CN107050199A - A kind of pharmaceutical composition for treating women postpartum disease - Google Patents
A kind of pharmaceutical composition for treating women postpartum disease Download PDFInfo
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- CN107050199A CN107050199A CN201611007454.7A CN201611007454A CN107050199A CN 107050199 A CN107050199 A CN 107050199A CN 201611007454 A CN201611007454 A CN 201611007454A CN 107050199 A CN107050199 A CN 107050199A
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Abstract
A kind of pharmaceutical composition for treating women postpartum disease and preparation method thereof, the pharmaceutical composition is made up of the medicine of following parts by weight：The shell of seaear, strophanthus divaricatus, fructus viticis, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae, are boiled, soaking technology is made by alcohol extracting, water.Postpartum disease 585 is treated, total effective rate is up to 96.8%, and effect substantially, and does not find adverse reaction and toxic side effect, illustrates that pharmaceutical composition of the present invention is evident in efficacy in treatment women postpartum disease, with good promotional value.
Description
Technical field
The present invention relates to field of medicine invention, and in particular to a kind of pharmaceutical composition and its system for treating women postpartum disease
Preparation Method.
Background technology
Postpartum disease, is called " puerperal fever ", is that women is producing child's period, in poor health because muscles and bones space between skin and muscles is opened greatly, inside and outside
Caused by empty not preventing wind-cold pathogen intrusion, prolonged lochia, the subinvolution of uterus, postpartum anemia, blood stasis are mainly shown as, underbelly is empty
Pendant, from head to foot pain, cold, afraid of the wind, cold perspiration, turning joint pain, get well clothing, and serious patient wears cotton dress etc. in hot day in summer.This
A little diseases not only have a strong impact on the mood and health of puerpera, and prevent puerpera from normal lactation baby.Postpartum disease is accomplished
Early prevention, early generation, early treatment, current treatment postpartum disease have no specific drug, cause many puerperas to fall life-long disease, therefore grind
The medicine for sending out to effect a radical cure postpartum disease a kind of is the direction that numerous developers make great efforts.
In order to solve the above problems, inventor have developed a kind of new drug for treating women postpartum disease.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating women postpartum disease.
Another object of the present invention provides a kind of preparation method for the pharmaceutical composition for treating women postpartum disease.
The pharmaceutical composition for the treatment women postpartum disease that the present invention is provided is made up of the medicine of following parts by weight：The shell of seaear
10-40 parts, 8-30 parts of strophanthus divaricatus, 5-15 parts of fructus viticis, 10-40 parts of radix stellariae dichotomae, 20-60 parts of Radix Angelicae Sinensis, 10-40 parts of Exocarpium Citri Rubrum, rhizoma nelumbinis
10-35 parts, 10-45 parts of pyrrosia lingua, 10-35 parts of rhizoma nardostachyos, 10-40 parts of the rhizoma bolbostemmae, 10-50 parts of granatum, 10-30 parts of radix glycyrrhizae.
