CN107158366A - It is a kind of to be suitable to antidiarrheal that 7 18 years old crowd takes and preparation method thereof and pharmaceutical formulation - Google Patents

It is a kind of to be suitable to antidiarrheal that 7 18 years old crowd takes and preparation method thereof and pharmaceutical formulation Download PDF

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Publication number
CN107158366A
CN107158366A CN201710345921.5A CN201710345921A CN107158366A CN 107158366 A CN107158366 A CN 107158366A CN 201710345921 A CN201710345921 A CN 201710345921A CN 107158366 A CN107158366 A CN 107158366A
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weight
parts
antidiarrheal
root
decoction
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林泽银
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HUANGPING XINGQIE NATIONAL FOLK CHINESE HERBAL MEDICINE SCIENCE DEVELOPMENT Co Ltd
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HUANGPING XINGQIE NATIONAL FOLK CHINESE HERBAL MEDICINE SCIENCE DEVELOPMENT Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
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    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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Abstract

It is suitable to antidiarrheal that 7 18 years old crowd takes and preparation method thereof and pharmaceutical formulation, category antidiarrheal field the present invention relates to a kind of.The pharmaceutical formulation includes：Maire sophora root, digua fig root, cordate houttuynia, the membrane of a chicken's gizzard, Radix Codonopsis, pilose gerbera herb, hook catechu, Asiatic plantain, hairy euphorbia, gaultherolin, digestive ferment and zinc.The medicament is made by pharmaceutical formulation, have effects that it is good prevent diarrhoea, the various symptom of diarrhea for the treatment of, the crowd being particularly suitable for use in 7 18 years old can be widely used in.The preparation method of the medicament includes：After maire sophora root, digua fig root, cordate houttuynia, the membrane of a chicken's gizzard, Radix Codonopsis, pilose gerbera herb, hook catechu, Asiatic plantain, hairy euphorbia and gaultherolin are mixed, extract, take away the puckery taste, taking off hardship, obtaining decoction, then adding digestive ferment and zinc into above-mentioned decoction again.Above-mentioned preparation method can reduce the bitter taste and astringent taste of medicine, to improve acceptance level of the patient to medicine on the basis of drug effect is fully ensured that.

Description

A kind of antidiarrheal taken suitable for 7-18 Sui crowd and preparation method thereof and medicine Formula
Technical field
The present invention relates to antidiarrheal field, and more particularly to a kind of antidiarrheal taken suitable for 7-18 Sui crowd and its Preparation method and pharmaceutical formulation.
Background technology
Diarrhoea is a kind of common sympton, refers to defecation frequency significantly more than the frequency being accustomed on ordinary days, excrement matter is thin, and moisture increases Plus, daily feces volume is more than 200g, or containing not digesting food or purulence blood, mucus.Diarrhoea is often accompanied by defecation urgency sense, anus not The symptoms such as suitable, incontinence.
Diarrhoea is divided to acute and chronic two class.Acute diarrhea is fallen ill drastically, and the course of disease is within 2-3 weeks.Chronic diarrhea refers to the course of disease More than two months or the intermittent phase in 2-4 weeks recurrent diarrhoea.Polarity enterogastritis is the acute inflammation of gastrointestinal mucosa, clinical Performance is mainly Nausea and vomiting, stomachache, diarrhoea, heating etc..Bacillary dysentery abbreviation bacillary dysentery, be as caused by shigella dysenteriae with Suffer from diarrhoea as the enteric infectious disease of cardinal symptom.Dysentery clinical manifestation is stomachache, diarrhoea, with symptoms such as systemic toxicity profiles.
The harm of diarrhoea mainly has：(1) diarrhoea can make water and electrolyte disturbance and disturbance of acid-base balance.Serious dehydration, electrolysis Matter is disorderly and acid poisoning can all produce serious infringement to body, such as rescues not in time, it is also possible to threat to life.(2) diarrhoea can draw Play malnutrition.(3) energy supply is not enough：The patient of long-term diarrhea, it will usually feel to feel dizzy, spiritlessness and weakness or not autonomous Tremble, in addition palpitation and short breath, dripping cold sweat.(4) hypovitaminosis：Long-term diarrhea can directly affect suction of the body to vitamin Receive, cause the shortage of vitamin.(5) anaemia：Due to Disorder of Digestion and A orption, protein and other hematopoiesis raw milk folic acid, dimension life Plain B12, irony etc. absorbs and reduces.(6) diarrhoea can decline the resistance of body.
The medicine for the treatment of diarrhoea has Western medicine and Chinese medicine at present, and still, Western medicine has gastrointestinal irritation is big, side effect is big etc. Shortcoming.
The content of the invention
The first object of the present invention is a kind of pharmaceutical formulation with anti-diarrhea effect of offer, and the pharmaceutical formulation is in antidiarrheal side The effect in face significantly, is widely used, be particularly suitable for use in 7-18 Sui crowd.
The second object of the present invention is a kind of above-mentioned antidiarrheal with anti-diarrhea effect of offer, and the medicament has preferable Effect of diarrhoea is prevented, can be widely applied for treating diarrhoea caused by the various causes of disease, be particularly suitable for use in the crowd of 7-18 Sui.
The third object of the present invention is to provide a kind of preparation method of above-mentioned antidiarrheal, and the preparation method is according to each medicine The property of thing, using different processing modes, can not only fully ensure that drug effect, moreover it is possible to reduce the bitter taste and astringent taste of medicine, from And improve acceptance level of the patient to medicine.
The present invention is solved its technical problem and realized using following technical scheme.
The present invention proposes a kind of antidiarrheal formula taken suitable for 7-18 Sui crowd, and it includes the crow of 26-35 parts by weight Beans root, the digua fig root of 17-21 parts by weight, the cordate houttuynia of 5-8 parts by weight, the membrane of a chicken's gizzard of 37-45 parts by weight, 20-26 parts by weight Radix Codonopsis, the pilose gerbera herb of 14-20 parts by weight, the hook catechu of 17-22 parts by weight, the Asiatic plantain of 20-24 parts by weight, 18-24 weight Part hairy euphorbia, the gaultherolin of 0.4-0.6 parts by weight, the zinc of the digestive ferment of 10-15 parts by weight and 3-6 parts by weight.
