CN107080240A - 一种缓解气滞血瘀的保健食品调理剂及其制备方法 - Google Patents
一种缓解气滞血瘀的保健食品调理剂及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种缓解气滞血瘀的保健食品调理剂，含有葛根、红花、越橘、桃仁、芹菜籽、山楂、淡竹叶，进一步的越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉的构成比例为1：1：2：1：2：2：1。本发明还提供了一种制备该缓解气滞血瘀的保健食品调理剂的方法。配方简单，主要成分由浓缩的食物粉制成，口感好，通过调节血液循环系统的机能，有效改善气滞血瘀症状，改善血压、肤色、血糖、血脂、睡眠、玻璃体混浊、月经不道及血粘度。
Description
技术领域
本发明涉及中医药领域，具体的涉及一种调理气滞血瘀的保健品。
背景技术
工作压力和生活压力导致很多人出气滞血瘀的表现，当前用于缓解气滞血瘀症状的产品大多是中草药(有的单方药，有的是复方药)，也有健字号的保健品。当前的产品由于产品配方不合理，或者原料中有效成份含量偏低，故改善速度太慢，效果大多数不理想。同时，由于现有产品多是以中药作为主要成分，长期服用易产生副作用。
申请号为201610143338.1的中国专利申请提供了一种治疗气滞血瘀的中药，该药物以川芎、红花、金钱草等为主要成分，具有活血化瘀、通达气血等功效，可扩张血管、增加血流量，符合传统中医学的理论，对气滞血瘀的疗效显著。然而其配方复杂，口感较差，且含有较多中药成分，不适于作为保健品长期服用。
申请号201310459677.7公开了一种治疗气滞血瘀证型胸痹的中药，其特征在于由以下重量配比的药材制成的：麻黄10克、连翘30克、薏苡仁30克、葛根24克、车前子15克、杜仲15克、炒土鳖虫10克、川牛膝15克、桂枝30克、蜈蚣1条、白芍30克、当归10克、大黄6克、黄芪30克、防已12克、甘草6克。该发明所提供的治疗气滞血瘀证型胸痹的中药，是将各种适宜的药材有机的组合在一起，各药物之间协同作用，具有活血化瘀，通脉止痛的功效，能有效治疗气滞血瘀证型胸痹。
发明内容
本发明提供了一种缓解气滞血瘀的保健食品调理剂，含有葛根、红花、越橘、桃仁、芹菜籽、山楂、淡竹叶。
优选的是，所述保健食品调理剂的原料包括越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉。
上述任一项优选的是，包括所述越橘粉5-15份、所述葛根粉5-15份、所述红花粉15-25份、所述桃仁粉5-15份、所述芹菜籽粉15-25份、所述山楂粉15-25分、所述淡竹叶粉5-15份。
上述任一项优选的是，越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉的构成比例为1：1：2：1：2：2：1。
上述任一项优选的是，所述保健食品调理剂为为粉状或片状药剂。
上述任一项优选的是，所述保健食品调理剂按照以下方式制备：
1)将所述越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉在配料车间过筛，过筛后所有物料在称量间进行称量；
2)把称量车间称量好物料传递窗传递到槽型混合车间，把物料投放到混合机里，按工艺要求设定混合时间，用不锈钢桶放出物料；
3)将混合好物料传递窗传递到压片车间进行压片；
4)将压片好的越橘葛根片传递窗到内包车间进行包装。
上述任一项优选的是，所述过筛的目数为80目。
上述任一项优选的是，所述压片过程设定的压力为3.8千牛，填充量5.2mm。
上述任一项优选的是，所述保健食品调理剂每片净含量标准为1克，净含量达到1.02-1.05克之间。
