CN107095822A - A kind of Chinese medicine composition and its production and use - Google Patents
A kind of Chinese medicine composition and its production and use Download PDFInfo
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61Q19/08—Anti-ageing preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of Chinese medicine composition and its production and use.The Chinese medicine composition of the present invention, by weight, preparing raw material includes 85~100 parts of Chinese medical extract and 0.1~1 part of ecological nutrient liquid.The present invention uses pure Chinese medicine composition, it is pure natural non-stimulated, it is applied in combination using several kinds of Chinese medicinal materials, can be with the regulation of qi and blood, it is promoting blood circulation and removing blood stasis, moisturizing is brightened, anti-wrinkle macrobiosis, with whitening, moisturizing, the multi-efficiency of anti-aging, in combination with inulin and alpha-glucan oligosaccharides, improve the living environment of probiotics, further adjust skin pH environment, recover the microbial barrier of skin, improve the self-regulatory mechanism of skin, the Absorption And Metabolism balance of the recovery skin of the present invention from inside to outside in all directions, institutional framework is balanced, pH is balanced and beneficial flora balance, multiple spot continuous action, reach the purpose of efficient skin care foster skin.
Description
Technical field
The invention belongs to cosmetic technical field, and in particular to a kind of Chinese medicine composition and its production and use.
Background technology
The tempo increase of modern humans' life, the daily schedule is irregular, endocrinopathy is easily caused, simultaneously because environment
Pollution is aggravated, and the external stimulus of skin is strengthened.Therefore, under the effect of inside and outside double factor, the balancing of skin is destroyed,
Skin problem is caused to take place frequently.
The balance of skin include the Absorption And Metabolism of skin, moisture deposit give, fat secretion, sensitivity response, pH environment, knot of tissue
The coordinated balance of the native physiological function such as structure, destroy skin balancing, may result in the reduction of skin sebum, water loss,
Pigment deposition, skin surface ecology flora is weakened, and loses the barrier function to bacterium, so that skin becomes coarse dimness,
It is fragile sensitive, easy aging.Therefore, recover the inherent balance of skin, be the key for solving skin problem.
CN104800136A discloses a kind of Chinese medicine cosmetic of the anti-aging of moisturizing whitening, and it is by following percentage by weight
The raw material of meter is made：Radix glycyrrhizae 0.5-5%, bighead atractylodes rhizome 0.5-5%, bletilla striata 2-15%, ginkgo 0.5-5%, American Ginseng 1-10%, the red sage root
10-20%, ginger 10-25%, the colloidal tio 2 1.8-2.2% of mass concentration 10%, glycerine 7-9%, ethanol 10-
14%th, methyl p-hydroxybenzoate 0.08-0.12%, surplus is deionized water, and obtained Chinese medicine cosmetic can effectively solve to protect
Wet, whitening and anti-aging Chinese medicine cosmetic problem.
CN105267123A discloses a kind of skin whitening, moisturizing toner and preparation method thereof, and it includes following parts by weight
Raw material：40-60 parts of water, 2-5 parts of glycerine, 2-5 parts of butanediol, 1-3 parts of pearl powder, 0.5-1 parts of sorbierite, milk protein 0.5-
10-35 parts of 1.5 parts, 2-5 parts of hyaluronic acid, 0.01-0.02 parts of essence and Chinese medical extract, the skin whitening, moisturizing toner are gently close
Skin, has effects that whitening, moisturizing anti-aging.
Function nursing type cosmetics on the market, it is most of using chemical synthesis material as main component, reach whitening, nti-freckle
The effects such as, this kind of cosmetic industry is strong, quick result, but simultaneously strong to skin irritation, is easily destroyed skin script oneself
My protection mechanism and balance, make skin produce dependence.
Meanwhile, also miscellaneous cosmetics based on Chinese medicine occupy certain market share, but this kind of skin care
Often function is single for product, it is impossible to use simultaneously, adds the time cost of skin care, does not meet the allegro life side of modern
Formula.
In addition, existing Chinese medicine cosmetic is more based on the foster nourishing of temperature, one-side reparation skin metabolism, and to skin
PH environment is adjusted and the reparation of skin flora barrier has no corresponding means, and the skin care time is long, is taken effect slow.
The content of the invention
In view of the shortcomings of the prior art, an object of the present invention is to provide a kind of Chinese medicine composition, natural gentle nothing
Stimulate, moistening effect is good, with good skin-care effect.