The present invention also proposes a kind of antidiarrheal taken suitable for 7-18 Sui crowd, and it is by the above-mentioned medicine with anti-diarrhea effect Composition formula is made.
The present invention also proposes a kind of preparation method for the antidiarrheal taken suitable for 7-18 Sui crowd, comprises the following steps： By in the maire sophora root of 26-35 parts by weight, the digua fig root of 17-21 parts by weight, the cordate houttuynia of 5-8 parts by weight, the chicken of 37-45 parts by weight Gold, the Radix Codonopsis of 20-26 parts by weight, the pilose gerbera herb of 14-20 parts by weight, 17-22 parts by weight hook catechu, 20-24 parts by weight After the gaultherolin mixing of Asiatic plantain, the hairy euphorbia of 18-24 parts by weight and 0.4-0.6 parts by weight, extract, take away the puckery taste, taking off hardship, obtaining To decoction, the digestive ferment of 10-15 parts by weight and the zinc of 3-6 parts by weight are then added into above-mentioned decoction again.
The beneficial effect of the pharmaceutical formulation of present pre-ferred embodiments is：Cordate houttuynia, pilose gerbera herb, Asiatic plantain and hairy euphorbia Have significantly to the one or more in the bacteriums such as mould, the streptococcus of hemolytic, staphylococcus aureus, Bacillus influenzae respectively Inhibitory action, after four kinds of herbaceous plant are mixed, can significantly improve the antidiarrheal effect of pharmaceutical formulation, and than by above-mentioned four kinds of grass It is better after the antidiarrheal effect superposition that this plant has when being used alone.
The membrane of a chicken's gizzard contains micro pepsin and amylase, can be used to delay with other digestive ferment collective effects in formula Digestive problems of the inside of human body to food are solved, improve enteron aisle digests and assimilates situation, alleviating diarrhoea symptom.
Radix Codonopsis and hook catechu not only can tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung, moreover it is possible to adjust gastrointestinal motility function, correct pathological state Gastrointestinal motility function it is disorderly, improve resistivity of the body to destructive stimulus, prevent diarrhoea from aggravating.
Gaultherolin can play certain effect of relieving the pain after patients diet's medicament to body；Further, since salicylic acid Methyl esters has certain fragrance, in the present embodiment, its can also in and/or the special fishy smell that has of partes tecta point cordate houttuynia Taste.
Zinc can recover the balance of water, electrolyte and soda acid in patient's body, make digestion and Metabolism of Normal.
Extraction step in preparation process, on the one hand can enable the active ingredient of each pharmaceutical formulation be fully dissolved out, another Aspect can also enable the volatile ingredient with peculiar smell in pharmaceutical formulation volatilize.In addition, taking away the puckery taste and taking off bitter step and be mainly and be Each pharmaceutical formulation of removing, bitter taste and astringent taste that particularly draft class material has, so that the bitter taste and astringent taste of medicine are reduced, Improve acceptance level of the patient to medicine.
The medicament being prepared by above-mentioned preparation method has effects that preferably to prevent diarrhoea.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional production that can be obtained by commercially available purchase Product.
Antidiarrheal of the embodiment of the present invention and preparation method thereof and pharmaceutical formulation are specifically described below.
The antidiarrheal provided in an embodiment of the present invention taken suitable for 7-18 Sui crowd, with the work(for preferably preventing from suffering from diarrhoea Effect.It is preferably Chinese drugs agentia, smaller to GI irritation and side effect compared to the Western medicine for antidiarrheal.
The medicament can for example include following pharmaceutical formulation：The maire sophora root of 26-35 parts by weight, the pachyrhizus of 17-21 parts by weight Root, the cordate houttuynia of 5-8 parts by weight, the membrane of a chicken's gizzard of 37-45 parts by weight, the Radix Codonopsis of 20-26 parts by weight, 14-20 parts by weight hair it is big Fourth grass, the hook catechu of 17-22 parts by weight, the Asiatic plantain of 20-24 parts by weight, the hairy euphorbia of 18-24 parts by weight, 0.4-0.6 weight Part gaultherolin, the zinc of the digestive ferment of 10-15 parts by weight and 3-6 parts by weight.
Further, as preferred, said medicine formula can for example include maire sophora root, the 18-20 of 28-32 parts by weight Digua fig root, the cordate houttuynia of 6-7 parts by weight, the membrane of a chicken's gizzard of 39-43 parts by weight, the Radix Codonopsis of 22-24 parts by weight, the 15-18 of parts by weight The pilose gerbera herbs of parts by weight, 19-21 parts by weight hook catechu, the Asiatic plantain of 21-23 parts by weight, the hairy euphorbia of 20-22 parts by weight, The zinc of the gaultherolins of 0.5 parts by weight, the digestive ferment of 12-14 parts by weight and 4-5 parts by weight.
Wherein, maire sophora root is the root of the southwestern Chinese scholartree of legume, and whole year can pluck, and source is wide, bitter and puckery flavor, generally by it For treating rheumatism arthralgia and myalgia etc..Digua fig root be moraceae plants pachyrhizus root, can clearing heat and promoting diuresis, diarrhoea, dysentery can be controlled.Choosing Take the rwo root class plant as the constituent of pharmaceutical formulation in the present embodiment, the two mutual cooperation can give full play to black beans The part antidiarrheal efficacy of root.
Cordate houttuynia, pilose gerbera herb, Asiatic plantain, hairy euphorbia are draft class plant.Cordate houttuynia bitter, cold nature, with clear The effect of thermal detoxification, inducing diuresis to remove edema, cures mainly dyspnea and cough due to lung-heat, eczema, oedema etc..Pilose gerbera herb relieve inflammation or internal heat anti-inflammatory and treatment flu With the effect of acute conjunctivitis.Asiatic plantain also known as wheel dish, with promoting diuresis for stranguria, it is clearing heat and detoxicating, clear liver and improve vision and eliminating the phlegm antidiarrheal Effect.Hairy euphorbia can clearing heat and detoxicating, removing dampness through diuresis and relieving itching, and have for bacillary dysentery, amoebic dysentery, enteritis etc. preferable Curative effect.