上述任一项优选的是，所述按工艺要求设定的混合时间为15分钟。
上述任一项优选的是，用于改善人体气滞血瘀的症状。
本发明还提供了一种制备缓解气滞血瘀的保健食品调理剂的方法，按照如下步骤制备：
1)所述保健食品调理剂的原料包括越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉，将所述原料在配料车间过筛，过筛后所有物料在称量间用电子秤进行称量；
2)把称量车间称量好物料传递窗传递到槽型混合车间，把物料投放到混合机里，按工艺要求设定混合时间用不锈钢桶放出物料；
3)将混合好物料传递窗传递到压片车间进行压片，设定净含量，每10分钟检查一次净含量；
4)将压片好的保健食品调理剂传递窗到内包车间进行包装、封口，封口完的越橘葛根片传递到外包装车间进行贴标，装箱；
5)将内包传递的保健食品调理剂瓶子贴标签，标签喷码生产日期，贴好瓶签越橘葛根片装入大箱；
6)产品化验室检测合格入库；
优选的是，所述原材料包括5-15份越橘粉、葛根粉5-15份、红花粉15-25份、桃仁粉5-15份、芹菜籽粉15-25份、山楂粉15-25分、淡竹叶粉5-15份。
上述任一项优选的是，越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉的构成比例为1：1：2：1：2：2：1。
上述任一项优选的是，所述过筛的目数为80目。
上述任一项优选的是，所述按工艺要求设定的混合时间为15分钟。
上述任一项优选的是，所述压片过程设定的压力为3.8千牛，填充量5.2mm。
上述任一项优选的是，所述设定的净含量为1克，检查后的净含量达到1.02-1.05克之间。
上述任一项优选的是，压片过程使用的压片机型号ZPW-19B。
本发明的有益效果在于，配方简单，主要成分由浓缩的食物粉制成，口感好，通过调节血液循环系统的机能，有效改善气滞血瘀症状，改善血压、肤色、血糖、血脂、睡眠、玻璃体混浊、月经不道及血粘度。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种缓解气滞血瘀的保健食品调理剂，含有葛根、红花、越橘、桃仁、芹菜籽、山楂、淡竹叶。以上述各种成分粉状制剂作为生产原料，其中越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉的比例为1：1：2：1：2：2：1。
其中各成分的主要功能为：
越橘的功能：提高细胞内的维他命C水平和降低毛细管渗透性和脆性；使毛细血管渗透性的正常化，增加毛细血管的柔韧性，可以纯净促进血管膨胀和伸缩性，防止血管破裂；改善氧气和血液传输至眼的能力；作为有力的抗氧化剂，能消除使血管硬化的自由基，预防动脉硬化，可保护眼睛免受自由基伤害，越橘既能强化眼睛里的毛细血管，当然也能强化身体其他器官组织里的毛细血管，达到预防各部器官血管病变；类黄酮物质抑制血小板凝固的作用，抗血小板凝集，可以预防血栓的形成，减少动脉硬化发生的频率。越橘中含有丰富的花青素，这是一种强效的抗氧化剂，能清除自由基，消除光线对视网膜细胞的氧化伤害，强化眼部微血管的弹性、促进血液循环、维系正常眼球压力，并抑制破坏眼部细胞的酵素。花青素是水溶性的，人体、血液内含有大量的水分易于机体吸收。当自由基侵害了细胞里的DNA时，便是癌症的开始，因此，越橘消灭自由基的作用使其可用于癌症的治疗。越橘其他作用：越橘其果汁里含大量多酚类黄酮物质，它有很强的抗氧化、抗病毒作用。经常喝越橘汁对慢性乙肝有明显改善作用；越橘果实含有鞣花酸、鞣花单宁、叶酸、花色素苷、类黄酮等特殊化合物成分，这些物质能使癌细胞急速增殖的酶的活性受到抑制；蔓越橘中所含的抗氧化剂比任何水果和蔬菜都多，其中的花青素对心脏病和癌症的治疗很有帮助，还可以防止大肠杆菌附着在膀胱壁上，导致尿道炎。主要功效：保护视力，防止失明、青光眼、白内障、视网膜出血、改善近视、黄斑退化、糖尿病性网膜症、色素性视网膜炎‘视网膜剥落及夜盲症等。其他效果：强化脑血管、预防脑血管的病变、强化心肌血管、强壮冠状动脉、强化肾脏血管、预防肾小球毛细血管破裂而出现血尿、尿道炎及膀胱炎。强化静脉血管、预防静脉曲张、防治溃疡。防止动脉硬化；预防血栓的形成。本发明首次将越橘应用于缓解气滞血瘀。
