CN107149637A - One kind is used for children's bacteriostatic gel and preparation method thereof - Google Patents
One kind is used for children's bacteriostatic gel and preparation method thereof Download PDFInfo
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- CN107149637A CN107149637A CN201710307637.9A CN201710307637A CN107149637A CN 107149637 A CN107149637 A CN 107149637A CN 201710307637 A CN201710307637 A CN 201710307637A CN 107149637 A CN107149637 A CN 107149637A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
One kind is used for children's bacteriostatic gel and preparation method thereof, and every kilogram of bacteriostatic gel is made up of following raw material：The 50g of kuh-seng 10, the 50g of chrysanthemum 10, the 50g of honeysuckle 10, asparagus juice（Fresh goods）100 350g, the 25g of folium artemisiae argyi 10, the 25g of peppermint 10, the 25g of schizonepeta 10, the 5g of borneol 1, the 10ml of spearmint oil 1, the 1.0g of ethylparaben 0.1, glycerine 50 100 ml, Carbomer940 10 20g, the 40g of triethanolamine 5, surplus pure water.Bacteriostatic gel of the present invention is nonirritant to skin and mucous membrane, will not cause allergic.The preparation technology of the antibacterial Native Gel agent of the present invention is simple, without large number quipments, only needs extraction equipment, Extraction solvent is pollution-free.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of bacteriostatic gel and preparation method thereof.
Background technology
Eczema is the scytitis as caused by various internal and external factors, symmetrical with fash diversity, violent itch, instead
Recurrence is made, and easily develops into chronic character, can betide any age, any position, any season, but often recur later in the winter time
Or aggravation.The morbidity of eczema is in rising trend in recent years, and this may be with Climate and Environment Variation, and a large amount of chemicals are in life
Using nervous, rhythm of life is accelerated, and dietary structure, which changes, relation.
Occur that fash person is rather common in pediatric disease, situation is complex, because of the particularity of children, contained gel component
Security be crucial.
The content of the invention
Goal of the invention:
It is an object of the invention to overcome the deficiencies of the prior art and provide it is a kind of be suitable for that children use without hormone and
The safe Native Gel agent of toxic component.
Technical scheme:
Every kilogram of bacteriostatic gel is made up of following raw material in the present invention：Kuh-seng 10-50g, chrysanthemum 10-50g, honeysuckle 10-
50g, asparagus juice (fresh goods) 100-350g, folium artemisiae argyi 10-25g, peppermint 10-25g, schizonepeta 10-25g, borneol 1-5g, spearmint oil 1-
10ml, ethylparaben 0.1-1.0g, glycerine 50-100ml, Carbomer940--10-20g, triethanolamine 5-40g, surplus are pure
Water purification.
It is preferred that the present invention in every kilogram of bacteriostatic gel be made up of following raw material：Kuh-seng 10-20g, chrysanthemum 10-20g, gold and silver
Flower 10-20g, asparagus juice (fresh goods) 100-200g, folium artemisiae argyi 10-20g, peppermint 1-20g, schizonepeta 1-20g, borneol 1-3g, spearmint
Oily 1-5ml, ethylparaben 0.2-0.5g, glycerine 50-70ml, Carbomer940--15-20g, triethanolamine 15-20g are remaining
Measure pure water.
Most preferably every kilogram of bacteriostatic gel is made up of following raw material in the present invention：One kind according to claim 1
For children's bacteriostatic gel, it is characterised in that every kilogram of bacteriostatic gel is made up of following raw material：Kuh-seng 20g, chrysanthemum 20g, gold
Honeysuckle flower 20g, asparagus juice (fresh goods) 110g, folium artemisiae argyi 20g, peppermint 15g, schizonepeta 15g, borneol 2g, spearmint oil 3ml, nipalgin second
Ester 0.3g, glycerine 70ml, Carbomer940--16g, triethanolamine 18g, surplus pure water.
