CN102038765A

CN102038765A - Qingpeng plaster for relieving pain and eliminating swelling and preparation method thereof

Info

Publication number: CN102038765A
Application number: CN2010106120672A
Authority: CN
Inventors: 刘鸿雁; 陈丽娟; 张国霞; 张樱山
Original assignee: Tibet Cheezheng Tibetan Medicine Co Ltd
Current assignee: Tibet Cheezheng Tibetan Medicine Co Ltd
Priority date: 2010-12-29
Filing date: 2010-12-29
Publication date: 2011-05-04
Anticipated expiration: 2030-12-29
Also published as: CN102038765B

Abstract

The invention discloses Qingpeng plaster for relieving pain and eliminating swelling. The Qingpeng plaster is prepared by changing auxiliary materials based on the prescription of traditional Tibetan medicine Qingpeng ointment. The Qingpeng plaster is convenient to carry and use, and has the advantages of strong penetration, remarkable curative effects, and the like. The Qingpeng plaster prepared by the preparation method does not contain any chemosynthetic stabilizing agent, thus being safe to use. In the preparation method, partial medicinal materials are extracted and partial medicinal materials are fried thus effectively preserving active ingredients in the medicinal materials, greatly improving the content of crude medicine material ingredients, improving the bioavailability, and achieving preferable curative effects. The medicine effect experiments prove that the Qingpeng plaster has the obvious effects of relieving pain and eliminating swelling.

Description

A kind of blue or green roc plaster that is used for alleviating pain and detumescence and preparation method thereof

Technical field

The present invention relates to a kind of plaster and preparation method thereof, particularly a kind of blue or green roc plaster that is used for alleviating pain and detumescence and preparation method thereof.

Background technology

To be the doctor among the people of Tibetan carry according to " Tibetan medicine doctor determine addendum release difficulty ", the Four-Volume Medical Code two secretaries blue or green roc ointment, and in conjunction with the classical Tibetan medicine and pharmacology proved recipe that practical experience is formed, prescription records in first 322 pages of " health drug standard promulgated by the ministries or commissions of the Central Government " 95 years version Tibetan medicines.The prescription of blue or green roc ointment is:

Herba Oxytropis falcatae 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g.

Preparation method: above nine flavors, except that other porphyrize powder of Moschus, all the other are ground into fine powder altogether, sieve, and add the Moschus fine powder, and mixing is with 8 years old urine of baby boys, Adeps Sus domestica or old butter furnishing ointment, promptly.

Function with cure mainly: alleviating pain and detumescence.Be used for the fever that swells and ache that gout, arthralgia chiefly caused by damp pathogen, " lower limb vasculitis ", " yellow fluid " disease etc. cause, herpes, pestilence pestilence fever etc.

Herba Oxytropis Kansuensis is the dry herb of leguminous plant Herba Oxytropis falcatae Oxytropis falcata Bunge and Herba Oxytropis chiliophyllae O.chiliophylla Royle.Excavate herb at the beginning of autumn late summer, clean earth, Ex-all is assorted takes out, and dries.

Sub-rhubarb extract is the dry root and rhizome of plant Polygonaceae Radix Rhei emodi Rheum emodii Wall., Radix Rhei acuminati Rheum acuminatum Hook.f.et Thoms., Lhasa rhubarb Rheum lhasaense A.J.Li et P.K.Hsiao, the yellow Rheum inopinatum of red large pulse Prain, Tibet rhubarb Rheum tibeticum Maxim.ex Hook.f..

Radix aconiti szechenyiani is the dried root of cohosh FUMAO Radix aconiti szechenyiani Aconitum flavum Hand.-Mazz. and Radix aconiti szechenyiani A.pendulumBusch..Autumn end is excavated root, removes fibrous root and silt, dries.

Fructus Chebulae's this product is the dry mature fruit of Combretum Racemosum plant Fructus Chebulae Terminalia chebula Retz. or fine hair Fructus Chebulae Terminaliachebula Retz.var.tomentella Kurt..Autumn, two season of winter gather during fruit maturation, remove impurity, dry.

Fructus Terminaliae Billericae adjoins the dry mature fruit of Li Le Terminalia billerica (Gaertn.) Roxb. for the Combretum Racemosum plant.Gather during fruit maturation winter, removes impurity, dries.

Fructus Phyllanthi is the dry mature fruit of euphorbia plant Fructus Phyllanthi Phyllanthus emblica L..Winter to time spring gathers during fruit maturation, removes impurity, drying.

Benzoinum is the dry resin of Styracaceae plant styrax tonkinensis Craib ex Hart Styrax tonkinensis (Pierre) Craib ex Hart..Trunk is collected effusive resin through damaging naturally or isolating trunk in summer, Qiu Erji, dries in the shade.

Herba Lycopodii is the dry stem of menispermaceae plant lobus cardiacus Herba Lycopodii Tinospora cordifolia (wulld) Miers or Herba Lycopodii T.sinensis (Lour.) Merr..Can adopt the whole year, cuts and get aerial parts, removes twig and leaf, and cutting is dried.

Moschus is the dry secretions in the ripe male body note capsule of animal in deer family woods Moschus moschiferous Moschus berezovskii Flerov, horse Moschus moschiferous Moschus sifanicusPrzewalski or former Moschus moschiferous Moschus moschiferus Linnaeus.Moschus is divided into artificial Moschus and natural Moschus, and the artificial Moschus wins from the sachet of tame Moschus moschiferous, and the natural Moschus wins from the sachet of wild Moschus moschiferous.Wild Moschus moschiferous how hunt by the extremely inferior in the winter time spring, after trapping, extracts sachet, dries in the shade, and practises claiming " hair shell Moschus "; Cut sachet open, remove softgel shell, practise title " Moschus core ".The family Moschus moschiferous is directly taken out Moschus core from its sachet, dry in the shade or use the exsiccator close drying.Usually also the muscone of synthetic is called the artificial Moschus, its main pharmacological and natural Moschus are basic identical, and physical behavior is similar, and clinical efficacy is definite, can be equal to the prescription use with the natural Moschus.

