CN107158187A - 心脏贴 - Google Patents

心脏贴 Download PDF

Info

Publication number
CN107158187A
CN107158187A CN201710584046.6A CN201710584046A CN107158187A CN 107158187 A CN107158187 A CN 107158187A CN 201710584046 A CN201710584046 A CN 201710584046A CN 107158187 A CN107158187 A CN 107158187A
Authority
CN
China
Prior art keywords
radix
eexternal
blood
chinese medicine
stasis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710584046.6A
Other languages
English (en)
Inventor
邹金樑
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201710584046.6A priority Critical patent/CN107158187A/zh
Publication of CN107158187A publication Critical patent/CN107158187A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

本发明涉及一种改善心脉痹阻的症状的外用中药贴剂，其是由重量配比为：红景天10‑30、西洋参5‑25、柴胡5‑15、甘草3‑12、当归5‑25、红花5‑25、赤芍6‑18、血竭6‑18、川芎5‑15、安息香5‑15、苏合香5‑15、薄荷脑5‑25的原料经过科学的提取和加工制备而成的。该贴剂通过透皮吸收给药，避免了药物对消化道及胃肠的刺激，减轻了肝脏与肾脏的负担，并且给药方便，药物起效快，能迅速缓解心脉痹阻症状发作时的心悸、疲劳、胸憋、胸闷、肩背串疼、呼吸困难等症状，有效预防心肌梗塞引起的突发性死亡，改善患者的生活质量。

