CN107158207A - 一种治疗颈椎病的丸剂药物及其制备方法 - Google Patents

一种治疗颈椎病的丸剂药物及其制备方法 Download PDF

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CN107158207A
CN107158207A CN201710394170.6A CN201710394170A CN107158207A CN 107158207 A CN107158207 A CN 107158207A CN 201710394170 A CN201710394170 A CN 201710394170A CN 107158207 A CN107158207 A CN 107158207A
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孙素蓉
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Chengdu Fengmi Biotechnology Co Ltd
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Abstract

本发明属于中药制剂领域，目的是根据中医对颈椎病的认识机理而提供的一种治疗颈椎病的丸剂药物，所述药物的各个组分及其质量份比如下：桂枝50g、葛根140g、黄芪300g、知母115g、红花95g、苍术120g、川芎95g、羌活200g、伸筋草200g、鹿衔草260g、当归120g、木瓜95g、川牛膝95g、延胡索120g、没药200g、防风95g、丹参120g、赤芍95g、桃仁120g、丝瓜络120g、续断200g；本发明提供的药物是一个标本兼治的中药组方。

Description

一种治疗颈椎病的丸剂药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗颈椎病的丸剂药物，特别是供颈椎病患者使用的丸剂药物及其制备方法的领域。
背景技术
祖国医学认为：颈椎病又称颈椎综合征，是颈椎骨关节炎、增生性颈椎炎、颈神经根综合征、颈椎间盘脱出症的总称,是一种以退行性病理改变为基础的疾患。主要由于颈椎长期劳损、骨质增生，或椎间盘脱出、韧带增厚，致使颈椎脊髓、神经根或椎动脉受压，出现一系列功能障碍的临床综合征。表现为椎节失稳、松动；髓核突出或脱出；骨刺形成；韧带肥厚和继发的椎管狭窄等，刺激或压迫了邻近的神经根、脊髓、椎动脉及颈部交感神经等组织，引起一系列症状和体征。
颈椎病可分为：颈型颈椎病、神经根型颈椎病、脊髓型颈椎病、椎动脉型颈椎病、交感神经型颈椎病、食管压迫型颈椎病。
那么，就如何找到一种可有效治疗上述颈椎病的药物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗颈椎病上，人们逐渐意识到了中医治疗颈椎病的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗颈椎病的现状，本发明的目的是在于提供一种治疗颈椎病的丸剂药物，以解决颈椎病患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述颈椎病。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗颈椎病的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝20～70g、葛根80～180g、黄芪100～380g、知母60～150g、红花50～120g、苍术80～160g、川芎50～120g、羌活100～260g、伸筋草150～260g、鹿衔草150～320g、当归80～160g、木瓜50～120g、川牛膝60～120g、延胡索80～160g、没药50～250g、防风50～120g、丹参80～160g、赤芍60～120g、桃仁80～160g、丝瓜络50～160g、续断100～250g。
一种治疗颈椎病的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝30～60g、葛根90～160g、黄芪115～330g、知母70～130g、红花60～105g、苍术90～140g、川芎60～105g、羌活115～230g、伸筋草170～230g、鹿衔草170～280g、当归90～140g、木瓜60～105g、川牛膝70～105g、延胡索90～140g、没药60～220g、防风60～105g、丹参90～140g、赤芍70～105g、桃仁90～140g、丝瓜络60～140g、续断115～220g。
一种治疗颈椎病的丸剂药物及其制备方法，其特征在于，所述“最佳方案”的药物的各个组分及其质量份比如下所示：
桂枝50g、葛根140g、黄芪300g、知母115g、红花95g、苍术120g、川芎95g、羌活200g、伸筋草200g、鹿衔草260g、当归120g、木瓜95g、川牛膝95g、延胡索120g、没药200g、防风95g、丹参120g、赤芍95g、桃仁120g、丝瓜络120g、续断200g。
一种治疗颈椎病的丸剂药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质、粉尘、干燥及灭菌后，按照质量份比共研为极细末待用；
B、按照传统制备中药水丸剂的方法，将研磨好的极细末药物过筛后，放入药器中混合拌均，然后制备成水丸剂（其水丸的粒度为：3.8mm～4.0mm），进而晒干，分装密封即可。
一种治疗颈椎病的丸剂药物及其制备方法，其特征在于，所述服用方法为：将制备好的水丸剂药物以每日三次服用，早中晚各服一次，给药量5g /次，温开水送服。30天为一个疗程，服药2～5个疗程，症状消失，病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
桂枝，性味：辛、甘、性温，具有散寒解表、温通经脉、通阳化气之功效，用于治疗风寒表证、寒湿痹痛、四肢厥冷、经闭痛经、癥瘕结块、胸痹、心悸、痰饮、小便不利；
葛根，性味： 甘、辛、平，具有解肌退热、发表透诊、生津止渴、升阳止泻之功效，用于治疗外感发热、头项强痛、麻疹初起、疹出不畅、温病口渴、消渴病、泄泻、痢疾、高血压、冠心病；
黄芪，性味：甘、微温，具有补气固表、利尿托毒、排脓、敛疮生肌之功效，用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病；
知母，性味：味苦、性寒，具有清热泻火、滋阴润燥、止渴除烦之功效，用于治疗温热病、高热烦渴、咳嗽气喘、燥咳、便秘、骨蒸潮热、虚烦不眠、消渴淋浊；
红花，性味：味辛、性温，具有活血能经、祛瘀止痛之功效，用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症；
苍术，性味：辛苦、温，具有健脾、燥湿、解郁、辟秽之功效，用于治疗湿盛困脾、倦怠嗜卧、脘痞腹胀、食欲不振、呕吐、泄泻、痢疾、疟疾、痰饮、水肿、时气感冒、风寒湿痹、足痿、夜盲等症；
川芎，性味：辛、温，具有行气开郁、法风燥湿、活血止痛之功效，用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛；
羌活，性味：辛苦、温，具有散表寒、祛风湿、利关节之功效，用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒；
伸筋草，性味：苦、辛、温、平，无毒，具有祛风散寒、除湿消肿、舒筋活血、止咳、解毒之功效，用于治疗风寒湿痹、关节酸痛、皮肤麻木、四肢软弱、水肿、跌打损伤、黄疸、咳嗽、疮疡、疱疹、烫伤；
鹿衔草，性味：甘、苦、性温，具有补肾强骨、祛风除湿、止咳、止血之功效，用于治疗肾虚腰痛、风湿痹痛、筋骨痿软、新久咳嗽、吐血、衄血、崩漏、外伤出血；
当归，性味：性温、味甘辛, 具有补血和血、调经止痛、润燥滑肠之功效，用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤；
木瓜，性味：酸、温，具有舒筋活络、和胃化湿之功效，用于治疗风湿痹痛、肢体酸重、筋脉拘挛、吐泻转筋、脚气水肿；
川牛膝，性味：甘、微苦、性平, 具有活血祛瘀、祛风利湿之功效，用于治疗血瘀经闭、难产、胞衣不下、产后瘀血腹痛、热淋、石淋、痛经、风湿腰膝疼痛；
延胡索，性味：辛苦、温，具有活血、散瘀、理气、止痛之功效，用于治疗心腹腰膝诸痛、月经不调、症瘕、崩中、产后血晕、恶露不尽、跌打损伤；
没药，性味：苦，平，具有散瘀止痛，外用消肿生肌之功效，用于治疗跌打淤血肿痛、痈疽肿痛、胸腹诸痛，外用治疮口久不收敛等症；
防风，性味：辛、甘、温，具有解表祛风、胜湿、止痉之功效，用于治疗感冒头痛、风湿痹痛、风疹瘙痒、破伤风；
丹参，性味：味苦、性微寒，具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效，用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、症瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒；
赤芍，性味：苦、微寒，具有清热凉血、活血祛瘀之功效，用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤；
桃仁，性味：苦甘、平，无毒，具有破血行瘀、润燥滑肠之功效，用于治疗经闭、癥瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘；
丝瓜络，性味：味苦、性凉，具有通经活络、解毒消肿之功效，用于治疗胸胁疼痛、风湿痹痛、经脉拘挛、乳汁不通、肺势咳嗽、痈前程疮毒、他痈等症；
续断，性味：味苦、辛、性微温，具有补肝肾、强筋骨、调血脉、止崩漏之功效，用于治疗腰背酸痛、肢节痿痹、跌扑创伤、损筋折骨、胎动漏红、血崩、遗精、带下、痈疽疮肿。
本发明药物是基于中医治疗颈椎病的原则，从依据颈椎病的病理机制及药理作用认为：就颈椎病，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述颈椎病的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗颈椎病的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝50g、葛根140g、黄芪300g、知母115g、红花95g、苍术120g、川芎95g、羌活200g、伸筋草200g、鹿衔草260g、当归120g、木瓜95g、川牛膝95g、延胡索120g、没药200g、防风95g、丹参120g、赤芍95g、桃仁120g、丝瓜络120g、续断200g。
实施例2：
一种治疗颈椎病的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝60g、葛根160g、黄芪330g、知母130g、红花105g、苍术140g、川芎105g、羌活230g、伸筋草230g、鹿衔草280g、当归140g、木瓜105g、川牛膝105g、延胡索140g、没药220g、防风105g、丹参140g、赤芍105g、桃仁140g、丝瓜络140g、续断220g。
实施例3：
一种治疗颈椎病的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝70g、葛根180g、黄芪380g、知母150g、红花120g、苍术160g、川芎120g、羌活260g、伸筋草260g、鹿衔草320g、当归160g、木瓜120g、川牛膝120g、延胡索160g、没药250g、防风120g、丹参160g、赤芍120g、桃仁160g、丝瓜络160g、续断250g。
典型病例
经临床诊断治疗颈椎病患者共1400例，年龄为53岁以上的765例，只有635例为53岁以下。1400例患者中痊愈的1325例，有效的75例，总有效率达100%。

