CN107125757A - Functional food composite and oral products and preparation method thereof and their application - Google Patents
Functional food composite and oral products and preparation method thereof and their application Download PDFInfo
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- CN107125757A CN107125757A CN201710228014.2A CN201710228014A CN107125757A CN 107125757 A CN107125757 A CN 107125757A CN 201710228014 A CN201710228014 A CN 201710228014A CN 107125757 A CN107125757 A CN 107125757A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 235000013376 functional food Nutrition 0.000 title claims abstract description 26
- 239000002131 composite material Substances 0.000 title claims abstract description 18
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- 239000002994 raw material Substances 0.000 claims abstract description 41
- 235000012661 lycopene Nutrition 0.000 claims abstract description 35
- 239000007901 soft capsule Substances 0.000 claims abstract description 35
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 31
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims abstract description 29
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- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims abstract description 29
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 27
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
- A23L29/04—Fatty acids or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to field of food, a kind of functional food composite is disclosed, the oral products containing the functional food composite, the preparation method of the oral products, and their applications in the functional food with anti-oxidation function is prepared.Specifically, the functional food composite contains lycopene raw material, grape seed extract and vitamin E raw material, wherein, relative to the lycopene raw material of 100 parts by weight, the content of the grape seed extract is 50 200 parts by weight, and the content of the vitamin E raw material is 50 100 parts by weight.The oral products that the present invention is provided can significantly reduce the content of the MDA in aged mouse body, meanwhile, GSH Px content and SOD activity can be significantly improved, the oral products that this explanation present invention is provided have good anti-oxidation function.Also, by being made into soft capsule dosage form, it is more beneficial for taking, has broad application prospects.
Description
Technical field
The present invention relates to field of food, in particular it relates to which a kind of functional food composite, contains the functional food group
The oral products of compound, the preparation method of the oral products, and they are in functional food of the preparation with anti-oxidation function
In application.
Background technology
Human body is in addition to the sufficient nutrition of food supply to be had, and with greater need for oxygen is obtained by constantly breathing, oxygen is more
Be necessary to body carries out each kinds of oxidation reaction, however when human body using oxygen progress some metabolic responses when, can not
Some unstable materials can be produced with avoiding, and these unstable materials are all oxygen " variable bodies ", their individual character is very
Vivaciously, do not like stay in original place with being firm and secure, or even like attacking others, do not liked because they are this by contained
Property, referred to as free radical.Active free radical has their lovely one sides, and human body needs to disappear by the activity of free radical sometimes
Go out some microorganisms for invading human bodies or abnormal cell.
Certainly, when the concentration of people's interior free yl is not very high, body has a set of perfect system by oneself to eliminate these
Free radical, the system is referred to as antioxidant system：But, very unfortunate, the space of life and form can cause interior free yl
Concentration is greatly increased, such as smoking, air pollution, water pollution, radioactive ray (x-ray, ultraviolet), and insecticide, life stress are big, motion
Excessively etc., the above can make the increased situation of number of free radical, referred to as oxidative pressure.Oxidative pressure is bigger, in vivo freely
The concentration of base is higher, now, and the antioxidant system in body will face the crisis not enough used.And excessive free radical or oxygen
Cell and tissue breakdown can be influenceed metabolic function, and can cause different health problems by agent.Such as some common cancers
Disease, artery sclerosis, diabetes, cataract, cardiovascular disease, senile dementia, arthritis etc., these diseases are considered to and free radical
It is related., can be pre- for many aging-related diseases as caused by free radical if excessive oxyradical can be eliminated
It is anti-.
Therefore, the enough antioxidants of human intake, to delaying body catagen speed, prevent skin aging, retain youth
Expression has great meaning.But, or the antioxidant antioxidant effect that presently, there are is not obvious, or to health
With certain infringement, be not suitable for long-term taking.Therefore, a kind of obvious antioxidant effect, edible safety are researched and developed and is suitable to long-term
The product used is significant to this area.