For up to this purpose, the present invention uses following technical scheme：
A kind of Chinese medicine composition, by weight, preparing raw material include 85~100 parts of Chinese medical extract and 0.1~1
Part ecological nutrient liquid, the parts by weight of such as Chinese medical extract are 85 parts, 86 parts, 87 parts, 88 parts, 89 parts, 90 parts, 91 parts, 92
Part, 93 parts, 94 parts, 95 parts, 96 parts, 97 parts, 98 parts, 99 parts, 100 parts, the parts by weight of ecological nutrient liquid are 0.1 part, 0.15 part,
0.2 part, 0.25 part, 0.3 part, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts,
2.4 parts, 2.6 parts, 2.8 parts, 3 parts.
In the present invention, by weight, the Chinese medical extract include 0~20 part Ligusticum wallichii, 0~20 part of the root of herbaceous peony, 0~
20 parts of Radix Angelicae Sinensis, 0.1~20 part of ginseng, 0.1~20 part of the bighead atractylodes rhizome, 0~20 part of the Radix Astragali, 0.1~20 part of PORIA ALBA, 0
~20 parts of the tuber of dwarf lilyturf, 0.5~20 part of the stem of noble dendrobium, 0~20 part of honey-fried licorice root, 0~10 part of ginger；The parts by weight of such as Ligusticum wallichii are
0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6
Part, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts；The root of herbaceous peony
Parts by weight be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 2 parts, 3 parts, 4
Part, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20
Part；The parts by weight of Radix Angelicae Sinensis be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 2
Part, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts,
19 parts, 20 parts；The parts by weight of ginseng be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9
Part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17
Part, 18 parts, 19 parts, 20 parts；The parts by weight of the bighead atractylodes rhizome be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8
Part, 0.9 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16
Part, 17 parts, 18 parts, 19 parts, 20 parts；The parts by weight of the Radix Astragali be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7
Part, 0.8 part, 0.9 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts,
15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts；The parts by weight of PORIA ALBA be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part,
0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13
Part, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts；The parts by weight of the tuber of dwarf lilyturf be 0.1 part, 0.2 part, 0.3 part, 0.4 part,
0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts,
12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts；The parts by weight of the stem of noble dendrobium be 0.1 part, 0.2 part, 0.3 part,
0.4 part, 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15
Part, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts；The parts by weight of honey-fried licorice root be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6
Part, 0.7 part, 0.8 part, 0.9 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts,
14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts；The parts by weight of ginger be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5
Part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts.
Wherein, the ligustrazine in Ligusticum wallichii can suppress the generation of free radical, effective scavenging activated oxygen, delay senility of humanbody,
Cytopathy is prevented, while ligustrazine can also suppress the activity of melanocyte, the generation of melanin is reduced, can play and brighten
The effect of except black；Albiflorin in the root of herbaceous peony can adjust immune, with preferable antiinflammatory action；Radix Angelicae Sinensis is rich in phthalide Ester,
NMF (NMF) in generation epidermal cell can be promoted, with moisture-keeping efficacy, be beneficial to stem cell and vascular endothelial cell
Propagation, skin microcirculation can be improved with promoting blood circulation and removing blood stasis, while angelica extract has good SOD samples activity, suppress super oxygen
Membrane lipid peroxidatio reaction and radical reaction caused by free radical, the complexion caused to free radical retardance is gloomy and sore swells have
Special efficacy；Ginseng extract can promote hyaluronic acid generation, strengthen epidermis cell plastid and vascular endothelial cell proliferation, suppress melanin
Cytoactive, with promoting blood circulation moisturizing, except black is brightened, effect of smoothing wrinkle macrobiosis；Rhizoma Atractylodis Macrocephalae extract is made to the propagation of laminin
With with the promotion generated to collagen, show that the extract can strengthen skin cell metabolism, play the role of anti-ageing；The Radix Astragali
In astragalus polyose and astragaloside there is the effect of strong elimination free radical, have anti-ageing effect；PORIA ALBA extract is to whole
Conjunction have promotion proliferation function, and the propagation of integrin can make the diameter and volume-diminished of the collagen of fibrous bud cell encapsulation,
, being capable of Firm smoothing wrinkle so as to there is contractive effect；It is in the tuber of dwarf lilyturf to contain saponin(e and anthraquinone more, with preferable bacteriostasis, table can be promoted
The propagation of hide fiber cell, quickly repairs damaged skin, can also promote arginase activities, strengthens the ability of skin water holding,
Profit supports skin；Herba Dendrobii extract can increase the CBF of capillary, and promoting blood circulation and removing blood stasis, hair tonic is anti-ageing；Honey-fried licorice root is rich in triterpenes
And flavone compound, for the relevant staphylococcus aureus inhibitory action of disease of skin substantially, anti-inflammation；Ginger is extracted
Thing has certain inhibitory action to germ, more there is middle benefit gas dispelling cold, the function of Back to Yang Tongmai；Many medicines are shared, can be living with the regulation of qi and blood
Blood stagnation resolvation, moisturizing is brightened, anti-wrinkle macrobiosis, the effect balanced from internal regulation skin metabolic balance and institutional framework is realized, by it
Applied in cosmetics, moisturizing, whitening and anti-aging effects can be played.