Composition during cordate houttuynia, pilose gerbera herb, Asiatic plantain and hairy euphorbia are formulated collectively as the present embodiment antidiarrheal Composition, can reach mitigation by the cellulose contained by herbaceous plant, volatile oil and antimicrobial factorses to diarrhoea.Experiment shows, Four kinds of herbaceous plant are respectively to one kind in the bacteriums such as mould, the streptococcus of hemolytic, staphylococcus aureus, Bacillus influenzae Or it is several have obvious inhibitory action, after four kinds of herbaceous plant are mixed, the antidiarrheal effect of pharmaceutical formulation can be significantly improved, and Have during than above-mentioned four kinds of herbaceous plant being used alone antidiarrheal effect superposition after it is better, illustrate cordate houttuynia, During pilose gerbera herb, Asiatic plantain and hairy euphorbia collective effect, part chemical substance there occurs chemical change or generate Cooperative effect, so as to reach excellent antidiarrheal effect.
The membrane of a chicken's gizzard can disperse accumulations be stagnant, strengthening the spleen and stomach.The membrane of a chicken's gizzard contains micro pepsin and amylase, above two enzyme It is used to alleviate digestive problems of the inside of human body to food as digestive ferment, therefore, regard the membrane of a chicken's gizzard as antidiarrheal agent in the present embodiment One of composition of composition formula, can improve enteron aisle in the range of to a certain degree digests and assimilates situation, alleviating diarrhoea symptom.
Generally patient's body is more empty after diarrhoea, and Radix Codonopsis is added in antidiarrheal formula and two kinds of strengthening the spleen and replenishing qi of catechu are hooked Medicinal material, not only can tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung, moreover it is possible to adjust gastrointestinal motility function, corrects the gastrointestinal motility function of pathological state Disorder, improves resistivity of the body to destructive stimulus, so as to prevent diarrhoea from aggravating.
When again because of diarrhoea, different degrees of pain more or less occurs in patient's belly, is the pain of reduction of patient, Gaultherolin is also added into the present embodiment in pharmaceutical formulation.On the one hand, gaultherolin can be played after patients diet Certain effect of relieving the pain；On the other hand, because gaultherolin has certain fragrance, in the present embodiment, it can also be neutralized Or cover the special fishy odor that part cordate houttuynia has.
From the above, maire sophora root, digua fig root, cordate houttuynia, the membrane of a chicken's gizzard, Radix Codonopsis, pilose gerbera herb, hook catechu, Asiatic plantain, fly Under the collective effect for raising grass and gaultherolin, the pharmaceutical formulation in the present embodiment not only has good antibacterial and antiviral work With in addition, also playing dual regulation in terms of body equilibrium between yin and yang is adjusted, and lead to immunoregulatory dual-use function Cross to the immune response effect in different phase, so as to improve the immunocompetence of diarrhea patient.
In addition, being also added into digestive ferment in the present embodiment, digestive ferment for example may include that weight ratio is 1-3：2.2-4：0.7- 1.2：1-1.5：0.5-0.8：0.4-0.8 amylase, conversion carbohydrase, protease, invertase, pancreatin and cellulase.
Wherein, amylase can effectively adjust the starch level in patient's body；Conversion carbohydrase can be adjusted effectively in patient's body The level of sugar；Protease can effectively adjust the protein level in patient's body；Pancreatin includes trypsase, amylopsin and pancreas fat Fat enzyme, can combine protein, starch and the fat content in effectively regulation patient's body such as above-mentioned protease and amylase；Cellulose Enzyme can effectively adjust the Cellulose Levels in patient's body.By the collective effect of above-mentioned different types of digestive ferment, can effectively it adjust The digestion level in diarrhoea person's body is saved, improves its digestive function, so that its defecation situation gradually recovers normal.
Because most of 7-18 Sui crowd is respectively provided with certain deviation food habit, cause the part population in mineral matter element There is certain shortage and imbalance in intake.Internal water, electrolyte and disturbance of acid-base balance can be made by being especially a lack of Zn-ef ficiency, and Digestion and metabolism disorder are caused, so as to cause diarrhoea.In view of the foregoing, zinc is further comprises in the pharmaceutical formulation of the present embodiment, To play preferably therapeutic effect to 7-18 Sui crowd.
Further to improve the antidiarrheal efficacy of said medicine formula, and there can be a variety of curative effects simultaneously, optionally, also On the basis of above-mentioned formula, the Chinese trumpet creeper, the ginger of 2-3 parts by weight, the grass of 7-9 parts by weight of 10-15 parts by weight can be added Coral, the acalypha copperleaf of 5-8 parts by weight, the Ramulus Taxilli of 3-7 parts by weight, the tooth soap of 5-8 parts by weight, the paniculate swallowwort of 2-3 parts by weight, 4- The microbial bacterial agent of 8 parts by weight and the adsorbent of 10-15 parts by weight.
Wherein, microbial bacterial agent and adsorbent main function are the further antidiarrheal abilities for improving said medicine formula.It is micro- It is 10-16 that bacteria agent, which can for example include weight ratio,：8-12：3-7 Bifidobacterium, lactobacillus acidophilus and Bifidus. Contribute to recover the ecological balance of normal intestinal flora using mentioned microorganism microbial inoculum, maintain good intestinal microecology.
Adsorbent for example may include hydroxy phosphorus Calx, edible silica gel, aluminum oxide, medical charcoal, white bole, montmorillonite and tannic acid Any one in albumen, can also include therein a variety of simultaneously.Above-mentioned adsorbent can be covered on intestinal mucosa, by with Mucin glycoprotein be combined with each other, and repairs and improve defense function of the gastrointestinal mucosa to virulence factor；Also, pathogen can also be adsorbed And toxin, worked by the content to enteron aisle and cause effect or by acting on intestinal wall, reduce the wriggling of intestinal wall and act as With.Wherein, montmorillonite has unique lamellar structure and heterogeneity distribution of charges, produces absorption affinity and electrostatic attraction, right The toxin of virus, germ and its generation in enteron aisle can play fixed and inhibitory action, and the material will not be inhaled by enteron aisle Receive, it is substantially harmless to human body.