It is suitable for the peace without hormone and toxic component that children use it is another object of the present invention to provide a kind of
The preparation method of All Pure Nature gel, step is as follows：
Carbomer940 is added in pure water, adds glycerine, obtains 5-12% solution, standby；Folium artemisiae argyi, peppermint, chaste tree
1. mustard, kuh-seng, chrysanthemum, honeysuckle add ethanol extraction filtrates；Borneol, ethylparaben, which are added in ethanol, to be dissolved, then Jia Liulan
2. sesame oil, obtain liquid；Fresh aloe juice will 1. and be 2. mixed and added into, resulting solution is dispersed in solution, triethanolamine be added afterwards, i.e.,
.It is preferred that, the preparation method of the safe Native Gel agent without hormone and toxic component of the invention used together in children,
Step is as follows：
1) recipe quantity Carbomer940 is taken to be added in pure water, aquation allows it to be fully swelled, and 5-12% is made
Carbomer940 solution；
2) glycerine of recipe quantity is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) folium artemisiae argyi, peppermint, schizonepeta of recipe quantity are taken, 75% addition folium artemisiae argyi, peppermint, 9 times of amount ethanol of schizonepeta, 70- is added
90 DEG C of backflow 1-2h, filtering, the collecting amount of filtrate is folium artemisiae argyi, peppermint, 3.5~4 times of schizonepeta, filtrate is standby；
4) 3) dregs of a decoction are merged with the kuh-seng, chrysanthemum, honeysuckle of recipe quantity, adds kuh-seng, chrysanthemum, 12 times of amounts of gold and silver flower pesticide
75% ethanol, 70-90 DEG C backflow 1-2h, filtering, collect extract solution, separately deposit.Add kuh-seng, chrysanthemum, honeysuckle in the dregs of a decoction again
75% ethanol of 10 times of amounts, 70-90 DEG C of backflow 0.5-1.5h, filtering discards the dregs of a decoction, merges extract solution, standby；
5) by 4) extract solution at 50-70 DEG C, vacuum distillation 0.5-1.5h, to without alcohol taste, filtering, filtrate collecting amount is hardship
Ginseng, chrysanthemum, 3.5~4 times of amounts of honeysuckle, it is standby.
6) 20ml of 95% ethanol is taken, is added after borneol, the ethylparaben of recipe quantity, stirring and dissolving, is added and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；Fresh aloe juice is added, is stirred well；Add 6), disperse equal
After even, the triethanolamine of recipe quantity is eventually adding, after fully stirring well, recipe quantity is added water to, stirs well, produce.
It is preferred that, step 7) in, to when adding 5) in 2), addition should want on a small quantity, multiple, side edged stir in 2), stir well.
Kuh-seng of the present invention, chrysanthemum, honeysuckle, asparagus juice (fresh goods), folium artemisiae argyi, peppermint, schizonepeta, borneol, spearmint
Oil is treatment eczema active ingredient.
Carbomer940 is gel-type vehicle, glycerine as gel-type vehicle NMF.
Triethanolamine is pH adjusting agent, adjusts gel-type vehicle viscosity.
Advantageous effect:
Inventive gel agent matrix flow is suitable, be easy to painting opens up, good with skin affinity, with natural botanical extraction liquid phase
Capacitive is good.
Bacteriostatic gel of the present invention is nonirritant to skin and mucous membrane, will not cause allergic.
The preparation technology of the antibacterial Native Gel agent of the present invention is simple, without large number quipments, only needs extraction equipment, Extraction solvent
It is pollution-free.
Embodiment:
Embodiment 1
1) 10g carbomers (Carbomer) 940 are taken to be added in 200ml pure water, aquation allows it to be fully swelled, and is made
5%Carbomer940 solution；
2) 50ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) schizonepeta of 10g folium artemisiae argyi, 10g peppermint and 10g is taken respectively, adds 75% ethanol 270ml, 70 DEG C of backflows
2h, filtering, filtrate collecting amount is 120ml, and filtrate is standby；
4) kuh-seng, chrysanthemum, each 10g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol 360ml, 70 DEG C of backflow 2h are added,
Filtering, collects extract solution, separately deposits.The dregs of a decoction add 75% ethanol 300ml again, and 70 DEG C of backflow 1.5h, filtering discards the dregs of a decoction, merging is carried
Liquid is taken, it is standby.
5) by 4) extract solution at 70 DEG C, vacuum distillation 0.5h, to without alcohol taste, collecting amount is 105ml, standby.
6) 20ml of 95% ethanol is taken, is added after 1g borneols, 0.1g ethylparabens, stirring and dissolving, is added 1ml and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；100g fresh aloe juices are added, are stirred well；Add 6),
After being uniformly dispersed, 5g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 2
1) 10g Carbomer940 are taken to be added in 100ml pure water, aquation allows it to be fully swelled, and is made 10%
Carbomer940 solution；
2) 70ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) schizonepeta of 15g folium artemisiae argyi, 15g peppermint and 15g is taken respectively, adds 75% ethanol 405ml, 70 DEG C of backflows
2h, filtering, collecting amount 180ml, filtrate is standby；
4) kuh-seng, chrysanthemum, each 15g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol 540ml, 70 DEG C of backflow 2h are added,
Filtering, collects extract solution, separately deposits.The dregs of a decoction add 75% ethanol 450ml again, and 70 DEG C of backflow 1.5h, filtering discards the dregs of a decoction, merging is carried
Liquid is taken, it is standby.
