CN107669836A - 冠心病心绞痛用中药配方及其制备方法 - Google Patents

冠心病心绞痛用中药配方及其制备方法 Download PDF

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CN107669836A
CN107669836A CN201710819922.9A CN201710819922A CN107669836A CN 107669836 A CN107669836 A CN 107669836A CN 201710819922 A CN201710819922 A CN 201710819922A CN 107669836 A CN107669836 A CN 107669836A
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赵书铭
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Abstract

本发明公开了一种冠心病心绞痛用中药配方，按重量份数是包括以下中药成分：当归13g，三七13g，丹参13g，石菖蒲13g，党参28g，黄芪28g，酸枣仁18g，炙甘草5~13g。本发明中药组合物的制备和使用方法：先将药材用冷水浸泡1小时，浸泡的水量以淹没药面3cm为宜，将药放在火上，用武火熬开，沸腾后改用文火保持微沸状态，第一次煎煮30分钟，将药液倒出，第二次煎煮加入以刚淹没药渣2cm的热水，煎煮30分钟，将药液倒出，将2次药液混合得1剂，每天1剂，早晚温服，2周为1个疗程。

Description

冠心病心绞痛用中药配方及其制备方法
技术领域
本发明属于中药组合物，具体地说，是涉及一种冠心病心绞痛用中药配方及其制备方法。
背景技术
冠心病心绞痛是指由于冠状动脉硬化或痉挛导致心肌缺血、缺氧所引起的心 绞痛，约占心绞痛患者的90％。该病为一种较常见的心血管疾病，中老年人为 高发人群，是世界上发达国家人口中最常见的死亡原因，也是我国近二十年来人 口的主要死因，已经成为威胁人类健康的主要疾病之一。冠心病心绞痛以前多发 于中老年患者，随着社会的发展，生活水平的提高，其发病年龄趋于年轻化。因 此，冠心病的发病率趋向提高之势，防治任务十分沉重，已引起国内外关注。随 着现代科学技术的发展，人们对冠心病的诊断和防治也取得了一些进展，如在检 查方面，由原来的常规心电图、负荷心电图检查，更新到动态心电图、超声心动 检查术、冠脉造影、电子束CT机的应用、生化检查和心功能测定方法也在不断改进，为早期诊断提供了良好的手段，在防治方面，建立了包括冠脉侧支循环和 冠状动脉搭桥术等，约物治疗方面，在扩张冠脉的基础上(硝酸酯、亚硝酸酯类)， 出现了钙离子拮抗剂、β-受体阻滞剂、溶栓约物的应用，为治疗冠心病心绞痛 提供了多种手段。然而临床实践表明，单纯西药治疗只治标不治本，尤其是药物 的副作用，使患者难以接受和长期服用。
冠心病心绞痛，属于中医学“胸痹心痛”的范畴，其发生多与年老体虚、饮食不当、寒邪内侵、情志失调等因素有关。《金匮要略•胸痹心痛短气病》指出胸痹心痛的病因病机为“阳微阴弦，即胸痹而痛，所以然者。责其极虚也。今阳虚在上焦，所以胸痹心痛者。以其阴弦故也。”其明确的指出该病是胸阳极虚，阴寒之邪痹阻产生的正虚邪实证。”《素问•经脉》云：“气绝则脉不通，脉不通则血不流。”王清任《医林改错》中指出 ：“元气既虚，必不能达于血管，血管无气必停留为瘀”，“运血者，气也”，“血不自行，随气而行。”这些理论提示了气虚血瘀是胸痹的基本病机。心主血脉，赖心气以推动，心气不足，无力推动血脉运行，则血脉缓慢血脉瘀阻心脉不通，不通则痛，发为本病。目前中医药的治病方案多从益气活血、益气养阴、活血化瘀、化痰祛瘀、宣痹通阳、理气化瘀法等方面。
随着中医药现代化进程的强势推进，国家投入大量的人力、物力进行相应的基础理论的研究，由此使得中药制剂在治疗冠心病心绞痛疗效方面有了显著的提高。目前一般的制药材料为檀香，但由于檀香取材困难，价格昂贵，增加了治疗成本。而且治疗效果也不显著。
发明内容
本发明针对现有技术中的不足之处，提供一种配制简便、成本低、疗效显著、无副作用的冠心病心绞痛用中药配方及其制备方法。
为了实现上述发明目的，本发明制成该药物有效成分的原料组成及其重量配比为：当归13g，三七13g，丹参13g，石菖蒲13g，党参28g，黄芪28g，酸枣仁18g，炙甘草5~13g。
本发明中药组合物的制备和使用方法：先将药材用冷水浸泡1小时，浸泡的水量以淹没药面3cm为宜，将药放在火上，用武火熬开，沸腾后改用文火保持微沸状态，第一次煎煮30分钟，将药液倒出，第二次煎煮加入以刚淹没药渣2cm的热水，煎煮30分钟，将药液倒出，将2次药液混合得1剂，每天1剂，早晚温服，2周为1个疗程。
发明用于治疗冠心病心绞痛的中药配方，选择天然药物，针对冠心病心痛病因病机，各味药材各具其效，互相协调，党参、黄芪温补阳气，气旺血自行；当归、三七、丹参化瘀活血止痛；石菖蒲化痰开窍；酸枣仁安神养心；炙甘草益气健脾，缓急止痛；诸药合用，能达益气通痹的功效。
具体实施方式
实施例1：一种治疗冠心病心绞痛的中药配方，按重量份数包括以下中药成分：当归13g，三七13g，丹参13g，石菖蒲13g，党参28g，黄芪28g，酸枣仁18g，炙甘草5~13g。
实施例2：如果患者血虚，在上述组分中加川芎13g，白芍13g，龙眼肉13g。
实施例3：如果患者心阳虚，在上述组分中加制附子13g，吴茱萸13g，肉桂13g。
实施例4：如果患者心阴虚，在上述组分中加麦冬13g，天冬13g，生地黄13g，太子参28g。
实施例5：如果患者胸闷痰多，在上述组分中加橘红18g，瓜蒌，13g，半夏13g。
先将药材用冷水浸泡1小时，浸泡的水量以淹没药面3cm为宜，将药放在火上，用武火熬开，沸腾后改用文火保持微沸状态，第一次煎煮30分钟，将药液倒出，第二次煎煮加入以刚淹没药渣2cm的热水，煎煮30分钟，将药液倒出，将2次药液混合得1剂，每天1剂，早晚温服，2周为1个疗程。
以下通过实用例来阐明本发明所述用于治疗冠心病心绞痛的中药配方的临床治疗效果。
1、临床资料
治疗病患133例，其中男性82例，女性51例，年龄在18岁-77岁之间，平均50.3±3.9 岁，病程为2周-23年，平均9.1±4.7年，诊断标准冠心病心绞痛的诊断参照《不稳定性心绞痛和非ST段抬高心肌梗死诊断 和治疗指南》(2007)及《慢性稳定性心绞痛诊断和治疗指南》(2007)、《中医心病诊断 疗效标准和用药规范》(2002)中的相关标准，痰浊闭阻证型的辨证参照《中医内科学》中 胸痹痰浊闭阻证的标准及《中医心病诊断疗效标准和用药规范》(2002)中的标准进行自拟。
2、疗效标准
显效：治疗后心绞痛消失或基本消失(每周发作不多于2次)，基本不用硝酸盐类药物者；
有效：治疗后心绞痛改善一度，即重度变中度，中度变轻度，轻度明显减轻而未达显效标准， 硝酸盐类药物减用一半以上者；
无效：治疗后心绞痛、硝酸盐类药物用量无改变或虽有所减少但未达到有效程度者；
加重：治疗后心绞痛发作次数、程度及持续时间增剧，硝酸盐类药物用量增加者。
3、治疗结果
心绞痛患者的临床症状改善总有效率为 93.98％，其中显效33例，约24.81％，有效92例，约69.17％，无效6例，约4.51％，加重2例，约1.51％。
典型案例：
谢某，男，72岁。患者冠心病13年，近几年发作逐渐次数增多，从每年发作一次二次，近几年每年发作5-6次，逐渐症状加重，近几个月来胸闷气短，胸部有紧束感，压迫感，每天发作2-4次，每次持续1-10分钟左右，高血压。于4月13日来诊治，改用中药治疗，经检查：心电图显示广泛性心肌缺血，结合病史，病症，心电图等诊断为冠心病、心绞痛、心内膜下心肌梗塞。治疗服用治疗冠心病、心绞痛的中药配方，1周后自觉症状减轻，治疗6个疗程后，心脏病症状消失，治愈，高血压几乎正常。