In the present invention, by weight, the ecological nutrient liquid includes inulin, alpha-glucans oligosaccharides and water.
Ecological nutrient liquid of the present invention is the FLORASKIN L ecological nutrient liquids that Xian Ting companies of France buy, its
INCI is entitled：Inulin, water, alpha-glucans oligosaccharides.
Wherein, inulin is deposit property polysaccharide in plant, and hygroscopicity is strong, with the ability for combining Free water, can reduce water
Divide activity, delay the evaporation of moisture, with good moisture-keeping efficacy；Inulin is combined with alpha-glucans oligosaccharides, natural sugar is formed
Class compound, with broad spectrum of activity, growth of probiotics is promoted by competitive inhibition, maintains skin microbial group balance,
Meanwhile, the presence of prebiotic bacterium colony is not only that skin provides microbial barrier and buffer zone, moreover it is possible to adjusts skin pH environment, ties up
The pH balances of skin are held, the problems such as reducing skin eczema, ox-hide moss, dry.
The invention provides a kind of moisturizing Chinese medicine composition, by weight, preparing raw material includes 0.1~3 part of oligomerization
Sodium Hyaluronate and 97~100 parts of Chinese medicine composition obtained above, such as parts by weight of oligomerization Sodium Hyaluronate are 0.1
Part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4
Part, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts, 2.1 parts, 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7
Part, 2.8 parts, 2.9 parts, 3 parts；The addition of oligomerization Sodium Hyaluronate can further pin moisture, allow Chinese medicine composition and other work(
The effect factor persistent can act on skin, complete its effect of performance.
The invention provides a kind of delay aging drug composition, by weight, preparing raw material includes 0.1~3 part of water
The weight of dissolubility silicone elastomer body and 97~100 parts of Chinese medicine composition obtained above, such as water-soluble silicon glue elastomer
Part for 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.1 parts, 1.2 parts, 1.3
Part, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts, 2.1 parts, 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6
Part, 2.7 parts, 2.8 parts, 2.9 parts, 3 parts；Water-soluble silicon glue elastomer can play a part of hiding the flaw, while its water solubility causes
It is easy to clean, without using makeup removal products, make its easy to use.
Present invention also offers a kind of whitening Chinese medicament composition, by weight, preparing raw material includes 0.1~3 part U.S.
White preparation and 97~100 parts of Chinese medicine composition obtained above, such as parts by weight of whitening preparation be 0.1 part, 0.2 part,
0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts,
1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts, 2.1 parts, 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, 2.8 parts,
2.9 parts, 3 parts；Preferably, the whitening preparation is the mixing of Vc ethylether, alpha-arbutin or Vc ethylether and alpha-arbutin
Thing.
From the above mentioned, the present invention recovers the Absorption And Metabolism of skin, institutional framework using Chinese medicine composition in regulation qi and blood
Balance, has inulin, the natural carbohydrate complexes of alpha-glucans oligosaccharides formation to maintain skin pH and ecological flora balance, coordinates again
Oligomerization Sodium Hyaluronate, water-soluble silicon glue elastomer, whitening preparation etc. immediately functional component, by it is inner and it is outer in all directions repair maintenance
Skin is balanced, and reaches the purpose of efficiently nursing skin.
The second object of the present invention is to provide a kind of preparation method of Chinese medicine composition, comprised the following steps：
1) respectively by Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, the stem of noble dendrobium, honey-fried licorice root, ginger
At least two medicinal material it is ground, cleaning, backflow water process, filtering, micro-filtration film process, be uniformly mixed according to a ratio and prepare Chinese medicine
Extract；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of Eco Battalion
Nutrient solution is mixed, and the Chinese medicine composition is made after stirring.