葛根的功能：增加心脑血管血流量；触痉止痛；辅助降血糖；解热消炎；促进黄褐斑消退；改善失眠和便秘。葛根的主要应用：升阳解肌，透疹止泻，除烦止渴。治伤寒、温热头痛项强，烦热消渴，泄泻，痢疾，癍疹不透，高血压，心绞痛，耳聋。葛根的作用：葛根中的大豆甙元具有抗乙酰胆碱作用，能够明显收缩平滑肌，被认为是葛根解痉作用的主要成分；葛根水煎剂、醇浸膏、总黄酮和葛根素均有明显的扩张冠状血管的作用，能使冠血流量增加，血管阻力降低；葛根醇浸膏、大豆甙元和葛根素均有明显的对抗乌头碱和氯化钡诱发的心律失常作用，葛根素还能明显缩短氯彷、肾上腺素诱发的家兔心律失常时间，葛根素能明显缩小心肌梗塞范围，被认为是一种β-肾上腺素受体阻滞剂；葛根总黄酮和葛根素能减慢心率，降低心脏总外周阻力，减少心肌耗氧量；提高心肌工作效率.葛根素还能明显减少缺血引起的心肌乳酸的产生，改善梗塞心肌的代谢；葛根总葛酮和葛根素能使血浆肾素活性和血管紧张素显著降低，血压下降.葛根素对微循环障碍有明显的改善作用，主要表现为增加微血管运动的振幅和提高局部微血流量；葛根总黄酮具有明显扩张脑血管的作用，改善脑微循环和外周循环.据报道，葛根素还能改善视网膜血管末稍单位的阻滞状态，从而提高视功能；葛根素能抑制二磷酸腺苷(ADP)诱导和5-HT(5-羟色胺)与ADP联合诱导的人和动物的血小板聚集；另外，葛根素还能明显抑制由凝血酶诱导的血小板中5-HT的释放，具有抗血栓形成作用；葛根素能对抗肾上腺素的升血糖作用，具有一定的降血糖能力；葛根总黄酮和醇提物能提高大鼠大脑皮层和海马乙酰胆碱含量，并降低海马乙酰胆碱转移酶活性，对抗东莨碱所效的大鼠记忆获得性障碍，这说明，葛根具有一定的改善学习记忆的能力。
红花的功能：增加冠脉血流量营养心肌；扩张全身动脉降血压；抗缺氧抗疲劳；镇静镇痛；抗炎；活化免疫细胞功能；增加脑血流量改善睡眠。红花对心血管系统的作用：抑制心脏作用：红花煎剂小剂量能使蟾蜍离体心脏及兔在体心脏轻度兴奋，使心跳有力，振幅加大；大剂量则对心脏有抑制作用，使心率减慢，心肌收缩力减弱，心搏出量减少；对冠脉血流量的作用:红花水提取物及红花水溶性混合物-红花黄色素有增加冠脉血流量及心肌营养性血流量的作用；而红花乙醇提取物的扩张冠脉及增加冠脉血流量的作用则不明显或无影响。红花的主要成分含红花甙又名红色素。另含红花黄色素。红花煎剂及流浸膏能使子宫发生紧张性或节律性收缩，对已孕子宫更明显，作用较迅速而持久，并有降压作用，且能维持较长时间。其水浸液有一定的扩张冠状动脉的作用，又对肠管、血管、支气管平滑肌有兴奋作用，可使肾血管收缩，肾血流量减少。
桃仁的功能：活血祛瘀；润肠通便；止咳平喘。桃仁的药理作用：祛瘀血作用：本品水煎醇沉液可使离体兔耳静脉血管流量增加，有舒张血管作用。给麻醉犬动脉注射，能增加股动脉血流量及降低血管阻力，对血管壁有直接扩张作用。本品还有抑制血液凝固和溶血作用。桃仁提取物50mg/ml，脾动脉内给药可使麻醉大鼠肝脏微循环内血流加速,并与剂量相关，提示对肝脏表面微循环有一定的改善作用；抗炎作用：本品在的蛋白成分中的两个均一蛋白成分，静脉注射给药，对二甲苯所致小鼠耳急性炎症反应，均有显著抑制作用；抗过敏作用：桃仁水提物能抑制小鼠血清中的皮肤过敏抗体及鼷鼠脾溶血性细胞的产生，其乙醇提取物口服能抑制小鼠含有皮肤过敏性抗体的抗血清引起的PCA反应(被动皮肤过敏反应)的色素渗出量；苦否仁甙，有镇咳作用。桃仁中的脂肪油(扁桃油)有驱虫作用，对蛲虫的驱虫效果为80.8％，对蛔虫效果为70％。
