CN107125438A - A kind of feed addictive tannic acid alkaloid and preparation method thereof and a kind of compound additive and a kind of feed - Google Patents
A kind of feed addictive tannic acid alkaloid and preparation method thereof and a kind of compound additive and a kind of feed Download PDFInfo
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- CN107125438A CN107125438A CN201610111092.XA CN201610111092A CN107125438A CN 107125438 A CN107125438 A CN 107125438A CN 201610111092 A CN201610111092 A CN 201610111092A CN 107125438 A CN107125438 A CN 107125438A
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Abstract
The invention provides a kind of feed addictive tannic acid alkaloid, it is prepared from by tannic acid and alkaloid.The feed addictive tannic acid alkaloid that the present invention is provided; tannic acid is combined with alkaloid in vitro; the infringement of this protein of pepsin is not resulted in, simultaneously as tannic acid alkaloid only can slowly discharge tannic acid in small enteral by enzymolysis side; solidify intestinal mucosa S-layer proteins; layer protecting film is formed, reduction is oozed out, mitigating stimulates and enterocinesia; there are convergence, anti-diarrhea effect, also significantly reduce destruction of the tannic acid to small intestine digestive ferment.Addition of the tannic acid alkaloid that the present invention is provided in feed is only 200 1000ppm (in terms of tannic acid), the convergence antibacterial that the tannic acid discharged after feed intake in intestines can play as high zinc prevents the effect of animal diarrhea, its consumption is few, and cost is relatively low.
Description
Technical field
The invention belongs to field of feed, and in particular to a kind of feed addictive tannic acid alkaloid and preparation method thereof with
And a kind of compound additive and a kind of feed
Background technology
Up to the present global feed industry has produced nearly 1,000,000,000 tons per year, wherein development of the China after 30 years, in 2014
Year has reached 1.97 hundred million tons.
Pig feed accounts for the 60-70% of Chinese market, wherein, suckling piglet material about more than 20% is 30,000,000 tons of suckling piglets
Material.3000 g ton zinc oxide (feed per ton g ton containing zinc 2250) are added in the feed for piglet to be used for preventing suckling piglet to draw
It is dilute, 6.75 ten thousand tons of zinc are there are about every year and are consumed by the feed for piglet, are calculated with nutritional need, and suckling piglet only needs 0.3 ten thousand tons, that is,
Saying every year has 6.45 ten thousand tons of zinc to be discharged in plant's surrounding environment, and although zinc be the necessary micro- but many of humans and animals
Many diseases are may result in, Japanese Scientists are thought, high zinc, the farmland after 17 years around pig farm are used in suckling piglet daily ration
Will be there is no cultivability, the grain that these good farmlands are produced can not be eaten again.Therefore, the feed for piglet is due to using high zinc
And the pollution caused is startling, 30 years, about up to a million tons zinc of China turned into the arch-criminal of pollution environment.
Zinc oxide has very good astriction, and prevention suckling piglet that can be highly stable is had loose bowels, other any methods,
Including the use of best antibiotic, so stable effect can not be all reached, and its useful effect dosage is 2000-
2500ppm, dosage is larger, and environmental pollution is larger, but is then unable to reach convergence effect less than the dosage.Just because of pollution be as
This is serious, and many scientists are making great efforts to explore, and in recent years, zinc oxide is coated with by the coating material such as useful stearic acid monoglycerides,
Zinc consumption subtracts, but effect is all very unstable；Useful sodium rice zinc oxide substitutes high zinc, but income is little.What is had uses Hydrolysable Tannins
Acid, which carrys out substitute antibiotics, certain effect, but usage amount is still very big, it is necessary to which Hydrolysable Tannins acid 750-1500 g tons, are used
Cost exceeds well over high zinc, thus effective application is not commercially available.
The content of the invention
In view of this, the technical problem to be solved in the present invention is to provide a kind of feed addictive tannic acid alkaloid and its system
Preparation Method and a kind of compound additive and a kind of feed, the biological base amount of feed addictive tannic acid that the present invention is provided are few, receive
Hold back effect good, and cost is low.
The invention provides a kind of feed addictive tannic acid alkaloid, it is prepared from by tannic acid and alkaloid.