The content of the invention
Combined the invention aims to the above mentioned problem for overcoming prior art to exist there is provided a kind of functional food
Thing, the oral products containing the functional food composite, the preparation method of the oral products, and they prepare have it is anti-
Application in the functional food of oxidative function, the oral products both have obvious antioxidant effect, and its Small side effects, fit
In long-term taking.
To achieve these goals, in a first aspect, the invention provides a kind of functional food composite, feature food
Product composition contains lycopene raw material, grape seed extract and vitamin E raw material, wherein, relative to described in 100 parts by weight
Lycopene raw material, the content of the grape seed extract is 50-200 parts by weight, and the content of the vitamin E raw material is 50-
100 parts by weight.
Second aspect, present invention also offers a kind of oral products, the oral products contain main active component, beeswax and plant
Thing oil, wherein, the main active component is above-mentioned functions food compositions.
The third aspect, present invention also offers a kind of preparation method of oral products, the preparation method includes：By main activity
Component, beeswax and vegetable oil are mixed, wherein, the main active component is above-mentioned functions food compositions.
Fourth aspect, is obtained the invention provides above-mentioned functions food compositions, above-mentioned oral products, above-mentioned preparation method
To oral products prepare be used for anti-oxidation function functional food in application.
The present invention is by the way that lycopene raw material, grape seed extract and vitamin E raw material are coordinated according to specific proportioning
Use, obvious antioxidant effect can be produced, and be nearly free from any side effect, suitable for long-term taking.Meanwhile, this hair
It is bright by the way that lycopene, grape seed extract and vitamin E raw material and beeswax and vegetable oil are mixed, and soft capsule is made
Type, this would be even more beneficial to take, has broad application prospects.
Embodiment
The end points and any value of disclosed scope are not limited to the accurate scope or value herein, these scopes or
Value should be understood to comprising the value close to these scopes or value.For number range, between the endpoint value of each scope, respectively
It can be combined with each other between the endpoint value of individual scope and single point value, and individually between point value and obtain one or more
New number range, these number ranges should be considered as specific open herein.
In a first aspect, the invention provides a kind of functional composition, the functional food composite contains lycopene
Raw material, grape seed extract and vitamin E raw material, wherein, relative to the lycopene raw material of 100 parts by weight, the Portugal
The content of grape seed extract is 50-200 parts by weight, and the content of the vitamin E raw material is 50-100 parts by weight.
In situations where it is preferred, relative to the lycopene raw material of 100 parts by weight, the grape seed extract contains
Measure as 65-150 parts by weight, the content of the vitamin E raw material is 60-90 parts by weight.
According to the present invention, the grape seed extract contains grape pip active component；Preferably, grape pip activity into
It is divided into catechins and/or OPC class material；It is highly preferred that in the grape seed extract, the grape pip
The content of active component is at least 60 weight %, more preferably at least more preferably at least 80 weight %, 90 weight %, further excellent
Choosing is at least 95 weight %, or the arbitrary value between above-mentioned numerical value.
In the present invention, to the form of the grape seed extract, there is no particular limitation, as long as wherein containing sufficient amount
Grape pip active component, for example, the grape seed extract can be with liquid dosage form, solid dosage forms or semisolid dosage form
Form provide.Preferably, the grape seed extract is provided in the form of dry powder.It is highly preferred that the grape seed extract
Particle diameter be less than or equal to 100 mesh.
In the present invention, to the source of the grape seed extract, there is no particular limitation, as long as wherein containing sufficient amount
Grape pip active component, for example, can be obtained by conventional commercially available means, conventional laboratory side can also be passed through
Method is voluntarily prepared, and can such as pass through water extraction, supercritical CO2Extraction method etc. is obtained.
In the present invention, to the form of the lycopene raw material, there is no particular limitation, as long as wherein containing sufficient amount
Lycopene, for example, the lycopene raw material can be in the form of liquid dosage form, solid dosage forms or semisolid dosage form
There is provided.Preferably, the lycopene raw material is provided in the form of dry powder.It is highly preferred that the particle diameter of the lycopene raw material
Less than or equal to 100 mesh.In addition, there is no particular limitation in source of the present invention to the lycopene raw material, as long as wherein containing
Enough lycopenes, can be obtained by conventional commercially available means, can also be by conventional laboratory method voluntarily
Prepare, obtained for example, the lycopene raw material can be extracted by tomato.In situations where it is preferred, the lycopene
The purity of raw material is at least 5 weight %, preferably 5-10 weight %.In the present invention, the purity of the lycopene raw material with
Lycopene sterling meter.