The doctor among the people of Tibetan is according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " record, in conjunction with long-term practical experience, with Herba Oxytropis falcatae, sub-rhubarb extract, Radix aconiti szechenyiani, Fructus Chebulae, Fructus Terminaliae Billericae, Fructus Phyllanthi, Benzoinum, Herba Lycopodii, Moschus are the blue or green roc ointment of the Tibetan medicine of raw material production, are subjected to the trust of extensive patients with notable therapeutic effect, but the blue or green roc ointment of traditional Tibetan medicine preparation technology is modulated into ointment after all crude drug fine powders are mixed, its technology is numerous and diverse, and batch production cycle is long, the production technology instability; Raw material and adjuvant source are unstable, are unfavorable for suitability for industrialized production; Part drug osmotic ability, bioavailability is low, can not guarantee curative effect fully, should not bring into play the curative effect of medicine; Product should not be deposited in addition, carries inconvenience; Because each side has greatly influenced the curative effect and the popularization of product.

Summary of the invention

It is that basic square tube is crossed the blue or green roc plaster that is used for alleviating pain and detumescence that the change adjuvant prepares that the object of the invention is to disclose a kind of prescription with the blue or green roc ointment of traditional Tibetan medicine, and the object of the invention also is to disclose the preparation method of this green grass or young crops roc plaster.

The present invention seeks to be achieved through the following technical solutions:

The crude drug of the blue or green roc plaster of the present invention forms and consumption is:

Herba Oxytropis Kansuensis 80-120 weight portion, sub-rhubarb extract 30-70 weight portion, Radix aconiti szechenyiani 50-100 weight portion, Fructus Chebulae (pitted) 80-120 weight portion, Fructus Terminaliae Billericae 80-120 weight portion, Fructus Phyllanthi 80-120 weight portion, Benzoinum 20-50 weight portion, Herba Lycopodii 130-170 weight portion, Moschus 10-40 weight portion.

The crude drug of the blue or green roc plaster of the present invention forms and consumption is preferably:

Herba Oxytropis Kansuensis 100 weight portions, sub-rhubarb extract 50 weight portions, Radix aconiti szechenyiani 75 weight portions, Fructus Chebulae (pitted) 100 weight portions, Fructus Terminaliae Billericae 100 weight portions, Fructus Phyllanthi 100 weight portions, Benzoinum 35 weight portions, Herba Lycopodii 150 weight portions, Moschus 25 weight portions.

The adjuvant of the blue or green roc plaster of the present invention forms and consumption is:

Red: one or more in Plumbum preparatium 150-1200 weight portion, Plumbum preparatium 450-2000 weight portion, Plumbum preparatium 100-1200 weight portion and the Plumbum preparatium 150-1500 weight portion;

Oil: one or more in Oleum Sesami 450-4800 weight portion, edible vegetable oil 500-3000 weight portion, salad oil 500-4000 weight portion and the Oleum sesami 600-2200 weight portion.

The adjuvant of the blue or green roc plaster of the present invention forms and consumption is preferably:

Plumbum preparatium 220 weight portions, Oleum Sesami 550 weight portions;

Or Plumbum preparatium 840 weight portions, salad oil 588 weight portions;

Or Plumbum preparatium 441 weight portions, edible vegetable oil 1102 weight portions;

Or Plumbum preparatium 330 weight portions, Oleum sesami 1323 weight portions;

Or Plumbum preparatium 794 weight portions, edible vegetable oil 1985 weight portions;

Or Plumbum preparatium 600 weight portions, Oleum sesami 1800 weight portions;

Or Plumbum preparatium 735 weight portions, salad oil 3675 weight portions;

Or Plumbum preparatium 1764 weight portions, Oleum Sesami 4410 weight portions;

Or Plumbum preparatium 880 weight portions, Oleum Sesami 2200 weight portions;

Or Plumbum preparatium 176 weight portions, salad oil 882 weight portions;

Or Plumbum preparatium 858 weight portions, edible vegetable oil 2572 weight portions;

Or Plumbum preparatium 352 weight portions, Oleum sesami 704 weight portions;

Or Plumbum preparatium 1320 weight portions, edible vegetable oil 660 weight portions;

Or Plumbum preparatium 588 weight portions, Oleum sesami 1470 weight portions;

Or Plumbum preparatium 368 weight portions, salad oil 1840 weight portions;

Or Plumbum preparatium 220 weight portions, Oleum Sesami 2205 weight portions.

The preparation method of the blue or green roc plaster of the present invention comprises the steps:

1. with Herba Oxytropis Kansuensis, sub-rhubarb extract, Radix aconiti szechenyiani, Fructus Chebulae (pitted), Fructus Terminaliae Billericae, Fructus Phyllanthi, Benzoinum and Herba Lycopodii remove impurity, clean system is mixed;

2. take by weighing above-mentioned hybrid medicine total amount 30%-60%, with the oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 2-5 hour under 280-320 ℃, adds red cream, the releasing fire-toxin received;

3. will remain hybrid medicine and be ground into coarse powder; Boil 1-4 time with 5-20 times of weight decocting, decocted collection respectively, merge extractive liquid, and volatile oil at every turn 0.5-3 hour, filter, under 65-95 ℃ of temperature, it is the concentrated solution of 1.0-1.5 that extracting solution is become relative density, volatile oil is joined in the concentrated solution, get concentrated solution a;

Maybe will remain hybrid medicine and be ground into coarse powder, the 30-90% alcohol reflux of usefulness 5-20 times of weight 1-4 time extracted 0.5-24 hour at every turn, collected extracting solution, filtered, and under 55-85 ℃ of temperature, extracting solution was condensed into the concentrated solution a that relative density is 1.0-1.5;

Maybe will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 0.6-1.2 times of weight 30-90% stirs and soaked into 0.5-2 hour, pack in the percolation jar, ethanol percolate extraction with 5-20 times of weight 30-90%, collect, merge percolate, filter, under 55-85 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.0-1.5;

Maybe will remain hybrid medicine and be ground into coarse powder, extract 1-4 time, flood 12-24 hour at every turn with the alcohol dipping of 5-20 times of weight 30-90%, collect, merge impregnation liquid, filter, under 55-85 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.0-1.5;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

5. with the plaster water proof heat fused of releasing fire-toxin, add the concentrated solution a that 3. above-mentioned steps obtains, go to add the b that 4. step obtains behind the water purification steam, stand, the back cream that stirs promptly gets the blue or green roc plaster of the present invention.