It is preferred that, the alkaloid be selected from leonurine, berberine, arecaline, wilfordine, matrine, ephedrine, not
Cryptocavine, sanguinarine, Chelerythrine, nicotine, caffeine, reserpine, quinine alkali, hyoscyamine, rutaecarpin, pseudoephedrine,
Oxymatrine, ammothamnine, demethyl ephedrine, codonopsine, theophylline, hydrastine, glycine betaine, Choline Chloride, mulberry
It is biological that leaf alkaloid, stachydrine, pipering, Stemona alkaloids, dendrobine, coculine, green grass or young crops rise alkali, capsaicine, aloperine, agate card
Alkali, cynomorium songaricum alkaloid, sparteine, orixine, carnitine, phellodendrine, rheum emodin, aloe-emodin, barley alkaloid and oat
The one or more of alkaloid.
The invention provides a kind of preparation method of above-mentioned feed addictive tannic acid alkaloid, comprise the following steps：By tan
Acid, alkaloid and solvent mixing, obtain tannic acid alkaloid.
It is preferred that, the mol ratio of the tannic acid and alkaloid is 1：(0.1~25).
Add present invention also offers a kind of compound additive, including tannic acid alkaloid and the feed of other prevention Animal diseases
Plus agent；
The tannic acid alkaloid is above-mentioned feed addictive tannic acid alkaloid；
The feed addictive of other prevention Animal diseases is selected from zinc oxide, carvacrol, origanum oil, cinnaldehydrum, cloves
Phenol, Thymol, lauric monoglyceride, enramycin, kitasamycin, terramycin, aureomycin, Bacitracin Zinc, sulfuric acid glue bar
Rhzomorph, salinomycin, avilamycin, Nosiheptide, flavomycoin, the sub- mycin of the plain Buddhist nun of dimension, Tylosin phosphate, apramycin sulfate,
One or more in Lincomycin Hydrochloride, Avilamycin and dusty yeast.
It is preferred that, the mass ratio of the tannic acid alkaloid and the feed addictive of other prevention Animal diseases is 100：
0.001-100000。
Present invention also offers a kind of feed addictive, including diluent and above-mentioned feed addictive tannic acid alkaloid；
The diluent is in stone flour, wheat bran, bean cake powder, bentonite, zeolite powder, corn flour and corn protein powder
It is one or more of；
The mass ratio of the diluent and the feed addictive tannic acid alkaloid is 100：0.0001-100000.
Present invention also offers a kind of feed, including above-mentioned feed addictive tannic acid alkaloid, the feed addictive tan
Addition of the sour alkaloid in feed is 0.001~100000mg/kg.
It is preferred that, the feed be used for feeding pig, turkey, chicken, duck, goose, black-bone chicken, quail, pigeon, ox, horse, sheep, dog,
Ermine, deer, cat, donkey, rabbit, fish, shrimp, crab, shellfish, tortoise, snake or yellow eel.
It is preferred that, the feed be mixed feed, mixed fodder, concentrated feed, mineral trace element premixed feed,
Vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk or customized feed.
Compared with prior art, the invention provides a kind of feed addictive tannic acid alkaloid, by tannic acid and alkaloid system
It is standby to form.The feed addictive tannic acid alkaloid that the present invention is provided, tannic acid is combined with alkaloid in vitro, does not result in stomach cardia
The infringement of this protein of enzyme, simultaneously as tannic acid alkaloid only can slowly discharge tannic acid in small enteral by enzymolysis side, makes intestines
Mucosal surface protein coagulation, forms layer protecting film, and reduction is oozed out, and mitigating stimulates and enterocinesia, there is convergence, anti-diarrhea effect,
Significantly reduce destruction of the tannic acid to small intestine digestive ferment.Addition of the tannic acid alkaloid that the present invention is provided in feed be only
The convergence that the tannic acid discharged after 200-1000ppm (in terms of tannic acid), feed intake in intestines can play as high zinc resists
Bacterium prevents the effect of animal diarrhea, and its consumption is few, and cost is relatively low.Also, the feed addictive tannic acid alkaloid that the present invention is provided
After added in feed, there is good improvement to the fur of suckling piglet, commodity is improved.In addition, also can be in summer poultry diet
Middle addition feed addictive tannic acid alkaloid, the problem of poultry summer water can be solved just.
Embodiment
The invention provides a kind of feed addictive tannic acid alkaloid, it is prepared from by tannic acid and alkaloid.