芹菜籽的功能：降血压；降血脂。芹菜籽富含碳水化合物和蛋白质，具有健胃、利尿、净血调经、降血压、镇静等作用，芹菜丰富的黄酮类物质可用于高血压引起的头晕头痛、心烦易怒等。每100克芹菜籽的营养成分包括：热量：14卡蛋白质：0.8克脂肪：0.1克碳水化合物：7.5克膳食纤维：14克；胡萝卜素：1微克维生素A(视黄醇)：10微克维生素B1(硫胺素)：0.01毫克；维生素B2(核黄素)：0.08毫克维生素B3(烟酸)：0.4毫克维生素C：12毫克；维生素E：2.21毫克钾：154毫克钠：73.8毫克钙：48毫克镁：10毫克；铁：0.8毫克锰：0.17毫克锌：0.46毫克磷：50毫克硒：0.47毫克；山楂的功能：降血脂；降血压；抗心脑缺血；活血化瘀；助消化；保护血管内皮细胞。本发明首次将芹菜籽应用于缓解气滞血瘀。
山楂的功能：降血脂；降血压；抗心脑缺血；活血化瘀；助消化；保护血管内皮细胞。
淡竹叶的功能：抗自由基；抗氧化；抗衰；降血脂和血胆固醇；解热；利尿。淡竹叶含有大量的黄酮、内酯、多糖、叶绿素、氨基酸、维生素、微量元素等营养素，竹叶黄酮具有良好的抗自由基能力，能有效调节人体血脂，并具有消炎、抗菌、抗病毒、抗氧化、提高免疫力的作用，是理想的纯天然营养品。淡竹叶内含有维生素A、C，有清热，消炎，利尿，通络等药效作用，常饮竹叶茶，轻身明目。本发明首次将淡竹叶用于缓解气滞血瘀。
以上成分相辅相成共同作用下，使本发明提供的缓解气滞血瘀的保健食品调理剂具有以下作用及功效：降低红细胞和血小板的粘附性缓解血瘀；解除血管平滑肌痉挛缓解气滞；提高细胞内的维他命C水平和降低毛细管渗透性和脆性；使毛细血管渗透性的正常化；改善氧气和血液传输至眼的能力，保护眼睛免受自由基伤害；抗血小板凝集；增加心脑血管血流量；触痉止痛；辅助降血糖；解热消炎；促进黄褐斑消退；改善失眠和便秘；增加冠脉血流量营养心肌；扩张全身动脉；降血压；抗缺氧抗疲劳；镇静镇痛；活化免疫细胞功能；增加脑血流量改善睡眠；活血祛瘀；利尿润肠通便；止咳平喘；降血脂；抗心脑缺血；活血化瘀；助消化；保护血管内皮细胞；抗自由基；抗氧化；抗衰；降血胆固醇。
上述七种浓缩的食物粉按照君臣佐使的原则进行科学配方而成，这个配方可以迅速解除血管壁中平滑肌痉挛、快速改善气滞，同时也可以迅速降低红细胞和血小板的粘附性、降低血脂、加速血液流动，从而快速改善血瘀。
本实施例提供的保健食品调理剂的效果为：食用本品一个月血压改善率100％，肤色改善率100％，血糖改善率95％，血脂改善率95％，睡眠改善率91％，玻璃体混浊改善90％，月经不道改善率100％，血粘度改善100％。
实施例2
一种缓解气滞血瘀的食疗调理剂，含有葛根、红花、越橘、桃仁、芹菜籽、山楂、淡竹叶，其中越橘粉5-15份、葛根粉5-15份、红花粉15-25份、桃仁粉5-15份、芹菜籽粉15-25份、山楂粉15-25分、淡竹叶粉5-15份。
本发明提供的缓解气滞血瘀的调理剂不含有麻黄、连翘、薏苡仁、车前子、杜仲、炒土鳖虫、川牛膝、桂枝、蜈蚣、白芍、当归、大黄、黄芪、防已、甘草、川芎、红花、泽兰、三七、降香、败酱草、生地黄、牡丹皮、地锦草、制附子、延胡索、丹皮黄连、金钱草、焦山栀、木香、银杏叶、丹参。因此，无毒副作用，口感好的有益效果。
本实施例中的调理剂具有与实施例1相同的作用和疗效。
实施例3
一种缓解气滞血瘀的食疗调理剂，由越橘粉5-15份、葛根粉5-15份、红花粉15-25份、桃仁粉5-15份、芹菜籽粉15-25份、山楂粉15-25分、淡竹叶粉5-15份组成。优选的越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉的构成比例为1：1：2：1：2：2：1。