According to the present invention, the vitamin E raw material can be natural vitamin E and/or the vitamin E of synthesis, preferably
For natural vitamin E.There is no particular limitation for form of the present invention to the vitamin E raw material, as long as wherein containing enough
The vitamin E component of amount, for example, the vitamin E can be provided in the form of pulvis or oil.The present invention gives birth to the dimension
There is no particular limitation in the source of plain E raw materials, as long as the wherein vitamin E component containing sufficient amount, for example, can pass through
Conventional commercially available means are obtained.In situations where it is preferred, the purity of the vitamin E raw material is at least 60 weight %, preferably extremely
It is 65 weight % less.In the present invention, the purity of the vitamin E raw material is in terms of vitamin E sterling.
The present invention it is a kind of preferred embodiment in, in order to further improve the anti-of the functional food composite
Oxidative function, the functional food composite also contains vegetable oil, and relative to the lycopene of 100 parts by weight, institute
The content for stating vegetable oil is 150-200 parts by weight, preferably 150-180 parts by weight.Preferably, the vegetable oil is selected from kardiseed
At least one of oil, evening primrose oil, linseed oil and olive oil, more preferably safflower seed oil.
Second aspect, present invention also offers a kind of oral products, the oral products contain main active component, beeswax and plant
Thing oil, wherein, the main active component is above-mentioned functions food compositions.
Taken for the ease of subject, the formulation of the oral products can be capsule and/or solution, preferably flexible glue
Capsule.
According to the present invention, on the basis of the total amount of the oral products, the content of the main active component is 45-74 weights
% is measured, the content of the beeswax is 1-10 weight %, and the content of the vegetable oil is 25-45 weight %；Preferably, with the mouth
On the basis of the total amount of system of mourning product, the content of the main active component is 55-65 weight %, and the content of the beeswax is 2-8 weights
% is measured, the content of the vegetable oil is 30-40 weight %.
According to the present invention, to the species of the vegetable oil, there is no particular limitation, if its be conducive to the mixing of component and
Suitable for being administered orally, it is preferable that the vegetable oil is in safflower seed oil, evening primrose oil, linseed oil and olive oil
It is at least one.In order to further improve the antioxygenic property of the oral products, the vegetable oil of the invention is preferably safflower
Seed oil.
In the present invention, to the source of the beeswax and vegetable oil, there is no particular limitation, for example, can pass through routine
Commercially available means obtain.
According to the present invention, the oral products be capsule when, main active component, beeswax and vegetable oil as capsule content
Thing, and the capsule micromicro of capsule thinks gelatine capsule skin and/or starch capsule skin, preferably gelatine capsule skin.
The present invention it is a kind of preferred embodiment in, the capsule skin contains following components：70-120 parts by weight
Gelatin, the glycerine of 25-50 parts by weight, the titanium dioxide of 3-20 parts by weight, the purified water of 70-120 parts by weight and 0.003-0.02
The pigment of parts by weight (as carmine).
In situations where it is preferred, the capsule skin contains following components：The gelatin of 90-100 parts by weight, 35-40 parts by weight
Glycerine, the titanium dioxide of 7-10 parts by weight, pigment (such as rouge of the purified water of 85-110 parts by weight and 0.01-0.015 parts by weight
Fat is red).
The third aspect, present invention also offers a kind of preparation method of oral products, the preparation method includes：By main activity
Component, beeswax and vegetable oil are mixed, wherein, the main active component is above-mentioned functions food compositions.
Taken for the ease of subject, the formulation of the oral products can be capsule and/or solution, preferably flexible glue
Capsule.