In the present invention, the step 1) detailed process be：Weigh Ligusticum wallichii, it is the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, white
At least two medicinal material in Poria cocos, the tuber of dwarf lilyturf, the stem of noble dendrobium, honey-fried licorice root, ginger, is cleaned two to three times with warm water, adds deionized water,
Vapor 3~5h of refluxing extraction, after being filtered with the filter cloth of two layers of 1200 mesh, carries out micro-filtrate membrane filtration, prepares Chinese medicine
Extract.
As the preferred scheme of the present invention, a kind of preparation method of moisturizing Chinese medicine composition comprises the following steps：
1) preparation of Chinese medical extract weigh Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, the stem of noble dendrobium,
The medicinal material of honey-fried licorice root at least two, is cleaned two to three times with warm water, adds deionized water, vapor 3~5h of refluxing extraction, with two
After the filter cloth of 1200 mesh of layer is filtered, micro-filtrate membrane filtration is carried out, Chinese medical extract is prepared；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of Eco Battalion
Nutrient solution is mixed, and stir obtained mixed liquor；
3) 0.1~3 part of oligomerization Sodium Hyaluronate by weight, is added to 97~100 parts of steps 2) made from mix
Close in liquid, stir, moisturizing Chinese medicine composition is made.
As another preferred scheme of the present invention, a kind of preparation method of delay aging drug composition, including following step
Suddenly：
1) preparation of Chinese medical extract：With boiling water by Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf,
At least two medicinal material in the stem of noble dendrobium, honey-fried licorice root, ginger is cleaned two to three times with warm water, adds deionized water, vapor backflow
3~5h is extracted, after being filtered with the filter cloth of two layers of 1200 mesh, micro-filtrate membrane filtration is carried out, prepares Chinese medical extract；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of Eco Battalion
Nutrient solution is mixed, and stir obtained mixed liquor；
3) 0.1~3 part of water-soluble silicon glue elastomer by weight, is added to 97~100 parts of steps 2) it is obtained
In mixed liquor, stir, delay aging drug composition is made.
As another preferred scheme of the present invention, a kind of preparation method of whitening Chinese medicament composition comprises the following steps：
1) preparation of Chinese medical extract：With boiling water by Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf,
At least two medicinal material in the stem of noble dendrobium, honey-fried licorice root, ginger is cleaned two to three times with warm water, adds deionized water, vapor backflow
3~5h is extracted, after being filtered with the filter cloth of two layers of 1200 mesh, micro-filtrate membrane filtration is carried out, prepares Chinese medical extract；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of Eco Battalion
Nutrient solution is mixed, and stir obtained mixed liquor；
3) 0.1~3 part of whitening preparation by weight, is added to 97~100 parts of steps 2) made from mixed liquor,
Stir, whitening Chinese medicament composition is made.
The third object of the present invention is to provide a kind of purposes of Chinese medicine composition, is applied to the preparation of cosmetics.
Compared with prior art, beneficial effects of the present invention are：
(1) present invention uses pure Chinese medicine composition, and pure natural non-stimulated, the gentle nourishes rough skin of deep layer improves skin blood and followed
Ring, deep layer repairs skin care, lifts skin self-regeneration function, natural gentle non-stimulated.
(2) present invention is applied in combination using several kinds of Chinese medicinal materials, can be promoting blood circulation and removing blood stasis with the regulation of qi and blood, and moisturizing is brightened, and anti-wrinkle is prolonged
Year, with whitening, moisturizing, anti-aging multi-efficiency, in cosmetics, a series of multifunctional cosmetics can be developed,
Efficient skin care, meets the allegro life style of modern humans.
(3) present invention combines inulin and alpha-glucans oligosaccharides, improves the living environment of probiotics, further regulation skin pH
Environment, recovers the microbial barrier of skin, improves the self-regulatory mechanism of skin.
(4) Chinese medicine composition of the invention, aquaporin AQP3 gene copy number is high, is up to 1.71, moisturizing
Effect is good；Absorption And Metabolism balance, institutional framework balance, pH balances and the benefit of the recovery skin of the present invention from inside to outside in all directions
Raw colony balance, multiple spot continuous action reaches the purpose of efficient skin care foster skin.
(5) preparation method of the invention is simple, wide market, is adapted to large-scale production.
Brief description of the drawings
Fig. 1 (1) to Fig. 1 (4) is the cellular morphology schematic diagram that HaCAT cells after 42h are administered in embodiments of the invention 1-4；
The cellular morphology schematic diagram of HaCAT cells after 42h is administered for the comparative example 1-8 of the present invention by Fig. 1 (5)-Fig. 1 (12)；
Fig. 2 is the quantitative real-time PCR detection aquaporin egg that embodiments of the invention 1-7 and comparative example 1-8 is carried out
The column schematic diagram of white AQP3 gene copy number.
