CN107137501A - It is a kind of to treat tinea pedis, the Chinese medicine composition of foot odour, preparation and preparation method thereof - Google Patents
It is a kind of to treat tinea pedis, the Chinese medicine composition of foot odour, preparation and preparation method thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tinea pedis, the Chinese medicine composition of foot odour, preparation and preparation method thereof are treated the invention provides a kind of.A kind of Chinese medicine composition for treating tinea pedis, foot odour, is consisted of the following composition：By weight percentage, shinyleaf yellowhorn fruit shell/carpopodium 80%~95%, kuh-seng 5%~20%.Two composition synergies of the present invention, start with from multiple dimensions, human body skin metabolic system, the undesirable element in immune system and external source harmful bacteria are eliminated comprehensively, while immunity of organisms is improved, bacterium can also be killed, promotes skin metabolism, so that final effectively cure tinea pedis foot odour.
Description
Technical field
The present invention relates to the field of Chinese medicines, tinea pedis, the Chinese medicine composition of foot odour, preparation and its system are treated more particularly, to a kind of
Preparation Method.
Background technology
Shiny-leaved yellowhorn (scientific name：Xanthoceras sorbifolium Bunge), Sapindaceae, shiny-leaved yellowhorn belong to machaka
Or dungarunga, it is high up to 5 meters；Sprig maroon is sturdy, and leaf connecting handle length is up to 30 centimetres；Leaflet is to life, and both sides are slightly asymmetric, top
End is tapering, and there is sharp keen sawtooth at base portion wedge shape, edge, and the inflorescence basidixed of hermaphrodite flower, male inflorescence axillary, uprightly, total bennet are short, petal
White, base portion aubergine or yellow, the horn shape appendage of floral disc are orange-yellow, and filigree is hairless；Capsule is up to 6 centimetres；Seed black
And it is glossy.Shiny-leaved yellowhorn spring blooms, autumn firstfruits.
Shiny-leaved yellowhorn be the distinctive rare woody oily section crop of China, be greening, it is edible, medicinal and making bio-fuel weight
Woody oil tree species are wanted, are paid close attention to extensively by academia in recent years.The medicinal parts such as its kernel, shell, carpopodium, branches and leaves are rich in three
Content is higher in the active ingredients such as terpene saponin(e, sterol, flavones, cumarin, tartaric acid, especially carpopodium and shell.
Triterpene saponins belong to nonionic surfactant, and pH value is between 6.0~7.0, with very low critical micell
Concentration (CMC) and surface tension (γ CMC), can with the multiple biological activities such as good antibacterial, anti-inflammatory, anti-oxidant, antimycotic
Be widely used in daily use chemicals industry, Triterpene saponins can as natural detergent, with preferable clean result, and not phosphorous, aluminium,
The materials such as benzene, body of not hurting sb.'s feelings, not polluted source, environmental protection is environment-friendly, is that a kind of more satisfactory hand cleanser, hair washing are fragrant
The raw materials such as ripple, shower cream, cosmetics, with larger research and development Exploitative potential.Triterpenes total saponins are to wine brewing sugar
There is stronger antibacterial activity to act on for saccharomycete and candida utili, also relatively strong to saccharomycete inhibitory action, therefore can
To help improve the skin problem such as skin whelk, blackspot, wrinkle, dry skin, coarse.
Sterol, flavones, cumarin, tartaric acid can help skin removed to be deposited in the aging cutin of outer layer.Therefore to shiny-leaved yellowhorn
Deep processing is carried out, the active ingredients such as Triterpene saponins, sterol, flavones, cumarin, tartaric acid are therefrom extracted, with great work
Industry meaning.
To sum up, Lignum Xanthoceratis extract has many physiologically actives, but treats some diseases using single Lignum Xanthoceratis extract
Effect is not notable when sick, it is impossible to extend to market, such as tinea pedis, and single shiny-leaved yellowhorn only has preventive effect, and
The tinea pedis suffered from can not be cured.Therefore, it is urgently to be resolved hurrily to study a kind of pharmaceutical composition containing shiny-leaved yellowhorn to be used to treat tinea pedis
One technical problem.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is a kind of Chinese medicine composition for treating tinea pedis, foot odour of offer, the Chinese medicine composition
Two composition synergies, have significant curative effect and higher cure rate to tinea pedis, foot odour.
The second object of the present invention is to provide the preparation made by above-mentioned Chinese medicine composition, and said preparation is topical administration,
It is easy to use, have no toxic side effect.