Claims (6)

1.一种冠心病心绞痛用中药配方，其特征在于：该中药配方按重量份数包括以下中药成分：当归13g，三七13g，丹参13g，石菖蒲13g，党参28g，黄芪28g，酸枣仁18g，炙甘草5~13g。
2.如权利要求1所述的冠心病心绞痛用中药配方，其特征在于：该中药配方还包括川芎13g，白芍13g，龙眼肉13g。
3.如权利要求1所述的冠心病心绞痛用中药配方，其特征在于：该中药配方还包括制附子13g，吴茱萸13g，肉桂13g。
4.如权利要求1所述的冠心病心绞痛用中药配方，其特征在于：该中药配方还包括麦冬13g，天冬13g，生地黄13g，太子参28g。
5.如权利要求1所述的冠心病心绞痛用中药配方，其特征在于：该中药配方还包括橘红18g，瓜蒌，13g，半夏13g。
6.如权利要求1所述的冠心病心绞痛用中药配方的制备方法，其特征在于：先将药材用冷水浸泡1小时，浸泡的水量以淹没药面3cm为宜，将药放在火上，用武火熬开，沸腾后改用文火保持微沸状态，第一次煎煮30分钟，将药液倒出，第二次煎煮加入以刚淹没药渣2cm的热水，煎煮30分钟，将药液倒出，将2次药液混合得1剂，每天1剂，早晚温服，2周为1个疗程。
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