5) by 4) extract solution at 50 DEG C, vacuum distillation 1.5h, to without alcohol taste, collecting amount is 158ml, standby.
6) 20ml of 95% ethanol is taken, is added after 2g borneols, 0.3g ethylparabens, stirring and dissolving, is added 5ml and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；110g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 5g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 3
1) 10g Carbomer940 are taken to be added in 85ml pure water, aquation allows it to be fully swelled, and is made 12%
Carbomer940 solution；
2) 100ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) schizonepeta of 25g folium artemisiae argyi, 25g peppermint and 25g is taken respectively, adds 75% ethanol 675ml, 90 DEG C of backflows
1h, filtering, collecting amount is 300ml, and filtrate is standby；
4) 75% ethanol 1800ml, 90 DEG C of backflows are added with adding kuh-seng, chrysanthemum, each 50g of honeysuckle to the 3) dregs of a decoction
1h, filtering is collected extract solution, separately deposited.The dregs of a decoction add 75% ethanol 1500ml again, and 90 DEG C of backflow 0.5h, filtering discards the dregs of a decoction, closed
And extract solution, it is standby.
5) by 4) extract solution at 50 DEG C, vacuum distillation 1h, to without alcohol taste, collecting amount is 525ml, standby.
6) 20ml of 95% ethanol is taken, is added after 5g borneols, 1.0g ethylparabens, stirring and dissolving, is added 5ml and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；150g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 5g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 4
1) 10g Carbomer940 are taken to be added in pure water, aquation allows it to be fully swelled, and is made 8%
Carbomer940 solution；
2) 70ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) 15g folium artemisiae argyi, peppermint, schizonepeta is taken respectively, adds 75% ethanol 405ml, 90 DEG C of backflow 1h, filtering, filtrate
Collecting amount is 180ml, and filtrate is standby；
4) kuh-seng, chrysanthemum, each 20g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol 720ml, 90 DEG C of backflow 1h are added,
Filtering, collects extract solution, separately deposits.The dregs of a decoction add 75% ethanol 600ml again, and 90 DEG C of backflow 0.5h, filtering discards the dregs of a decoction, merging is carried
Liquid is taken, it is standby.
5) by 4) extract solution at 50 DEG C, vacuum distillation 1h, to without alcohol taste, collecting amount is 240ml, standby.
6) 20ml of 95% ethanol is taken, is added after 2g borneols, 0.3g ethylparabens, stirring and dissolving, is added 3ml and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；110g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 5g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 5
1) 20g Carbomer940 are taken to be added in 170ml pure water, aquation allows it to be fully swelled, and is made 12%
Carbomer940 solution；
2) 70ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) 20g folium artemisiae argyis, 15g peppermints, 15g schizonepeta are taken, 75% ethanol 450ml, 90 DEG C of backflow 1h is added, filters, collect
Measure as 200ml, filtrate is standby；
4) kuh-seng, chrysanthemum, each 20g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol 720ml, 90 DEG C of backflow 1h are added,
Filtering, collects extract solution, separately deposits.The dregs of a decoction add 75% ethanol 600ml again, and 90 DEG C of backflow 0.5h, filtering discards the dregs of a decoction, merging is carried
Liquid is taken, it is standby.
5) by 4) extract solution at 50 DEG C, vacuum distillation 1h, to without alcohol taste, collecting amount is 210ml, standby.
6) 20ml of 95% ethanol is taken, is added after 2g borneols, 0.3g ethylparabens, stirring and dissolving, is added 3ml and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；110g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 40g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 6
1) 15g Carbomer940 are taken to be added in 125ml pure water, aquation allows it to be fully swelled, and is made 12%
Carbomer940 solution；
2) 70ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) take 20g folium artemisiae argyis, 15g peppermints, 15g schizonepeta, add 75% ethanol 450ml, 90 DEG C of backflow 1h, collecting amount is
200ml, filtrate is standby；
4) kuh-seng, chrysanthemum, each 20g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol 720ml, 90 DEG C of backflow 1h are added,
Filtering, collects extract solution, separately deposits.The dregs of a decoction add 75% ethanol 600ml again, and 90 DEG C of backflow 0.5h, filtering discards the dregs of a decoction, merging is carried
Liquid is taken, it is standby.