The third object of the present invention is the preparation method for providing above-mentioned preparation, and flow is simple, can effectively protect drug effect into
The activity divided.
In order to realize the above object the invention provides following technical scheme：
A kind of Chinese medicine composition for treating tinea pedis, foot odour, is consisted of the following composition：By weight percentage,
Shinyleaf yellowhorn fruit shell/carpopodium 80%~95%,
Kuh-seng 5%~20%.
Kuh-seng is cold in nature, has heat-clearing and damp-drying drug, effect of desinsection, kuh-seng bath can remove damp-heat in lower-JIAO, and desinsection is antipruritic, right
Pruitus has good mitigation, can Bergamot Mint Extract, dredge and restrain pore, remove skin endotoxin contamination,
Its abundant herbal nutrition promotes the growth and reparation of damaged blood vessels nerve cell, recovers subcutaneous capillary cell viability, flesh
Skin, which reappears, to compact fine and smooth, plays a part of beauty and skin care.Banlangen and oxymatrine in kuh-seng have obvious rise to make in vain
With having obvious therapeutic action to Neuroleptic Leukocytopenia caused by endoxan, X-ray and cobalt radiation exposure.Kuh-seng also has anti-
Inflammation effect, matrine oozes out increase, Rat Carrageenan to mouse peritoneal caused by auricle edema caused by mouse knoting oil, acetic acid
Colloidality footpad swelling, there is inhibitory action.
In the present invention, the shell and carpopodium of shiny-leaved yellowhorn are all rich in Triterpene saponins, and it has emulsification cleaning effect and stronger
Antibacterial activity；The shell and carpopodium of shiny-leaved yellowhorn are also rich in sterol, flavones, and it has the effect for removing aging cutin layer, Wen Guan
The shell and carpopodium of fruit are acted synergistically using above characteristic with the matrine in kuh-seng, can not only improve immunity of organisms, and
The many bacteriums for causing tinea pedis foot odour can be killed, improve the skin condition suffered from tinea pedis, the symptoms such as swelling, blister, erosion are eliminated,
Promote the metabolism of corresponding skin.As can be seen here, in the composition that the present invention is provided, the emphasis of two components is different, but
By both coordinateds, start with from multiple dimensions, eliminate comprehensively in human body skin metabolic system, immune system it is bad because
Element and external source harmful bacteria, while immunity of organisms is improved, moreover it is possible to kill bacterium, promote skin metabolism, so that
It is final effectively to cure tinea pedis foot odour.
Formula can also further optimize above, to obtain more preferable therapeutic effect, and for example formula is：
By weight percentage,
Shinyleaf yellowhorn fruit shell/carpopodium 85%~92%,
Kuh-seng 8%~15%.
Composition described above is mainly by external curing tinea pedis foot odour, for exterior-applied formulation, the presence shape of composition
Formula or quality are had a major impact to the drug effect of product, in order to improve drug effect, and preferred pair composition is extracted, and is then made
Agent, preferably extracting method are：
It is 1 by solid-liquid ratio using 10%~60% methanol or 10%~60% ethanol as solvent:8~1:15th, 30 DEG C~
Extracted at 90 DEG C multiple.
Using above solvent extraction, more preferably, contained active component enriches the quality of obtained extract, both comprising water-soluble
Property material, also comprising alcohol-soluble material, the collaboration of two kinds of compositions can more improve the therapeutic effect to tinea pedis foot odour.
Preferably, the method for the extraction is：30 DEG C~60 DEG C are first heated to, 30~60min is impregnated, then heats to 80
DEG C~90 DEG C of 20~40min of refluxing extraction.
Two steps of the extraction process sub-dip stain and backflow, make water-soluble and Alcohol soluble composition fully discharge, were impregnating
It can also be stirred in journey, accelerate the flowing of material, mixing speed is preferably 20~100 revs/min.
Preferably, also include after leaching：Decolourize, concentrate, dry.
Decolourize further removal of impurities, it is convenient after concentrate drying to preserve, and applicable formulation is more rich.
Preferably, the method for the decolouring is：The activity of 0.1~0.5 times of its weight is added into solution to be decolourized
Charcoal, completes to filter after absorption.Wherein, filtering is filtered preferably in centrifuge, and rotating speed is preferably 3000 revs/min.
Preferably, the method for the concentration is：In vacuum -0.01~-0.092MPa, 0.1~0.5MPa of steam pressure
Under water content 40wt%~50wt% concentrate is made；
The method of the drying is：It is spray-dried at 150 DEG C~220 DEG C of EAT.