Embodiment
Technical scheme is further illustrated below by embodiment.
Unless specific instructions, various raw materials of the invention are commercially available buys, or is prepared according to the conventional method of this area
Obtain.
Embodiment 1
Weigh Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, the stem of noble dendrobium, each 1g of honey-fried licorice root, ginger
0.5g, is cleaned two to three times, adds deionized water, and vapor 3~5h of refluxing extraction was carried out with the filter cloth of two layers of 1200 mesh
Filter, 10~15min is centrifuged by filtrate, is taken supernatant to carry out micro-filtrate membrane filtration, is prepared Chinese medical extract.
Sample is made in the Chinese medical extract of preparation and is designated as sample L, quantitative real-time PCR detection aquaporin egg is carried out
White AQP3 gene copy number, gene copy number is 1.3 units.
HaCaT cells are inoculated in 96 orifice plates, 37 DEG C of incubator cultures, after after cell attachment, HaCaT cells are given containing sample
Product L nutrient solution, is cultivated using inverted microscope observation cellular morphology after 42h, 42h, can by microscope shown in such as Fig. 1 (1)
To observe, after administration 42h, HaCAT cellular morphologies are without significant change.
Embodiment 2
By weight, L99.3 parts of sample, 0.2 part of ecological nutrient liquid, 0.5 part of hyaluronic acid are taken, is well mixed in being made
Drug composition.
Sample is made in the Chinese medicine composition of preparation and is designated as sample M, quantitative real-time PCR detection aquaporin egg is carried out
White AQP3 gene copy number, gene copy number is 1.26 units.
In the nutrient solution that sample M is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (2), it can be seen that sample M HaCAT cellular morphologies are added after 42h without significant change.
Embodiment 3
By weight, L99.8 parts of sample, 0.2 part of ecological nutrient liquid are taken, obtained Chinese medicine composition is well mixed.
Sample is made in the Chinese medicine composition of preparation and is designated as sample N, quantitative real-time PCR detection aquaporin egg is carried out
White AQP3 gene copy number, gene copy number is 1.71 units.
In the nutrient solution that sample N is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (3), it can be seen that sample N HaCAT cellular morphologies are added after 42h without significant change.
Embodiment 4
By weight, L89.3 parts of sample, 0.2 part of ecological nutrient liquid, 0.5 part of hyaluronic acid, 10 parts of glycerine are taken, is mixed
Chinese medicine composition is uniformly made.
Sample is made in the Chinese medicine composition of preparation and is designated as sample O, quantitative real-time PCR detection aquaporin egg is carried out
White AQP3 gene copy number, gene copy number is 0.65 unit.
In the nutrient solution that sample O is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (4), it can be seen that sample O HaCAT cellular morphologies are added after 42h without significant change.
Embodiment 5
By weight, take L99.2 parts of sample, 0.2 part of ecological nutrient liquid, add 0.3 part potassium sorbate, 0.6 part
Sodium benzoate is well mixed obtained Chinese medicine composition as preservative.
Sample is made in the Chinese medicine composition of preparation and is designated as sample N1, quantitative real-time PCR detection aquaporin is carried out
Albumin A QP3 gene copy number, gene copy number is 0.64 unit.
In the nutrient solution that sample N1 is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Sample N1 HaCAT cellular morphologies are added after form, 42h without significant change.
Embodiment 6
By weight, L98.5 parts of sample, 0.2 part of ecological nutrient liquid, the Phenoxyethanol of 1 part of addition, 0.3 part of mountain are taken
Potassium sorbate, 0.6 part of sodium benzoate are well mixed obtained Chinese medicine composition as preservative.
Sample is made in the Chinese medicine composition of preparation and is designated as sample N2, quantitative real-time PCR detection aquaporin is carried out
Albumin A QP3 gene copy number, gene copy number is 0.85 unit.
In the nutrient solution that sample N2 is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Sample N2 HaCAT cellular morphologies are added after form, 42h without significant change.
Embodiment 7
By weight, L98.3 parts of sample, 0.2 part of ecological nutrient liquid are taken, the Phenoxyethanol for adding 1.5 parts is used as anti-corrosion
Agent, is well mixed obtained Chinese medicine composition.
Sample is made in the Chinese medicine composition of preparation and is designated as sample N3, quantitative real-time PCR detection aquaporin is carried out
Albumin A QP3 gene copy number, gene copy number is 0.72 unit.
In the nutrient solution that sample N3 is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Sample N3 HaCAT cellular morphologies are added after form, 42h without significant change.
