CN107080245A - A kind of kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation - Google Patents
A kind of kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
The invention discloses a kind of kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, comprise the following steps：Cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, fructus alpiniae oxyphyllae are crushed, sieving continues to grind to form powdery, added water, and heats up, and insulation is placed, and is dried to obtain mixed material；Add edible glucose, maltodextrin, food additives, compound disintegrant into mixed material to be well mixed, granulate, vacuum drying is added in rotary blender and mixed, tabletting obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.Gained kidney tonifying of the invention, fill blood, antifatigue compound Chinese caterpillar fungus preparation is using above-mentioned raw materials mutual cooperation, nutriment extremely enriches, with enhancing metabolism, strengthen immune function of human body, kidney tonifying, fill blood, it is antifatigue, and not mucous membrane completely, preservation process is difficult the moisture absorption, while good into disintegration effect after stomach, it is easy to which human consumption absorbs.
Description
Technical field
The present invention relates to technical field of health care food, more particularly to a kind of kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation
Preparation method.
Background technology
Cordyceps sinensis is the stroma and larva corpse that section ergot fungus cordyceps sinensis are colonized on Hepialidae insect larvae
Complex, main active is that cordycepin, cordycepic acid, Cordyceps sinensis polysaccharide etc. are beneficial to the material of absorption of human body, is exempted from regulation
The multiple efficacies such as epidemic disease systemic-function, antitumor, antifatigue.The fleshy root of ginseng is famous strong tonic, it is adaptable to adjust blood
Pressure, cardiac function of recovering, neurasthenia and the disease such as in poor health, also have eliminating the phlegm, stomach invigorating, diuresis, it is excited the effects such as.Donkey-hide gelatin, is mended
Blood enriching yin, moisturizes, hemostasis.For blood deficiency chlorosis, dizziness palpitaition, dysphoria and insomnia, xeropulmonary cough.Cordyceps sinensis, ginseng, the processing of donkey-hide gelatin
Excellent performance, nutritious, tool relevant expert's research, daily ingestion of a certain amount of above-mentioned material is to control body weight, holding form, drop
Low blood pressure, prevention and control cardiovascular and cerebrovascular disease, anti-aging, radiation proof, prevention and control cataract, enhancing autoimmunity etc.
There is extremely important effect.Existing cordyceps and ginseng donkey-hide gelatin product is, using cordyceps sinensis, ginseng, donkey-hide gelatin as raw material, to add auxiliary
Material is processed, but the easy moisture absorption of process of cordyceps and ginseng donkey-hide gelatin product storage at present, and the shelf-life is short, into enteron aisle after disintegration rate expire
Foot not demand, it would be highly desirable to solve.
The content of the invention
Based on background technology exist technical problem, the present invention propose a kind of kidney tonifying, fill blood, antifatigue compound cordyceps sinensis
The preparation method of preparation, the raw material of resulting product cooperates, and nutriment extremely enriches, with enhancing metabolism, strengthen
Immune function of human body, kidney tonifying, fill blood, antifatigue, and not mucous membrane completely, preservation process is difficult the moisture absorption, while into stomach
Disintegration effect is good afterwards, it is easy to which human consumption absorbs.
A kind of kidney tonifying proposed by the present invention, fill blood, antifatigue compound Chinese caterpillar fungus preparation, comprise the following steps：
S1, by cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, fructus alpiniae oxyphyllae crush,
Sieving, continues to grind to form powdery, adds water, and heats up, and insulation is placed, and is dried to obtain mixed material；
S2, add edible glucose, maltodextrin, food additives, compound disintegrant into mixed material and be well mixed,
Granulation, vacuum drying, add rotary blender in mix, tabletting obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Preferably, in S1, by cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, benefit
Intelligence benevolence is crushed, and is crossed 80 mesh sieves, is continued to grind to form powdery, is added water to water content for 40-60wt%, is warming up to 60-70 DEG C, insulation is put
Put 2-8 days, be dried to obtain mixed material.
Preferably, in S1, cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, intelligence development
The weight ratio of benevolence is 30-50：20-30：5-18：1-4：2-6：1-4：1-5：1-3：1-8：2-8.