The tannic acid alkaloid that the present invention is provided is prepared from by tannic acid and alkaloid, wherein, the tannic acid, also known as tannin
Acid, tannic acid, tannic acid, gallotannic acid, larch roasting glue, sour two gallic acids, charcoal Buddhist nun, soft acid, be with obtained in Chinese gall one
Kind of tannin, be yellow or light brown lightweight without crystalline substance powder or scale, odorless is micro- to have special odor, and taste is extremely puckery, is dissolved in water and second
Alcohol, is soluble in glycerine, is practically insoluble in ether, chloroform, benzene, and its aqueous solution meets with iron salt solutions becomes black-and-blue therefore big
Amount is used for doing blue ink.Tannic acid can make protein coagulating, for leather industry, pigskin, ox-hide etc. be processed into it is beautiful, clean,
Flexible, long-lived leather.
The molecular weight of tannic acid is 1701.20,210~215 DEG C of fusing point, 187 DEG C of flash-point, and molecular formula is C76H52O46, tannin
Acid is not single compound, and chemical composition is more complicated.
In the present invention, the tannic acid is selected from condensed tannin acid or hydrolyzable tannic acid.
Wherein, the condensed tannin acid is that the 2nd of flavanols in the derivative of flavanols, molecule passes through C-C keys and youngster
Tea phenol or benzenetriol are combined.Its structure is shown in formula I：
There is ester bond in the molecule of the hydrolyzable tannic acid, be the nutgall phenolic ester of glucose.Its structure such as Formula II or
Shown in formula III：
Hydrolyzable tannic acid be by gallate, or gallate the ester that is constituted with polyalcohol of derivative phenol carboxylic acid, in soda acid and
Under enzyme effect, the polyalcohol and phenol carboxylic acid of generation, the difference of the polyhydric phenols carboxylic acid produced according to hydrolysis, most of hydrolysis are single
It is peaceful to be subdivided into gallotannin and Ellagitannins again.
Wherein, gallotannin, i.e. nutgall tannin have formula IV structure：
In formula IV, G is galloyl, with Formula V structure：
Ellagitannins has Formula IV structure：
In Formula IV, G is galloyl, with Formula VII structure：
Tannic acid used in the present invention is condensed tannin acid or hydrolyzable tannic acid, but can not be the tannic acid hydrolyzed.
Because only that unhydrolysed tannic acid can just reach very strong astriction.
The alkaloid is preferably leonurine, berberine, arecaline, wilfordine, matrine, ephedrine, not hidden product
Alkali, sanguinarine, Chelerythrine, nicotine, caffeine, reserpine, quinine alkali, hyoscyamine, rutaecarpin, pseudoephedrine, oxidation
Matrine, ammothamnine, demethyl ephedrine, codonopsine, theophylline, hydrastine, glycine betaine, Choline Chloride, mulberry leaf life
Alkaloids, stachydrine, pipering, Stemona alkaloids, dendrobine, coculine, green grass or young crops rise alkali, capsaicine, aloperine, agate card alkaloid,
Cynomorium songaricum alkaloid, sparteine, orixine, carnitine, phellodendrine, rheum emodin, aloe-emodin, barley alkaloid and oat are biological
The one or more of alkali.One or more more preferably in berberine, capsaicine and sanguinarine.
Wherein, berberine tannate is a kind of important alkaloid, is the Chinese medicine of China's application for a long time.Can from the coptis, golden cypress,
Extracted in the plants such as barberry.It has significant bacteriostasis.Conventional hydrochloric acid berberine tannate is called Berberine hydrochloride.Tan
Sour jamaicin can be to resisting pathogenic microbes, to various bacteria such as shigella dysenteriae, tubercle bacillus, pneumococcus, typhoid bacillus and white
Larynx bacillus etc. has inhibitory action, wherein acting on most strong to shigella dysenteriae, is commonly used to the digestion such as treatment bacterial gastroenteritis, dysentery
Tract disease.Clinic is mainly used in treatment bacillary dysentery and enterogastritis, and it is without the resistance to the action of a drug and side effect.
The structure of berberine is as shown in Formula VIII：
Because solubility of the berberine salt in water is all smaller, for example hydrochloride is 1: 500, and sulfate is 1:30,
So trying not to be reacted with tannic acid with hydrochloride.