本实施例中的调理剂具有与实施例1相同的作用和疗效。
实施例4
一种缓解气滞血瘀的食疗调理剂，其组成为越橘粉10份、葛根粉10份、红花粉20份、桃仁粉10份、芹菜籽粉20份、山楂粉20分、淡竹叶粉10份。
实施例5
一种缓解气滞血瘀的食疗调理剂，其组成为越橘粉8份、葛根粉8份、红花粉20份、桃仁粉8份、芹菜籽粉20份、山楂粉20分、淡竹叶粉8份。
实施例6
一种缓解气滞血瘀的食疗调理剂，其组成为越橘粉10份、葛根粉10份、红花粉15份、桃仁粉10份、芹菜籽粉15份、山楂粉15分、淡竹叶粉10份。
实施例7
制备方法：
1、将产品检验合格的原料越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉按工艺处方配比在配料车间过筛80目，过筛后所有物料在称量间用电子秤进行称量；
2、把称量车间称量好物料传递窗传递到槽型混合车间，把物料投放到CH-200混合机里，按工艺要求设定混合时间15分钟用不锈钢桶放出物料；
3、将混合好物料传递窗传递到压片车间进行压片，压片机型号ZPW-19B,压片机压力为3.8千牛，填充量5.2mm，每片净含量1克，每10分钟检查一次净含量，要求净含量达到1.02-1.05克之间；
4、将压片好的越橘葛根片传递窗到内包车间进行包装，每瓶装60克，每瓶放一袋2克干燥剂，瓶口铝箔封口，封口完的越橘葛根片传递到外包装车间进行贴标，装箱；
5、将内包传递的越橘葛根片瓶子贴标签，标签喷码生产日期，贴好瓶签越橘葛根片装入大箱，每箱装120瓶；
6、产品化验室检测合格入库。
其中，越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉的构成比例为1：1：2：1：2：2：1。
说明：
ZPW-19B压片机为现有技术中的压片机型号，压片时转盘的速度、物料的充填深度、压片厚度均可调节。
CH-200混合机为现有技术中的混合机型号，广泛用于制药，食品、化工、电子等行业的干粉及糊状物料的混合，特别适用于均匀要求高，物料比重差大，和一定的含水量物料混合。
本实施例利用上述机器但并不局限于此，具有相同功能的仪器均适用于本发明。
一、血压改善率100％
I级高血压患者90例，男女各45例，年龄45-65岁，随机分为两组，对照组(淀粉胶囊2粒，每粒1.0g，一日2次)，研究组(本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次)，每组45人，所有患者服药一个月为一疗程，连续服用3个疗程后停药观察。检测血压指标。
II级高血压患者90例，男女各45例，年龄45-65岁，随机分为两组，对照组(淀粉胶囊2粒，每粒1.0g，一日2次)，研究组(本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次)，每组45人，所有患者服药一个月为一疗程，连续服用3个疗程后停药观察。检测血压指标。
III级高血压患者90例，男女各45例，年龄45-65岁，随机分为两组，对照组(淀粉胶囊2粒，每粒1.0g，一日2次)，研究组(本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次)，每组45人，所有患者服药一个月为一疗程，连续服用3个疗程后停药观察。检测血压指标。
表1患者服药前后血压对比
上述指标均采用均数表示，P*＜0.05具有显著性意义。从表1可以得出，本发明所制备的缓解气滞血瘀的食疗调理剂具有明显的改善血压的作用。
二、肤色改善率100％