The materials such as above-mentioned Chinese trumpet creeper and Chloranthus glaber can make this pharmaceutical formulation with a variety of other curative effects：As Chinese trumpet creeper can make This pharmaceutical formulation has promoting circulation of blood dissolving stasis and antipruritic effect；Ginger makes this pharmaceutical formulation have inducing sweat and dispelling exogenous evils, the work of warm lung cough-relieving With；Chloranthus glaber can make this pharmaceutical formulation have the effect of swelling and pain relieving, anti-inflammation；Acalypha copperleaf can be such that this pharmaceutical formulation has only Blood antibacterial and the effect of removing toxic substances；Ramulus Taxilli can make this pharmaceutical formulation have decompression, the effect of regulation heart rate；Tooth soap can make this medicine There is formula eliminating the phlegm to have one's ideas straightened out, the effect of mass dissipating and swelling eliminating；Paniculate swallowwort can have this pharmaceutical formulation to ease pain and treatment pain in the back, abdominal distension Effect.
From the above, the various composition in pharmaceutical formulation has good by collective effect in the medicament for ensuring the present embodiment After good antidiarrheal efficacy, it also add its promoting circulation of blood dissolving stasis, antipruritic, warm lung cough-relieving, swelling and pain relieving, decompression and regulation heart rate etc. and make With.And the formula material in medicament uses natural products, and for Western medicine, the stimulation to intestines and stomach is smaller, and side effect Also it is smaller.Therefore, the application of the medicament in the present embodiment and the application equal expanded of crowd.
Optionally, the preparation method of the above-mentioned medicament in the present embodiment may comprise steps of：By weight Meter, by above-mentioned maire sophora root, above-mentioned digua fig root, above-mentioned cordate houttuynia, the above-mentioned the membrane of a chicken's gizzard, above-mentioned Radix Codonopsis, above-mentioned pilose gerbera herb, above-mentioned hook After catechu, above-mentioned Asiatic plantain, above-mentioned hairy euphorbia and the mixing of above-mentioned gaultherolin, extract, take away the puckery taste, taking off hardship, obtaining decoction.Then Above-mentioned digestive ferment and above-mentioned zinc are added into above-mentioned decoction again.
Specifically, for example can be by above-mentioned cordate houttuynia, above-mentioned pilose gerbera herb, above-mentioned Asiatic plantain and above-mentioned hairy euphorbia, first It is secondary to extract, obtain the first decoction.By above-mentioned maire sophora root, above-mentioned digua fig root, the above-mentioned the membrane of a chicken's gizzard, above-mentioned Radix Codonopsis, above-mentioned hook catechu and on State after gaultherolin mixing, second of extraction obtains the second decoction.Then above-mentioned first decoction and above-mentioned second decoction are mixed, Take away the puckery taste again, take off hardship.
Or, before extraction, in addition to count by weight, by above-mentioned Chinese trumpet creeper, above-mentioned ginger, above-mentioned Chloranthus glaber, on State acalypha copperleaf, above-mentioned Ramulus Taxilli, above-mentioned tooth soap, above-mentioned paniculate swallowwort, mentioned microorganism microbial inoculum and above-mentioned adsorbent and above-mentioned black beans Root, above-mentioned digua fig root, above-mentioned cordate houttuynia, the above-mentioned the membrane of a chicken's gizzard, above-mentioned Radix Codonopsis, above-mentioned pilose gerbera herb, above-mentioned hook catechu, above-mentioned Chinese herbaceous peony Careless, above-mentioned hairy euphorbia and the mixing of above-mentioned gaultherolin.
Wherein, the purpose of extraction is partly in order to enable the active ingredient of each pharmaceutical formulation to be fully dissolved out, the opposing party Face can also enable the volatile ingredient with peculiar smell in pharmaceutical formulation volatilize.Hardship is taken away the puckery taste and taken off primarily to removing each medicine Formula, bitter taste and astringent taste that particularly draft class material has, so as to reduce the bitter taste and astringent taste of medicine, improve patient to medicine The acceptance level of thing.
Optionally, 12-36h can for example be handled under conditions of 45-60 DEG C by being extracted for the first time in the present embodiment；Second Secondary extraction can for example handle 24-48h under conditions of 10-30 DEG C.
The characteristics of being and combine pharmaceutical formulation composition in the present embodiment is extracted in two times carries out special setting.Extract for the first time Formula, i.e. cordate houttuynia, pilose gerbera herb, Asiatic plantain and hairy euphorbia be respectively provided with different degrees of excitant taste, especially fish raw meat Grass, majority of populations is respectively provided with certain conflict psychology to these excitant tastes.Therefore, by above-mentioned substance at 45-60 DEG C Extracted under higher temperature, most of volatile materials for producing penetrating odor can be enable to volatilize and remove, and together When also ensure in the temperature range, the contained active ingredient with antidiarrheal efficacy is not by high temperature in said medicine formula Destruction is denatured.Second of extraction considers extraction cost and extraction time, and residue is treated into extract under normal temperature condition, namely Extracted under conditions of 10-30 DEG C, it is possible to decrease extraction cost.
By above-mentioned extraction time twice, the antidiarrheal composition in each formula components can be able to fully extract.Again because of first The temperature of secondary relatively second extraction of extraction is higher, and the extraction efficiency in same time is better than second of extraction, therefore considers, The time extracted for the first time is smaller than the time of second of extraction.
Because above-mentioned digestive ferment and zinc easily before medicament is also introduced into stomach by the various acid-base materials in body shadow Ring, therefore the present embodiment can also carry out microencapsulation processing to material both this, make its Surface coating protective layer, then add medicine In liquid.So that patient is when taking medicament, digestive ferment and zinc can smoothly enter stomach, then gradually be absorbed by stomach, with up to The curative effect that should have to it.