5) by 4) extract solution at 50 DEG C, vacuum distillation 1h, to without alcohol taste, collecting amount is 210ml, standby.
6) 20ml of 95% ethanol is taken, is added after 2g borneols, 0.3g ethylparabens, stirring and dissolving, is added 3ml and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；110g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 30g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 7
1) 16g Carbomer940 are taken to be added in 135ml pure water, aquation allows it to be fully swelled, and is made 12%
Carbomer940 solution；
2) 70ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) 20g folium artemisiae argyis, 15g peppermints, 15g schizonepeta are taken, 75% ethanol 450ml, 90 DEG C of backflow 1h is added, filters, collect
Measure as 175~200ml, filtrate is standby；
4) kuh-seng, chrysanthemum, each 20g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol 720ml, 90 DEG C of backflow 1h are added,
Filtering, collects extract solution, separately deposits.The dregs of a decoction add 75% ethanol 600ml again, and 90 DEG C of backflow 0.5h, filtering discards the dregs of a decoction, merging is carried
Liquid is taken, it is standby.
5) by 4) extract solution at 50 DEG C, vacuum distillation 1h, to without alcohol taste, collecting amount is 210ml, standby.
6) 20ml of 95% ethanol is taken, is added after 2g borneols, 0.3g ethylparabens, stirring and dissolving, is added 3ml and stay orchid
Sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；110g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 18g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 8
1) 16g Carbomer940 are taken to be added in 135ml pure water, aquation allows it to be fully swelled, and is made 12%
Carbomer940 solution；
2) 70ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) take 20g folium artemisiae argyis, 15g peppermints, 15g schizonepeta, add 75% ethanol, the addition of ethanol is folium artemisiae argyi, peppermint and
9 times of mass parts of schizonepeta, 90 DEG C of backflow 1h, filtering, collecting amount is 3.5 times of folium artemisiae argyi, peppermint and schizonepeta quality, and filtrate is standby；
4) kuh-seng, chrysanthemum, each 20g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol is added, amount of alcohol added is hardship
12 times of ginseng, the quality of chrysanthemum and honeysuckle, 90 DEG C of backflow 1h, filtering is collected extract solution, separately deposited.The dregs of a decoction add 75% ethanol again,
Amount of alcohol added be kuh-seng, chrysanthemum, 10 times of honeysuckle, 90 DEG C of backflow 0.5h, filtering discards the dregs of a decoction, merges extract solution, standby.
5) by 4) extract solution at 50 DEG C, vacuum distillation 1h, to without alcohol taste, collecting amount is kuh-seng, chrysanthemum and honeysuckle
It is 3.5 times, standby.
6) 20ml of 95% ethanol is taken, is added after 2g borneols, 0.3g ethylparabens, stirring and dissolving, is added 10ml and stay
Blue sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；350g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 40g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Experimental example 9：
1) 20g Carbomer940 are taken to be added in 135ml pure water, aquation allows it to be fully swelled, and is made 12%
Carbomer940 solution；
2) 80ml glycerine is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) take 15g folium artemisiae argyis, 20g peppermints, 13g schizonepeta, add 75% ethanol, the addition of ethanol is folium artemisiae argyi, peppermint and
9 times of mass parts of schizonepeta, 90 DEG C of backflow 1h, filtering, collecting amount is 4 times of folium artemisiae argyi, peppermint and schizonepeta quality, and filtrate is standby；
4) kuh-seng, chrysanthemum, each 20g of honeysuckle are added into the 3) dregs of a decoction, 75% ethanol is added, amount of alcohol added is hardship
12 times of ginseng, the quality of chrysanthemum and honeysuckle, 90 DEG C of backflow 1h, filtering is collected extract solution, separately deposited.The dregs of a decoction add 75% ethanol again,
Amount of alcohol added be kuh-seng, chrysanthemum, 10 times of honeysuckle, 90 DEG C of backflow 0.5h, filtering discards the dregs of a decoction, merges extract solution, standby
With.
5) by 4) extract solution at 60 DEG C, vacuum distillation 1.5h, to without alcohol taste, collecting amount is kuh-seng, chrysanthemum and honeysuckle
4 times, it is standby.