Preferably, in S2, it is combined disintegrant and is prepared using following technique：Polyvinyl alcohol, dioxane are well mixed, plus
Enter pyridine, succinic anhydride return stirring, add the stirring of deacetylation hyaluronic acid, add ethanol solution and extremely precipitate complete, filtering,
Washing, adds Ac-Di-Sol, is stirred at room temperature, and cools, and stands, freeze-drying, adds atoleine stirring, adds
After solid paraffin dissolving completely, add magnesium stearate and be uniformly mixing to obtain compound disintegrant.
Preferably, in S2, it is combined disintegrant and is prepared using following technique：Polyvinyl alcohol, dioxane are well mixed, plus
Enter pyridine, succinic anhydride return stirring 50-100min, reflux temperature is 70-80 DEG C, add deacetylation hyaluronic acid stirring 2-
4h, it is that 70-80wt% ethanol solutions are complete to precipitating to add concentration, is filtered, washing adds Ac-Di-Sol, room
Temperature stirring 15-30min, is cooled to 1-2 DEG C, stands 10-18h, and freeze-drying adds atoleine stirring 30-40min, stirring
Speed is 2400-2800r/min, is added after solid paraffin dissolving completely, adds magnesium stearate and is uniformly mixing to obtain compound disintegration
Agent.
Preferably, in S2, it is combined disintegrant and is prepared using following technique：By weight by 2-7 parts of polyvinyl alcohol, 20-40
Part dioxane is well mixed, and adds 0.1-0.2 parts of pyridines, 5-10 parts of succinic anhydride return stirring 50-100min, reflux temperature
For 70-80 DEG C, 10-20 part deacetylation hyaluronic acids stirring 2-4h are added, it is 70-80wt% ethanol solutions to sinking to add concentration
Form sediment complete, filter, washing adds 4-10 parts of Ac-Di-Sols, 15-30min is stirred at room temperature, be cooled to 1-2 DEG C, it is quiet
10-18h is put, is freeze-dried, 30-40 parts of atoleine stirring 30-40min are added, mixing speed is 2400-2800r/min, plus
Enter after 2-8 parts of solid paraffin dissolvings completely, add 1-4 parts of magnesium stearates and be uniformly mixing to obtain compound disintegrant.
Preferably, in S2, edible glucose, maltodextrin, food additives, compound disintegrant are added into mixed material
Well mixed, granulation, 60-70 DEG C of vacuum drying 2-4h is added and 30-50min is mixed in rotary blender, tabletting obtain kidney tonifying,
Fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Preferably, in S2, mixed material, edible glucose, maltodextrin, food additives, the weight of compound disintegrant
Than for 100：1-4：1-2：1-2：0.5-1.
Preferably, in S2, food additives are D-sorbite and/or magnesium stearate.
Gained kidney tonifying of the invention, fill blood, antifatigue compound Chinese caterpillar fungus preparation is using cordyceps militaris sporocarp, ginseng, donkey-hide gelatin as major ingredient
Composition, nutritious, anti-aging can effectively strengthen autoimmunity, kidney tonifying, fill blood, antifatigue effect it is notable；Using Fu
Siberian cocklebur, radix glycyrrhizae, RHIIZOMA DIOSCOREAE from Henan of China, fructus alpiniae oxyphyllae are used in combination, and can strengthen major ingredient effect, and nourshing kidney, tonifying liver, strengthening the spleen and replenishing qi strengthen muscles and bones, and can eliminate body
Interior rubbish, strengthens human body cell metabolism, prevents muscle skeleton aging, balanced human's blood pressure；And dried orange peel, Chinese cassia tree, matrimony vine are simultaneously
With with diuresis anti-inflammatory, disappear wind clearing damp, can fatigue-relieving, senile-resistant efficacy；Above-mentioned all medicinal powder is broken, grinding, after water logging again with it is multiple
Close disintegrant to coordinate, the not mucous membrane, and preservation process is difficult the moisture absorption completely in granulation and tabletting, while into being disintegrated after stomach
Effect is good, it is easy to which human consumption absorbs.The present invention compound disintegrant in, succinic anhydride after polyvinyl alcohol is handled with acetyl
Change cross-linking hyaluronic acid formation active ester compound, further acted on Ac-Di-Sol, not only remain friendship
Join the superdisintegrant effect of sodium carboxymethylcellulose, and ageing resistace is good, coordinates atoleine and atoleine high-speed stirring
After mixing, hydrophobic performance is excellent, while magnesium stearate is distributed wherein with molecular state, makes the present invention not sticking to mould completely, greatly drops
Low cleaning work amount.