Capsaicine, molecular formula is C18H27NO3, molecular weight：305.41, its chemical name is：(anti-)-N- [(4- hydroxyls -3-
Methoxyphenyl)-methyl] -8- methyl -6- nonenyl acid amides, it is soluble in methanol, ethanol, acetone, chloroform and ether, also may be used
It is dissolved in alkaline aqueous solution.It has Formula IX structure,
Sanguinarine, molecular formula：C20H14NO4, molecular weight：332.33, it is dissolved in methanol, ethanol solution, it has Formula X knot
Structure：
The alkaloids such as above-mentioned berberine, capsaicine, sanguinarine and tannic acid combine to form tannic acid alkaloid, small into animal
Intestines, are decomposed in small intestine intestinal juice, free alkaloid and tannic acid are produced, so as to play antibacterial and astriction.
Tannic acid alkaloid of the present invention is light brown or yellow powder, and odorless, tasteless does not dissolve in water, chloroform, ethanol, second
Ether, does not decompose in stomach after livestock and poultry feeding, is decomposed in small intestinal segment and discharge tannic acid, solidify intestinal mucosa S-layer proteins, form one
Layer diaphragm, reduction is oozed out, and mitigating stimulates and enterocinesia, there is convergence, anti-diarrhea effect.
Tannic acid alkaloid ratio rise Italy apply magnificent Products it is excellent can treasured have significant advantage.First, in tannic acid alkaloid
Tannic acid in vitro with alkaloid combine, the infringement of this protein of pepsin is not resulted in, also due to tannic acid alkaloid
Tannic acid can slowly only be discharged by enzymolysis side in small enteral, destruction of the tannic acid to small intestine digestive ferment, suckling piglet is also significantly reduced
It is not perfect enough due to developing after 28 ages in days before and after wean, various digestive ferments inherently hyposecretion, and metabolism pole now
To be vigorous, " excellent can be precious " must be combined first with the pepsin in stomach by after feed intake, be caused stomach cardia short and cause son
Pig feedback strengthens compensation mechanism, and overlord is firmly upper to bend, and excessively strengthens the secretion of pepsin in the case of not yet full grown,
This is obviously adversely affected to late growing stage, after " excellent can precious " addition, including the enhanced original of pepsin activity
Cause.Also, tannic acid alkaloid also will not contaminate black feed as Hydrolysable Tannins acid " excellent can precious ", allow feed commodity to decline.
Addition of the tannic acid alkaloid that the present invention is provided in feed is only 200-1000ppm (in terms of tannic acid), animal
The convergence antibacterial that the tannic acid discharged after feeding in intestines can play as high zinc prevents the effect of animal diarrhea, and it is used
Amount is few, and cost is relatively low.Also, after the feed addictive tannic acid alkaloid that the present invention is provided is added in feed, to suckling piglet
Fur has good improvement, and commodity is improved.
Meanwhile, the feed addictive tannic acid alkaloid can also be added in summer poultry diet, successfully solve poultry
Summer water just the problem of, particularly egg fowl, because summer high temperature is drunk water more, causes avirulence water just, can brought to egg product
Very big pollution, makes egg commodity degradation, and storage period shortens, and tannic acid alkaloid is successfully solved to trouble and do not solved for many years
Certainly egg fowl water just problem.
Present invention also offers a kind of preparation method of above-mentioned feed addictive tannic acid alkaloid, comprise the following steps：Will
Tannic acid, alkaloid and solvent mixing, obtain tannic acid alkaloid.
Specifically, alkaloid is dissolved in solvent, alkaloid solution is obtained；
Tannic acid is added into the alkaloid solution, after mixing, tannic acid alkaloid is obtained.
In the present invention, the solvent is preferably water, acetone, ethanol, methanol or glycerine.The tannic acid and alkaloid rub
That ratio preferably 1：(0.1~25), more preferably 1：(0.3~2).
The present invention is added after tannic acid into the alkaloid solution, is had a large amount of sediments and is produced, after cooling, will be described heavy
Starch is centrifuged, drying, obtains tannic acid alkaloid.Wherein solvent can be recycled.
Add present invention also offers a kind of compound additive, including tannic acid alkaloid and the feed of other prevention Animal diseases
Plus agent.