It is preferred that, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：12-38 parts of the shell of seaear, cloth
10-28 parts of slag leaf, 6-14 parts of fructus viticis, 13-37 parts of radix stellariae dichotomae, 25-55 parts of Radix Angelicae Sinensis, 12-38 parts of Exocarpium Citri Rubrum, 13-32 parts of rhizoma nelumbinis, stone
15-40 parts of Wei, 13-32 parts of rhizoma nardostachyos, 13-37 parts of the rhizoma bolbostemmae, 15-45 parts of granatum, 13-27 parts of radix glycyrrhizae.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Shell of seaear 15-35
Part, 12-26 parts of strophanthus divaricatus, 7-13 parts of fructus viticis, 17-33 parts of radix stellariae dichotomae, 30-50 parts of Radix Angelicae Sinensis, 15-35 parts of Exocarpium Citri Rubrum, rhizoma nelumbinis 17-29
Part, 20-35 parts of pyrrosia lingua, 17-29 parts of rhizoma nardostachyos, 18-32 parts of the rhizoma bolbostemmae, 20-40 parts of granatum, 16-25 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Shell of seaear 20-
30 parts, 15-23 parts of strophanthus divaricatus, 8-12 parts of fructus viticis, 21-29 parts of radix stellariae dichotomae, 35-45 parts of Radix Angelicae Sinensis, 20-30 parts of Exocarpium Citri Rubrum, rhizoma nelumbinis 20-
27 parts, 23-32 parts of pyrrosia lingua, 20-26 parts of rhizoma nardostachyos, 21-29 parts of the rhizoma bolbostemmae, 25-35 parts of granatum, 18-23 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：The shell of seaear 25
Part, 19 parts of strophanthus divaricatus, 10 parts of fructus viticis, 25 parts of radix stellariae dichotomae, 40 parts of Radix Angelicae Sinensis, 25 parts of Exocarpium Citri Rubrum, 24 parts of rhizoma nelumbinis, 28 parts of pyrrosia lingua, rhizoma nardostachyos
23 parts, 25 parts of the rhizoma bolbostemmae, 30 parts of granatum, 21 parts of radix glycyrrhizae.
Pharmaceutical composition of the present invention also contains pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention be solid pharmaceutical preparation or liquid preparation, the solid pharmaceutical preparation be tablet, capsule,
Granula or pill；The liquid preparation is oral liquid.
The preparation method of pharmaceutical composition of the present invention comprises the following steps：By the shell of seaear, strophanthus divaricatus, fructus viticis,
Radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae pulverize and sieve, and are carried with pharmaceutically acceptable
Body or diluent are well mixed, are prepared into preparation.
The preparation method of pharmaceutical composition of the present invention comprises the following steps：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
Add 3-7 times of 75% ethanol measured to soak 4-9 days, filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds 5-9 times
The water heating of amount is decocted 2-4 times, each 1-3 hours, filtering, and filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 12-17 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby
With；
4) above-mentioned standby fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
It is preferred that, the preparation method of pharmaceutical composition of the present invention comprises the following steps：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 5 times of amounts soaks 6 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 7 times of amounts
Heating is decocted 3 times, and 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 15 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
The parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of amount refers to the weight ratio of medicinal material again.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler,
One or more in adhesive, disintegrant, lubricant, surfactant or flavouring.
Wherein described filler is selected from starch, sucrose, lactose, mannitol, sorbierite, xylitol, microcrystalline cellulose or Portugal
Grape sugar etc.；
Described adhesive is selected from cellulose derivative, alginates, gelatin or polyvinylpyrrolidone etc.；
The disintegrant is selected from microcrystalline cellulose, sodium carboxymethyl starch, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or Ac-Di-Sol；
The lubricant is selected from stearic acid, polyethylene glycol, calcium carbonate, sodium acid carbonate, silica, talcum powder or stearic acid
Magnesium；
The surfactant is selected from neopelex, stearic acid, Pluronic F68, fat
Sorb is smooth or polysorbate (tween) etc. for fat acid；
The flavouring is selected from Aspartame, Sucralose or saccharin sodium.
The pharmaceutical composition that the present invention is provided has advantages below：
The present invention is treating women postpartum disease such as：Deficient qi and blood, eyes are shed tears to the wind, afraid of the wind, cold perspiration, turning joint pain
There is good effect in terms of pain, treat postpartum disease 585, total effective rate is up to 96.8%, and effect substantially, and is not found not
Good reaction and toxic side effect, illustrate that pharmaceutical composition of the present invention is evident in efficacy in treatment women postpartum disease, with good promotion price
Value.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription：Shell of seaear 10g, strophanthus divaricatus 8g, fructus viticis 5g, radix stellariae dichotomae 10g, Radix Angelicae Sinensis 20g, Exocarpium Citri Rubrum 10g, rhizoma nelumbinis 10g, stone
Wei 10g, rhizoma nardostachyos 10g, rhizoma bolbostemmae 10g, granatum 10g, radix glycyrrhizae 10g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 3 times of amounts soaks 4 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 5 times of amounts
Heating is decocted 2 times, and 1 hour every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 17 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2), 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 2/5, load
Capsule, is made capsule.