According to the present invention, on the basis of the total amount of the oral products, the consumption of the main active component is 45-74 weights
% is measured, the consumption of the beeswax is 1-10 weight %, and the consumption of the vegetable oil is 25-45 weight %；Preferably, with the mouth
On the basis of the total amount of system of mourning product, the consumption of the main active component is 55-65 weight %, and the consumption of the beeswax is 2-8 weights
% is measured, the consumption of the vegetable oil is 30-40 weight %.
According to the present invention, to the species of the vegetable oil, there is no particular limitation, if its be conducive to the mixing of component and
Suitable for being administered orally, it is preferable that the vegetable oil is in safflower seed oil, evening primrose oil, linseed oil and olive oil
It is at least one；Preferably safflower seed oil.
In the present invention, to the source of the beeswax and vegetable oil, there is no particular limitation, for example, can pass through routine
Commercially available means obtain.
There is no particular limitation for addition sequence of the present invention to the main active component, beeswax and vegetable oil, can be simultaneously
Add, can also sequentially add.
The present invention it is a kind of preferred embodiment in, the preparation method comprises the following steps：
(1) beeswax is premixed with vegetable oil, obtains premix；
(2) premix is mixed with main active component；
Wherein, in step (1), the condition of the premix includes：Temperature is 60-80 DEG C, and the time is 3-20min；It is preferred that
Ground, in step (2), the condition of the mixing includes：Temperature is 30-50 DEG C, and the time is 5-15min.
In the present invention, in step (1), to the mode of the premix, there is no particular limitation, can be this area
Conventional selection, as long as can be well mixed raw material, it is for instance possible to use stirring, vortex, blending, kneading etc., are preferably
Stirring.
In the present invention, in step (2), to the mode of the mixing, there is no particular limitation, can be this area
Conventional selection, as long as can be well mixed raw material, it is for instance possible to use stirring, vortex, blending, kneading etc., are preferably
Stirring.
According to the present invention, the compound that the preparation method can also include obtaining mixed process wraps up capsule skin；It is excellent
Selection of land, the capsule skin is gelatine capsule skin and/or starch capsule skin, preferably gelatine capsule skin.
The present invention it is a kind of preferred embodiment in, the capsule skin contains following components：70-120 parts by weight
Gelatin, the glycerine of 25-50 parts by weight, the titanium dioxide of 3-20 parts by weight, the purified water of 70-120 parts by weight and 0.03-0.2 weights
Measure the pigment (as carmine) of part.
In situations where it is preferred, the capsule skin contains following components：The gelatin of 85-110 parts by weight, 35-40 parts by weight
Glycerine, the titanium dioxide of 7-10 parts by weight, pigment (such as kermes of the purified water of 85-110 parts by weight and 0.1-0.15 parts by weight
It is red).
In the present invention, the capsule micromicro is with according to above-mentioned formula, and each component is added to changing in glue tank and carries out gel,
Obtain glue；Then compound above-mentioned steps (2) obtained carries out pelleting, sizing with the glue, dries and pack successively
Processing, to obtain soft capsule.
Fourth aspect, present invention also offers above-mentioned functions food compositions, above-mentioned oral products, above-mentioned preparation method
Application of the obtained oral products in the functional food with anti-oxidation function is prepared.
The present invention will be described in detail by way of examples below.
In the following Examples and Comparative Examples,
Grape seed extract is remote into creating Science and Technology Ltd. purchased from Wuhan, pulvis, crosses 100 mesh sieves, grape pip activity into
Point the weight % of content >=98；
Lycopene is purchased from Xi'an Ze Lang bio tech ltd, and purity is 6 weight %, and pulvis crosses 100 mesh sieves；
Natural VE is purchased from Shaanxi Sen Fu natural products Co., Ltd, and purity is 66.5 weight %, and pulvis crosses 100 mesh
Sieve；
Remaining reagent passes through the commercially available of routine.
Embodiment 1
The present embodiment is used to illustrate oral products of the invention provided and preparation method thereof.