Wherein, tannic acid alkaloid feed addictive tannic acid alkaloid described above；
The feed addictive of other prevention Animal diseases is selected from zinc oxide, carvacrol, origanum oil, cinnaldehydrum, cloves
Phenol, Thymol, lauric monoglyceride, enramycin, kitasamycin, terramycin, aureomycin, Bacitracin Zinc, sulfuric acid glue bar
Rhzomorph, salinomycin, avilamycin, Nosiheptide, flavomycoin, the sub- mycin of the plain Buddhist nun of dimension, Tylosin phosphate, apramycin sulfate,
One or more in Lincomycin Hydrochloride, Avilamycin and dusty yeast.
The mass ratio of the tannic acid alkaloid and the feed addictive of other prevention Animal diseases is 100：(0.001~
100000), preferably 100：(0.01~10000), more preferably 100：(0.1~1000), most preferably 100：(1~100).
Present invention also offers a kind of feed addictive, including diluent and feed addictive tannic acid life described above
Alkaloids；
The diluent is in stone flour, wheat bran, bean cake powder, bentonite, zeolite powder, corn flour and corn protein powder
It is one or more of；
The mass ratio of the diluent and the feed addictive tannic acid alkaloid is 100：0.0001-100000, preferably
For 100：(0.01~10000), more preferably 100：(0.1~1000), most preferably 100：(1~100).
Present invention also offers a kind of feed, including feed addictive tannic acid alkaloid described above, the feed adds
It is preferably (0.01~10000) mg/kg plus addition of the agent tannic acid alkaloid in feed is 0.001~100000mg/kg,
More preferably (0.1~5000) mg/kg, is most preferably (200~1000) mg/kg (in terms of tannic acid).
The feed be used for feeding pig, turkey, chicken, duck, goose, black-bone chicken, quail, pigeon, ox, horse, sheep, dog, ermine, deer, cat,
Donkey, rabbit, fish, shrimp, crab, shellfish, tortoise, snake or yellow eel.
In the present invention, the form of the feed is preferably that mixed feed, mixed fodder, concentrated feed, mineral matter are micro
Element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk or customized feed.
The feed addictive tannic acid alkaloid that the present invention is provided, tannic acid is combined with alkaloid in vitro, does not result in stomach egg
The infringement of this protein of white enzyme, simultaneously as tannic acid alkaloid only can slowly discharge tannic acid in small enteral by enzymolysis side, makes
Intestinal mucosa S-layer proteins are solidified, and form layer protecting film, and reduction is oozed out, and mitigating stimulates and enterocinesia, there is convergence, anti-diarrhea effect,
Also significantly reduce destruction of the tannic acid to small intestine digestive ferment.Addition of the tannic acid alkaloid that the present invention is provided in feed be only
The convergence that the tannic acid discharged after 200-1000ppm (in terms of tannic acid), feed intake in intestines can play as high zinc resists
Bacterium prevents the effect of animal diarrhea, and its consumption is few, and cost is relatively low.Also, the feed addictive tannic acid alkaloid that the present invention is provided
After added in feed, there is good improvement to the fur of suckling piglet, commodity is improved.In addition, also can be in summer poultry diet
Middle addition feed addictive tannic acid alkaloid, the problem of poultry summer water can be solved just.
For a further understanding of the present invention, a kind of feed addictive tannic acid that the present invention is provided is given birth to reference to embodiment
Alkaloids and preparation method thereof and a kind of compound additive and a kind of feed are illustrated, and protection scope of the present invention is not by following
The limitation of embodiment.
Embodiment 1
1000 kilograms of deionized water is added in 2000 liters of stainless steel cauldrons, 80 degree are warming up to, 100 kilograms of small tillers are added
Alkali, is fully dissolved into clear solution, adds 350 kilograms of tannic acids, stirs 60 minutes, cooling, has a large amount of precipitations to generate, centrifugation,
Drying, liquid circulation is used, and obtains 330 kilograms of tannic acid berberines, wherein tannic acid 71.5%, berberine 29.5%.
Embodiment 2
Added in 2000 liters of stainless steel cauldrons and remove 1000 kilograms of acetone, added 100 kilograms of capsaicines, be fully dissolved into
Clear solution, adds 580 kilograms of tannic acids, closed, is warming up to 60 degree, stirs 60 minutes, cooling, there is a large amount of precipitation generations, from
The heart, drying, liquid circulation is used, and obtains 657 kilograms of tannic acid capsaicines, wherein tannic acid 84.8%, berberine 15.2%.