Description

心脏贴
技术领域
本发明涉及一种改善心脉痹阻的症状的外用中药贴剂，属于中药技术领域。
背景技术
心脉痹阻证是由于各种致病因素，导致心脏脉络痹阻不通而出现的以心悸、心痛、痛引肩背为主的证候。常见有以下四个证型。瘀血内阻型：多因阳气不足，或气机阻滞，血运迟缓，血滞成瘀，瘀阻心脏脉络所引起的心胸剌痛，固定不移，口唇紫暗等证候。痰湿困遏型：胸阳不足，气化失司，水湿内停，湿聚成痰，或因嗜食肥甘，导致痰湿停聚，阻遏胸阳，心脉不通而出现心胸闷痛，痰多乏力，头身困重的症状。寒邪凝滞型：寒邪内侵，困遏胸阳或胸阳不足，阴寒凝滞，气血运行不畅，心脉不通而出现的心痛剧烈，畏寒肢冷的症状。气机郁结型：情志不畅，肝气郁结，气机阻滞，心脉不通，故出现心胸胀痛，善叹息，随情志变化而症状增减等证候。
在临床上，中医在治疗心脉痹阻证时，会根据病人不同的症型来给与不同的处方用药，如瘀血内阻型，治疗宜活血化瘀，理气止痛，方用血府逐瘀汤(《医林改错》)，王清任认为：“立血府逐瘀汤，治胸中血府血瘀之症”；痰湿困遏型，治疗宜宣通胸阳，化痰通络，方用瓜蒌薤白半夏汤(《金匮要略》)，张仲景认为：“胸痹不得卧，心痛彻背者，瓜蒌楼薤白半夏汤主之”；寒邪凝滞型，治疗宜温经散寒，宣通胸阳，方用瓜蒌薤白白酒汤合乌头赤石脂汤(《金匮要略》)；气机郁结型，治疗宜理气开郁，活血止痛，方用复元活血汤(《医学发明》)。然而对于不同病人要准确的辩证分型并不是一件容易的事，而且这些药物都是口服用药，煎煮、服药麻烦，而心脉痹阻证的病人一般都已经患病较久，也需要较长期的用药，汤药和看病对于病人很不方便。为了解决上述问题，急需研究出一种各种症型的心脉痹阻证病人都能使用的方便的药物。然而适合各种症型用的药物并不是将所有药物的简单叠加，而是需要精心组方，才能使其中的药物都充分发挥起作用，达到最佳的疗效。
外用给药，使药物透皮吸收是中药的新技术。采用该技术能将药力直接渗透到病灶部位，大大缩减了药物在体内的运行时间，减少了药物对其他脏器的损伤，所以见效快，迅速缓解心脏不适等症状，故非常适用于心肌缺血、动脉硬化、心肌炎、心肌梗塞、窦性心律失常、心律不齐、心动过速、心动过缓等具有心脉痹阻证的人群。
并且将原来内服的药物改成外用的药物也不是简单的剂型转换，这是由于有些口服药物可能引起皮肤过敏，或者有难闻的气味，或是其有效成分并不能通过皮肤有效的吸收，这些都是需要克服的技术问题。
发明内容
为解决现有技术中存在的技术问题，本发明提供一种改善心脉痹阻的症状的外用中药贴剂及其制备方法，以实现以下发明目的：
该贴剂通过透皮吸收给药，避免了药物对消化道及胃肠的刺激，减轻了肝脏与肾脏的负担，并且给药方便，药物起效快，能迅速缓解心脉痹阻症状发作时的心悸、疲劳、胸憋、胸闷、肩背串疼、呼吸困难等症状，有效预防心肌梗塞引起的突发性死亡，改善患者的生活质量。
并且发明人通过临床大量观察和实验，虽然辨证施治的治疗效果会更加显著，但临床上发现瘀血内阻型、痰湿困遏型、寒邪凝滞型、气机郁结型这四种不同症型的心脉痹阻患者虽然各自最严重的病因可能有所不同，但在临床上患者常兼具不同症型，不能决然区分开，而且有时还难以确定最主要症型。由于分型辩治需要具有丰富经验的医师来操作，这对广大突发疾病或不便就医的患者带来极大的不便。然而并不是将针对不同症型的药物简单混合就可以达到对各种症型病人理想的治疗效果的，因此在确定能同时适用于多种症型患者的组方时，仍需要合理确定组方的君臣佐使，以及药物之间的配伍。例如祛寒湿的药物不一定有利于活血化瘀，而行气的药物也不一定有利于祛寒湿，因此发明人通过许多临床病例和反复实验才得出了本申请的处方，使其能广泛适用于不同症型的心脉痹阻患者。
为解决上述技术问题，本发明采取的技术方案如下：
一种改善心脉痹阻的症状的外用中药贴剂，其是由下述重量配比的原料制成的：红景天10-30、西洋参5-25、柴胡5-15、甘草3-12、当归5-25、红花5-25、赤芍6-18、血竭6-18、川芎5-15、安息香 5-15、苏合香5-15、薄荷脑5-25。
优选地，所述外用中药贴剂是由下述重量配比的原料制成的：红景天15-25、西洋参10-20、柴胡6-12、甘草5-10、当归10-20、红花10-20、赤芍8-16、血竭8-16、川芎6-12、安息香6-12、苏合香6-12、薄荷脑10-20。
更优选地，所述的外用中药贴剂是由下述重量配比的原料制成的：红景天20、西洋参15、柴胡10、甘草6、当归15、红花15、赤芍12、血竭12、川芎10、安息香10、苏合香10、薄荷脑15。
一种改善心脉痹阻的症状的外用中药贴剂的制备方法，包括下述步骤：
a)称取指定重量的红景天、西洋参、柴胡、甘草、当归、红花、赤芍、川芎，混合，粉碎，提取两次，每次用药材重量5-10倍的水提取，将提取液混合，减压浓缩后，加入乙醇至乙醇浓度为70％，过滤，除去沉淀，取上清液，再次浓缩制成浸膏A，
b)称取指定重量的血竭、安息香、苏合香混合，粉碎，提取两次，每次用药材重量5-10倍的50-80％的乙醇水溶液提取，将提取液混合，减压浓缩成浸膏B，
c)称取指定重量的薄荷脑，粉碎，得粉末C，
d)将浸膏A、浸膏B、粉末C加入到制备外用贴剂的基质中，充分混合，搅拌均匀；制备贴剂。
所述的外用中药贴剂用于改善心脉痹阻症状的用途。
所述的心脉痹阻症状包括心悸、疲劳、胸憋、胸闷、肩背串疼、呼吸困难等；心脉痹阻还可以是包括瘀血内阻型、痰湿困遏型、寒邪凝滞型、气机郁结型。
所述的外用中药贴剂用于预防心肌梗塞引起的突发性死亡。
本发明的外用心脏贴的使用方法，使用时贴于心前区，左乳下心。

Claims (8)