The preparation method of the blue or green roc plaster of the present invention preferably includes following steps:

2. take by weighing above-mentioned hybrid medicine total amount 30%, with the oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 4 hours under 300 ℃, adds red cream, the releasing fire-toxin received;

3. will remain hybrid medicine and be ground into coarse powder; Boil 3 times with 6 times of weight decoctings, decocted 1 hour at every turn, collection respectively, merge extractive liquid, and volatile oil filter, and under 75 ℃ of temperature, it is the concentrated solution of 1.35-1.45 that extracting solution is become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Maybe will remain hybrid medicine and be ground into coarse powder,, extract 1 hour at every turn, collect extracting solution, filter, under 65 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.35-1.45 with 40% alcohol reflux of 6 times of weight 3 times;

Maybe will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 0.8 times of weight 40% stirs and soaked into 1 hour, pack in the percolation jar, ethanol percolate extraction with 6 times of weight 40%, collect, merge percolate, filter, under 65 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.25-1.35;

Maybe will remain hybrid medicine and be ground into coarse powder, extract 3 times, flood 16 hours at every turn, collect, merge impregnation liquid, filter, under 65 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.25-1.35 with the alcohol dipping of 6 times of weight 40%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

2. take by weighing above-mentioned hybrid medicine total amount 40%, with the oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 3 hours under 320 ℃, adds red cream, the releasing fire-toxin received;

3. will remain hybrid medicine and be ground into coarse powder; Boil 2 times with 10 times of weight decoctings, decocted 1.5 hours at every turn, collection respectively, merge extractive liquid, and volatile oil filter, and under 80 ℃ of temperature, it is the concentrated solution of 1.25-1.35 that extracting solution is become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Maybe will remain hybrid medicine and be ground into coarse powder,, extract 1.5 hours at every turn, collect extracting solution, filter, under 70 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with 60% alcohol reflux of 10 times of weight 2 times;

Maybe will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 1 times of weight 60% stirs and soaked into 0.5 hour, pack in the percolation jar, ethanol percolate extraction with 10 times of weight 60%, collect, merge percolate, filter, under 70 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.15-1.25;

Maybe will remain hybrid medicine and be ground into coarse powder, extract 2 times, flood 20 hours at every turn, collect, merge impregnation liquid, filter, under 70 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with the alcohol dipping of 10 times of weight 60%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

2. take by weighing above-mentioned hybrid medicine total amount 50%, with the oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 5 hours under 280 ℃, adds red cream, the releasing fire-toxin received;

3. will remain hybrid medicine and be ground into coarse powder; Boil 1 time with 15 times of weight decoctings, decocted 3 hours at every turn, collection respectively, merge extractive liquid, and volatile oil filter, and under 85 ℃ of temperature, it is the concentrated solution of 1.05-1.15 that extracting solution is become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Maybe will remain hybrid medicine and be ground into coarse powder,, extract 24 hours at every turn, collect extracting solution, filter, under 75 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.05-1.15 with 75% alcohol reflux of 15 times of weight 1 time;

Maybe will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 0.8 times of weight 75% stirs and soaked into 1 hour, pack in the percolation jar, ethanol percolate extraction with 15 times of weight 75%, collect, merge percolate, filter, under 75 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.05-1.15;

Maybe will remain hybrid medicine and be ground into coarse powder, extract 1 time, flood 24 hours at every turn, collect, merge impregnation liquid, filter, under 75 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.05-1.15 with the alcohol dipping of 15 times of weight 75%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

2. take by weighing above-mentioned hybrid medicine total amount 60%, with the oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 2 hours under 300 ℃, adds red cream, the releasing fire-toxin received;

3. will remain hybrid medicine and be ground into coarse powder; Boil 4 times with 18 times of weight decoctings, decocted 0.5 hour at every turn, collection respectively, merge extractive liquid, and volatile oil filter, and under 90 ℃ of temperature, it is the concentrated solution of 1.15-1.25 that extracting solution is become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Maybe will remain hybrid medicine and be ground into coarse powder,, extract 0.5 hour at every turn, collect extracting solution, filter, under 80 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with 80% alcohol reflux of 18 times of weight 4 times;

Maybe will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 0.6 times of weight 80% stirs and soaked into 2 hours, pack in the percolation jar, ethanol percolate extraction with 18 times of weight 80%, collect, merge percolate, filter, under 80 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.15-1.25;

Maybe will remain hybrid medicine and be ground into coarse powder, extract 4 times, flood 12 hours at every turn, collect, merge impregnation liquid, filter, under 80 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with the alcohol dipping of 18 times of weight 80%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

The blue or green roc plaster of the present invention is compared with the blue or green roc ointment of prior art has following characteristics:

1, the blue or green roc plaster of the present invention have easy to carry, easy to use, advantage such as penetration is strong, evident in efficacy.

2, the plaster made of the inventive method does not add the stabilizing agent of any chemosynthesis, and is safe in utilization.

3, the present invention adopts the fried preparation method of part medicinal material extract part medical material, has both kept effective ingredient in the medical material effectively, has improved the content of crude drug composition again greatly, has improved bioavailability, makes curative effect better.

Following experimental example and embodiment are used to further specify but are not limited to the present invention.