Comparative example 1
Using commercially available prod as NMF, its INCI is entitled：Water, erythrite, neosine HCL, are designated as sample P, carry out real
When fluorescence quantitative PCR method detection aquaporin AQP3 gene copy number, gene copy number is 0.4 unit.
In the nutrient solution that sample P is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (5), it can be seen that though the HaCAT cellular morphologies of sample P are added after 42h without significant change, dead cell
Increase.
Comparative example 2
Using commercially available aquaporin NMF product as NMF, its INCI is entitled：Water, PCA potassium, flat peach cactus
Stem extraction, quantitative real-time PCR detection aquaporin AQP3 gene copy number, gene will be carried out by being designated as sample Q
Copy number is 0.15 unit.
In the nutrient solution that sample Q is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (6), it can be seen that sample Q HaCAT cell mortalities are added after 42h.
Comparative example 3
Using commercially available prod as NMF, its INCI is entitled：It is glycerine, water, Anjidew NL50, urea, trehalose, hexylene glycol, poly-
Quaternary ammonium salt -51, pungent glycol, Sodium Hyaluronate, are designated as sample R, carry out quantitative real-time PCR detection aquaporin AQP3
Gene copy number, gene copy number is 0.12 unit.
In the nutrient solution that sample R is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (7), it can be seen that sample R HaCAT cell mortalities are added after 42h.
Comparative example 4
Using commercially available prod as NMF, its INCI is entitled：Xylitol glucoside, anhydro xylitol, xylitol, note
For sample U, quantitative real-time PCR detection aquaporin AQP3 gene copy number, gene copy number 0.36 are carried out
Unit.
In the nutrient solution that sample U is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (8), it can be seen that atrophy occurs for the HaCAT cellular morphologies that sample U is added after 42h, and cell quantity subtracts
It is few.
Comparative example 5
Using the sour sodium product of commercial clear matter as NMF, its INCI is entitled：Sodium Hyaluronate, is designated as sample V, carries out
Quantitative real-time PCR detection aquaporin AQP3 gene copy number, gene copy number is 0.68 unit.
In the nutrient solution that sample V is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (9), it can be seen that sample V HaCAT cellular morphologies are added after 42h without significant change.
Comparative example 6
Using commercially available prod as NMF, its INCI is entitled：Water, glycerine, glycosylglycerol, are designated as sample W, carry out real
When fluorescence quantitative PCR method detection aquaporin AQP3 gene copy number, gene copy number is 0.55 unit.
In the nutrient solution that sample W is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (10), it can be seen that sample W HaCAT cellular morphologies are added after 42h without significant change.
Comparative example 7
Using commercially available prod as NMF, its INCI is entitled：Glycerine, hydrolysis glycosaminoglycan, are designated as sample X, enter
Row quantitative real-time PCR detection aquaporin AQP3 gene copy number, gene copy number is 0.65 unit.
In the nutrient solution that sample X is added to HaCaT cells, cultivate and inverted microscope observation cell is utilized after 42h, 42h
Shown in form, such as Fig. 1 (11), it can be seen that atrophy occurs for the HaCAT cellular morphologies that sample X is added after 42h, and cell quantity subtracts
It is few.
Comparative example 8
Using water as comparative example, in the nutrient solution for adding water to HaCaT cells, after culture 42h, observed using inverted microscope
Shown in HaCaT cellular morphologies, such as Fig. 1 (12), HaCAT cellular morphologies are without significant change.
Wherein, aquaporin AQP3 is detected to the quantitative real-time PCR that embodiment 1-4 and comparative example 1-8 is carried out
Gene copy number result it is as shown in Figure 2.By embodiment 1-4 and comparative example 1-8 aquaporin AQP3 gene copy number
As can be seen that the gene copy number of the Chinese medicine composition of the present invention is more, illustrate more, the moisturizing of aquaporin AQP3 expression
Effect is good.Relative to comparative example 1-8, the preservative with sample ingredient in comparative example is with the addition of in embodiment 5-7, and amount ratio is contrasted
It is bigger in example, but obtained aquaporin AQP3 gene copy number data are still higher than comparative example, this explanation Chinese traditional medicine composition
Moistening effect is obvious.Obtained data are lower than the data of embodiment 1-4 not adding preservative agents after embodiment 5-7 addition preservatives, this
Also illustrate, preservative has certain damage to cell, destroy cell results, cause aquaporin AQP3 gene copy number number
According to decreasing.