The feature and performance to the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：26 parts by weight Maire sophora root, the digua fig root of 17 parts by weight, the cordate houttuynia of 5 parts by weight, the membrane of a chicken's gizzard of 37 parts by weight, the Radix Codonopsis of 20 parts by weight, 14 The pilose gerbera herb of parts by weight, the hook catechu of 17 parts by weight, the Asiatic plantain of 20 parts by weight, the hairy euphorbia of 18 parts by weight, 0.4 parts by weight Gaultherolin, the zinc of the digestive ferment of 10 parts by weight and 3 parts by weight.
Wherein, it is 1 that digestive ferment, which includes weight ratio,：2.2：0.7：1：0.5：0.4 amylase, conversion carbohydrase, protease, sugarcane Carbohydrase, pancreatin and cellulase.
The preparation method of the medicament includes：
Maire sophora root, digua fig root, cordate houttuynia, the membrane of a chicken's gizzard, Radix Codonopsis, pilose gerbera herb, hook catechu, car during said medicine is formulated After preceding grass, hairy euphorbia and gaultherolin mixing, extract, take away the puckery taste, taking off hardship, obtaining decoction, then being added again into above-mentioned decoction Digestive ferment and zinc.
Embodiment 2
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：35 parts by weight Maire sophora root, the digua fig root of 21 parts by weight, the cordate houttuynia of 8 parts by weight, the membrane of a chicken's gizzard of 45 parts by weight, the Radix Codonopsis of 26 parts by weight, 20 The pilose gerbera herb of parts by weight, the hook catechu of 22 parts by weight, the Asiatic plantain of 24 parts by weight, the hairy euphorbia of 24 parts by weight, 0.6 parts by weight Gaultherolin, the zinc of the digestive ferment of 15 parts by weight and 6 parts by weight.
Wherein, it is 3 that digestive ferment, which includes weight ratio,：4：1.2：1.5：0.8：0.8 amylase, conversion carbohydrase, protease, sugarcane Carbohydrase, pancreatin and cellulase.
The preparation method of the medicament includes：
Cordate houttuynia, pilose gerbera herb, Asiatic plantain and hairy euphorbia during said medicine is formulated are handled under conditions of 45 DEG C 36h, obtains the first decoction；After maire sophora root, digua fig root, the membrane of a chicken's gizzard, Radix Codonopsis, hook catechu and gaultherolin are mixed, in 10 DEG C Under the conditions of handle 48h, obtain the second decoction；Then above-mentioned first decoction and the second decoction are mixed, then takes away the puckery taste, take off hardship, decoction is obtained, Then digestive ferment and zinc are added into above-mentioned decoction again.
Embodiment 3
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：30.5 weight The maire sophora root of part, the digua fig root of 19 parts by weight, the cordate houttuynia of 6.5 parts by weight, the membrane of a chicken's gizzard of 41 parts by weight, the party of 23 parts by weight Ginseng, the pilose gerbera herb of 17 parts by weight, 19.5 parts by weight hook catechu, the Asiatic plantain of 22 parts by weight, the hairy euphorbia of 21 parts by weight, The zinc of the gaultherolin of 0.5 parts by weight, the digestive ferment of 12.5 parts by weight and 4.5 parts by weight.
Wherein, it is 2 that digestive ferment, which includes weight ratio,：3.1：0.95：1.25：0.65：0.6 amylase, conversion carbohydrase, albumen Enzyme, invertase, pancreatin and cellulase.
The preparation method of the medicament includes：
Cordate houttuynia, pilose gerbera herb, Asiatic plantain and hairy euphorbia during said medicine is formulated are handled under conditions of 60 DEG C 12h, obtains the first decoction；After maire sophora root, digua fig root, the membrane of a chicken's gizzard, Radix Codonopsis, hook catechu and gaultherolin are mixed, in 30 DEG C Under the conditions of handle 24h, obtain the second decoction；Then above-mentioned first decoction and the second decoction are mixed, then takes away the puckery taste, take off hardship, decoction is obtained, Then digestive ferment and zinc are added into above-mentioned decoction again.
Embodiment 4
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：28 parts by weight Maire sophora root, the digua fig root of 18 parts by weight, the cordate houttuynia of 6 parts by weight, the membrane of a chicken's gizzard of 39 parts by weight, the Radix Codonopsis of 22 parts by weight, 15 The pilose gerbera herb of parts by weight, the hook catechu of 19 parts by weight, the Asiatic plantain of 21 parts by weight, the hairy euphorbia of 20 parts by weight, 0.5 parts by weight Gaultherolin, the zinc of the digestive ferment of 12 parts by weight and 4 parts by weight.
The composition of above-mentioned digestive ferment and the preparation method of the medicament are consistent with embodiment 1.
Embodiment 5
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：32 parts by weight Maire sophora root, the digua fig root of 20 parts by weight, the cordate houttuynia of 7 parts by weight, the membrane of a chicken's gizzard of 43 parts by weight, the Radix Codonopsis of 24 parts by weight, 18 The pilose gerbera herb of parts by weight, the hook catechu of 21 parts by weight, the Asiatic plantain of 23 parts by weight, the hairy euphorbia of 22 parts by weight, 0.5 parts by weight Gaultherolin, the zinc of the digestive ferment of 14 parts by weight and 5 parts by weight.
The composition of above-mentioned digestive ferment and the preparation method of the medicament are consistent with embodiment 2.
Embodiment 6
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：30 parts by weight Maire sophora root, the digua fig root of 19 parts by weight, the cordate houttuynia of 6.5 parts by weight, the membrane of a chicken's gizzard of 41 parts by weight, the Radix Codonopsis of 23 parts by weight, Hook catechu, the Asiatic plantain of 22 parts by weight, the weight of hairy euphorbia 0.5 of 21 parts by weight of the pilose gerbera herb of 16.5 parts by weight, 20 parts by weight Measure the zinc of the gaultherolin, the digestive ferment of 13 parts by weight and 4.5 parts by weight of part.
