CN107090406B - 微液滴式pcr芯片及其制造方法 - Google Patents
微液滴式pcr芯片及其制造方法 Download PDFInfo
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- CN107090406B CN107090406B CN201710154270.1A CN201710154270A CN107090406B CN 107090406 B CN107090406 B CN 107090406B CN 201710154270 A CN201710154270 A CN 201710154270A CN 107090406 B CN107090406 B CN 107090406B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/145—Detecting door closure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
- B01L2300/049—Valves integrated in closure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1861—Means for temperature control using radiation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Micromachines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710154270.1A CN107090406B (zh) | 2017-03-15 | 2017-03-15 | 微液滴式pcr芯片及其制造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710154270.1A CN107090406B (zh) | 2017-03-15 | 2017-03-15 | 微液滴式pcr芯片及其制造方法 |
Publications (2)
Publication Number | Publication Date |
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CN107090406A CN107090406A (zh) | 2017-08-25 |
CN107090406B true CN107090406B (zh) | 2019-07-16 |
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CN201710154270.1A Active CN107090406B (zh) | 2017-03-15 | 2017-03-15 | 微液滴式pcr芯片及其制造方法 |
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CN (1) | CN107090406B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109647546A (zh) * | 2017-10-12 | 2019-04-19 | 中国科学院大连化学物理研究所 | 一种气动阀辅助的双水相液滴芯片 |
CN111323399A (zh) * | 2018-12-15 | 2020-06-23 | 中国科学院深圳先进技术研究院 | 多色荧光同步检测的液滴微流控芯片 |
CN111004708B (zh) * | 2019-12-24 | 2023-05-30 | 中国科学院长春光学精密机械与物理研究所 | Pcr温度循环控制方法及旋转驱动式pcr温度循环控制装置 |
CN113604344B (zh) * | 2021-08-11 | 2024-03-22 | 北京慧智医疗器械有限公司 | 一种高通量一体式微液滴数字pcr的实现系统 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2414059B (en) * | 2004-05-10 | 2008-06-11 | E2V Tech Uk Ltd | Microfluidic device |
CN103343092B (zh) * | 2013-07-19 | 2014-12-03 | 中国科学院上海微系统与信息技术研究所 | 基于矿物油饱和pdms材料的数字pcr芯片的制作方法 |
CN103451088B (zh) * | 2013-08-23 | 2015-01-21 | 上海交通大学 | 一种微液滴式pcr芯片及其制作方法 |
CN104109628B (zh) * | 2014-07-17 | 2016-04-13 | 重庆大学 | 基于激光加热的液滴式pcr反应器 |
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2017
- 2017-03-15 CN CN201710154270.1A patent/CN107090406B/zh active Active
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Effective date of registration: 20200826 Address after: 518055 Nanshan District, Xili, Shenzhen, Guangdong, 1068 A-301, Xue Yuan Avenue, Shenzhen University town. Patentee after: Shenzhen shen-tech advanced Cci Capital Ltd. Address before: 1068 No. 518055 Guangdong city in Shenzhen Province, Nanshan District City Xili University School Avenue Patentee before: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY Effective date of registration: 20200826 Address after: 518055 Shenzhen Institute of advanced technology, Chinese Academy of Sciences, No. 1068, Xueyuan Avenue, Taoyuan Street, Nanshan District, Shenzhen City, Guangdong Province Patentee after: Shenzhen National Research Institute of high performance Medical Devices Co.,Ltd. Address before: 518055 Nanshan District, Xili, Shenzhen, Guangdong, 1068 A-301, Xue Yuan Avenue, Shenzhen University town. Patentee before: Shenzhen shen-tech advanced Cci Capital Ltd. |
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Effective date of registration: 20220428 Address after: 518000 A704, building 1, Yinxing Zhijie phase II, No. 1301-76, sightseeing Road, Xinlan community, Guanlan street, Longhua District, Shenzhen, Guangdong Patentee after: Shenzhen guochuanghuikang Medical Device Technology Co.,Ltd. Address before: B714, Shenzhen Institute of advanced technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Taoyuan Street, Nanshan District, Shenzhen, Guangdong 518055 Patentee before: Shenzhen National Research Institute of high performance Medical Devices Co.,Ltd. |
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