对40名肤色暗沉志愿者进行测试，志愿者年龄30-60岁，男女各20名，服用本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次，连续服用三个月后，所有志愿者的均恢复为肤色红黄隐显,明润而有光泽，明显改善。
三、血糖改善改善率95％
II型糖尿病患者90例，男女各45例，年龄35-65岁，随机分为两组，对照组(淀粉胶囊2粒，每粒1.0g，一日2次)，研究组(本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次)，每组45人，所有患者服药一个月为一疗程，连续服用3个疗程后停药观察。检测血糖指标。
表2患者服药前后血糖比较
上述指标均采用均数±标准差表示，应用t检测统计方法对结果进行统计分析，P*＜0.05具有显著性意义。从表2可以得出，本发明所制备的缓解气滞血瘀的食疗调理剂具有明显的降低血糖的作用。同时，研究组45例II型糖尿病患者在长期服用本发明的缓解气滞血瘀的食疗调理剂后，43名患者餐前及餐后水平显著降低，2人效果不显著，血糖改善率达到了100％，而对照组餐前及餐后血糖值基本维持在原有水平。
四、血脂改善率95％
高血脂患者90例，男女各45例，年龄35-65岁，随机分为两组，对照组(淀粉胶囊2粒，每粒1.0g，一日2次)，研究组(本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次)，每组45人，所有患者服药一个月为一疗程，连续服用3个疗程后停药观察。检测血糖指标。
表3患者服药前后血脂比较
上述指标均采用均数表示，P*＜0.05具有显著性意义。从表3可以得出，本发明所制备的缓解气滞血瘀的食疗调理剂具有明显的改善血脂的作用，45例患者中有43人的血脂中总胆固醇、甘油三酯、低密度脂蛋白的水平显著降低，2人效果不明显，血脂改善率达到95％。
五、睡眠改善率91％
本发明人于2016年对200例失眠患者进行临床观察治疗，年龄20到80岁不等。治疗方法：水送服用，每日2粒(每粒1.0克)，睡前温服，一个月为一疗程，连续服用3疗程。
疗效评定标准：
治愈：每天熟睡时间达到6h；
改善：每天熟睡时间达到4h；
无效：每天熟睡时间小于4h。
表4患者个人信息和疗效情况
| 年龄 | 病例 | 治愈 | 改善 | 无效 |
| 20-35 | 16 | 10 | 3 | 3 |
| 35-45 | 34 | 9 | 23 | 2 |
| 45-60 | 41 | 19 | 21 | 1 |
| 60-75 | 46 | 13 | 31 | 2 |
| ＞75 | 63 | 18 | 35 | 10 |
| 合计 | 200 | 69 | 113 | 18 |
通过表5中上述数据可知，在服用本发明的缓解气滞血瘀的食疗调理剂之后，治疗失眠的作用明显，其有效率为91％，其中治愈率为34.5％，改善率为56.5％，无效率0.09％。
六、玻璃体混浊改善90％
对100名玻璃体混浊患者进行测试，患者年龄40-70岁，男女各50名，服用本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次，连续服用6个月后，90名患者玻璃体混浊得到改善，改善率为90％。玻璃体混浊改善的标准为：玻璃体内不透明体减少或消失，患者眼前黑影飘动的症状消失。
七、月经不调改善率100％
对100名月经不调志愿者进行测试，志愿者年龄20-45岁，服用本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次，连续服用6个月后，所有月经不调志愿者的症状得到改善，改善率为100％。月经不调改善的标准为：月经出血量回复正常，月经前、经期时的腹痛或全身症状消失，月经周期回复正常(一个周期20到45天)。
八、血粘度改善100％