(1) preparation of content
54g safflower seed oils and 18g beeswaxs are heated to 70 DEG C, after beeswax melts completely, continues to stir 15min, obtains
Beeswax suspension, then adds 110g safflower seed oils in beeswax suspension.Continue to stir, treat that above-mentioned suspension temperature is less than 50
DEG C when, add 68g natural VEs, stirring mixing 5min；Then 100g lycopenes, stirring mixing 5min are added；Finally plus
Enter 100g grape seed extracts, stirring mixing 5min obtains total suspension, crosses colloid mill, then cross 100 mesh sieves, standing takes off
Bubble, obtains content solution.
(2) preparation of capsule hide glue gelatin
By in 850g purified waters, 400g glycerine, 70g titanium dioxide and 1g pigments (famille rose) inputization glue tank, start and stir
Oar is mixed, when temperature reaches 70 DEG C in change glue tank, 900g gelatin is put into, and continues to be heated to 75 DEG C, insulated and stirred 1h, until bright
Glue all dissolves, and obtains glue mixed material.Then, glue mixed material is vacuumized, to glue bubble-free, deflated.Again will
Glue after deflation crosses 100 mesh stainless steel mesh, stands 5h in insulation glue-storing barrel, keeps 55 DEG C of glue.
(3) preparation of soft capsule
450g soft capsule contents and 1000g glues are existed in (18-24 DEG C, relative humidity 30-40%) under environmental condition
Suppressed in full-automatic pellet press, then in turn through sizing, dry, lamp inspection and packaging, to obtain soft capsule A1, wherein, flexible glue
Capsule A1 content content is 0.45g/.
Embodiment 2
The present embodiment is used to illustrate oral products of the invention provided and preparation method thereof.
(1) preparation of content
45g safflower seed oils and 22.5g beeswaxs are heated to 70 DEG C, after beeswax melts completely, continues to stir 15min, obtains
To beeswax suspension, then 90.5g safflower seed oils are added in beeswax suspension.Continue to stir, treat that above-mentioned suspension temperature is low
When 50 DEG C, 77g natural VEs, stirring mixing 5min are added；Then 86g lycopenes, stirring mixing 5min are added；Most
129g grape seed extracts are added afterwards, and stirring mixing 5min obtains total suspension, crosses colloid mill, then cross 100 mesh sieves, stands
Bubble is taken off, content solution is obtained.
(2) preparation of capsule hide glue gelatin
By in 1100g purified waters, 380g glycerine, 70g titanium dioxide and 1.1g pigments (famille rose) inputization glue tank, start
Agitating paddle, when changing that temperature reaches 70 DEG C in glue tank, puts into 1000g gelatin, and continues to be heated to 75 DEG C, insulated and stirred 1h, directly
All dissolved to gelatin, obtain glue mixed material.Then, glue mixed material is vacuumized, to glue bubble-free, deflated.
The glue after deflation is crossed into 100 mesh stainless steel mesh again, 5h is stood in insulation glue-storing barrel, keeps 55 DEG C of glue.
(3) preparation of soft capsule
450g soft capsule contents and 1000g glues are existed in (18-24 DEG C, relative humidity 30-40%) under environmental condition
Suppressed in full-automatic pellet press, then in turn through sizing, dry, lamp inspection and packaging, to obtain soft capsule A2, wherein, flexible glue
Capsule A2 content content is 0.45g/.
Embodiment 3
The present embodiment is used to illustrate oral products of the invention provided and preparation method thereof.
(1) preparation of content
60g safflower seed oils and 22g beeswaxs are heated to 70 DEG C, after beeswax melts completely, continues to stir 15min, obtains
Beeswax suspension, then adds 120g safflower seed oils in beeswax suspension.Continue to stir, treat that above-mentioned suspension temperature is less than 50
DEG C when, add 68g natural VEs, stirring mixing 5min；Then 110g lycopenes, stirring mixing 5min are added；Finally plus
Enter 70g grape seed extracts, stirring mixing 5min obtains total suspension, crosses colloid mill, then sieve, standing takes off bubble, obtains
To content solution.