Embodiment 3
1000 kilograms of deionized water is added in 2000 liters of stainless steel cauldrons, 500 kilograms of ethanol adds 100 kilograms of blood
Root alkali, is fully dissolved into clear solution, adds 512 kilograms of tannic acids, closed, is warming up to 80 degree, stirs 60 minutes, and cooling has
A large amount of precipitation generations, are centrifuged, drying, liquid circulation is used, and obtains 612 kilograms of tannic acid sanguinarine, wherein tannic acid 83.7%, sanguinarine
16.3%.
Embodiment 4：
By 100 kilograms of tannic acid berberine, it is mixed with 40 kilograms of cornstarch containing being tannic acid 51.1%, berberine
21.1% feed addictive A.
Embodiment 5
100 kilograms of tannic acid capsaicine, 54 kilograms are made containing tannic acid 55%, capsaicine 10%, dusty yeast 35% with dusty yeast
Compound tannalbin yeast feed additive B
Embodiment 6
100 kilograms of tannic acid sanguinarine, 25 kilograms are configured to contain tannic acid 67%, zinc oxide 20%, sanguinarine with zinc oxide
13% compound tannic acid sanguinarine zinc oxide feed addictive C.
Embodiment 7
100 kilograms of tannic acid berberine, contains tannic acid 51.1%, small tiller with 10 kilograms of eugenol, 30 kilograms of compositions of Thymol
Alkali 21.1%, eugenol 7.1%, the compound tannic acid berberine plants essential oil feed addictive D of Thymol 21.4%.
Embodiment 8
100 kilograms of tannic acid berberine prepares composition and contains tannic acid 35.75%, small tiller with 20% 100 kilograms of colistin sulfate
The feed addictive E of alkali 14.75%, colistine sulfate 10%.
Embodiment 9
Use dregs of beans 648kg, fish meal 30kg, (high protein) whey powder 120kg, big north agriculture mine trace element vitamin premix
Material 200kg, tannic acid berberine 2kg (containing tannic acid 1430mg/kg) are closed, preparation obtains the sucking pig concentrate feed of 21-60 ages in days 20%
Embodiment 10
Formula according to table 1 weighs raw material configuration feed.
The feed formula of table 1
In above-mentioned feed formula, the 2500mg/kg of capsaicine containing tannic acid.
In table 1, the specific formula of many ore deposits of pig is shown in Table 2
The many ore deposit formulas of the pig of table 2
| Composition | Content |
| Copper sulphate | 0.16 |
| Ferrous sulfate | 0.1436 |
| Zinc sulfate | 0.1 |
| Manganese sulfate | 0.0384 |
| Organic Iron | 0.04 |
| KI 1% | 0.01 |
| Sodium selenite 1% | 0.005 |
| Afforest cobalt 1.2% | 0.004 |
| Stone flour | 0.499 |
| Niacinamide | 0.085 |
| It is total | 1 |
In table 1, the formula of pig multidimensional is shown in Table 3：
The pig multidimensional of table 3 is formulated
| Composition | Content |
| VA | 0.05 |
| VD3 | 0.013 |
| VE | 0.15 |
| VK3 | 0.01176 |
| VB1 | 0.00588 |
| VB2 | 0.0225 |
| VB6 | 0.00732 |
| VB12 | 0.00507 |
| Niacinamide | 0.085 |
| Pantothenic acid | 0.04444 |
| Folic acid | 0.00313 |
| Biotin | 0.02 |
| Antioxidant tertiary butyl hydroquinone | 0.0005 |
| Beneficial U.S.'s peptide | 0.1 |
| Rice chaff | 0.4814 |
| It is total | 1 |
Embodiment 11
Weigh successively：53.1 kilograms of ferrous sulfate, 50 kilograms of copper sulphate, 140.27 kilograms of zinc oxide, manganese sulfate 7.81 are public
Jin, 35 kilograms of zinc sulfate, 3 kilograms of KI, 1.5 kilograms of sodium selenite, 4 kilograms of cobalt chloride, 60 kilograms of 15% Bacitracin Zinc,
10% 12.5 kilograms of colomycin, 15 kilograms of piglet multidimensional (magnificent sieve), 25.82 kilograms of complex enzyme, 25 kilograms of sweetener, strong frankincense
5 kilograms, 12.5 kilograms of 8% enramycin, 9 kilograms of arsanilic acid, 0.5 kilogram of antioxidant tertiary butyl hydroquinone and embodiment
1 40 kilograms of the feed addictive of berberine containing tannic acid prepared, mixing obtains 500 kilograms of 1% premix of sucking pig, wherein, containing tannin
Sour 28600mg/kg.
