, go the dregs of a decoction to stay medicine oil, refined oil 2-5 hours at 240-260 DEG C, add camphor tree Pellet receives cream, releases fire-toxin；Then remaining hybrid medicine is ground into coarse powder, extracted with 5-20 times of weight 30-90% alcohol dipping 1-4 times, dipping 12-24 hours, collect, merge maceration extract, extract solution at a temperature of 55-85 DEG C, is condensed into phase by filtration every time To the concentrate that density is 1.0-1.5；Finally the plaster water proof released fire-toxin is heated and melted, obtained concentrate is added, removes Vapor, adds ointment bases and is sufficiently stirred for, and mixes, filling, produces.
Embodiment 3
A kind of ointment for being used to treat onychomycosis, is made up of the raw material of following weight：23 parts of rhizoma imperatae, windproof 22 parts, chaste tree 23 parts of mustard, 14 parts of the root bark of tree peony, 14 parts of the root bark of Chinese wolf-berry, 20 parts of pipewort, 15 parts of Sculellaria barbata, 10-18 parts of felwort, 13 parts of eucommia vine, three White 13 parts of grass, 23 parts of spina gleditsiae, 13 parts of dark plum, 18 parts of Poria cocos, 14 parts of thizoma curculiginis, 300 parts of minium, 800 parts of salad oil.It is prepared Method, comprises the following steps：First by windproof, schizonepeta, the root bark of tree peony, the root bark of Chinese wolf-berry, eucommia vine, saururus chinensis, spina gleditsiae removal of impurities, net system is mixed Close；Carried out with salad oil behind frying, frying Wai Hei Neihuang County, go the dregs of a decoction to stay medicine oil, refined oil 2-5 hours at 240-260 DEG C, added Minium receives cream, releases fire-toxin；Then remaining hybrid medicine is ground into coarse powder, carried with 5-20 times of weight 30-90% alcohol dipping Take 1-4 times, every time dipping 12-24 hours, collect, merge maceration extract, at a temperature of 55-85 DEG C, extract solution is condensed into for filtration Relative density is 1.0-1.5 concentrate；Finally the plaster water proof released fire-toxin is heated and melted, obtained concentrate is added, goes Water purification steam, adds ointment bases and is sufficiently stirred for, and mixes, filling, produces.

Claims (5)

1. a kind of ointment for being used to treat onychomycosis, it is characterised in that be made up of the raw material of following weight：Rhizoma imperatae 20-25 Part, windproof 20-24 parts, 20-25 parts of schizonepeta, 12-16 parts of the root bark of tree peony, 11-16 parts of the root bark of Chinese wolf-berry, 18-22 parts of pipewort, Sculellaria barbata 13- 17 parts, 10-18 parts of felwort, 10-15 parts of eucommia vine, 10-15 parts of saururus chinensis, 20-26 parts of spina gleditsiae, 10-15 parts of dark plum, Fu 16-20 parts of Siberian cocklebur, 12-16 parts of thizoma curculiginis, 150-400 parts of minium, 500-1100 parts of salad oil.
2. a kind of ointment for being used to treat onychomycosis according to claim 1, it is characterised in that：By following weight Raw material is made：23 parts of rhizoma imperatae, windproof 22 parts, 23 parts of schizonepeta, 14 parts of the root bark of tree peony, 14 parts of the root bark of Chinese wolf-berry, 20 parts of pipewort, Sculellaria barbata 15 Part, 10-18 parts of felwort, 13 parts of eucommia vine, 13 parts of saururus chinensis, 23 parts of spina gleditsiae, 13 parts of dark plum, 18 parts of Poria cocos, thizoma curculiginis 14 Part, 300 parts of minium, 800 parts of salad oil.
3. a kind of preparation method for being used to treat the ointment of onychomycosis according to claim 1, it is characterised in that this method bag Include following steps：First by windproof, schizonepeta, the root bark of tree peony, the root bark of Chinese wolf-berry, eucommia vine, saururus chinensis, spina gleditsiae removal of impurities, net system, mixing；Use color Draw oil to carry out behind frying, frying Wai Hei Neihuang County, go the dregs of a decoction to stay medicine oil, refined oil 2-5 hours at 240-260 DEG C, add minium and receive Cream, releases fire-toxin；Then remaining hybrid medicine is ground into coarse powder, 1-4 is extracted with 5-20 times of weight 30-90% alcohol dipping Secondary, dipping 12-24 hours, collect, merge maceration extract, at a temperature of 55-85 DEG C, extract solution is condensed into relatively for filtration every time Density is 1.0-1.5 concentrate；Finally the plaster water proof released fire-toxin is heated and melted, obtained concentrate is added, removes water purification Steam, adds ointment bases and is sufficiently stirred for, and mixes, filling, produces.
4. a kind of preparation method for being used to treat the ointment of onychomycosis according to claim 3, it is characterised in that：At 250 DEG C Lower oil refining 3 hours, adds minium and receives cream, release fire-toxin.
5. a kind of preparation method for being used to treat the ointment of onychomycosis according to claim 3, it is characterised in that：In 65-75 At a temperature of DEG C, extract solution is condensed into the concentrate that relative density is 1.2-1.3.
CN201710469190.5A 2017-06-20 2017-06-20 It is a kind of to be used to treat ointment of onychomycosis and preparation method thereof Pending CN107184849A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038765A (en) * 2010-12-29 2011-05-04 西藏奇正藏药股份有限公司 Qingpeng plaster for relieving pain and eliminating swelling and preparation method thereof
CN103720941A (en) * 2013-12-30 2014-04-16 刘代红 Traditional Chinese medicinal onychomycosis soaking preparation
CN104069403A (en) * 2014-07-11 2014-10-01 皖南医学院 Traditional Chinese medicine formula for treating leuconychia and preparation method of traditional Chinese medicine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038765A (en) * 2010-12-29 2011-05-04 西藏奇正藏药股份有限公司 Qingpeng plaster for relieving pain and eliminating swelling and preparation method thereof
CN103720941A (en) * 2013-12-30 2014-04-16 刘代红 Traditional Chinese medicinal onychomycosis soaking preparation
CN104069403A (en) * 2014-07-11 2014-10-01 皖南医学院 Traditional Chinese medicine formula for treating leuconychia and preparation method of traditional Chinese medicine

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