Claims (3)

1.一种治疗颈椎病的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝20～70g、葛根80～180g、黄芪100～380g、知母60～150g、红花50～120g、苍术80～160g、川芎50～120g、羌活100～260g、伸筋草150～260g、鹿衔草150～320g、当归80～160g、木瓜50～120g、川牛膝60～120g、延胡索80～160g、没药50～250g、防风50～120g、丹参80～160g、赤芍60～120g、桃仁80～160g、丝瓜络50～160g、续断100～250g。
2.根据权利要求1所述的治疗颈椎病的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝30～60g、葛根90～160g、黄芪115～330g、知母70～130g、红花60～105g、苍术90～140g、川芎60～105g、羌活115～230g、伸筋草170～230g、鹿衔草170～280g、当归90～140g、木瓜60～105g、川牛膝70～105g、延胡索90～140g、没药60～220g、防风60～105g、丹参90～140g、赤芍70～105g、桃仁90～140g、丝瓜络60～140g、续断115～220g。
3.根据权利要求1至2所述的治疗颈椎病的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
桂枝50g、葛根140g、黄芪300g、知母115g、红花95g、苍术120g、川芎95g、羌活200g、伸筋草200g、鹿衔草260g、当归120g、木瓜95g、川牛膝95g、延胡索120g、没药200g、防风95g、丹参120g、赤芍95g、桃仁120g、丝瓜络120g、续断200g。
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