The composition of above-mentioned digestive ferment and the preparation method of the medicament are consistent with embodiment 3.
Embodiment 7
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：26 parts by weight Maire sophora root, the digua fig root of 17 parts by weight, the cordate houttuynia of 5 parts by weight, the membrane of a chicken's gizzard of 37 parts by weight, the Radix Codonopsis of 20 parts by weight, 14 The pilose gerbera herb of parts by weight, the hook catechu of 17 parts by weight, the Asiatic plantain of 20 parts by weight, the hairy euphorbia of 18 parts by weight, 0.4 parts by weight Gaultherolin, the digestive ferment of 10 parts by weight, the zinc of 3 parts by weight, the Chinese trumpet creeper of 10 parts by weight, the ginger of 2 parts by weight, 7 weights Measure the Chloranthus glaber of part, the acalypha copperleaf of 5 parts by weight, the Ramulus Taxilli of 3 parts by weight, the tooth soap of 5 parts by weight, the paniculate swallowwort of 2 parts by weight, 4 The adsorbent of the microbial bacterial agent of parts by weight and 10 parts by weight.
It is 3 that digestive ferment, which contains weight ratio,：4：1.2：1.5：0.8：0.8 amylase, conversion carbohydrase, protease, invertase, Pancreatin and cellulase；It is 10 that microbial bacterial agent, which contains weight ratio,：8：3 Bifidobacterium, lactobacillus acidophilus and Bifidus； Adsorbent contains hydroxy phosphorus Calx.
The preparation method of the medicament includes：
Maire sophora root, digua fig root, cordate houttuynia, the membrane of a chicken's gizzard, Radix Codonopsis, pilose gerbera herb, hook catechu, car during said medicine is formulated Preceding grass, hairy euphorbia, gaultherolin, Chinese trumpet creeper, ginger, Chloranthus glaber, acalypha copperleaf, Ramulus Taxilli, tooth soap, paniculate swallowwort, microbial bacteria After agent and adsorbent mixing, extract, take away the puckery taste, taking off hardship, obtaining decoction, then adding digestive ferment and zinc into above-mentioned decoction again.
Embodiment 8
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：30.5 weight The maire sophora root of part, the digua fig root of 19 parts by weight, the cordate houttuynia of 6.5 parts by weight, the membrane of a chicken's gizzard of 41 parts by weight, the party of 23 parts by weight Ginseng, the pilose gerbera herb of 17 parts by weight, 19.5 parts by weight hook catechu, the Asiatic plantain of 22 parts by weight, the hairy euphorbia of 21 parts by weight, The gaultherolin of 0.5 parts by weight, the digestive ferment of 12.5 parts by weight, the zinc of 4.5 parts by weight, the Chinese trumpet creeper of 15 parts by weight, 3 weight The ginger of part, the Chloranthus glaber of 9 parts by weight, the acalypha copperleaf of 8 parts by weight, the Ramulus Taxilli of 7 parts by weight, the tooth soap of 8 parts by weight, 3 weight Part paniculate swallowwort, the adsorbent of the microbial bacterial agent of 8 parts by weight and 15 parts by weight.
It is 2 that digestive ferment, which includes weight ratio,：3.1：0.95：1.25：0.65：0.6 amylase, conversion carbohydrase, protease, sugarcane Carbohydrase, pancreatin and cellulase；It is 16 that microbial bacterial agent, which contains weight ratio,：12：7 Bifidobacterium, lactobacillus acidophilus and Bi Fei Moral Salmonella；Adsorbent contains edible silica gel and montmorillonite.
The preparation method of the medicament includes：
Cordate houttuynia, pilose gerbera herb, Asiatic plantain and hairy euphorbia during said medicine is formulated are handled under conditions of 52.5 DEG C 24h, obtains the first decoction；By Chinese trumpet creeper, ginger, Chloranthus glaber, acalypha copperleaf, Ramulus Taxilli, tooth soap, paniculate swallowwort, microbial bacterial agent, absorption After agent, maire sophora root, digua fig root, the membrane of a chicken's gizzard, Radix Codonopsis, hook catechu and gaultherolin mixing, 36h is handled under conditions of 20 DEG C, Obtain the second decoction；Then above-mentioned first decoction and the second decoction are mixed, then takes away the puckery taste, take off hardship, decoction is obtained, then again to above-mentioned medicine The digestive ferment and zinc added in liquid after microcapsules processing.
Embodiment 9
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：30 parts by weight Maire sophora root, the digua fig root of 19 parts by weight, the cordate houttuynia of 6.5 parts by weight, the membrane of a chicken's gizzard of 41 parts by weight, the Radix Codonopsis of 23 parts by weight, Hook catechu, the Asiatic plantain of 22 parts by weight, the hairy euphorbia of 21 parts by weight, 0.5 weight of the pilose gerbera herb of 16.5 parts by weight, 20 parts by weight The gaultherolin of amount part, the digestive ferment of 13 parts by weight, the zinc of 4.5 parts by weight, the Chinese trumpet creeper of 12.5 parts by weight, 2.5 parts by weight Ginger, the Chloranthus glaber of 8 parts by weight, the acalypha copperleaf of 6.5 parts by weight, the Ramulus Taxilli of 5 parts by weight, the tooth soap of 6.5 parts by weight, 2.5 The adsorbent of the paniculate swallowwort of parts by weight, the microbial bacterial agent of 6 parts by weight and 12.5 parts by weight.
It is 2 that digestive ferment, which includes weight ratio,：3.1：0.95：1.25：0.65：0.6 amylase, conversion carbohydrase, protease, sugarcane Carbohydrase, pancreatin and cellulase；It is 13 that microbial bacterial agent, which contains weight ratio,：10：5 Bifidobacterium, lactobacillus acidophilus and Bi Fei Moral Salmonella；Adsorbent contains aluminum oxide and medical charcoal.
