CN107158482A - 一种介入医疗器械 - Google Patents

一种介入医疗器械 Download PDF

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Publication number
CN107158482A
CN107158482A CN201610124449.8A CN201610124449A CN107158482A CN 107158482 A CN107158482 A CN 107158482A CN 201610124449 A CN201610124449 A CN 201610124449A CN 107158482 A CN107158482 A CN 107158482A
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medical device
interventional medical
sulfonic acid
acid group
styrene
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CN201610124449.8A
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齐坤
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Tianjin Ding Fan Technology Co Ltd
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Tianjin Ding Fan Technology Co Ltd
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Priority to CN201610124449.8A priority Critical patent/CN107158482A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本申请涉及医疗器械领域，特别是涉及一种介入医疗器械。一种介入医疗器械，所述介入医疗器械外表面设置有一层含有磺酸基团的聚合物的涂层，所述含有磺酸基团的聚合物为磺化的热塑性弹性体。所述磺化的热塑性弹性体为磺化苯乙烯‑烯烃共聚物。所述苯乙烯‑烯烃共聚物为苯乙烯‑异丁烯二嵌段或三嵌段共聚物。所述苯乙烯‑异丁烯二嵌段或三嵌段共聚物中苯乙烯重量百分含量为20％～45％。所述最外层涂层中的含有磺酸基团的聚合物的磺化率为10％～30％。本发明提供的介入医疗器械植入人体后，在体液环境下，材料表面磺酸基团的存在，不仅使得材料能够形成一薄层分子水平的亲水膜，而且表面带负电荷，与细胞相容性增强。

Description

一种介入医疗器械
技术领域
本申请涉及医疗器械领域，特别是涉及一种介入医疗器械。
背景技术
介入医疗器械是近二十年来新兴的医疗器械技术。其中，支架在介入医疗器械领域的表现尤其突出。对于因血管阻塞或其他原因而引起的血管疾病中，支架被证明是一种比较成功的长期植入血管的介入医疗器械。在手术时，将支架通过输送器输送到血管的阻塞病变部位，然后释放支架，利用支架膨胀将阻塞的血管撑开，使阻塞的血管保持畅通。为提高介入医疗器械在体内的生物相容效果和治疗效果，还可以在这些器械体某一局部或全部的表面上涂覆药物和/或聚合物。目前常用的聚合物材料主要有聚甲基丙烯酸酯类聚合物、含氟聚合物、聚乙烯类聚合物或聚苯乙烯类聚合物，这些聚合物在应用之初均为工业应用，生物相容性较差。因此现有的介入医疗器械在长期植入人体后，由于生物相容性较差会导致较为严重的血栓及术后并发症。
发明内容
为解决上述技术问题，本发明提供一种介入医疗器械，技术方案如下：一种介入医疗器械，所述介入医疗器械外表面设置有一层涂层，且所述涂层中的材料为含有磺酸基团的聚合物。所述含有磺酸基团的聚合物为磺化的热塑性弹性体。所述磺化的热塑性弹性体为磺化苯乙烯-烯烃共聚物。所述苯乙烯-烯烃共聚物为苯乙烯-异丁烯二嵌段或三嵌段共聚物。所述苯乙烯-异丁烯二嵌段或三嵌段共聚物中苯乙烯重量百分含量为20％～45％。所述最外层涂层中的含有磺酸基团的聚合物的磺化率为10％～30％。
本发明的积极效果是：本发明提供的介入医疗器械中，涂层材料为含有磺酸基团的聚合物，该磺酸基团的存在，赋予了聚合物与肝素相同的表面特性和适当的亲水性。当该介入医疗器械植入人体后，在体液环境下，材料表面磺酸基团的存在，不仅使得材料能够形成一薄层分子水平的亲水膜，而且表面带负电荷，与细胞相容性增强。
具体实施方式
下面对本发明的优选实施例进行详细阐述，以使本发明的优点和特征能更易于被 本领域技术人员理解。
实施例1
一种介入医疗器械，所述介入医疗器械外表面设置有一层涂层，且所述涂层中的材料为苯乙烯-烯烃共聚物为苯乙烯-异丁烯二嵌段或三嵌段共聚物。所述苯乙烯-异丁烯二嵌段或三嵌段共聚物中苯乙烯重量百分含量为20％。所述最外层涂层中的含有磺酸基团的聚合物的磺化率为10％。
实施例2
一种介入医疗器械，所述介入医疗器械外表面设置有一层涂层，且所述涂层中的材料为苯乙烯-烯烃共聚物为苯乙烯-异丁烯二嵌段或三嵌段共聚物。所述苯乙烯-异丁烯二嵌段或三嵌段共聚物中苯乙烯重量百分含量为30％。所述最外层涂层中的含有磺酸基团的聚合物的磺化率为20％。
实施例3
一种介入医疗器械，所述介入医疗器械外表面设置有一层涂层，且所述涂层中的材料为苯乙烯-烯烃共聚物为苯乙烯-异丁烯二嵌段或三嵌段共聚物。所述苯乙烯-异丁烯二嵌段或三嵌段共聚物中苯乙烯重量百分含量为45％。所述最外层涂层中的含有磺酸基团的聚合物的磺化率为30％。

Claims (4)

1.一种介入医疗器械，所述介入医疗器械外表面设置有一层涂层，且所述涂层中的材料为含有磺酸基团的聚合物。
2.根据权利要求1所述，所述含有磺酸基团的聚合物为磺化的热塑性弹性体。所述磺化的热塑性弹性体为磺化苯乙烯-烯烃共聚物。所述苯乙烯-烯烃共聚物为苯乙烯-异丁烯二嵌段或三嵌段共聚物。
3.根据权利要求2所述，所述苯乙烯-异丁烯二嵌段或三嵌段共聚物中苯乙烯重量百分含量为20％～45％。
4.根据权利要求2所述，所述最外层涂层中的含有磺酸基团的聚合物的磺化率为10％～30％。
CN201610124449.8A 2016-03-07 2016-03-07 一种介入医疗器械 Pending CN107158482A (zh)

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CN201610124449.8A CN107158482A (zh) 2016-03-07 2016-03-07 一种介入医疗器械

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102274550A (zh) * 2010-06-13 2011-12-14 微创医疗器械(上海)有限公司 一种介入医疗器械

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102274550A (zh) * 2010-06-13 2011-12-14 微创医疗器械(上海)有限公司 一种介入医疗器械

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