The screening experiment of the blue or green roc plaster of experimental example 1 the present invention adjuvant

1. You optimization test

Take by weighing Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Moschus is ground to form fine powder; Take by weighing 30% of above-mentioned all the other medical material total amounts, respectively with Oleum Sesami, edible vegetable oil, salad oil, the Oleum sesami system of exploding of 3 times of medical material gross weights, behind the outer black Neihuang County of fried system, remove slag and stay medicine oil, oil refining adds Plumbum preparatium respectively and receives cream, releasing fire-toxin to dripping into pearl again; To remain pulverizing medicinal materials and become coarse powder, boil 3 times, decoct 1 hour at every turn with 6 times of weight decoctings, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a; The plaster water proof heating of releasing fire-toxin is dissolved, go to add concentrated solution a and Moschus fine powder behind the water purification steam, stand, the back cream that stirs carries out outward appearance and observes, and the results are shown in Table 1.

The screening test result of table 1 oil

According to above result, the present invention selects Oleum Sesami, edible vegetable oil, salad oil, Oleum sesami to the medical material system of exploding, and wherein the effect of edible vegetable oil is best.

2. Dan optimization test

Take by weighing Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Moschus is ground to form fine powder; Take by weighing 30% of above-mentioned all the other medical material total amounts, with the edible vegetable oil system of exploding of 3 times of medical material gross weights, behind the outer black Neihuang County of the system of exploding, remove slag and stay medicine oil, oil refining adds Plumbum preparatium, Plumbum preparatium, Plumbum preparatium, Plumbum preparatium receipts cream respectively, releasing fire-toxin to dripping into pearl again; To remain pulverizing medicinal materials and become coarse powder, boil 3 times, decoct 1 hour at every turn with 6 times of weight decoctings, collection, merge extractive liquid, and volatile oil filter, under 80 ℃ of temperature, it is the concentrated solution of 1.35-1.45 that extracting solution is become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a; The plaster water proof heating of releasing fire-toxin is dissolved, go to add concentrated solution a and Moschus fine powder behind the water purification steam, stand, the back cream that stirs carries out outward appearance and observes, and the results are shown in Table 2.

The screening test result of table 2 pellet

According to above result, the present invention selects Plumbum preparatium, Plumbum preparatium, Plumbum preparatium, Plumbum preparatium to receive cream, and wherein the effect of Plumbum preparatium is best.

3. the optimization test of edible vegetable oil and Plumbum preparatium amount

Take by weighing Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, earlier Moschus is ground to form fine powder; Take by weighing 30% of above-mentioned all the other medical material total amounts, with the edible vegetable oil system of exploding of 3 times of medical material gross weights, behind the outer black Neihuang County of fried system, remove slag and stay medicine oil, oil refining adds Plumbum preparatium again and receives cream to dripping into pearl again, releasing fire-toxin, wherein, the amount of the temperature of oil refining, time and adding Plumbum preparatium is all by shown in the table 3; To remain pulverizing medicinal materials and become coarse powder, boil 3 times, decoct 1 hour at every turn with 6 times of weight decoctings, collection, merge extractive liquid, and volatile oil filter, under 80 ℃ of temperature, it is the concentrated solution of 1.35-1.45 that the extracting solution extracting solution is become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a; The plaster water proof heating of releasing fire-toxin is dissolved, go to add concentrated solution a and Moschus fine powder behind the water purification steam, stand, back cream stirs;

This experiment with the proportioning (g/g) of Plumbum preparatium, Oleum Sesami, oil refining temperature (℃), the oil refining time (h) is factor, adopt L9 (34) orthogonal table investigate its softening point to plaster (℃), peel strength (N), hold the influence of viscous force (N) index, factor level sees Table 3;

Table 3 factor level table

(1) assay method of index

The mensuration of peel strength: according to plaster adhesive force algoscopy (Chinese Pharmacopoeia version appendix in 2005 the XII E) three therapeutic methods of traditional Chinese medicine (mensuration of peel strength);

The wide 50mm of bread board, long 125mm gets remollescent test sample 5g stand and is applied to backing cloth middle part, fits in the bread board while hot, be pressed into the 500g counterweight that to stick together area be 30mm * 50mm, mastic is thick to be 2.0mm, in 37 ℃ of constant temperature 30min, backing cloth is done 180 ° of doublings, be sandwiched on the hand-held pointer tension and compression ergometer, pulling force when survey mastic and bread board are peeled off, data are got 5 times and are measured average, the results are shown in Table 4;

Hold the mensuration of viscous force: according to plaster adhesive force algoscopy (Chinese Pharmacopoeia version appendix in 2005 XII E) second method (holding the mensuration of viscous force);

The wide 50mm of bread board, long 125mm gets remollescent test sample 5g stand and is applied to backing cloth middle part, takes advantage of heat to fit in the bread board, be pressed into the 500g counterweight that to stick together area be 30mm * 50mm, mastic is thick to be 2.0mm, in 37 ℃ of constant temperature 30min, an end of bread board is fixed, the backing cloth of the other end is sandwiched on the hand-held pointer tension and compression ergometer, pulling force when surveying mastic and bread board disconnection, data are got 5 times and are measured average, the results are shown in Table 4;

Softening point measurement: check according to softening point of ointment algoscopy (Chinese Pharmacopoeia version appendix in 2005 XII D), the results are shown in Table 4;

Table 4 orthogonal experiments

According to the orthogonal test table analysis: show that by R value size in the orthogonal test table each factor is followed successively by A, B, C from big to small to softening point, the influence degree of holding the viscous force index, and peel strength index influence degree is followed successively by A, C, B from big to small; Apparent analysis result shows: the optimum condition of softening point index is A ₂B ₂C ₃, the optimum condition of peel strength index is A ₂B ₃C ₃The optimum condition of holding the viscous force index is A ₃B ₂C ₁, to take all factors into consideration above three and investigate index, therefore preferred process conditions are A ₂B ₂C ₃Promptly by Plumbum preparatium: edible vegetable oil proportioning (g/g) be 1: 2.5, oil refining temperature (℃) be 300 ℃, oil refining time (h) for the plaster soft durometer of the quantitative criteria refining of 4.0h, paste, take off pull functional.

