CN107073129B - 亲水性药物的靶向递送 - Google Patents

亲水性药物的靶向递送 Download PDF

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Publication number
CN107073129B
CN107073129B CN201580048892.5A CN201580048892A CN107073129B CN 107073129 B CN107073129 B CN 107073129B CN 201580048892 A CN201580048892 A CN 201580048892A CN 107073129 B CN107073129 B CN 107073129B
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sulfonate
ester
sulfate
amphiphilic
solubility
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CN201580048892.5A
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English (en)
Chinese (zh)
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CN107073129A (zh
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I·洛克特
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Double Bond Pharmaceuticals AB
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Double Bond Pharmaceuticals AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580048892.5A 2014-09-10 2015-09-09 亲水性药物的靶向递送 Active CN107073129B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1400427 2014-09-10
SE1400427-9 2014-09-10
PCT/SE2015/000055 WO2016039678A1 (en) 2014-09-10 2015-09-09 Targeted delivery of hydrophilic drugs

Publications (2)

Publication Number Publication Date
CN107073129A CN107073129A (zh) 2017-08-18
CN107073129B true CN107073129B (zh) 2021-10-15

Family

ID=55459328

Family Applications (1)

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CN201580048892.5A Active CN107073129B (zh) 2014-09-10 2015-09-09 亲水性药物的靶向递送

Country Status (11)

Country Link
US (2) US10034838B2 (https=)
EP (1) EP3191138B1 (https=)
JP (1) JP6951971B2 (https=)
KR (1) KR20170054459A (https=)
CN (1) CN107073129B (https=)
AU (1) AU2015316252A1 (https=)
CA (1) CA2958820A1 (https=)
EA (1) EA033526B1 (https=)
IL (1) IL250637A0 (https=)
MX (1) MX2017003049A (https=)
WO (1) WO2016039678A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017153052A1 (en) * 2016-03-07 2017-09-14 Double Bond Pharmaceuticals Ab Targeted delivery of hydrophilic drugs to lung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384081B2 (en) * 1998-10-09 2002-05-07 Charles L. Berman Treatment of diseases of the eye characterized by the formation of metalloproteinase
CN101134119A (zh) * 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
CN101327190A (zh) * 2008-07-29 2008-12-24 北京大学 一种供注射用的抗肿瘤长循环靶向脂质体
CN102131483A (zh) * 2008-02-08 2011-07-20 昌达生物科技公司 可控给药非聚合组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
US6613358B2 (en) * 1998-03-18 2003-09-02 Theodore W. Randolph Sustained-release composition including amorphous polymer
CA2324254C (en) * 1998-03-18 2005-01-04 University Technology Corporation Sustained-release composition including amorphous polymer
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
US20040161466A1 (en) 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
GB2415904B (en) 2005-02-07 2006-10-25 Chiron Corp Preparing aldesleukin for pharmaceutical use
WO2009078756A1 (en) 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
CA2806157C (en) * 2010-07-26 2016-11-22 Les Laboratoires Servier Methods and compositions for liver cancer therapy
KR101728011B1 (ko) 2013-01-23 2017-04-20 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 덱스트란 메타크릴레이트 및 생체적합성 음이온성 고분자를 포함하는 생분해성 마이크로 비드 및 이의 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384081B2 (en) * 1998-10-09 2002-05-07 Charles L. Berman Treatment of diseases of the eye characterized by the formation of metalloproteinase
CN101134119A (zh) * 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
CN102131483A (zh) * 2008-02-08 2011-07-20 昌达生物科技公司 可控给药非聚合组合物
CN101327190A (zh) * 2008-07-29 2008-12-24 北京大学 一种供注射用的抗肿瘤长循环靶向脂质体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A NOVEL APPROACH TO FORMULATION OF ANTICANCER DRUGS IN NANOPARTICLES;Xinyi Gu;《XP055471017》;20080101;第39-70页 *

Also Published As

Publication number Publication date
US20170239192A1 (en) 2017-08-24
US20190046462A1 (en) 2019-02-14
JP6951971B2 (ja) 2021-10-20
JP2017527593A (ja) 2017-09-21
KR20170054459A (ko) 2017-05-17
WO2016039678A1 (en) 2016-03-17
EP3191138B1 (en) 2024-05-29
EP3191138A1 (en) 2017-07-19
AU2015316252A1 (en) 2017-03-09
CA2958820A1 (en) 2016-03-17
EP3191138A4 (en) 2018-06-20
IL250637A0 (en) 2017-04-30
EP3191138C0 (en) 2024-05-29
US10034838B2 (en) 2018-07-31
EA201790272A1 (ru) 2017-07-31
CN107073129A (zh) 2017-08-18
US10973772B2 (en) 2021-04-13
MX2017003049A (es) 2017-05-23
EA033526B1 (ru) 2019-10-31

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