The preparation method of the medicament includes：
Cordate houttuynia, pilose gerbera herb, Asiatic plantain and hairy euphorbia during said medicine is formulated are handled under conditions of 52.5 DEG C 24h, obtains the first decoction；By Chinese trumpet creeper, ginger, Chloranthus glaber, acalypha copperleaf, Ramulus Taxilli, tooth soap, paniculate swallowwort, microbial bacterial agent, absorption After agent, maire sophora root, digua fig root, the membrane of a chicken's gizzard, Radix Codonopsis, hook catechu and gaultherolin mixing, 36h is handled under conditions of 20 DEG C, Obtain the second decoction；Then above-mentioned first decoction and the second decoction are mixed, then takes away the puckery taste, take off hardship, decoction is obtained, then again to above-mentioned medicine The digestive ferment and zinc added in liquid after microcapsules processing.
Embodiment 10
The present embodiment provides a kind of medicament with anti-diarrhea effect, and the medicament is made by agents formula：32 parts by weight Maire sophora root, the digua fig root of 20 parts by weight, the cordate houttuynia of 7 parts by weight, the membrane of a chicken's gizzard of 43 parts by weight, the Radix Codonopsis of 24 parts by weight, 18 Hook catechu, the Asiatic plantain of 23 parts by weight, the hairy euphorbia of 22 parts by weight and 0.5 weight of the pilose gerbera herb of parts by weight, 21 parts by weight The gaultherolin of part, the digestive ferment of 14 parts by weight, the zinc of 5 parts by weight, the Chinese trumpet creeper of 12.5 parts by weight, the life of 2.5 parts by weight Ginger, the Chloranthus glaber of 8 parts by weight, the acalypha copperleaf of 6.5 parts by weight, the Ramulus Taxilli of 5 parts by weight, the tooth soap of 6.5 parts by weight, 2.5 weight Part paniculate swallowwort, the adsorbent of the microbial bacterial agent of 6 parts by weight and 12.5 parts by weight.
It is 3 that digestive ferment, which includes weight ratio,：4：1.2：1.5：0.8：0.8 amylase, conversion carbohydrase, protease, invertase, Pancreatin and cellulase；It is 13 that microbial bacterial agent, which contains weight ratio,：10：5 Bifidobacterium, lactobacillus acidophilus and Bi Fei De Shi Bacterium；Adsorbent contains white bole and tannalbin.
The preparation method of the medicament includes：
Cordate houttuynia, pilose gerbera herb, Asiatic plantain, hairy euphorbia, Chinese trumpet creeper, Chloranthus glaber, acalypha copperleaf during said medicine is formulated, Ramulus Taxilli, tooth soap and paniculate swallowwort handle 32h under conditions of 50 DEG C, obtain the first decoction；By microbial bacterial agent, adsorbent, Wu Dou After root, digua fig root, the membrane of a chicken's gizzard, Radix Codonopsis, hook catechu and gaultherolin mixing, 48h is handled under conditions of 20 DEG C, the second medicine is obtained Liquid；Then above-mentioned first decoction and the second decoction are mixed, then takes away the puckery taste, take off hardship, decoction is obtained, is then added again into above-mentioned decoction Digestive ferment and zinc after microcapsules processing.
Test example
Repetition prepares above-described embodiment to prepare enough medicaments.With reference to clinical test to 1- of the embodiment of the present invention 10 medicaments with anti-diarrhea effect provided are evaluated the therapeutic effect of diarrhoea.
First, testing program：
1st, case selection
This group of case is diarrhea patient, meet include, exclusion standard, age 7-18 Sui, average 13 years old.It is randomly divided into 11 Group, every group each 20, wherein test group is 1-10 groups, and control group is the 11st group.The age of 11 groups of patients, sex, the state of an illness Etc. data, there was no significant difference, with comparativity.
2nd, therapeutic scheme：
1-10 groups (test group) patient takes the medicament with anti-diarrhea effect of embodiment 1-10 offers, daily three respectively It is secondary, each taking 200mL.11st group of (control group) patient is treated using traditional remedies, that is, is taken to rush down to stand and stopped, stop by rushing down to stand The specification of medicine is taken.
Record the state of an illness of 1 week interior patient after drug administration, and according to " effect is notable ", " effective ", engineering noise and " deterioration " Four grades are evaluated come the therapeutic action to medicament.
3rd, clinical evaluation standard：
Effect is notable：Diarrhoea number of times is significantly reduced in 1d after medication, and defecation recovers normal completely in 2d.
Effectively：Diarrhoea number of times is greatly decreased in 2d after medication, and defecation is normal in 3d, and defecation recovers just completely in 4d Often.
It is invalid：Take medicine after 4d, diarrhoea number of times is without significant change.
Deteriorate：Take medicine after 4d, diarrhoea number of times increases, aggravation.
2nd, result of the test：
As shown in table 1：
The clinical test results of table 1
As can be seen from Table 1, the medicament with anti-diarrhea effect that the present invention is provided is preferable to the therapeutic effect of diarrhoea, mainly Show：Take after the medicament, the interior diarrhoea number of times of 1d is significantly reduced most patients after the tablet has been ingested, and defecation is completely extensive in 2d It is multiple normal；Only small part patient, diarrhoea number of times is greatly reduced in 2d after the tablet has been ingested, and defecation is normal in 3d, is arranged in 4d Just recover completely normal.Compared to control group, significantly, anti-diarrhea effect is good for the curative effect of medicine that 1-10 of the embodiment of the present invention is provided.Its Reason is to be also added into digestive ferment and zinc in the corresponding embodiment 1-10 of this test group 1-10 pharmaceutical formulation, being capable of specific aim Ground solves digestion level and metaboilic level in age level crowd's body, so as to play preferably therapeutic effect to diarrhoea.
Curative effect of medicine of the test group 7-10 compared with test group 1-6 more preferably, the reason is that test group 7-10 is compared with test group 1-6 In pharmaceutical formulation add Chinese trumpet creeper, ginger, Chloranthus glaber, acalypha copperleaf, Ramulus Taxilli, tooth soap, paniculate swallowwort, microbial bacterial agent and Adsorbent, maire sophora root, digua fig root, cordate houttuynia, the membrane of a chicken's gizzard, Radix Codonopsis, Mao great in said medicine composition and test group 1-6 are formulated Fourth is careless, hook under the synergy of catechu, Asiatic plantain, hairy euphorbia and gaultherolin, further increases the antidiarrheal effect of medicament.