Embodiment 2
Prescription：Shell of seaear 40g, strophanthus divaricatus 30g, fructus viticis 15g, radix stellariae dichotomae 40g, Radix Angelicae Sinensis 60g, Exocarpium Citri Rubrum 40g, rhizoma nelumbinis 35g,
Pyrrosia lingua 45g, rhizoma nardostachyos 35g, rhizoma bolbostemmae 40g, granatum 50g, radix glycyrrhizae 30g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 7 times of amounts soaks 9 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 9 times of amounts
Heating is decocted 4 times, and 3 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 17 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2) 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 1/5, mix,
Granulation, is dried, and whole grain obtains the granule of the application.
Embodiment 3
Prescription：Shell of seaear 12g, strophanthus divaricatus 10g, fructus viticis 6g, radix stellariae dichotomae 13g, Radix Angelicae Sinensis 25g, Exocarpium Citri Rubrum 12g, rhizoma nelumbinis 13g,
Pyrrosia lingua 15g, rhizoma nardostachyos 13g, rhizoma bolbostemmae 13g, granatum 15g, radix glycyrrhizae 13g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 4 times of amounts soaks 5 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 6 times of amounts
Heating is decocted 3 times, and 3 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 13 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2), 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 2/5, load
Capsule, is made capsule.
Embodiment 4
Prescription：Shell of seaear 38g, strophanthus divaricatus 28g, fructus viticis 14g, radix stellariae dichotomae 37g, Radix Angelicae Sinensis 55g, Exocarpium Citri Rubrum 38g, rhizoma nelumbinis 32g,
Pyrrosia lingua 40g, rhizoma nardostachyos 32g, rhizoma bolbostemmae 37g, granatum 45g, radix glycyrrhizae 27g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 6 times of amounts soaks 8 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 8 times of amounts
Heating is decocted 3 times, and 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 16 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2) 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 1/5, dry,
Tabletting, produces the tablet of the application.
Embodiment 5
Prescription：Shell of seaear 15g, strophanthus divaricatus 12g, fructus viticis 7g, radix stellariae dichotomae 17g, Radix Angelicae Sinensis 30g, Exocarpium Citri Rubrum 15g, rhizoma nelumbinis 17g,
Pyrrosia lingua 20g, rhizoma nardostachyos 17g, rhizoma bolbostemmae 18g, granatum 20g, radix glycyrrhizae 16g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 5 times of amounts soaks 6 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 7 times of amounts
Heating is decocted 3 times, and 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 15 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2) 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 1/5, mix,
Granulation, is dried, and whole grain obtains the granule of the application.
Embodiment 6
Prescription：Shell of seaear 35g, strophanthus divaricatus 26g, fructus viticis 13g, radix stellariae dichotomae 33g, Radix Angelicae Sinensis 50g, Exocarpium Citri Rubrum 35g, rhizoma nelumbinis 29g,
Pyrrosia lingua 35g, rhizoma nardostachyos 29g, rhizoma bolbostemmae 32g, granatum 40g, radix glycyrrhizae 25g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 5 times of amounts soaks 6 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 7 times of amounts
Heating is decocted 3 times, and 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 15 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2), 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 2/5, load
Capsule, is made capsule.
Embodiment 7
Prescription：Shell of seaear 20g, strophanthus divaricatus 15g, fructus viticis 8g, radix stellariae dichotomae 21g, Radix Angelicae Sinensis 35g, Exocarpium Citri Rubrum 20g, rhizoma nelumbinis 20g,
Pyrrosia lingua 23g, rhizoma nardostachyos 20g, rhizoma bolbostemmae 21g, granatum 25g, radix glycyrrhizae 18g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 5 times of amounts soaks 6 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 7 times of amounts
Heating is decocted 3 times, and 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 15 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2), 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 2/5, load
Capsule, is made capsule.