(2) preparation of capsule hide glue gelatin
By in 900g purified waters, 360g glycerine, 100g titanium dioxide and 1.5g pigment inputization glue tanks, agitating paddle is started,
When temperature reaches 70 DEG C in change glue tank, 900g gelatin is put into, and continues to be heated to 75 DEG C, insulated and stirred 1h, until gelatin is complete
Portion dissolves, and obtains glue mixed material.Then, glue mixed material is vacuumized, to glue bubble-free, deflated.It will deflate again
Glue afterwards crosses 100 mesh stainless steel mesh, stands 5h in insulation glue-storing barrel, keeps 55 DEG C of glue.
(3) preparation of soft capsule
450g soft capsule contents and 1000g glues are existed in (18-24 DEG C, relative humidity 30-40%) under environmental condition
Suppressed in full-automatic pellet press, then in turn through sizing, dry, lamp inspection and packaging, to obtain soft capsule A3, wherein, flexible glue
Capsule A3 content content is 0.45g/.
Embodiment 4
The present embodiment is used to illustrate oral products of the invention provided and preparation method thereof.
(1) preparation of content
40g safflower seed oils and 23g beeswaxs are heated to 70 DEG C, after beeswax melts completely, continues to stir, obtains beeswax and mix
Suspension, then adds 75g safflower seed oils in beeswax suspension.Continue to stir, when above-mentioned suspension temperature is less than 50 DEG C, plus
Enter 78g natural VEs, stirring mixing 5min；Then 78g lycopenes, stirring mixing 5min are added；It is eventually adding 156g Portugals
Grape seed extract, stirring mixing 5min, obtains total suspension, crosses colloid mill, then crosses 100 mesh sieves, and standing takes off bubble, obtained
Content solution.
(2) preparation of capsule hide glue gelatin
By in 850g purified waters, 400g glycerine, 70g titanium dioxide and 1g pigments (famille rose) inputization glue tank, start and stir
Oar is mixed, when temperature reaches 70 DEG C in change glue tank, 900g gelatin is put into, and continues to be heated to 75 DEG C, insulated and stirred 1h, until bright
Glue all dissolves, and obtains glue mixed material.Then, glue mixed material is vacuumized, to glue bubble-free, deflated.Again will
Glue after deflation crosses 100 mesh stainless steel mesh, stands 5h in insulation glue-storing barrel, keeps 55 DEG C of glue.
(3) preparation of soft capsule
450g soft capsule contents and 1000g glues are existed in (18-24 DEG C, relative humidity 30-40%) under environmental condition
Suppressed in full-automatic pellet press, then in turn through sizing, dry, lamp inspection and packaging, to obtain soft capsule A4, wherein, flexible glue
Capsule A4 content content is 0.45g/.
Embodiment 5
The present embodiment is used to illustrate oral products of the invention provided and preparation method thereof.
(1) preparation of content
70g safflower seed oils and 36g beeswaxs are heated to 70 DEG C, after beeswax melts completely, continues to stir, obtains beeswax and mix
Suspension, then adds 140g safflower seed oils in beeswax suspension.Continue to stir, when above-mentioned suspension temperature is less than 50 DEG C,
Add 53.5g natural VEs, stirring mixing 5min；Then 107g lycopenes, stirring mixing 5min are added；It is eventually adding
53.5g grape seed extracts, stirring mixing 5min, obtain total suspension, cross colloid mill, then cross 100 mesh sieves, and standing takes off gas
Bubble, obtains content solution.
(2) preparation of capsule hide glue gelatin
By in 850g purified waters, 400g glycerine, 70g titanium dioxide and 1g pigments (famille rose) inputization glue tank, start and stir
Oar is mixed, when temperature reaches 70 DEG C in change glue tank, 900g gelatin is put into, and continues to be heated to 75 DEG C, insulated and stirred 1h, until bright
Glue all dissolves, and obtains glue mixed material.Then, glue mixed material is vacuumized, to glue bubble-free, deflated.Again will
Glue after deflation crosses 100 mesh stainless steel mesh, stands 5h in insulation glue-storing barrel, keeps 55 DEG C of glue.
(3) preparation of soft capsule
450g soft capsule contents and 1000g glues are existed in (18-24 DEG C, relative humidity 30-40%) under environmental condition
Suppressed in full-automatic pellet press, then in turn through sizing, dry, lamp inspection and packaging, to obtain soft capsule A5, wherein, flexible glue
Capsule A5 content content is 0.45g/.