Gained kidney tonifying of the invention, fill blood, antifatigue compound Chinese caterpillar fungus preparation is using above-mentioned raw materials mutual cooperation, nutriment
Extremely enrich, the effects such as with enhancing metabolism, strengthening immune function of human body, fatigue-relieving, anti-aging, be aided with table grapes
Sugar, maltodextrin, with the good effect of low-heat, easy to digest, stability, filling effect is good, and thickening property is strong, and sweet taste is pure, mouthfeel
It is splendid.Gained kidney tonifying of the invention, fill blood, that antifatigue compound Chinese caterpillar fungus preparation is adapted to crowd is wide, suitable for people of all ages, have no toxic side effect,
It can be eaten for a long time.Inventive article disintegration time is up to 25-30min, and the disintegration time than general tablet reduces 5-10min, and
Nutriment result of extraction is good.
Embodiment
Below, technical scheme is described in detail by specific embodiment.
Embodiment 1
A kind of kidney tonifying proposed by the present invention, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, including following step
Suddenly：
S1, by cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, fructus alpiniae oxyphyllae crush,
Sieving, continues to grind to form powdery, adds water, and heats up, and insulation is placed, and is dried to obtain mixed material；
S2, add edible glucose, maltodextrin, food additives, compound disintegrant into mixed material and be well mixed,
Granulation, vacuum drying, add rotary blender in mix, tabletting obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Embodiment 2
A kind of kidney tonifying proposed by the present invention, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, including following step
Suddenly：
S1, by weight by 30 parts of cordyceps militaris sporocarps, 30 parts of ginsengs, 5 parts of donkey-hide gelatin, 4 parts of Poria cocos, 2 portions of radix glycyrrhizaes, 4 parts of dried orange peels,
1 part of Chinese cassia tree, 3 parts of matrimony vines, 1 part of RHIIZOMA DIOSCOREAE from Henan of China, 8 parts of fructus alpiniae oxyphyllaes are crushed, and are crossed 80 mesh sieves, are continued to grind to form powdery, add water to water content
For 40wt%, 70 DEG C are warming up to, insulation is placed 2 days, is dried to obtain mixed material；
S2,4 parts of edible glucoses of addition, 1 part of maltodextrin, 2 parts of food additions into 100 parts of mixed materials by weight
Agent, 0.5 portion of compound disintegrant are well mixed, granulation, 70 DEG C of vacuum drying 2h, are added in rotary blender and are mixed 50min, tabletting
Obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Embodiment 3
A kind of kidney tonifying proposed by the present invention, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, including following step
Suddenly：
S1, by weight by 50 parts of cordyceps militaris sporocarps, 20 parts of ginsengs, 18 parts of donkey-hide gelatin, 1 part of Poria cocos, 6 portions of radix glycyrrhizaes, 1 part it is old
Skin, 15 parts of Chinese cassia trees, 1 part of matrimony vine, 8 parts of RHIIZOMA DIOSCOREAE from Henan of China, 2 parts of fructus alpiniae oxyphyllaes are crushed, and are crossed 80 mesh sieves, are continued to grind to form powdery, add water to and contain
Water is 60wt%, is warming up to 60 DEG C, insulation is placed 8 days, is dried to obtain mixed material；
S2,1 part of edible glucose of addition, 2 parts of maltodextrins, 1 part of food addition into 100 parts of mixed materials by weight
Agent, 1 portion of compound disintegrant are well mixed, granulation, 60 DEG C of vacuum drying 4h, are added in rotary blender and are mixed 30min, tabletting is obtained
To kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Compound disintegrant is prepared using following technique：Polyvinyl alcohol, dioxane are well mixed, pyridine, amber is added
Acid anhydrides return stirring, adds the stirring of deacetylation hyaluronic acid, adds ethanol solution and extremely precipitates complete, filters, washing, addition is handed over
Join sodium carboxymethylcellulose, be stirred at room temperature, cool, stand, freeze-drying adds atoleine stirring, adds solid paraffin molten
After solution is complete, adds magnesium stearate and be uniformly mixing to obtain compound disintegrant.