Embodiment 12
By lysine hydrochloride 250kg, import (Peru) fish meal 200kg, (high protein) whey powder 350kg and implementation
Tannic acid berberine 200kg prepared by example 1, mixing, the high protein sucking pig for being configured to (the berberine 100000mg/kg containing tannic acid) is determined
Feed 1000kg processed.
Embodiment 13
The piglet 96 of the miscellaneous 21 age in days wean of the long ternary of Du is chosen, 4 groups respectively, every group of 4 repetitions each repeat 6 pigs,
Male and female half and half, sets respectively：
The high zinc antibiotic A groups of control group：Add the g ton of zinc oxide 3000 (Dietary zinc is 2250PPM)+antibiotic addition quinoline
The g ton of+10% aureomycin of 300 g ton of enramycin 750 of the g ton+4% of ethanol 100；
Test group is respectively B, C, D group, and the g ton of tannic acid berberine 500 of the preparation of embodiment 1, embodiment 2 are added respectively and is made
The g ton of tannic acid sanguinarine 500 prepared by the standby g ton of tannic acid capsaicine 500, embodiment 3, each test group does not increase zinc, only
Plus the g ton (zinc 120PPM) of monohydrate zinc sulphate 400, other feed ingredients are the same.Other described feed ingredient compositions are shown in Table 4：
Other feed ingredient contents of table 4
The nutrient composition content of above-mentioned feed is shown in Table 5.
Nutritional ingredient in the feed of table 5
| Nutritional ingredient | |
| Crude protein/% | 19.5 |
| Calcium/% | 0.8 |
| Total phosphorus/% | 0.69 |
| Lysine/% | 1.45 |
| Egg+cystine/% | 0.81 |
| Threonine/% | 0.91 |
| Digestible energy (kilocalorie/kilogram) | 3450 |
Above-mentioned 96 weanling pigs use identical feeding management, and free choice feeding, by the feeding experiment of 30 days, is as a result shown in
Table 6.
Result after 6 weaning pig feeding of table 30 days
In table 6, a, b represent level of difference, and letter is identical, represents no significant difference (P>0.05)；It is alphabetical different, table
It is shown with significant difference (P<0.05)；There are two letters different, indicate pole significant difference (P<0.01).
Result above shows that the diarrhea rate pole of tannic acid alkaloid feed addictive each group is substantially less than high zinc group, illustrates it
Complete alternative high zinc, but the feedstuff-meat ratio of each group has been raised, after showing that tannic acid discharges tannic acid in small intestine alkaloid
Still there is certain destruction to enteral digestive ferment, each test group feed intake is improved, and illustrates the health status of pig
It is better than high zinc group.
Embodiment 14
High term is chosen come the white shell egg chicken 500 that navigates, is divided into 5 groups, every group of 5 repetitions are each to repeat 20, set successively：
Blank control A groups；
Test each g ton of the berberine of addition tannic acid respectively 50 of B, C, D group, the g ton of tannic acid capsaicine 50, tannic acid sanguinarine 50
G ton；
Other ration ingredients of A, B, C, D group addition are consistent, and the formula of other ration ingredients is corn 57.4%, wheat
Bran 3%, dregs of beans 20%, fish meal 2%, rapeseed meal 4%, cotton dregs 3%, calcium monohydrogen phosphate 1.3%, stone flour 8%, salt 0.3% and 1% are big
Northern agriculture laying hen premix.
Manage the conditions such as ventilation, illumination consistent, first pre- to raise seven days, formal test 30 days is collected lay eggs daily, observes chicken
Fecal pollution egg quantity is as criterion, and test period is on July 29,30 days to 2015 June in 2015, as a result as follows：
It the results are shown in Table 7：
Table 7 is come the raising result for the white shell egg chicken that navigates
In table 7, a, b represent level of difference, and letter is identical, represents no significant difference (P>0.05)；It is alphabetical different, table
It is shown with significant difference (P<0.05)；There are two letters different, indicate pole significant difference (P<0.01).
Upper table illustrates, after laying hen addition tannic acid alkaloid, is compared with blank group, the fecal pollution number of egg extremely significantly under
Drop.
