CN107074921B - 重组克氏锥虫jl7抗原变体及其用于检测查加斯病的用途 - Google Patents

重组克氏锥虫jl7抗原变体及其用于检测查加斯病的用途 Download PDF

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CN107074921B
CN107074921B CN201580058514.5A CN201580058514A CN107074921B CN 107074921 B CN107074921 B CN 107074921B CN 201580058514 A CN201580058514 A CN 201580058514A CN 107074921 B CN107074921 B CN 107074921B
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trypanosoma cruzi
polypeptide
cruzi
trypanosoma
amino acid
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CN107074921A (zh
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D.罗斯勒
B.乌普迈尔
T.扎尔恩特
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F Hoffmann La Roche AG
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Priority claimed from EP15161274.4A external-priority patent/EP3072902A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905—Protozoa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/44—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from protozoa
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201580058514.5A 2014-11-06 2015-11-04 重组克氏锥虫jl7抗原变体及其用于检测查加斯病的用途 Active CN107074921B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14192004.1 2014-11-06
EP14192004.1A EP3018479A1 (en) 2014-11-06 2014-11-06 Antigen composition for detecting Chagas disease
EP15161274.4A EP3072902A1 (en) 2015-03-27 2015-03-27 Recombinant Trypanosoma cruzi JL7 antigen variants and their use for detecting Chagas disease
EP15161274.4 2015-03-27
PCT/EP2015/075692 WO2016071393A1 (en) 2014-11-06 2015-11-04 Recombinant trypanosoma cruzi jl7 antigen variants and their use for detecting chagas disease

Publications (2)

Publication Number Publication Date
CN107074921A CN107074921A (zh) 2017-08-18
CN107074921B true CN107074921B (zh) 2021-03-16

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US (1) US10228370B2 (enExample)
EP (1) EP3215849B1 (enExample)
JP (2) JP7173732B2 (enExample)
CN (1) CN107074921B (enExample)
MX (1) MX2017005644A (enExample)
WO (1) WO2016071393A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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WO2023182521A1 (ja) * 2022-03-25 2023-09-28 積水メディカル株式会社 免疫学的測定用試薬及び免疫学的測定方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009158729A2 (en) * 2008-06-27 2009-12-30 The Infectious Disease Research Institute Inc. Compounds and methods for diagnosis and treatment of chagas disease
CN102762588A (zh) * 2009-11-13 2012-10-31 波尔多第二大学 抗锥虫病的治疗和诊断应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228372B1 (en) * 1997-04-15 2001-05-08 Corixa Corporation Compounds and methods for the detection and prevention of T. cruzi infection
EP0976763B1 (en) 1998-07-30 2003-11-05 Innogenetics N.V. Antigens and immunoassays for diagnosing Chagas' disease
PE20050942A1 (es) 2003-12-04 2005-11-10 Louis V Kirchhoff Polipeptidos recombinantes para diagnosticar la infeccion con el trypanosoma cruzi
CA2700000A1 (en) 2007-07-30 2009-02-05 Rick L. Tarleton Diagnostic assay for trypanosoma cruzi infection
WO2010142829A1 (es) 2009-06-12 2010-12-16 Consejo Superior De Investigaciones Científicas (Csic) Método de obtención de datos útiles para el diagnóstico diferencial de la enfermedad de chagas, y para evaluar la respuesta al tratamiento

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009158729A2 (en) * 2008-06-27 2009-12-30 The Infectious Disease Research Institute Inc. Compounds and methods for diagnosis and treatment of chagas disease
CN102762588A (zh) * 2009-11-13 2012-10-31 波尔多第二大学 抗锥虫病的治疗和诊断应用

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
An improved serodiagnostic test for Chagas’ disease employing a mixture of Trypanosoma cruzi recombinant antigens;Umezawa E S et al;《Transfusion》;20030131;第43卷(第1期);第91页左栏、讨论第2段以及表1 *
Ariel A. Valiente-Gabioud et al.Effect of repetitiveness on the immunogenicity and antigenicity of Trypanosoma cruzi FRA protein.《Experimental Parasitology》.2010,第127卷(第3期), *
Chagas disease-specific antigens: characterization of epitopes in CRA/FRA by synthetic peptide mapping and evaluation by ELISA-peptide assay;Carolina G Bottino et al;《BMC Infectious Diseases》;20130120;第13卷(第1期);全文 *
Comparison of Recombinant Trypanosoma cruzi Peptide Mixtures versus Multiepitope Chimeric Proteins as Sensitizing Antigens for Immunodiagnosis;Cecilia Camussone et al;《Clinical and vaccine immunology》;20090630;第16卷(第6期);全文 *
Effect of repetitiveness on the immunogenicity and antigenicity of Trypanosoma cruzi FRA protein;Ariel A. Valiente-Gabioud et al;《Experimental Parasitology》;20101129;第127卷(第3期);第673页左栏第2段，2.材料与方法2.1~2.4，3结果3.4第4段，4.讨论第1段以及图3 *
Organization and expression of the gene encoding an immunodominant repetitive antigen associated to the cytoskeleton of Trypanosoma cruzi;Paulo C.Cotrim et al;《Molecular and Biochemical Parasitology》;19950430;第71卷(第1期);全文 *
The Repetitive Cytoskeletal Protein H49 of Trypanosoma cruzi Is a Calpain-Like Protein Located at the Flagellum Attachment Zone;Alexandra Galetovic et al;《PLOS ONE》;20111111;第6卷(第11期);全文 *

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Publication number Publication date
JP7356467B2 (ja) 2023-10-04
JP7173732B2 (ja) 2022-11-16
BR112017007592A2 (pt) 2018-02-27
JP2017533913A (ja) 2017-11-16
US10228370B2 (en) 2019-03-12
EP3215849B1 (en) 2018-12-19
CN107074921A (zh) 2017-08-18
MX2017005644A (es) 2017-06-29
JP2021098746A (ja) 2021-07-01
WO2016071393A1 (en) 2016-05-12
EP3215849A1 (en) 2017-09-13
US20170248598A1 (en) 2017-08-31

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