Comparative example 1
Carried out according to the method for embodiment 1, except that, in step (1), use identical weight natural VE
Instead of the lycopene used in embodiment 1, to obtain soft capsule D1, wherein, soft capsule D1 content content is 0.45g/
Grain.
Comparative example 2
Carried out according to the method for embodiment 1, except that, in step (1), use identical weight natural VE
Instead of the grape seed extract used in embodiment 1, to obtain soft capsule D2, wherein, soft capsule D2 content content is
0.45g/.
Comparative example 3
Carried out according to the method for embodiment 1, except that, in step (1), use identical weight grape seed extract
Instead of the natural VE used in embodiment 1, to obtain soft capsule D3, wherein, soft capsule D3 content content is
0.45g/.
Comparative example 4
Carried out according to the method for embodiment 1, except that, in step (1), the consumption of lycopene is 50g, grape
The consumption of seed extract is 120g, and the consumption of natural VE is 98g, to obtain soft capsule D4, wherein, soft capsule D4's is interior
Tolerant content is 0.45g/.
Comparative example 5
Carried out according to the method for embodiment 1, except that, in step (1), the consumption of lycopene is 220g, Portugal
The consumption of grape seed extract is 24g, and the consumption of natural VE is 24g, to obtain soft capsule D5, wherein, soft capsule D5's is interior
Tolerant content is 0.45g/.
Comparative example 6
Carried out according to the method for embodiment 1, except that, using the carrotene of identical weight (purchased from Jiaxing day and really
Bio tech ltd, pulvis crosses 100 mesh sieves) lycopene is replaced, to obtain soft capsule D6, wherein, soft capsule D6's is interior
Tolerant content is 0.45g/.
Test case 1
(1) to the effect of aged mouse oxidation resistance
From August experiment mice more than age, control group and administration group, every group 15 are randomly divided into according to body weight.Respectively give
The daily gavage respectively of medicine group mouse gives the content solution obtained in embodiment 1-5 and comparative example 1-6, and daily dosage is
100mg/kg, control group gives the safflower seed oil of same volume.By daily single, successive administration 30 days, give respectively at first
24h after 24h and last dose, takes blood, respectively using superoxide dismutase (SOD) kit, MDA (MDA) reagent before medicine
Box and glutathione peroxidase (GSH-Px) kit (mentioned reagent box is purchased from Nanjing and builds up Bioengineering Research Institute)
Determine the content with SOD, MDA and GSH-Px in mice serum after administration before administration.As a result as shown in table 1, experimental result is with same
The average value of the result of each experimental animal is represented (n=15) in one group.
Table 1
(2) human experiment is tested
Health and the subject 20 without special medical history, continuous clothes are selected in the personnel for participating in human experiment from entering one's name voluntarily
The soft capsule A1 obtained with embodiment 1, continuously takes 30 days, 2 times a day, and dose for each person every day is 1.
Preceding 24h is taken first respectively at subject and last is taken rear 24h and drawn blood, and uses SOD kits, MDA
Kit and GSH-Px kits (mentioned reagent box is purchased from Nanjing and builds up Bioengineering Research Institute) determine SOD in serum,
MDA and GSH-Px content.As a result as shown in table 2, as a result represented (n=20) with average value.
Find simultaneously, subject during soft capsule A1 is taken without any adverse reaction appearance and the state of mind well,
In addition, individual subject exist before medication fatigue, the symptom such as agitation, soreness and weakness of waist and knees, poor sleep in after medication
Improve.
Table 2
The oral products that the present invention is provided it can be seen from the result of above test case 1 can significantly reduce aged mouse
Internal MDA content, meanwhile, GSH-Px content and SOD activity can be significantly improved, the mouth that this explanation present invention is provided
System of mourning product have good anti-oxidation function.Tested and found by human experiment, oral products of the invention not only can be obvious
The oxidation resistance of subject is improved, and it is without any side effects to human body, and soft capsule dosage form is made into, this will more have
Beneficial to taking, have broad application prospects.