Embodiment 4
A kind of kidney tonifying proposed by the present invention, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, including following step
Suddenly：
S1, by weight by 35 parts of cordyceps militaris sporocarps, 28 parts of ginsengs, 8 parts of donkey-hide gelatin, 3 parts of Poria cocos, 3 portions of radix glycyrrhizaes, 3 parts of dried orange peels,
2 parts of Chinese cassia trees, 2.5 parts of matrimony vines, 3 parts of RHIIZOMA DIOSCOREAE from Henan of China, 6 parts of fructus alpiniae oxyphyllaes are crushed, and are crossed 80 mesh sieves, are continued to grind to form powdery, add water to aqueous
Measure as 45wt%, be warming up to 68 DEG C, insulation is placed 4 days, is dried to obtain mixed material；
S2, by weight 3 portions of edible glucoses, 1.2 portions of maltodextrins, 1.8 portions of food of addition into 100 parts of mixed materials
Additive, 0.6 portion of compound disintegrant are well mixed, granulation, 68 DEG C of vacuum drying 2.5h, are added in rotary blender and are mixed
45min, tabletting obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Compound disintegrant is prepared using following technique：Polyvinyl alcohol, dioxane are well mixed, pyridine, amber is added
Acid anhydrides return stirring 80min, reflux temperature is 75 DEG C, adds deacetylation hyaluronic acid stirring 3h, and addition concentration is 75wt%
Ethanol solution is complete to precipitating, and filters, and washing adds Ac-Di-Sol, 25min is stirred at room temperature, 1.5 are cooled to
DEG C, 14h is stood, freeze-drying adds atoleine stirring 35min, mixing speed is 2600r/min, adds solid paraffin molten
After solution is complete, adds magnesium stearate and be uniformly mixing to obtain compound disintegrant.
Embodiment 5
A kind of kidney tonifying proposed by the present invention, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, including following step
Suddenly：
S1, by weight by 45 parts of cordyceps militaris sporocarps, 22 parts of ginsengs, 12 parts of donkey-hide gelatin, 2 parts of Poria cocos, 5 portions of radix glycyrrhizaes, 2 parts it is old
Skin, 4 parts of Chinese cassia trees, 1.5 parts of matrimony vines, 7 parts of RHIIZOMA DIOSCOREAE from Henan of China, 4 parts of fructus alpiniae oxyphyllaes are crushed, and are crossed 80 mesh sieves, are continued to grind to form powdery, add water to and contain
Water is 55wt%, is warming up to 62 DEG C, insulation is placed 6 days, is dried to obtain mixed material；
S2, by weight 2 portions of edible glucoses, 1.8 portions of maltodextrins, 0.6 portion of sorb of addition into 100 parts of mixed materials
Sugar alcohol, 0.6 portion of magnesium stearate, 0.8 portion of compound disintegrant are well mixed, and granulation, 62 DEG C of vacuum drying 3.5h add rotation mixing
Mix 35min in machine, tabletting obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Compound disintegrant is prepared using following technique：2 parts of polyvinyl alcohol, 40 parts of dioxane are mixed equal by weight
It is even, 0.1 part of pyridine, 10 parts of succinic anhydride return stirring 50min are added, reflux temperature is 80 DEG C, adds 10 parts of deacetylations saturating
Bright matter acid stirring 4h, it is that 70wt% ethanol solutions are complete to precipitating to add concentration, is filtered, washing adds 10 parts of cross-linked carboxymethyls
Sodium cellulosate, is stirred at room temperature 15min, is cooled to 2 DEG C, stands 10h, and freeze-drying adds 40 parts of atoleine stirring 30min,
Mixing speed is 2800r/min, is added after 2 parts of solid paraffin dissolvings completely, 4 parts of magnesium stearates of addition are uniformly mixing to obtain compound
Disintegrant.