Prepare product and carry out moisture-keeping efficacy test：Using ordinary emulsion class product as base-material, wherein, product 1 to be measured is all
Using base-material, product 2 to be measured uses percentage by weight for 90% base-material, adds percentage by weight and is made for 10% embodiment 3
The Chinese medicine composition obtained, product 3 to be measured uses percentage by weight for 89.95% base-material, and addition percentage by weight is 10%
Chinese medicine composition made from embodiment 3 and the hyaluronic acid that percentage by weight is 0.05%, by product 1-3 to be measured through moisturizing work(
Effect test, specific method of testing is as follows：
1) subject is selected, the subject that forearm skin quality is dryness is chosen, moisture value is included less than 45；
2) subject is allowed in air-conditioned room (rest 20 minutes in 20~21 DEG C of temperature, relative humidity 40~50%)；
3) CK testers are used：Multi probe skin measurement system MPA6 (Multi Probe Adapter)-CM825 is visited
Head measurement moisture；
4) spread product, product consumption is 1.9~2.1mg/cm2；
5) 1h after spread product, 3h, 6h time points test skin moisture content, skin moisture content rate of change such as table 1
It is shown.
Table 1
Relative to common type of latex type product product 1 to be measured it can be seen from the data of table 1, the Chinese medicine of the present invention with the addition of
The product to be measured 2,3 of composition is respectively provided with preferable moistening effect.
Applicant states that the present invention illustrates detailed process equipment and the technological process of the present invention by above-described embodiment,
But the invention is not limited in above-mentioned detailed process equipment and technological process, that is, do not mean that the present invention has to rely on above-mentioned detailed
Process equipment and technological process could be implemented.Person of ordinary skill in the field it will be clearly understood that any improvement in the present invention,
Addition, selection of concrete mode of equivalence replacement and auxiliary element to each raw material of product of the present invention etc., all fall within the present invention's
Within the scope of protection domain and disclosure.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that by weight, preparing raw material includes 85~100 parts of Chinese medical extract
And 0.1~1 part of ecological nutrient liquid.
2. Chinese medicine composition according to claim 1, it is characterised in that by weight, the Chinese medical extract includes 0
~20 parts of Ligusticum wallichii, 0~20 part of the root of herbaceous peony, 0~20 part of Radix Angelicae Sinensis, 0.1~20 part of ginseng, 0.1~20 part of the bighead atractylodes rhizome, 0~
20 parts of the Radix Astragali, 0.1~20 part of PORIA ALBA, 0~20 part of the tuber of dwarf lilyturf, 0.5~20 part of the stem of noble dendrobium, 0~20 part of honey-fried licorice root, 0
~10 parts of ginger.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that the ecological nutrient liquid includes inulin, α-Portugal
Chitosan oligosaccharide and water.
4. a kind of moisturizing Chinese medicine composition, it is characterised in that by weight, the oligomerization that preparing raw material includes 0.1~3 part is transparent
Matter acid sodium and 97~100 parts of the Chinese medicine composition as described in one of claim 1-3.
5. a kind of delay aging drug composition, it is characterised in that by weight, preparing raw material includes 0.1~3 part of water solubility
Silicone elastomer body and 97~100 parts of the Chinese medicine composition as described in one of claim 1-3.
6. a kind of whitening Chinese medicament composition, it is characterised in that by weight, preparing raw material includes 0.1~3 part of whitening preparation
And 97~100 parts of the Chinese medicine composition as described in one of claim 1-3；
Preferably, the whitening preparation is the mixture of Vc ethylether, alpha-arbutin or Vc ethylether and alpha-arbutin.
7. the preparation method of a kind of Chinese medicine composition as described in one of claim 1-3, it is characterised in that including following step
Suddenly：
1) preparation of Chinese medical extract：Respectively by Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, the stem of noble dendrobium,
At least two medicinal material in honey-fried licorice root, ginger is ground, cleaning, backflow water process, filtering, micro-filtration film process, it is mixed by proportioning
Conjunction uniformly prepares Chinese medical extract；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of ecological nutrient liquid
Mixing, is made the Chinese medicine composition after stirring.
8. preparation method according to claim 7, it is characterised in that the step 1) detailed process be：Weigh Ligusticum wallichii,
At least two medicinal material in the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, the stem of noble dendrobium, honey-fried licorice root, ginger, with temperature
Water is cleaned two to three times, addition deionized water, vapor 3~5h of refluxing extraction, after being filtered with the filter cloth of two layers of 1200 mesh,
Micro-filtrate membrane filtration is carried out, Chinese medical extract is prepared.