Concentration and the cooperation of dry two step processes are extremely important, and higher efficiency ratio can not only be obtained using process above,
And the quality of products obtained therefrom is preferable.
If preparing spray by extract of above-mentioned concentrate, 60~90 times of water dilution need to be added, foot is used further to.
As described above, the quality of extract is extremely important to drug effect, the extract of the present invention preferably following quality：
The extract includes saponin(e, flavones and sterol, and the mass ratio of saponin(e, flavones and sterol is 15~17:12
~14:1.6~2.
Wherein, the mass ratio of saponin(e, flavones and sterol can be 15:14:1.6, or 17:12:2, or 17:13:1.8
Deng.
The formulation that the present invention is applicable has spray or solid soap agent or loose powder agent.
Wherein, loose powder agent is similar to spray, and difference is only that spray has been prepared, i.e., by i.e. use, and loose powder
Agent needs are now with the current, i.e., patient is voluntarily dissolved with water, then soak.
Solid soap agent is Mobyneb product, both can be used for cleaning foot, can be used for treating tinea pedis foot odour again, and
Holding time is long, it is clear that its application market is more extensive.
Making solid soap agent is needed to add required soap base, and essence and/or toner etc. can also be added on this basis
Auxiliary material.
Unsuitable too high or too low, the preferably accounting 0.1wt%~10wt% of content of the extract in soap agent.
This soap agent can use following preparation method：
First by the soap base heating and melting, then add the extract and remaining composition, afterwards by -0.01~-
0.05Mpa vacuum drying, grinding, extrusion, are produced.
To sum up, compared with prior art, invention achieves following technique effect：
(1) using the synergy between shinyleaf yellowhorn fruit shell, carpopodium and kuh-seng, improve and curative effect is controlled to tinea pedis foot odour
Really, it is mainly reflected in shortening treatment cycle and improves the aspect of cure rate two；
(2) quality of extract is improved by improving the extraction process of composition, curative effect is controlled so as to further increase
Really；
(3) provide a kind of use be more convenient, make simpler spray, soap, be the extensive of composition of the invention
Using offer prerequisite.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, but ability
Field technique personnel will be understood that following described embodiment is a part of embodiment of the invention, rather than whole embodiments,
The present invention is merely to illustrate, and is not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument
Unreceipted production firm person, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
A kind of Chinese medical extract
1st, feeding：Percentage composition, shinyleaf yellowhorn fruit shell 80%, kuh-seng 20%, are well mixed by weight, be ground into≤5mm
Particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:15 ratio adds the methanol that content is 60%,
30 DEG C are heated up to, under conditions of 20 revs/min of mixer rotating speed, extraction time 30 minutes, then it is warming up to 80 DEG C of 40 points of holdings
Clock, methanol at reflux solvent；Operate, extracted twice more than repeating.
3rd, extract solution twice is merged, according to 10:5 ratio adds activated carbon and carries out decolorization, in 3000 revs/min of rotating speed
Separation of solid and liquid is carried out in the centrifuge of clock, filtered fluid is reclaimed.
4th, the concentrate of water content 50% is made in vacuum -0.092MPa, steam pressure 0.5MPa in filtered fluid.
5th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 150 DEG C of EAT.
As a result：
In resulting powdered extract, the mass ratio of saponin(e, flavones and sterol is 15.02:14:1.6.
The extract can directly steep pin and use, and specific method is：
2 grams of extracts are taken, are added in 2L 38 DEG C~45 DEG C warm water, pin is soaked 5~10 minutes in this water, dried
Moisture on pin.If using this water washing shoe-pad, socks, to remove tinea pedis, foot odour it is better.
Embodiment 2
With embodiment 1 differ only in the 2nd step is extracted when 60% methanol used replace with water.
As a result：
In resulting powdered extract, the mass ratio of saponin(e, flavones and sterol is 12:12:1.7.
Embodiment 3
Difference with embodiment 1 60% methanol used when being to extract the 2nd step replaces with 10% methanol, specific experiment
Process is：
1st, feeding：Percentage composition, shinyleaf yellowhorn fruit shell 80%, kuh-seng 20%, are well mixed by weight, be ground into≤5mm
Particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:8 ratio adds the methanol that content is 10%, plus
Temperature is to 60 DEG C, under conditions of 100 revs/min of mixer rotating speed, extraction time 60 minutes, then is warming up to 90 DEG C of 20 points of holdings
Clock, methanol at reflux；Operate, extracted twice more than repeating.