Blue or green roc plaster of experimental example 2 the present invention and blue or green roc ointment stability contrast test data

(1) test specimen:

The blue or green roc ointment of tradition: XiZang QiZheng Tibetan pharmaceuticals Co., Ltd provides;

Blue or green roc ointment 1: preparation method: 1. Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g are made only, pulverize, mix homogeneously, standby; 2. take by weighing 50% of above-mentioned mixed material medicine total amount,, decoct 3 times down, fried in shallow oil 2 hours at every turn, collect extracting solution and volatile oil respectively in 85 ℃ with the water of 2.13kg; Filter, concentrated extracting solution is 1.0～1.5 concentrated solution to relative density; Volatile oil is joined in the concentrated solution; 3. above-mentioned remaining mixed material medicated powder is broken into the medicated powder of 100 μ m, mixes, get mixed liquor a with the above-mentioned concentrated solution that contains volatile oil; Mixed liquor a is joined in the water of 50 times of weight, stir, obtain mixed liquor b; 4. mixed liquor b is mixed with 2: 1: 1 weight ratio with liquid paraffin and Tween-80, emulsifying gets emulsifying ointment; 5. the Moschus of 25g is joined in the water of 375 grams and grinds, cross 150 mesh sieves after, join in the above-mentioned emulsifying ointment and stir, promptly get QINGPENG GAOJI;

Blue or green roc ointment 2: preparation method: 1. Herba Oxytropis Kansuensis 13.5g, sub-rhubarb extract 6.5g, Radix aconiti szechenyiani 10.5g, Fructus Chebulae (pitted) 13.5g, Fructus Terminaliae Billericae 13.5g, Fructus Phyllanthi 13.5g, Benzoinum 4.5g, Herba Lycopodii 20.5g are made only, pulverize, mix homogeneously, standby; 2. take by weighing 50% of mixed powder gross weight, the alcohol reflux with 50% 1 time extracted 1.5 hours, and alcohol adding amount is 20 times of medical material gross weight, and 50 ℃ of temperature are collected extracting solution; Filter, be condensed into proportion and be 1.0 concentrated solution, standby; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01～200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby; 4. get the 100g lanoline, gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after Moschus 3.5g stirs;

Blue or green roc ointment 3: preparation method: 1. Moschus 3.4g is ground to form fine powder; 2. Herba Oxytropis Kansuensis, sub-rhubarb extract, Radix aconiti szechenyiani, Fructus Chebulae (pitted), Fructus Terminaliae Billericae, Fructus Phyllanthi, Benzoinum, Herba Lycopodii are picked totally, got Herba Oxytropis Kansuensis 13.6g, sub-rhubarb extract 6.8g, Radix aconiti szechenyiani 10.2g, Fructus Chebulae (pitted) 13.6g, Fructus Terminaliae Billericae 13.6g, Fructus Phyllanthi 13.6g, Benzoinum 4.7g, Herba Lycopodii 20.4g and mix the back micronizing to become particle diameter be 0.01-0.1 μ m micropowder; 3. be mixed and made into ointment base with Tween-80 42g, liquid paraffin 16.8g, glycerol 2g, water 50g; 4. with technology 1. and 2. medicated powder mix with ointment base, make ointment, discharging, packing are promptly;

The blue or green roc plaster of the present invention: embodiment 6 is prepared from the description according to the present invention.

(2) experimental condition:

Time: from continuous three months of beginning in zero month, investigated once in every month, investigate once June again;

Temperature: room temperature

Relative humidity: relative humidity is 35%～75%

(3) testing result: see Table 5;

The stable comparative test result of blue or green roc plaster of table 5 the present invention and blue or green roc ointment

The result shows, it is little that the blue or green roc plaster of the present invention and existing ointment are compared abnormal smells from the patient, and outward appearance is moist, and is glossy, good stability.

Blue or green roc plaster of experimental example 3 the present invention and blue or green roc ointment contrast test action time data

1, test specimen:

Blue or green roc ointment all is prepared from by method described in the above-mentioned experimental example 2 for 1,2,3 groups;

The blue or green roc plaster of the present invention: embodiment 15 is prepared from the description according to the present invention.

2, experimental technique

The present invention adopts the transdermal test method that exsomatizes, and gets white mice, etherization, carefully cut off back wool with shears, put to death, peel off skin of back, remove subcutaneous fat and mucous tissue, after cleaning with physiological saline solution, place the joint portion of the vertical diffusion cell of Franz, dermis of skin is towards receiving liquid, accurately take by weighing above-mentioned blue or green roc ointment and the present invention, evenly coat skin surface, reception tank adds 30ml receiver media (constant temperature (32 ± 1) ℃, mixing speed 100r/min).Respectively at 0,1,3,6,9,12,24h sampling 2ml (replenishing receiver media 2ml simultaneously) puts in the 25ml measuring bottle, be diluted to scale with methanol solution, as need testing solution, operate with method with blank sample, make blank solution, with its accumulative total transit dose of high effective liquid chromatography for measuring, experimental result is seen accompanying drawing 1.The result shows that the blue or green roc plaster of the present invention is than all rising appreciably the action time of traditional blue or green roc ointment.

The blue or green roc plaster of experimental example 4 the present invention is to the analgesic activity of the hot whipping of mice

1, reagent, animal and instrument

(1) reagent

The blue or green roc plaster of the present invention: embodiment 3 is prepared from the description according to the present invention.

(2) animal

90 of healthy 4 monthly age male mice in kunming, body weight (20 ± 2) g provides production licence number by Lanzhou University medical college zoopery center: No. 20050007, SCXK (sweet), the quality certification number: No. 0000285.Laboratory temperature: (20-25) ℃, humidity: (40-70) %.