Embodiment 6
A kind of kidney tonifying proposed by the present invention, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, including following step
Suddenly：
S1, by weight by 40 parts of cordyceps militaris sporocarps, 25 parts of ginsengs, 10 parts of donkey-hide gelatin, 2.5 parts of Poria cocos, 4 portions of radix glycyrrhizaes, 2.5 parts
Dried orange peel, 3 parts of Chinese cassia trees, 2 parts of matrimony vines, 5 parts of RHIIZOMA DIOSCOREAE from Henan of China, 5 parts of fructus alpiniae oxyphyllaes are crushed, and are crossed 80 mesh sieves, are continued to grind to form powdery, add water to and contain
Water is 50wt%, is warming up to 65 DEG C, insulation is placed 5 days, is dried to obtain mixed material；
S2, by weight 2.5 portions of edible glucoses, 1.5 portions of maltodextrins, 1 portion of sorb of addition into 100 parts of mixed materials
Sugar alcohol, 0.5 portion of magnesium stearate, 0.7 portion of compound disintegrant are well mixed, and granulation, 65 DEG C of vacuum drying 3h add rotary blender
Middle mixing 40min, tabletting obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
Compound disintegrant is prepared using following technique：7 parts of polyvinyl alcohol, 20 parts of dioxane are mixed equal by weight
It is even, 0.2 part of pyridine, 5 parts of succinic anhydride return stirring 100min are added, reflux temperature is 70 DEG C, adds 20 parts of deacetylations saturating
Bright matter acid stirring 2h, it is that 80wt% ethanol solutions are complete to precipitating to add concentration, is filtered, washing adds 4 parts of cross-linked carboxymethyl fibres
The plain sodium of dimension, is stirred at room temperature 30min, is cooled to 1 DEG C, stands 18h, and freeze-drying adds 30 parts of atoleine stirring 40min, stirred
Speed is mixed for 2400r/min, is added after 8 parts of solid paraffin dissolvings completely, 1 part of magnesium stearate is added and is uniformly mixing to obtain compound collapse
Solve agent.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (9)
1. a kind of kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is characterised in that comprise the following steps：
S1, by cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, fructus alpiniae oxyphyllae crush, mistake
Sieve, continues to grind to form powdery, adds water, and heats up, and insulation is placed, and is dried to obtain mixed material；
S2, add edible glucose, maltodextrin, food additives, compound disintegrant into mixed material and be well mixed, make
Grain, vacuum drying, add rotary blender in mix, tabletting obtain kidney tonifying, fill blood, antifatigue compound Chinese caterpillar fungus preparation.
2. according to claim 1 kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is characterised in that S1
In, cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, fructus alpiniae oxyphyllae are crushed, 80 mesh are crossed
Sieve, continues to grind to form powdery, adds water to water content for 40-60wt%, is warming up to 60-70 DEG C, insulation is placed 2-8 days, dry
To mixed material.
3. kidney tonifying according to claim 1 or claim 2, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, its feature exists
In in S1, cordyceps militaris sporocarp, ginseng, donkey-hide gelatin, Poria cocos, radix glycyrrhizae, dried orange peel, Chinese cassia tree, matrimony vine, RHIIZOMA DIOSCOREAE from Henan of China, the weight ratio of fructus alpiniae oxyphyllae are
30-50：20-30：5-18：1-4：2-6：1-4：1-5：1-3：1-8：2-8.
4. according to any one of the claim 1-3 kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is special
Levy and be, in S2, be combined disintegrant and prepared using following technique：Polyvinyl alcohol, dioxane are well mixed, addition pyridine,
Succinic anhydride return stirring, adds the stirring of deacetylation hyaluronic acid, adds ethanol solution and extremely precipitates complete, filters, washing, plus
Enter Ac-Di-Sol, be stirred at room temperature, cool, stand, freeze-drying adds atoleine stirring, adds solid stone
After wax dissolving completely, add magnesium stearate and be uniformly mixing to obtain compound disintegrant.