Embodiment 8
Prescription：Shell of seaear 30g, strophanthus divaricatus 23g, fructus viticis 12g, radix stellariae dichotomae 29g, Radix Angelicae Sinensis 45g, Exocarpium Citri Rubrum 30g, rhizoma nelumbinis 27g,
Pyrrosia lingua 32g, rhizoma nardostachyos 26g, rhizoma bolbostemmae 29g, granatum 35g, radix glycyrrhizae 23g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 5 times of amounts soaks 6 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 7 times of amounts
Heating is decocted 3 times, and 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 15 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2), 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 2/5, load
Capsule, is made capsule.
Embodiment 9
Prescription：Shell of seaear 25g, strophanthus divaricatus 19g, fructus viticis 10g, radix stellariae dichotomae 25g, Radix Angelicae Sinensis 40g, Exocarpium Citri Rubrum 25g, rhizoma nelumbinis 24g,
Pyrrosia lingua 28g, rhizoma nardostachyos 23g, rhizoma bolbostemmae 25g, granatum 30g, radix glycyrrhizae 21g.
Preparation method：
1) medicine of parts by weight is weighed respectively, it is standby；
2) by the shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae
75% ethanol for adding 5 times of amounts soaks 6 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water of 7 times of amounts
Heating is decocted 3 times, and 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 15 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) by step 2), 3) standby fine powder be well mixed, add the starch for accounting for well mixed fine powder weight 2/5, load
Capsule, is made capsule.
In order to further sketch beneficial effects of the present invention, inventor has done clinical test.
1st, case is originated
Patient after 585 famous products is randomly selected in volunteer to be tested, the age between 22-39 Sui, average age 27
In year, patient clinical symptom is：Deficient qi and blood, eyes are shed tears to the wind, afraid of the wind, cold perspiration, turning joint pain.
2nd, treatment method
Above-mentioned patient is equally divided into 9 groups, there was no significant difference between each group, this 9 groups of patients are taken into the present invention respectively
Embodiment 1-9 medicine, 3 times a day, each 3g are continuously taken 2-4 weeks.
3rd, criterion of therapeutical effect
Efficacy assessment standard：Efficacy assessment standard reference《Traditional Chinese medicine Clinical Researches of New Drugs guideline》Formulate：
It is effective：Clinical symptom and sign disappears；
Effectively：Clinical symptom and sign substantially or mostly disappears；
It is invalid：Clinical symptom and sign is without improvement.
4th, experimental result
Most patients are having the sensation that symptom substantially mitigates in 5 days or so according to the inventive method using medicine, clothes
After 4 weeks, deficient qi and blood, eyes are shed tears to the wind, afraid of the wind, cold perspiration, and turning joint pain symptom is disappeared or fully recovered, and effect is shown in Table
1：
The curative effect statistical form of table 1
| Group | It is effective | Effectively | It is invalid | It is total | Efficient (%) |
| Embodiment 1 | 60 | 3 | 2 | 65 | 96.9% |
| Embodiment 2 | 59 | 3 | 3 | 65 | 95.4% |
| Embodiment 3 | 61 | 3 | 1 | 65 | 98.5% |
| Embodiment 4 | 60 | 3 | 2 | 65 | 96.9% |
| Embodiment 5 | 58 | 4 | 3 | 65 | 95.4% |
| Embodiment 6 | 61 | 2 | 2 | 65 | 96.9% |
| Embodiment 7 | 60 | 2 | 3 | 65 | 95.4% |
| Embodiment 8 | 59 | 4 | 2 | 65 | 96.9% |
| Embodiment 9 | 61 | 3 | 1 | 65 | 98.5% |
Postpartum disease 585 is treated, total effective rate is up to 96.8%, and effect substantially, and does not find adverse reaction and poison pair
Effect, illustrates that pharmaceutical composition of the present invention is evident in efficacy in treatment female postpartum disease, with good promotional value.