3rd, extract solution twice is merged, according to 10:1 ratio adds activated carbon and carries out decolorization, in 3000 revs/min of rotating speed
Separation of solid and liquid is carried out in the centrifuge of clock, filtered fluid is reclaimed.
4th, the concentrate of water content 40% is made in vacuum -0.01MPa, steam pressure 0.5MPa in filtered fluid.
5th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 220 DEG C of EAT.
As a result：
In resulting powdered extract, the mass ratio of saponin(e, flavones and sterol is 17:12:2.
Embodiment 4
Difference with embodiment 1 60% methanol used when being to extract the 2nd step replaces with 10% ethanol, specific experiment
Process is：
1st, feeding：Percentage composition by weight, shinyleaf yellowhorn fruit shell and carpopodium altogether 80%, kuh-seng 20% is well mixed, and is crushed
Into≤5mm particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:It is molten for 10% ethanol that 10 ratio adds content
Agent, is heated up to 60 DEG C, under conditions of 40 revs/min of mixer rotating speed, extraction time 80 minutes, then is warming up to 90 DEG C of holdings 20
Minute, refluxing ethanol solvent；Operate, extracted twice more than repeating.
3rd, extract solution twice is merged, according to 10:5 ratio adds activated carbon and carries out decolorization, in 3000 revs/min of rotating speed
Separation of solid and liquid is carried out in the centrifuge of clock, filtered fluid is reclaimed.
4th, the concentrate of water content 40% is made in vacuum -0.01MPa, steam pressure 0.5MPa in filtered fluid.
5th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 150 DEG C of EAT.
Embodiment 5
Difference with embodiment 1 60% methanol used when being to extract the 2nd step replaces with 60% ethanol, specific experiment
Process is：
1st, feeding：Percentage composition, shinyleaf yellowhorn fruit shell 90%, kuh-seng 10%, are well mixed by weight, be ground into≤5mm
Particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:It is molten for 60% ethanol that 8 ratio adds content
Agent, is heated up to 60 DEG C, under conditions of 60 revs/min of mixer rotating speed, extraction time 90 minutes, then is warming up to 80 DEG C of holdings 40
Minute, methanol at reflux or alcohol solvent；Operate, extracted twice more than repeating.
3rd, extract solution twice is merged, according to 10:5 ratio adds activated carbon and carries out decolorization, in 3000 revs/min of rotating speed
Separation of solid and liquid is carried out in the centrifuge of clock, filtered fluid is reclaimed.
4th, the concentrate of water content 40%~50% is made in vacuum -0.092MPa, steam pressure 0.1 in filtered fluid.
5th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 150 DEG C of EAT.
Embodiment 6
From embodiment 1 differ only in shinyleaf yellowhorn fruit shell, kuh-seng proportioning it is different, be 92：8.
Embodiment 7
From embodiment 1 differ only in shinyleaf yellowhorn fruit shell, kuh-seng proportioning it is different, be 85：15.
Embodiment 8 to 14
Treat the spray of tinea pedis foot odour：
Deionized water is added into the gained powdered extract of embodiment 1 to 7, the accounting of water is 90%, filling after mixing uniformly
In squash type spray bottle, obtain have remove tinea pedis, the spray of foot odour function, living toe, instep, sole spray,
It can reach removal tinea pedis, the effect of foot odour.
Embodiment 15
Treat the soap of tinea pedis foot odour：
Adding in the pill tank of soap base, 60 DEG C~80 DEG C of the keeping temperature under conditions of 40 revs/min of mixer rotating speed,
The above-described embodiment 1 for adding soap base parts by weight 0.1% is extract obtained with fragrance for detergents, soap toning raw material；Stirring 60 minutes,
By -0.05Mpa vacuum drying, three-roll grinder, banded extruder, printer, packaging；It can be prepared by having and remove tinea pedis, pin
The soap of smelly function.
Comparative example 1
Whole kuh-sengs are replaced with into shinyleaf yellowhorn fruit shell with differing only in for embodiment 8.
Comparative example 2
Whole shinyleaf yellowhorn fruit shells are replaced with into kuh-seng with differing only in for embodiment 8.
Comparative example 3
Example IV in patent application CN102784341A.
Comparative example 4
The weight for differing only in shinyleaf yellowhorn fruit shell and kuh-seng from embodiment 1, than different, is 75:25.
Antifungic action is tested
Strain：Trichophyton rubrum, trichophyton gypseum, acrothesium floccosum, dog microspore tinea bacterium, Candida albicans, institute
It is Sharpe improved culture medium with culture medium.