5. according to any one of the claim 1-4 kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is special
Levy and be, in S2, be combined disintegrant and prepared using following technique：Polyvinyl alcohol, dioxane are well mixed, addition pyridine,
Succinic anhydride return stirring 50-100min, reflux temperature is 70-80 DEG C, adds deacetylation hyaluronic acid stirring 2-4h, adds
Concentration is that 70-80wt% ethanol solutions are complete to precipitating, and is filtered, washing adds Ac-Di-Sol, is stirred at room temperature
15-30min, is cooled to 1-2 DEG C, stands 10-18h, and freeze-drying adds atoleine stirring 30-40min, and mixing speed is
2400-2800r/min, is added after solid paraffin dissolving completely, is added magnesium stearate and is uniformly mixing to obtain compound disintegrant.
6. according to any one of the claim 1-5 kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is special
Levy and be, in S2, be combined disintegrant and prepared using following technique：By weight by 2-7 parts of polyvinyl alcohol, 20-40 parts of dioxies six
Ring is well mixed, and adds 0.1-0.2 parts of pyridines, 5-10 parts of succinic anhydride return stirring 50-100min, reflux temperature is 70-80
DEG C, 10-20 parts of deacetylation hyaluronic acid stirring 2-4h are added, it is that 70-80wt% ethanol solutions are complete to precipitating to add concentration,
Filtering, washing adds 4-10 parts of Ac-Di-Sols, 15-30min is stirred at room temperature, and is cooled to 1-2 DEG C, stands 10-
18h, freeze-drying adds 30-40 parts of atoleine stirring 30-40min, mixing speed is 2400-2800r/min, adds 2-8
After part solid paraffin dissolving completely, add 1-4 parts of magnesium stearates and be uniformly mixing to obtain compound disintegrant.
7. according to any one of the claim 1-6 kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is special
Levy and be, in S2, edible glucose, maltodextrin, food additives, compound disintegrant mixing are added into mixed material
Even, granulation, 60-70 DEG C of vacuum drying 2-4h is added in rotary blender and is mixed 30-50min, tabletting obtain kidney tonifying, fill blood,
Antifatigue compound Chinese caterpillar fungus preparation.
8. according to any one of the claim 1-7 kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is special
Levy and be, in S2, mixed material, edible glucose, maltodextrin, food additives, the weight ratio of compound disintegrant are 100：
1-4：1-2：1-2：0.5-1.
9. according to any one of the claim 1-7 kidney tonifying, fill blood, the preparation method of antifatigue compound Chinese caterpillar fungus preparation, it is special
Levy and be, in S2, food additives are D-sorbite and/or magnesium stearate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107822103A (en) * | 2017-10-25 | 2018-03-23 | 太和县三九药业有限公司 | One kind is built up health fatigue-relieving compound cordyceps preparation and preparation method thereof |
| CN109875040A (en) * | 2019-04-17 | 2019-06-14 | 安徽金源药业有限公司 | A kind of alleviation physical fatigue, beautifying face and moistering lotion cordyceps and ginseng Colla Corii Asini and preparation method |
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| CN106280892A (en) * | 2016-08-26 | 2017-01-04 | 安徽开林新材料股份有限公司 | A kind of ageing-resistant and there is the epoxy coating of excellent mechanical performance |
| CN106615477A (en) * | 2017-01-22 | 2017-05-10 | 新乡市人分九种健康管理有限公司 | Compound substitutional tea with functions of warming kidney and tonifying qi, and preparation method of compound substitute tea |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106280892A (en) * | 2016-08-26 | 2017-01-04 | 安徽开林新材料股份有限公司 | A kind of ageing-resistant and there is the epoxy coating of excellent mechanical performance |
| CN106615477A (en) * | 2017-01-22 | 2017-05-10 | 新乡市人分九种健康管理有限公司 | Compound substitutional tea with functions of warming kidney and tonifying qi, and preparation method of compound substitute tea |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107822103A (en) * | 2017-10-25 | 2018-03-23 | 太和县三九药业有限公司 | One kind is built up health fatigue-relieving compound cordyceps preparation and preparation method thereof |
| CN109875040A (en) * | 2019-04-17 | 2019-06-14 | 安徽金源药业有限公司 | A kind of alleviation physical fatigue, beautifying face and moistering lotion cordyceps and ginseng Colla Corii Asini and preparation method |
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Application publication date: 20170822 |