CN107074920A - 芋螺毒素多肽κ‑CPTx‑btl03、其制备方法及应用 - Google Patents

芋螺毒素多肽κ‑CPTx‑btl03、其制备方法及应用 Download PDF

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Publication number
CN107074920A
CN107074920A CN201480082282.2A CN201480082282A CN107074920A CN 107074920 A CN107074920 A CN 107074920A CN 201480082282 A CN201480082282 A CN 201480082282A CN 107074920 A CN107074920 A CN 107074920A
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Prior art keywords
conotoxin polypeptide
conotoxin
polypeptide
preparation
btl03
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CN201480082282.2A
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CN107074920B (zh
Inventor
林志龙
闻博
童婷
刘杰
杜朝钦
莫芬
彭超
石琼
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Shenzhen Huada Sansheng Garden Technology Co ltd
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BGI Shenzhen Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

一种芋螺毒素多肽κ‑CPTx‑btl03，其制备方法以及应用。所述的芋螺毒素多肽由29个氨基酸组成，分子量为3141.43道尔顿，全序列为RTNCGETCLKDEQCVGACQICVPSQLKCL。所述的芋螺毒素多肽具有抑制钾离子通道电流作用和镇痛作用，可应用于疼痛、癫痫、中风、痉挛、肌肉松弛、帕金森病、老年痴呆症、抑郁、成瘾、心血管疾病、癌症、炎症等疾病治疗的药物开发和临床应用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201480082282.2A 2014-09-30 2014-09-30 芋螺毒素多肽κ-CPTx-btl03、其制备方法及应用 Active CN107074920B (zh)

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PCT/CN2014/087983 WO2016049873A1 (zh) 2014-09-30 2014-09-30 芋螺毒素多肽κ-CPTx-btl03、其制备方法及应用

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CN107074920A true CN107074920A (zh) 2017-08-18
CN107074920B CN107074920B (zh) 2020-07-28

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Country Link
US (1) US10662228B2 (zh)
EP (1) EP3202782B1 (zh)
CN (1) CN107074920B (zh)
WO (1) WO2016049873A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016101276A1 (zh) * 2014-12-26 2016-06-30 深圳华大基因研究院 芋螺毒素肽κ-CPTx-btl03、其制备方法及应用
CN115353555B (zh) * 2022-08-22 2024-04-30 山东大学 季铵化壳寡糖-μ-芋螺毒素结合物及其制备方法与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034925A1 (en) * 1996-03-18 1997-09-25 University Of Utah Research Foundation Conotoxin peptide pviia
WO2001021648A1 (en) * 1999-09-22 2001-03-29 Cognetix, Inc. Uses of kappa-conotoxin pviia
CN103483439A (zh) * 2012-06-15 2014-01-01 海南大学 αO-超家族芋螺毒素肽、其药物组合物及用途
CN103570808A (zh) * 2012-08-07 2014-02-12 海南大学 α-芋螺毒素肽TxIB/Txd4、其药物组合物及用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1796413A (zh) * 2004-12-30 2006-07-05 海南大学 新的t－超家族芋螺毒素肽，其编码多核苷酸及用途
CN1796412A (zh) 2004-12-30 2006-07-05 海南大学 新的o－超家族芋螺毒素肽，其编码多核苷酸及用途
WO2016101276A1 (zh) * 2014-12-26 2016-06-30 深圳华大基因研究院 芋螺毒素肽κ-CPTx-btl03、其制备方法及应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034925A1 (en) * 1996-03-18 1997-09-25 University Of Utah Research Foundation Conotoxin peptide pviia
WO2001021648A1 (en) * 1999-09-22 2001-03-29 Cognetix, Inc. Uses of kappa-conotoxin pviia
CN103483439A (zh) * 2012-06-15 2014-01-01 海南大学 αO-超家族芋螺毒素肽、其药物组合物及用途
CN103570808A (zh) * 2012-08-07 2014-02-12 海南大学 α-芋螺毒素肽TxIB/Txd4、其药物组合物及用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
朱翠等: "几类新家族芋螺毒素研究进展", 《中国海洋药物》 *

Also Published As

Publication number Publication date
EP3202782A4 (en) 2018-02-28
CN107074920B (zh) 2020-07-28
US20170298104A1 (en) 2017-10-19
EP3202782B1 (en) 2019-10-16
US10662228B2 (en) 2020-05-26
WO2016049873A1 (zh) 2016-04-07
EP3202782A1 (en) 2017-08-09

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