(3) instrument

SW-200 photo-thermal tail pain tester; The portable balance of electronics (model: YB1201, Haikang, Shanghai Electronic Instruments Plant, precision 0.01g) etc.

2, method and result

(1) method

Get 90 of Kunming mouses, be divided into 9 groups at random, every group 10, be made as dosage group (VII), the blue or green roc plaster high dose group (VIII) of the present invention, positive drug antondin group (IX) in matched group (I), traditional blue or green roc ointment group (II), blue or green roc ointment 1 group of (III), blue or green roc ointment 2 groups of (IV), blue or green roc ointment 3 groups of (V), the blue or green roc plaster low dose group (VI) of the present invention, the blue or green roc plaster of the present invention respectively.During test, animal is put in the Mus tube, tail falls in outside the tube down naturally, use manual time-keeping, with start photo-thermal to the time that the Mus tail is swung rapidly be incubation period of whipping reaction as the threshold of pain, regulating load voltage is to about the 20V, make the basic threshold of pain (pain threshold before the administration) comparatively sensitive for the stimulus intensity of 2-4s, survey 3 times earlier during on-test, each 5min at interval, getting its average is the basic threshold of pain.For preventing skin scald, illumination deadline, 10s exceeded.Each group purifies the mouse back hair with barium sulfide before the experiment, during experiment respectively at back depilation place administration, model control group gives the substrate that equivalent does not contain medicine, 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, 3 groups of blue or green roc ointment, the blue or green roc ointment group of tradition, smear administration, dosage is 1.66g crude drug/kg, the blue or green roc plaster of the present invention low dose group (the 0.83g crude drug/kg), dosage group in the blue or green roc plaster of the present invention (the 1.66g crude drug/kg), the blue or green roc plaster of the present invention high dose group (the 3.32g crude drug/kg), positive drug antondin group intraperitoneal injection (0.7g/kg), 1h behind the single-dose, 2h, 4h measures TFL more respectively, calculate the analgesia rate, analgesia rate=(TFL-threshold of pain)/threshold of pain * 100%.

(2) statistical analysis

All data mean ± standard deviation Expression adopts the SPSS11.5 statistical software to carry out date processing.Carry out one factor analysis of variance, check with LSD when variance has homogeneous, heterogeneity of variance Dunnett ' s T3 check is carried out comparing between each group.P＜0.05 or P＜0.01 expression difference has significance.

(3) result

Data result shows, the analgesic effect of all the administration groups except that matched group with administration after 2 hours best, compare with matched group, other each groups all have significant difference (P＜0.05 or P＜0.01), 2 hours traditional blue or green roc ointment groups after the prompting administration, 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, 3 groups of blue or green roc ointment, the blue or green roc plaster of the present invention is low, in, high dose group all can obviously improve the threshold of pain of radiant heat irradiation mice, 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, there is not significant difference (P＞0.05) between 3 groups three groups of the blue or green roc ointment, with dosage group in the blue or green roc plaster of the present invention, all has significant difference (P＜0.01) between the high dose group, point out 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, 3 groups of blue or green roc ointment, 2 hours analgesic activity after administration is suitable, but be better than traditional blue or green roc ointment group, in the blue or green roc plaster of the present invention, the analgesic activity of high dose group; The analgesic activity of the basic, normal, high dosage group of the blue or green roc plaster of the present invention both had been better than traditional blue or green roc ointment group, be better than 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, 3 groups of blue or green roc ointment again, the analgesic activity that the basic, normal, high dosage group of the blue or green roc plaster of the present invention is described is best, all administration groups analgesic activity of 4 hours after 1 hour and administration after the administration is suitable, as table 6.

The blue or green roc plaster of table 6 the present invention is to the analgesic activity of the hot whipping of mice

Compare with matched group: ^△P＜0.05, ^{△ △}P＜0.01.

The blue or green roc plaster of experimental example 5 the present invention on Carrageenan causes the influence of rat paw edema

1, reagent, animal and instrument

(1) reagent

The blue or green roc plaster of the present invention: embodiment 9 is prepared from the description according to the present invention.

(2) animal

80 of healthy adult SD rats, body weight 150-180g provides production licence number by Lanzhou University medical college zoopery center: No. 20050007, SCXK (sweet), the quality certification number: No. 0000285.Laboratory temperature: (20-25) ℃, humidity: (40-70) %.

(3) instrument

Carrageenin, Sigma company, lot number 121K1653; The portable balance of electronics (model: YB1201, Haikang, Shanghai Electronic Instruments Plant, precision 0.01g); Syringe (specification: 1ml); YLS-7B toes volumetric measurement instrument; Psychrometer; Picric acid.

2, method and result

(1) method

80 of male SD rats, be divided into 8 groups at random, be made as respectively: dosage group (VII), the blue or green roc plaster high dose group (VIII) of the present invention in model control group (I), traditional blue or green roc ointment group (III), blue or green roc ointment 1 group of (III), blue or green roc ointment 2 groups of (IV), blue or green roc ointment 3 groups of (V), the blue or green roc plaster low dose group (VI) of the present invention, the blue or green roc plaster of the present invention.Each group purifies the mouse back hair with barium sulfide before the experiment, during experiment respectively at back depilation place administration, model control group gives the substrate that equivalent does not contain medicine, 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, 3 groups of blue or green roc ointment, traditional blue or green roc ointment group, smear administration, dosage is 1.66g crude drug/kg, the blue or green roc plaster of the present invention low dose group (dosage group in 0.83g crude drug/kg), the blue or green roc plaster of the present invention (1.66g crude drug/kg), the blue or green roc plaster of the present invention high dose group (the 3.32g crude drug/kg), successive administration 7 days, every day 1 time.The last administration is wiped after half an hour and is tried thing, with warm water with drug of topical application place wiped clean.The experimenter is stretching with the animal right hind then, with No. 26 subcutaneous parts of upwards injecting in the earlier self-sustaining sole of the foot of needle applicator middle part, turn the syringe needle carrageenin 0.1ml of injection 1% downwards then, respectively at before the injection and injection back 1h, 2h, 3h, 6h, measure swelling foot sole of the foot portion volume with YLS-7B toes volumetric measurement instrument.