The preferred embodiment of the present invention described in detail above, still, the present invention is not limited thereto.In the skill of the present invention
In art concept, technical scheme can be carried out a variety of simple variants, including each technical characteristic with it is any its
Its suitable method is combined, and these simple variants and combination should equally be considered as content disclosed in this invention, belong to
Protection scope of the present invention.
Claims (10)
1. a kind of functional food composite, it is characterised in that the functional food composite contains lycopene raw material, grape
Seed extract and vitamin E raw material, wherein, relative to the lycopene raw material of 100 parts by weight, the grape seed extract
Content be 50-200 parts by weight, the content of the vitamin E raw material is 50-100 parts by weight.
2. functional food composite according to claim 1, wherein, relative to the lycopene of 100 parts by weight
Raw material, the content of the grape seed extract is 65-150 parts by weight, and the content of the vitamin E raw material is 60-90 parts by weight.
3. functional food composite according to claim 1 or 2, wherein, the grape seed extract contains grape pip
Active component；
Preferably, the grape pip active component is catechins and/or OPC class material；
It is highly preferred that in the grape seed extract, the content of the grape pip active component is at least 60 weight %；
It is further preferred that the particle diameter of the grape seed extract is less than or equal to 100 mesh.
4. functional food composite according to claim 1 or 2, wherein, the purity of the lycopene raw material is at least
For 5 weight %, preferably 5-10 weight %；
Preferably, the vitamin E raw material is natural vitamin E and/or the vitamin E of synthesis, preferably natural dimension life
Plain E；
Preferably, the purity of the vitamin E raw material is at least 60 weight %, more preferably at least 65 weight %.
5. a kind of oral products, the oral products contain main active component, beeswax and vegetable oil, it is characterised in that the main work
Property component be functional food composite in claim 1-4 described in any one.
6. oral products according to claim 5, wherein, the formulations of the oral products is capsule and/or solution, excellent
Elect soft capsule as；
Preferably, on the basis of the total amount of the oral products, the content of the main active component is 45-74 weight %, described
The content of beeswax is 1-10 weight %, and the content of the vegetable oil is 25-45 weight %；
Preferably, on the basis of the total amount of the oral products, the content of the main active component is 55-65 weight %, described
The content of beeswax is 2-8 weight %, and the content of the vegetable oil is 30-40 weight %；
Preferably, the vegetable oil is selected from least one of safflower seed oil, evening primrose oil, linseed oil and olive oil, preferably
For safflower seed oil.
7. a kind of preparation method of oral products, it is characterised in that the preparation method includes：By main active component, beeswax and plant
Thing oil is mixed, wherein, the main active component is the functional food combination described in any one in claim 1-4
Thing.
8. preparation method according to claim 7, wherein, the formulations of the oral products is capsule and/or solution, excellent
Elect soft capsule as；
Preferably, on the basis of the total amount of the oral products, the consumption of the main active component is 45-74 weight %, described
The consumption of beeswax is 1-10 weight %, and the consumption of the vegetable oil is 25-45 weight %；
Preferably, on the basis of the total amount of the oral products, the consumption of the main active component is 55-65 weight %, described
The consumption of beeswax is 2-8 weight %, and the consumption of the vegetable oil is 30-40 weight %；
Preferably, the vegetable oil is selected from least one of safflower seed oil, evening primrose oil, linseed oil and olive oil, preferably
For safflower seed oil.
9. the preparation method according to claim 7 or 8, wherein, the preparation method comprises the following steps：
(1) beeswax is premixed with vegetable oil, obtains premix；
(2) premix is mixed with main active component；
Wherein, in step (1), the condition of the premix includes：Temperature is 60-80 DEG C, and the time is 3-20min；
Preferably, in step (2), the condition of the mixing includes：Temperature is 30-50 DEG C, and the time is 5-15min.
10. the oral system described in functional food composite, claim 5 or 6 in claim 1-4 described in any one
The oral products that preparation method in product, claim 7-9 described in any one is obtained are preparing the work(with anti-oxidation function
Application in energy property food.
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Application publication date: 20170905 |