1.一种改善心脉痹阻的症状的外用中药贴剂，其是由下述重量配比的原料制成的：红景天10-30、西洋参5-25、柴胡5-15、甘草3-12、当归5-25、红花5-25、赤芍6-18、血竭6-18、川芎5-15、安息香5-15、苏合香5-15、薄荷脑5-25。
2.根据权利要求1所述的外用中药贴剂，其是由下述重量配比的原料制成的：红景天15-25、西洋参10-20、柴胡6-12、甘草5-10、当归10-20、红花10-20、赤芍8-16、血竭8-16、川芎6-12、安息香6-12、苏合香6-12、薄荷脑10-20。
3.根据权利要求2所述的外用中药贴剂，其是由下述重量配比的原料制成的：红景天20、西洋参15、柴胡10、甘草6、当归15、红花15、赤芍12、血竭12、川芎10、安息香10、苏合香10、薄荷脑15。
4.一种权利要求1-3任一项的改善心脉痹阻的症状的外用中药贴剂的制备方法，包括下述步骤：
a)称取指定重量的红景天、西洋参、柴胡、甘草、当归、红花、赤芍、川芎，混合，粉碎，提取两次，每次用药材重量5-10倍的水提取，将提取液混合，减压浓缩后，加入乙醇至乙醇浓度为70％，过滤，除去沉淀，取上清液，再次浓缩制成浸膏A，
b)称取指定重量的血竭、安息香、苏合香混合，粉碎，提取两次，每次用药材重量5-10倍的50-80％的乙醇水溶液提取，将提取液混合，减压浓缩成浸膏B，
c)称取指定重量的薄荷脑，粉碎，得粉末C，
d)将浸膏A、浸膏B、粉末C加入到制备外用贴剂的基质中，充分混合，搅拌均匀；制备贴剂。
5.权利要求4的方法所制备的外用中药贴剂用于改善心脉痹阻症状的用途。
6.权利要求5所述的用途，其特征在于心脉痹阻症状包括心悸、疲劳、胸憋、胸闷、肩背串疼、呼吸困难等。
7.权利要求1所述的外用中药贴剂用于预防心肌梗塞引起的突发性死亡。
8.权利要求5所述的用途，其特征在于心脉痹阻包括瘀血内阻型、痰湿困遏型、寒邪凝滞型、气机郁结型。
CN201710584046.6A 2017-07-18 2017-07-18 心脏贴 Pending CN107158187A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710584046.6A CN107158187A (zh) 2017-07-18 2017-07-18 心脏贴

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710584046.6A CN107158187A (zh) 2017-07-18 2017-07-18 心脏贴

Publications (1)

Publication Number Publication Date
CN107158187A true CN107158187A (zh) 2017-09-15

Family

ID=59816991

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710584046.6A Pending CN107158187A (zh) 2017-07-18 2017-07-18 心脏贴

Country Status (1)

Country Link
CN (1) CN107158187A (zh)

Similar Documents

Publication Publication Date Title
CN102988821B (zh) 一种治疗癌病手术、化疗、放疗后的中药组合物及其制备方法
CN101612349B (zh) 治疗冠心病的药物
CN104940810A (zh) 一种治疗心绞痛的中药组合物
CN103599483A (zh) 一种治疗冠心病的中药配方
CN102133288B (zh) 治疗心绞痛的中药制剂
CN102988887A (zh) 一种治疗卵巢囊肿的中药
CN103007214B (zh) 一种治疗心悸的中药组合物
CN104606561A (zh) 一种治疗自汗的中药组合物
CN102526189B (zh) 一种治疗冠心病心绞痛的中药组合物
CN103798472B (zh) 一种保健茶及保健养生制剂
CN105362797A (zh) 一种治疗心肌炎的中药
CN103550477B (zh) 一种治疗带状疱疹的药剂
CN107158187A (zh) 心脏贴
CN104888133A (zh) 一种治疗冠心病的中药组合物
CN104117018A (zh) 一种治疗冠心病的中药组合物
CN105079438B (zh) 一种治疗病毒性心肌炎的药物制剂
CN103736051A (zh) 一种血管瘤护理药物及其制作方法
CN110841007B (zh) 一种治疗脑中风后遗症的中药组合物及其应用
CN108096433A (zh) 治疗老年性冠心病气虚血瘀证的中药胶囊及其制备方法
CN101983712A (zh) 冠心病的新型治疗药物
CN107669836A (zh) 冠心病心绞痛用中药配方及其制备方法
CN107213219A (zh) 治疗心脑血管疾病的中药配方
CN108310207B (zh) 一种治疗心力衰竭的药物组合物及其制备方法
CN105434890A (zh) 一种治疗放射性口腔炎的中药组合物
CN104826080A (zh) 一种治疗心绞痛的中药制剂

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170915