Equally, we turkey, duck, goose, black-bone chicken, quail, pigeon, ox, horse, sheep, dog, ermine, deer, cat, donkey, rabbit, fish,
Shrimp, crab, shellfish, tortoise, snake, the feed applications tannic acid alkaloid of yellow eel can also obtain preferable Antidiarrheic effect and good productivity
Energy.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of feed addictive：Tannic acid alkaloid；Characterized in that, being prepared from by tannic acid and alkaloid.
2. feed addictive tannic acid alkaloid according to claim 1, it is characterised in that the alkaloid is selected from motherwort
Alkali, berberine, arecaline, wilfordine, matrine, ephedrine, allocryptopine, sanguinarine, Chelerythrine, nicotine, coffee
Alkali, reserpine, quinine alkali, hyoscyamine, rutaecarpin, pseudoephedrine, oxymatrine, ammothamnine, demethyl ephedrine,
Codonopsine, theophylline, hydrastine, glycine betaine, Choline Chloride, Folium Mori alkaloid, stachydrine, pipering, Stemona alkaloids, stone
Dry measure used in former times alkali, coculine, green grass or young crops rise alkali, capsaicine, aloperine, agate card alkaloid, cynomorium songaricum alkaloid, sparteine, orixine, carnitine,
One or more in phellodendrine, rheum emodin, aloe-emodin, barley alkaloid and oat alkaloid.
3. a kind of preparation method of feed addictive tannic acid alkaloid as described in claim 1~2 any one claim,
It is characterised in that it includes following steps：
Tannic acid, alkaloid and solvent are mixed, tannic acid alkaloid is obtained.
4. preparation method according to claim 3, it is characterised in that the mol ratio of the tannic acid and alkaloid is 1：(0.1
~25).
5. a kind of compound additive, it is characterised in that the feed addictive including tannic acid alkaloid with other prevention Animal diseases；
The tannic acid alkaloid is the feed addictive tannic acid alkaloid described in claim 1~2 any one claim；
The feed addictive of other prevention Animal diseases is selected from zinc oxide, carvacrol, origanum oil, cinnaldehydrum, eugenol, hundred
In fragrant phenol, lauric monoglyceride, enramycin, kitasamycin, terramycin, aureomycin, Bacitracin Zinc, colistine sulfate,
The sub- mycin of the plain Buddhist nun of salinomycin, avilamycin, Nosiheptide, flavomycoin, dimension, Tylosin phosphate, apramycin sulfate, hydrochloric acid woods
One or more that can be in mycin, Avilamycin and dusty yeast.
6. compound additive according to claim 5, it is characterised in that the tannic acid alkaloid and other prevention animal diseases
The mass ratio of the feed addictive of disease is 100：0.001-100000.
7. a kind of feed addictive, it is characterised in that including diluent and claim 1~2 any one claim institute
The feed addictive tannic acid alkaloid stated；
The one kind of the diluent in stone flour, wheat bran, bean cake powder, bentonite, zeolite powder, corn flour and corn protein powder
Or it is several；
The mass ratio of the diluent and the feed addictive tannic acid alkaloid is 100：0.0001-100000.
8. a kind of feed, it is characterised in that including the feed addictive tan described in claim 1~2 any one claim
Sour alkaloid, addition of the feed addictive tannic acid alkaloid in feed is 0.001~100000mg/kg.
9. feed according to claim 8, it is characterised in that the feed is used for feeding pig, turkey, chicken, duck, goose, crow
Chicken, quail, pigeon, ox, horse, sheep, dog, ermine, deer, cat, donkey, rabbit, fish, shrimp, crab, shellfish, tortoise, snake or yellow eel.
10. feed according to claim 8, it is characterised in that the feed is mixed feed, mixed fodder, concentration feeding
Material, mineral trace element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk or
Customized feed.
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| CN201610111092.XA CN107125438A (en) | 2016-02-29 | 2016-02-29 | A kind of feed addictive tannic acid alkaloid and preparation method thereof and a kind of compound additive and a kind of feed |
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| CN201610111092.XA CN107125438A (en) | 2016-02-29 | 2016-02-29 | A kind of feed addictive tannic acid alkaloid and preparation method thereof and a kind of compound additive and a kind of feed |
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| CN113180142A (en) * | 2021-05-31 | 2021-07-30 | 广州朴成农牧科技有限公司 | Fermented feed and preparation method and application thereof |
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