Model case：
Case 1：Field, the girl baby of natural labor one before 27 years old, 1 month, postpartum pale complexion, turning joint pain take this hair
The medicine of bright embodiment 1, turning joint without pain after 1 week continues to take 10 days, and each symptom disappears, recovery from illness.
Case 2：Xiao, the next girl baby of caesarean birth before 29 years old, 2 months, postpartum waist-leg ache, eyes tearing against wind are taken
The pharmaceutical composition of embodiments of the invention 2, symptom mitigation after 3 days continues to take 15 days, and each symptom disappears, recovery from illness.
Case 3：Guo, the boy baby of natural labor one before 32 years old, 1 month, after discharge, afraid of the wind, cold perspiration, waist-leg ache, immunity
Lowly, easy catching a cold headache, takes the pharmaceutical composition of embodiments of the invention 3, symptom mitigation after 5 days, and after 20 days, symptom disappears
Lose, recovery from illness.
Case 4：Certain is shut out, the next girl baby of caesarean birth, afraid of the wind, cold perspiration, turning joint pain before 33 years old, 3 months.Take this
The pharmaceutical composition of inventive embodiments 4, symptom mitigation after 3 days, after 15 days, symptom disappears, recovery from illness.
Case 5：Xiao, the boy baby of caesarean birth one before 35 years old, 3 months, after discharge, empty and bearing-down sensation of the lower abdomen, pain, turning joint pain
Bitterly.The pharmaceutical composition of the embodiment of the present invention 5 is taken, symptom mitigation after 3 days continues to take after 15 days, symptom disappears, recovery from illness.
Case 6：Certain is paid, the girl baby of caesarean birth one before 28 years old, 2 months.After discharge, eyes tearing against wind, cold perspiration, chilly,
Waist-leg ache,.The pharmaceutical composition of the embodiment of the present invention 6 is taken, symptom mitigation after 3 days continues to take after 16 days, symptom disappears
Lose, recovery from illness.
Case 7：Lee, the girl baby of caesarean birth one before 35 years old, 1 month, after discharge, anaemia, headache, chilly, waist-leg ache, eye
Eyeball tearing against wind.The pharmaceutical composition of the embodiment of the present invention 7 is taken, symptom mitigation after 2 days continues to take after 18 days, symptom disappears
Lose, recovery from illness.
Case 8：Lee, the girl baby of natural labor one before 29 years old, 3 months, after discharge, afraid of the wind, cold perspiration, hypoimmunity are taken
The pharmaceutical composition of embodiments of the invention 8, symptom disappears after 20 days, and is difficult sick, recovery from illness.
Case 9：Bai, the girl baby of caesarean birth one before 29 years old, 2 months, after discharge, has a delicate constitution, and colourless sweating is afraid of from head to foot
It is cold.The pharmaceutical composition of the embodiment of the present invention 9 is taken, sb.'s illness took a favorable turn after 3 days, continue to take 12 days, fully recovered.
Although above having made to retouch in detail to the present invention with general explanation, embodiment and experiment
State, but on the basis of the present invention, some modifications can be made to it or are improved, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (10)
1. a kind of pharmaceutical composition for treating women postpartum disease, it is characterised in that the pharmaceutical composition by following parts by weight medicine
Thing is made：10-40 parts of the shell of seaear, 8-30 parts of strophanthus divaricatus, 5-15 parts of fructus viticis, 10-40 parts of radix stellariae dichotomae, 20-60 parts of Radix Angelicae Sinensis, Exocarpium Citri Rubrum
10-40 parts, 10-35 parts of rhizoma nelumbinis, 10-45 parts of pyrrosia lingua, 10-35 parts of rhizoma nardostachyos, 10-40 parts of the rhizoma bolbostemmae, 10-50 parts of granatum, radix glycyrrhizae
10-30 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：12-38 parts of the shell of seaear, 10-28 parts of strophanthus divaricatus, 6-14 parts of fructus viticis, 13-37 parts of radix stellariae dichotomae, 25-55 parts of Radix Angelicae Sinensis, Exocarpium Citri Rubrum
12-38 parts, 13-32 parts of rhizoma nelumbinis, 15-40 parts of pyrrosia lingua, 13-32 parts of rhizoma nardostachyos, 13-37 parts of the rhizoma bolbostemmae, 15-45 parts of granatum, radix glycyrrhizae
13-27 parts.