6) 20ml of 95% ethanol is taken, is added after 2g borneols, 0.3g ethylparabens, stirring and dissolving, is added 10ml and stay
Blue sesame oil, is stirred well, standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；300g fresh aloe juices are added, are stirred well；Add 6), point
After dissipating uniformly, 18g triethanolamine is eventually adding, after fully stirring well, 1000g is added water to, stirs well, produce.
Clinical case
60 eczema patients, are divided into treatment group and each 30 of control group, line number are entered to 60 eczema patients after off-test
According to analysis, total effectses compare such as table 1 before and after treatment
Show that treatment group's curative effect is better than control group through statistical analysis
Skin irritation test
300~400g of weight albino guinea-pigs 12 are taken, male and female half and half are randomly divided into matrix group and tested material group, every group 6
Only.Using consubstantiality left and right sides self-contrast method.First 24 hours of experiment, animal back both sides unhairing is applied to 8%Na2S, after 10 minutes
Scrubbed with gauze, unhairing scope about 3cm × 3cm.Tested material group in hair removal section even application gel 1g/ only, matrix group
In hair removal section even application matrix 1g/ only, covered with sterilization mull, immobilization with adhesive tape of desensitizing after 6 hours, removes gauze temperature
Water cleans skin, observe each cavy remove 1 after tested material, 24,48 and 72 hours when coating part whether there is erythema and oedema, by table
2 skin wound repair standards are scored, and stimulus intensity evaluation is carried out by the skin irritatin intensity evaluation standard of table 3.
The skin wound repair standards of grading of table 2
The skin irritatin intensity evaluation standard of table 3
Skin irritation test result result of the test shows that each time point medicine-feeding part is equal in 72 hours after gel administration
Have no obvious erythema and oedema.It is shown in Table 4
Claims (6)
1. one kind is used for children's bacteriostatic gel, it is characterised in that every kilogram of bacteriostatic gel is made up of following raw material：Kuh-seng 10-
50g, chrysanthemum 10-50g, honeysuckle 10-50g, asparagus juice (fresh goods) 100-350g, folium artemisiae argyi 10-25g, peppermint 10-25g, schizonepeta
10-25g, borneol 1-5g, spearmint oil 1-10ml, ethylparaben 0.1-1.0g, glycerine 50-100ml, Carbomer940--
10-20g, triethanolamine 5-40g, surplus pure water.
A kind of be used for children's bacteriostatic gel 2. according to claim 1, it is characterised in that every kilogram of bacteriostatic gel by with
Lower raw material composition：Kuh-seng 10-20g, chrysanthemum 10-20g, honeysuckle 10-20g, asparagus juice (fresh goods) 100-200g, folium artemisiae argyi 10-
20g, peppermint 1-20g, schizonepeta 1-20g, borneol 1-3g, spearmint oil 1-5ml, ethylparaben 0.2-0.5g, glycerine 50-
70ml, Carbomer940--15-20g, triethanolamine 15-20g, surplus pure water.
A kind of be used for children's bacteriostatic gel 3. according to claim 1, it is characterised in that every kilogram of bacteriostatic gel by with
Lower raw material composition：Kuh-seng 20g, chrysanthemum 20g, honeysuckle 20g, asparagus juice (fresh goods) 110g, folium artemisiae argyi 20g, peppermint 15g, schizonepeta
15g, borneol 2g, spearmint oil 3ml, ethylparaben 0.3g, glycerine 70ml, Carbomer940--16g, triethanolamine 18g,
Surplus pure water.
4. it is according to claim 1 a kind of for children's bacteriostatic gel preparation method, it is characterised in that step is as follows：
Carbomer940 is added in pure water, adds glycerine, obtains solution, standby；Folium artemisiae argyi, peppermint, schizonepeta kuh-seng, chrysanthemum, gold and silver
1. flower adds ethanol extraction filtrates；Borneol, ethylparaben, which are added in ethanol, to be dissolved, then adds spearmint oil, obtains liquid 2.；Will 1.
2. fresh aloe juice is mixed and added into, resulting solution is dispersed in gel, triethanolamine is added afterwards, is produced.