9. the preparation method according to claim 7 or 8, it is characterised in that comprise the following steps：
1) preparation of Chinese medical extract weigh Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, the stem of noble dendrobium, process it is sweet
At least two medicinal material in grass, ginger, is cleaned two to three times with warm water, addition deionized water, and vapor refluxing extraction 3~
5h, after being filtered with the filter cloth of two layers of 1200 mesh, carries out micro-filtrate membrane filtration, prepares Chinese medical extract；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of ecological nutrient liquid
Mixing, stir obtained mixed liquor；
3) 0.1~3 part of oligomerization Sodium Hyaluronate by weight, is added to 97~100 parts of steps 2) made from mixed liquor
In, stir, moisturizing Chinese medicine composition is made；
Preferably, the preparation method comprises the following steps：
1) preparation of Chinese medical extract：With boiling water by Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, stone
At least two medicinal material in dry measure used in former times, honey-fried licorice root, ginger is cleaned two to three times with warm water, adds deionized water, and vapor backflow is carried
3~5h is taken, after being filtered with the filter cloth of two layers of 1200 mesh, micro-filtrate membrane filtration is carried out, prepares Chinese medical extract；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of ecological nutrient liquid
Mixing, stir obtained mixed liquor；
3) 0.1~3 part of water-soluble silicon glue elastomer by weight, is added to 97~100 parts of steps 2) obtained mixing
In liquid, stir, delay aging drug composition is made；
Preferably, the preparation method comprises the following steps：
1) preparation of Chinese medical extract：With boiling water by Ligusticum wallichii, the root of herbaceous peony, Radix Angelicae Sinensis, ginseng, the bighead atractylodes rhizome, the Radix Astragali, PORIA ALBA, the tuber of dwarf lilyturf, stone
At least two medicinal material in dry measure used in former times, honey-fried licorice root, ginger is cleaned two to three times with warm water, adds deionized water, and vapor backflow is carried
3~5h is taken, after being filtered with the filter cloth of two layers of 1200 mesh, micro-filtrate membrane filtration is carried out, prepares Chinese medical extract；
2) by weight, by step 1) made from 85~100 parts of Chinese medical extract and 0.1~1 part of ecological nutrient liquid
Mixing, stir obtained mixed liquor；
3) 0.1~3 part of whitening preparation by weight, is added to 97~100 parts of steps 2) made from mixed liquor, stirring
Uniformly, whitening Chinese medicament composition is made.
10. a kind of purposes of Chinese medicine composition, it is characterised in that be applied to the preparation of cosmetics.
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| CN108079270A (en) * | 2018-01-17 | 2018-05-29 | 科丽思化妆品（上海）有限公司 | A kind of anti acne of traditional Chinese medicine composition and its preparation method and application |
| CN109260124A (en) * | 2018-11-30 | 2019-01-25 | 成都珂萝瑞诗化妆品有限公司 | A kind of women secret nursing lubricating fluid and preparation method thereof |
| CN111388403A (en) * | 2020-04-12 | 2020-07-10 | 广州市索柔生物科技有限公司 | Prebiotic composition and application thereof |
| CN114432178A (en) * | 2022-03-03 | 2022-05-06 | 广州欣蔓化妆品有限公司 | Skin micro-ecological balance composition and preparation method and application thereof |
| CN114848568A (en) * | 2022-06-01 | 2022-08-05 | 广州富煜陇生物科技有限公司 | Compound plant extract with moisturizing effect and preparation and application thereof |
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| CN102302440A (en) * | 2011-09-23 | 2012-01-04 | 孙丽华 | Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition |
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| CN108079270A (en) * | 2018-01-17 | 2018-05-29 | 科丽思化妆品（上海）有限公司 | A kind of anti acne of traditional Chinese medicine composition and its preparation method and application |
| CN109260124A (en) * | 2018-11-30 | 2019-01-25 | 成都珂萝瑞诗化妆品有限公司 | A kind of women secret nursing lubricating fluid and preparation method thereof |
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| CN114432178A (en) * | 2022-03-03 | 2022-05-06 | 广州欣蔓化妆品有限公司 | Skin micro-ecological balance composition and preparation method and application thereof |
| CN114848568A (en) * | 2022-06-01 | 2022-08-05 | 广州富煜陇生物科技有限公司 | Compound plant extract with moisturizing effect and preparation and application thereof |
| CN114848568B (en) * | 2022-06-01 | 2023-09-01 | 广州富煜陇生物科技有限公司 | Compound plant extract with moisturizing effect and preparation and application thereof |
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