(2) statistical analysis

All data mean ± standard deviation

Expression adopts the SPSS11.5 statistical software to carry out date processing.Relatively carry out one factor analysis of variance between group, check with LSD when variance has homogeneous, heterogeneity of variance Dunnett ' s T3 check is carried out comparing between each group.P＜0.05 or P＜0.01 expression difference has significance.This group self cross-reference adopts pairing T Test check.

3, result

Carrageenin causes the inflammatory model that the rat paw edema model is classics, and 2.5-3h reaches the foot swelling peak behind the injection carrageenin, reaches about 0.64ml, returns to 0.45ml behind the 6h gradually.So estimate curative effect of medication the best with the swelling situation behind the injection carrageenin 3h.

Data result shows, behind the injection carrageenin during 3h: model control group and other each groups all have significant difference (P＜0.01), point out traditional blue or green roc ointment group and 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, 3 groups of blue or green roc ointment, the basic, normal, high dosage group of the blue or green roc plaster of the present invention all can suppress carrageenin and cause rat paw edema; There is not significant difference (P＞0.05) between 3 groups three groups of 1 group of blue or green roc ointment during 3h behind the injection carrageenin, 2 groups of blue or green roc ointment, blue or green roc ointment, and all has significant difference (P＜0.05 or P＜0.01) between the blue or green roc plaster of the present invention high dose group, point out the antiinflammatory action of 1 group of blue or green roc ointment, 2 groups of blue or green roc ointment, 3 groups of blue or green roc ointment suitable, not as the antiinflammatory action of the blue or green roc plaster of the present invention high dose group; The antiinflammatory action of the middle and high dosage group of the blue or green roc plaster of the present invention both had been better than traditional blue or green roc ointment group, be better than 3 groups of blue or green roc ointment again, the antiinflammatory action that the middle and high dosage group of the blue or green roc plaster of the present invention is described is best, and the antiinflammatory action of the middle and high dosage group of the blue or green roc plaster of the present invention is suitable, there was no significant difference (P＞0.05) is as table 7.

The blue or green roc plaster of table 7 the present invention on Carrageenan causes the influence of rat paw edema

Compare with model control group: ^△P＜0.05, ^{△ △}P＜0.01; Compare with the blue or green roc plaster of the present invention high dose group: ^★P＜0.05, ^★ ^★P＜0.01.

Description of drawings

Fig. 1: blue or green roc plaster of the present invention and blue or green roc ointment comparison diagram action time.

Following embodiment all can realize the effect of above-mentioned experimental example.

The specific embodiment

Embodiment 1: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 220g, Oleum Sesami 550g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 30%, with the Oleum Sesami system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 4 hours under 300 ℃, adds Plumbum preparatium and receives cream, releasing fire-toxin;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 2: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 840g, salad oil 588g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 40%, with the salad oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 3 hours under 320 ℃, adds Plumbum preparatium and receives cream, releasing fire-toxin;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 3: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 441g, edible vegetable oil 1102g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 50%, with the edible vegetable oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 5 hours under 280 ℃, adds Plumbum preparatium and receives cream, releasing fire-toxin;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 4: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 330g, Oleum sesami 1323g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 60%, with the Oleum sesami system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 2 hours under 300 ℃, adds Plumbum preparatium and receives cream, releasing fire-toxin;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 5: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 794g, edible vegetable oil 1985g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 30%, with the edible vegetable oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 4 hours under 300 ℃, adds Plumbum preparatium and receives cream, releasing fire-toxin;

3. will remain hybrid medicine and be ground into coarse powder,, extract 1 hour at every turn, collect extracting solution, filter, under 65 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.35-1.45 with 40% alcohol reflux of 6 times of weight 3 times;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 6: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 600g, Oleum sesami 1800g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 40%, with the Oleum sesami system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 3 hours under 320 ℃, adds Plumbum preparatium and receives cream, releasing fire-toxin;

3. will remain hybrid medicine and be ground into coarse powder,, extract 1.5 hours at every turn, collect extracting solution, filter, under 70 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with 60% alcohol reflux of 10 times of weight 2 times;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 7: the blue or green roc plaster of the present invention

Crude drug is formed:

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 735g, salad oil 3675g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 50%, with the salad oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 5 hours under 280 ℃, adds Plumbum preparatium and receives cream, releasing fire-toxin;

3. will remain hybrid medicine and be ground into coarse powder,, extract 24 hours at every turn, collect extracting solution, filter, under 75 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.05-1.15 with 75% alcohol reflux of 15 times of weight 1 time;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 8: the blue or green roc plaster of the present invention

Crude drug is formed:

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 1764g, Oleum Sesami 4410g;

Method for making:

3. will remain hybrid medicine and be ground into coarse powder,, extract 0.5 hour at every turn, collect extracting solution, filter, under 80 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with 80% alcohol reflux of 18 times of weight 4 times;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 9: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 880g, Oleum Sesami 2200g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 30%, with the Oleum Sesami system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 4 hours under 300 ℃, adds the Plumbum preparatium and receives cream, releasing fire-toxin;

3. will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 0.8 times of weight 40% stirs and soaked into 1 hour, pack in the percolation jar, ethanol percolate extraction with 6 times of weight 40%, collect, merge percolate, filter, under 65 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.25-1.35;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 10: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 176g, salad oil 882g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 40%, with the salad oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 3 hours under 320 ℃, adds the Plumbum preparatium and receives cream, releasing fire-toxin;

3. will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 1 times of weight 60% stirs and soaked into 0.5 hour, pack in the percolation jar, ethanol percolate extraction with 10 times of weight 60%, collect, merge percolate, filter, under 70 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.15-1.25;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 11: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 858g, edible vegetable oil 2572g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 50%, with the edible vegetable oil system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 5 hours under 280 ℃, adds the Plumbum preparatium and receives cream, releasing fire-toxin;