5. it is according to claim 4 a kind of for children's bacteriostatic gel preparation method, it is characterised in that step is as follows：
1) recipe quantity Carbomer940 is taken to be added in pure water, aquation allows it to be fully swelled, and 5-12% is made
Carbomer940 solution；
2) glycerine of recipe quantity is added into Carbomer940 solution, and stirring is uniformly dispersed, standby；
3) folium artemisiae argyi, peppermint, schizonepeta of recipe quantity are taken, 75% ethanol is added, amount of alcohol added is 9 times of folium artemisiae argyi, peppermint and schizonepeta
Amount, 70-90 DEG C of backflow 1-2h, filtering, the collecting amount of filtrate is folium artemisiae argyi, peppermint, 3.5~4 times of schizonepeta, filtrate is standby；
4) 3) dregs of a decoction are merged with the kuh-seng, chrysanthemum, honeysuckle of recipe quantity, adds kuh-seng, chrysanthemum, 12 times of gold and silver flower pesticide and measure
75% ethanol, 70-90 DEG C of backflow 1-2h, filtering is collected extract solution, separately deposited.The dregs of a decoction add kuh-seng, chrysanthemum, 10 times of honeysuckle again
75% ethanol of amount, 70-90 DEG C of backflow 0.5-1.5h, filtering discards the dregs of a decoction, merges extract solution, standby.
5) by 4) extract solution at 50-70 DEG C, vacuum distillation 0.5-1.5h, to without alcohol taste, filtering, filtrate collecting amount be kuh-seng,
Chrysanthemum, 3.5~4 times of amounts of honeysuckle, it is standby.
6) 20ml of 95% ethanol is taken, adds after borneol, the ethylparaben of recipe quantity, stirring and dissolving, adds spearmint oil,
Stir well, it is standby.
7) to above-mentioned 2) middle addition 5), stir well；Add 3), stir well；Fresh aloe juice is added, is stirred well；Add 6), be uniformly dispersed
Afterwards, the triethanolamine of recipe quantity is eventually adding, after fully stirring well, recipe quantity is added water to, stirs well, produce.
6. it is according to claim 5 a kind of for children's bacteriostatic gel preparation method, it is characterised in that：Step 7) in,
To when adding 5) in 2), addition should want on a small quantity, multiple, side edged stir in 2), stir well.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113081928A (en) * | 2021-04-29 | 2021-07-09 | 云南赛森生物科技有限公司 | Plant bacteriostatic gel and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7357950B2 (en) * | 2003-03-21 | 2008-04-15 | Elizabeth Anne Mazzio | Topical treatment for dyshidrosis (pompholyx) and dry skin disorders |
| CN101721594A (en) * | 2008-10-27 | 2010-06-09 | 成都永康制药有限公司 | Chinese medicinal ointment with antibacterial and antipruritic effects and preparation method thereof |
| CN102114216A (en) * | 2010-12-03 | 2011-07-06 | 郑延明 | Externally applied antibacterial and antiphlogistic medicament and preparation method thereof |
| CN104922248A (en) * | 2015-06-11 | 2015-09-23 | 吉林大学珠海学院 | Antibacterial and anti-inflammatory Chinese herbal compound gel and preparation method thereof |
| CN106389238A (en) * | 2016-12-09 | 2017-02-15 | 申艾平 | Floral water |
-
2017
- 2017-05-03 CN CN201710307637.9A patent/CN107149637A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7357950B2 (en) * | 2003-03-21 | 2008-04-15 | Elizabeth Anne Mazzio | Topical treatment for dyshidrosis (pompholyx) and dry skin disorders |
| CN101721594A (en) * | 2008-10-27 | 2010-06-09 | 成都永康制药有限公司 | Chinese medicinal ointment with antibacterial and antipruritic effects and preparation method thereof |
| CN102114216A (en) * | 2010-12-03 | 2011-07-06 | 郑延明 | Externally applied antibacterial and antiphlogistic medicament and preparation method thereof |
| CN104922248A (en) * | 2015-06-11 | 2015-09-23 | 吉林大学珠海学院 | Antibacterial and anti-inflammatory Chinese herbal compound gel and preparation method thereof |
| CN106389238A (en) * | 2016-12-09 | 2017-02-15 | 申艾平 | Floral water |
Non-Patent Citations (4)
| Title |
|---|
| 卢屮等: "辨证治疗婴儿湿疹50例", 《中国民间疗法》 * |
| 吴胜华等: "复方止痒凝胶剂的制备与临床应用", 《海峡药学》 * |
| 张毅: "四黄五倍子汤加味外治婴幼儿湿疹65例", 《新中医》 * |
| 秦太峰: "《云南特色天然香料资源开发与利用》", 30 September 2011, 中国农业科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113081928A (en) * | 2021-04-29 | 2021-07-09 | 云南赛森生物科技有限公司 | Plant bacteriostatic gel and preparation method and application thereof |
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