In addition, by contrast, test group 1-10 is also preferable to the diarrhea patient antidiarrheal effect of other age brackets compared with control group, The vertical 1d-2d in advance that stops, which can relatively be rushed down, not etc. does not make patient cure completely.Illustrate that the antidiarrheal that the present embodiment is provided is suffered from diarrhoea to most of Patient has good therapeutic effect.
In summary, it is provided in an embodiment of the present invention to have effects that the pharmaceutical formulation of anti-diarrhea effect shows in terms of antidiarrheal Write, be widely used；The medicament being formulated including said medicine, has effects that preferably to prevent diarrhoea, can be widely applied for treatment each Plant and suffered from diarrhoea caused by the cause of disease.Also, the preparation method of above-mentioned medicament, according to the property of each medicine, using different processing modes, Drug effect can not only be fully ensured that, moreover it is possible to reduce the bitter taste and astringent taste of medicine, so as to improve acceptance level of the patient to medicine.
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.The reality of the present invention The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made Every other embodiment, belongs to the scope of protection of the invention.

Claims (10)

1. a kind of antidiarrheal formula taken suitable for 7-18 Sui crowd, it is characterised in that the black beans including 26-35 parts by weight Root, the digua fig root of 17-21 parts by weight, the cordate houttuynia of 5-8 parts by weight, the membrane of a chicken's gizzard of 37-45 parts by weight, the party of 20-26 parts by weight Ginseng, the hook catechu of the pilose gerbera herb of 14-20 parts by weight, 17-22 parts by weight, the Asiatic plantain of 20-24 parts by weight, 18-24 parts by weight Hairy euphorbia and the gaultherolins of 0.4-0.6 parts by weight, the digestive ferment of 10-15 parts by weight and 3-6 parts by weight zinc.
2. antidiarrheal formula according to claim 1, it is characterised in that it is 1-3 that the digestive ferment, which includes weight ratio,： 2.2-4：0.7-1.2：1-1.5：0.5-0.8：0.4-0.8 amylase, conversion carbohydrase, protease, invertase, pancreatin and fiber Plain enzyme.
3. antidiarrheal formula according to claim 2, it is characterised in that the pharmaceutical formulation also includes 10-15 weight The Chinese trumpet creeper of part, the ginger of 2-3 parts by weight, the Chloranthus glaber of 7-9 parts by weight, the acalypha copperleaf of 5-8 parts by weight, the mulberry of 3-7 parts by weight The suction of parasitism, the tooth soap of 5-8 parts by weight, the paniculate swallowwort of 2-3 parts by weight, the microbial bacterial agent of 4-8 parts by weight and 10-15 parts by weight Attached dose.
4. antidiarrheal formula according to claim 3, it is characterised in that the microbial bacterial agent is including weight ratio 10-16：8-12：3-7 Bifidobacterium, lactobacillus acidophilus and Bifidus.
5. antidiarrheal formula according to claim 3, it is characterised in that the adsorbent includes hydroxy phosphorus Calx, food With any one in silica gel, aluminum oxide, medical charcoal, white bole, montmorillonite and tannalbin.
6. a kind of antidiarrheal taken suitable for 7-18 Sui crowd, it is characterised in that the medicament is by any one of claim 1-5 Described antidiarrheal formula is made.
7. a kind of preparation method for the antidiarrheal taken suitable for 7-18 Sui crowd, it is characterised in that comprise the following steps：
By the maire sophora root of 26-35 parts by weight, the digua fig root of 17-21 parts by weight, the cordate houttuynia of 5-8 parts by weight, 37-45 parts by weight The membrane of a chicken's gizzard, the Radix Codonopsis of 20-26 parts by weight, the pilose gerbera herb of 14-20 parts by weight, the hook catechu of 17-22 parts by weight, 20-24 weight Part Asiatic plantain, after the gaultherolin mixing of the hairy euphorbia of 18-24 parts by weight and 0.4-0.6 parts by weight, extract, take away the puckery taste, take off Hardship, obtains decoction, then adds the digestive ferment of 10-15 parts by weight and the zinc of 3-6 parts by weight into the decoction again.
8. the preparation method of antidiarrheal according to claim 7, it is characterised in that the cordate houttuynia, the hair is big Fourth is careless, the Asiatic plantain and the hairy euphorbia, extracts for the first time, obtains the first decoction；By the maire sophora root, the digua fig root, institute State after the membrane of a chicken's gizzard, the Radix Codonopsis, the hook catechu and gaultherolin mixing, second of extraction obtains the second decoction；Mixing First decoction and second decoction, then take away the puckery taste, take off hardship, obtain the decoction again.
9. the preparation method of antidiarrheal according to claim 7, it is characterised in that mix the digestive ferment with the zinc Microencapsulation is handled after conjunction, is then added in the decoction.
10. the preparation method of antidiarrheal according to claim 7, it is characterised in that before extraction, by 10-15 parts by weight Chinese trumpet creeper, the ginger of 2-3 parts by weight, the Chloranthus glaber of 7-9 parts by weight, the acalypha copperleaf of 5-8 parts by weight, the mulberry of 3-7 parts by weight post Life, the tooth soap of 5-8 parts by weight, the paniculate swallowwort of 2-3 parts by weight, the microbial bacterial agent of 4-8 parts by weight, the absorption of 10-15 parts by weight Agent and the maire sophora root, the digua fig root, the cordate houttuynia, the membrane of a chicken's gizzard, the Radix Codonopsis, the pilose gerbera herb, the hook Catechu, the Asiatic plantain, the hairy euphorbia and gaultherolin mixing.
CN201710345921.5A 2017-05-16 2017-05-16 It is a kind of to be suitable to antidiarrheal that 7 18 years old crowd takes and preparation method thereof and pharmaceutical formulation Pending CN107158366A (en)

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Application publication date: 20170915