高血粘度患者90例，男女各45例，年龄35-65岁，随机分为两组，对照组(淀粉胶囊2粒，每粒1.0g，一日2次)，研究组(本发明的缓解气滞血瘀的食疗调理剂2粒，每粒1.0g，一日2次)，每组45人，所有患者服药一个月为一疗程，连续服用3个疗程后停药观察，进行全血相对粘度测试。以水的粘度为1，测试温度为37摄氏度的全血相对粘度。
表5患者服药前后血粘度对比
上述指标均采用均数表示，P*＜0.05具有显著性意义。从表5可以得出，本发明所制备的缓解气滞血瘀的食疗调理剂具有明显的改善血粘度的作用，45例患者的血粘度均有明显下降，血粘度改善率达到100％。
Claims (10)
1.一种缓解气滞血瘀的保健食品调理剂，含有葛根、红花，其特征在于，还含有越橘、桃仁、芹菜籽、山楂和淡竹叶。
2.如权利要求1所述的保健食品调理剂，其特征在于，所述保健食品调理剂的原料包括越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉和淡竹叶粉。
3.如权利要求1所述的保健食品调理剂，其特征在于，包括所述越橘粉5-15份、所述葛根粉5-15份、所述红花粉15-25份、所述桃仁粉5-15份、所述芹菜籽粉15-25份、所述山楂粉15-25分、所述淡竹叶粉5-15份。
4.如权利要求3所述的保健食品调理剂，其特征在于，越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉的构成比例为1：1：2：1：2：2：1。
5.如权利要求4所述的保健食品调理剂，其特征在于，所述保健食品调理剂为粉状或片状药剂。
6.如权利要求5所述的保健食品调理剂，其特征在于，所述保健食品调理剂按照以下方式制备：
1）将所述越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉在配料车间过筛，过筛后所有物料在称量间进行称量；
2）把称量车间称量好物料传递窗传递到槽型混合车间，把物料投放到混合机里，按工艺要求设定混合时间，用不锈钢桶放出物料；
3）将混合好物料传递窗传递到压片车间进行压片；
4）将压片好的越橘葛根片传递窗到内包车间进行包装。
7.如权利要求6所述的保健食品调理剂，其特征在于，所述过筛的目数为80目。
8.如权利要求6所述的保健食品调理剂，其特征在于，所述压片过程设定的压力为3.8千牛，填充量5.2mm。
9.如权利要求8所述的保健食品调理剂，其特征在于，所述保健食品调理剂每片净含量标准为1克。
10.一种制备缓解气滞血瘀的保健食品调理剂的方法，按照如下步骤制备：
1）所述保健食品调理剂的原料包括越橘粉、葛根粉、红花粉、桃仁粉、芹菜籽粉、山楂粉、淡竹叶粉，将所述原料在配料车间过筛，过筛后所有物料在称量间用电子秤进行称量；
2）把称量车间称量好物料传递窗传递到槽型混合车间，把物料投放到混合机里，按工艺要求设定混合时间用不锈钢桶放出物料；
3）将混合好物料传递窗传递到压片车间进行压片，设定净含量，每10分钟检查一次净含量；
4）将压片好的保健食品调理剂传递窗到内包车间进行包装，每瓶装60克，每瓶放一袋2克干燥剂，瓶口铝箔封口，封口完的越橘葛根片传递到外包装车间进行贴标，装箱；
5）将内包传递的保健食品调理剂瓶子贴标签，标签喷码生产日期，贴好瓶签越橘葛根片装入大箱，每箱装120瓶；
6）产品化验室检测合格入库。
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| CN110959656A (zh) * | 2019-11-26 | 2020-04-07 | 江苏巨托生物科技有限公司 | 一种具有保健功能的饼干及其制备方法 |
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