Method is：After each strain is passed on, 0.2mL is taken uniformly to be seeded in the training of Sharpe flat board after being diluted with sterile saline
Support on base；Medicine to be measured etc. is refitted on flat board；Flat board is placed in 28 DEG C of insulating boxs and cultivated, is treated around negative control
Cover with after fungi, start to measure inhibition zone diameter, judge fungistatic effect.
As a result it is as shown in table 1.
The inhibition zone diameter of table 1 (mm)
From result, the present invention is significantly higher than ratio to causing the fungi of tinea pedis foot odour to have significant fungistatic effect
Compared with example, especially single composition.
Clinical experience example
1st, male, 20 years old, hobby wore the higher shoes of the closed performances such as sneakers, sneakers, but has serious foot odour.With this
2 grams of extracts powdered (embodiment 1), is added in 2L warm water, bubble pin after 5~10 minutes, three days stink substantially eliminate, seven days
After be completely eliminated.Use once weekly later, so far half a year, then do not occurred the phenomenon of foot odour.
2nd, it is male, 83 years old, occur white skin for many years with tinea pedis, between toe, whenever season alternation Changes in weather, entirely
Pin itch is hard to bear.Using the spray of the extract of embodiment 8, between toe, instep, sole spray, apply this extract, continuously use
After five days, tinea pedis symptom is relieved, and the white skin after ten days between toe disappears；The old scytoblastema of keratinization of sole originally disappears
Lose；After continuously using one month, it is changed to weekly using once.By an autumn and winter and the seasonal variations of Winter-Spring, do not occur complete yet
The situation of pin itch.
In addition, the present invention has also counted the cure rate of 8 to 15 pairs of tinea pedis foot odours of embodiment, it is 100%.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of Chinese medicine composition for treating tinea pedis, foot odour, it is characterised in that consist of the following composition：By weight percentage,
Shinyleaf yellowhorn fruit shell/carpopodium 80%~95%,
Kuh-seng 5%~20%.
2. Chinese medicine composition according to claim 1, it is characterised in that by weight percentage,
Shinyleaf yellowhorn fruit shell/carpopodium 85%~92%,
Kuh-seng 8%~15%.
3. a kind of preparation for treating tinea pedis, foot odour, it is characterised in that the preparation includes the Chinese medicine group described in claim 1 or 2
The extract that compound is obtained through solvent extraction；
The method of the extraction is：
It is 1 by solid-liquid ratio using 10%~60% methanol or 10%~60% ethanol as solvent:8~1:15th, at 30 DEG C~90 DEG C
Lower extraction is multiple.
4. preparation according to claim 3, it is characterised in that in the extraction, also include after leaching：Decolourize,
Concentrate, dry；
Preferably, the method for the decolouring is：The activated carbon of 0.1~0.5 times of its weight is added into solution to be decolourized, it is complete
Filtered after into absorption.
5. preparation according to claim 4, it is characterised in that the method for the concentration is：Vacuum -0.01~-
Water content 40wt%~50wt% concentrate is made under 0.092MPa, 0.1~0.5MPa of steam pressure；
The method of the drying is：It is spray-dried at 150 DEG C~220 DEG C of EAT.
6. preparation according to claim 3, it is characterised in that the method for the extraction is：30 DEG C~60 DEG C are first heated to,
30~60min is impregnated, 80 DEG C~90 DEG C 20~40min of refluxing extraction are then heated to.
7. the preparation according to any one of claim 3~6, it is characterised in that the extract includes saponin(e, flavones and steroid
Alcohol, and the mass ratio of saponin(e, flavones and sterol is 15~17:12~14:1.6~2.
8. preparation according to claim 3, it is characterised in that the preparation is spray or solid soap agent；
Preferably, the solvent of the spray is water.
9. preparation according to claim 8, it is characterised in that the solid soap agent also includes soap base；It is preferred that also including perfume
Essence and/or toner；
Preferably, the weight content of extract described in the solid soap agent is 0.1%~10%.
10. the preparation method of the preparation described in claim 9, it is characterised in that by the soap base heating and melting, then add institute
Extract and remaining composition are stated, process -0.01~-0.05Mpa vacuum drying afterwards, grinding, extrusion are produced.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115300559A (en) * | 2022-02-12 | 2022-11-08 | 兰州理工大学 | Application of xanthoceras sorbifolia husk saponin in resisting trichophyton rubrum and extraction and purification method thereof |
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