3. will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 0.8 times of weight 75% stirs and soaked into 1 hour, pack in the percolation jar, ethanol percolate extraction with 15 times of weight 75%, collect, merge percolate, filter, under 75 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.05-1.15;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 12: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 352g, Oleum sesami 704g;

Method for making:

2. take by weighing above-mentioned hybrid medicine total amount 60%, with the Oleum sesami system of exploding, behind the outer black Neihuang County of fried system, go medicinal residues to stay medicine oil, oil refining is 2 hours under 300 ℃, adds the Plumbum preparatium and receives cream, releasing fire-toxin;

3. will remain hybrid medicine and be ground into coarse powder, the ethanol that adds medicated powder weight 0.6 times of weight 80% stirs and soaked into 2 hours, pack in the percolation jar, ethanol percolate extraction with 18 times of weight 80%, collect, merge percolate, filter, under 80 ℃ of temperature, extracting solution is condensed into the concentrated solution a that relative density is 1.15-1.25;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 13: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 1320g, edible vegetable oil 660g;

Method for making:

3. will remain hybrid medicine and be ground into coarse powder, extract 3 times, flood 16 hours at every turn, collect, merge impregnation liquid, filter, under 65 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.25-1.35 with the alcohol dipping of 6 times of weight 40%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 14: the blue or green roc plaster of the present invention

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 588g, Oleum sesami 1470g;

Method for making:

3. will remain hybrid medicine and be ground into coarse powder, extract 2 times, flood 20 hours at every turn, collect, merge impregnation liquid, filter, under 70 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with the alcohol dipping of 10 times of weight 60%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 15: the blue or green roc plaster of the present invention

Crude drug is formed:

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 368g, salad oil 1840g;

Method for making:

3. will remain hybrid medicine and be ground into coarse powder, extract 1 time, flood 24 hours at every turn, collect, merge impregnation liquid, filter, under 75 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.05-1.15 with the alcohol dipping of 15 times of weight 75%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Embodiment 16: the blue or green roc plaster of the present invention

Crude drug is formed:

Herba Oxytropis Kansuensis 100g, sub-rhubarb extract 50g, Radix aconiti szechenyiani 75g, Fructus Chebulae (pitted) 100g, Fructus Terminaliae Billericae 100g, Fructus Phyllanthi 100g, Benzoinum 35g, Herba Lycopodii 150g, Moschus 25g, Plumbum preparatium 220g, Oleum Sesami 2205g;

Method for making:

3. will remain hybrid medicine and be ground into coarse powder, extract 4 times, flood 12 hours at every turn, collect, merge impregnation liquid, filter, under 80 ℃ of temperature, extracting solution will be condensed into the concentrated solution a that relative density is 1.15-1.25 with the alcohol dipping of 18 times of weight 80%;

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

Claims

1. blue or green roc plaster that is used for alleviating pain and detumescence, its crude drug is formed and consumption is: Herba Oxytropis Kansuensis 80-120 weight portion, sub-rhubarb extract 30-70 weight portion, Radix aconiti szechenyiani 50-100 weight portion, Fructus Chebulae (pitted) 80-120 weight portion, Fructus Terminaliae Billericae 80-120 weight portion, Fructus Phyllanthi 80-120 weight portion, Benzoinum 20-50 weight portion, Herba Lycopodii 130-170 weight portion, Moschus 10-40 weight portion; It is characterized in that this cream drug adjuvant is formed and consumption is:

2. blue or green roc plaster as claimed in claim 1 is characterized in that this cream drug adjuvant is formed and consumption is:

Plumbum preparatium 220 weight portions, Oleum Sesami 550 weight portions;

Or Plumbum preparatium 840 weight portions, salad oil 588 weight portions;

Or Plumbum preparatium 330 weight portions, Oleum sesami 1323 weight portions;

Or Plumbum preparatium 600 weight portions, Oleum sesami 1800 weight portions;

Or Plumbum preparatium 735 weight portions, salad oil 3675 weight portions;

Or Plumbum preparatium 1764 weight portions, Oleum Sesami 4410 weight portions;

Or Plumbum preparatium 880 weight portions, Oleum Sesami 2200 weight portions;

Or Plumbum preparatium 176 weight portions, salad oil 882 weight portions;

Or Plumbum preparatium 352 weight portions, Oleum sesami 704 weight portions;

Or Plumbum preparatium 588 weight portions, Oleum sesami 1470 weight portions;

Or Plumbum preparatium 368 weight portions, salad oil 1840 weight portions;

Or Plumbum preparatium 220 weight portions, Oleum Sesami 2205 weight portions.

3. blue or green roc plaster as claimed in claim 1 or 2 is characterized in that the crude drug composition and the consumption of this plaster is preferably:

4. as the preparation method of the arbitrary described blue or green roc plaster of claim 1-3, it is characterized in that this method comprises the steps:

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

5. with the plaster water proof heat fused of releasing fire-toxin, add the concentrated solution a that 3. above-mentioned steps obtains, go to add the b that 4. step obtains behind the water purification steam, stand, the back cream that stirs promptly gets blue or green roc plaster.

5. the preparation method of blue or green roc plaster as claimed in claim 4 is characterized in that this method comprises the steps:

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

6. the preparation method of blue or green roc plaster as claimed in claim 4 is characterized in that this method comprises the steps:

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

7. the preparation method of blue or green roc plaster as claimed in claim 4 is characterized in that this method comprises the steps:

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

8. the preparation method of blue or green roc plaster as claimed in claim 4 is characterized in that this method comprises the steps:

4. the Moschus grinding is made to be uniformly dispersed, obtain b;

9. blue or green roc plaster as claimed in claim 1 or 2 is used for the application of the medicine of alleviating pain and detumescence in preparation.

10. blue or green roc plaster as claimed in claim 3 is used for the application of the medicine of alleviating pain and detumescence in preparation.