3. pharmaceutical composition according to claim 2, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：15-35 parts of the shell of seaear, 12-26 parts of strophanthus divaricatus, 7-13 parts of fructus viticis, 17-33 parts of radix stellariae dichotomae, 30-50 parts of Radix Angelicae Sinensis, Exocarpium Citri Rubrum
15-35 parts, 17-29 parts of rhizoma nelumbinis, 20-35 parts of pyrrosia lingua, 17-29 parts of rhizoma nardostachyos, 18-32 parts of the rhizoma bolbostemmae, 20-40 parts of granatum, radix glycyrrhizae
16-25 parts.
4. pharmaceutical composition according to claim 3, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：20-30 parts of the shell of seaear, 15-23 parts of strophanthus divaricatus, 8-12 parts of fructus viticis, 21-29 parts of radix stellariae dichotomae, 35-45 parts of Radix Angelicae Sinensis, Exocarpium Citri Rubrum
20-30 parts, 20-27 parts of rhizoma nelumbinis, 23-32 parts of pyrrosia lingua, 20-26 parts of rhizoma nardostachyos, 21-29 parts of the rhizoma bolbostemmae, 25-35 parts of granatum, radix glycyrrhizae
18-23 parts.
5. pharmaceutical composition according to claim 4, it is characterised in that the pharmaceutical composition by following parts by weight medicine
It is made：25 parts of the shell of seaear, 19 parts of strophanthus divaricatus, 10 parts of fructus viticis, 25 parts of radix stellariae dichotomae, 40 parts of Radix Angelicae Sinensis, 25 parts of Exocarpium Citri Rubrum, 24 parts of rhizoma nelumbinis,
28 parts of pyrrosia lingua, 23 parts of rhizoma nardostachyos, 25 parts of the rhizoma bolbostemmae, 30 parts of granatum, 21 parts of radix glycyrrhizae.
6. the pharmaceutical composition according to claim any one of 1-5, it is characterised in that the pharmaceutical composition also contains pharmacy
Upper acceptable carrier or diluent.
7. pharmaceutical composition according to claim 6, it is characterised in that described pharmaceutical composition is solid pharmaceutical preparation or liquid
Preparation, the solid pharmaceutical preparation is tablet, capsule, granule or pill；The liquid preparation is oral liquid.
8. a kind of preparation method for preparing the pharmaceutical composition described in claim any one of 1-5, it is characterised in that this method bag
Include following steps：By the shell of seaear, strophanthus divaricatus, fructus viticis, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, pomegranate
Skin, radix glycyrrhizae pulverize and sieve, and are well mixed with pharmaceutically acceptable carrier or diluent, are prepared into preparation.
9. a kind of preparation method for preparing the pharmaceutical composition described in claim any one of 1-5, it is characterised in that this method bag
Include following steps：
1) medicine of parts by weight is weighed respectively, it is standby；
2) shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae are added
3-7 times of 75% ethanol measured soaks 4-9 days, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds 5-9 times to measure
Water heating is decocted 2-4 times, each 1-3 hours, filtering, filtrate concentration, dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 12-17 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
10. the preparation method of pharmaceutical composition according to claim 9, it is characterised in that this method comprises the following steps：
1) medicine of parts by weight is weighed respectively, it is standby；
2) shell of seaear, strophanthus divaricatus, radix stellariae dichotomae, Radix Angelicae Sinensis, Exocarpium Citri Rubrum, rhizoma nelumbinis, pyrrosia lingua, rhizoma nardostachyos, the rhizoma bolbostemmae, granatum, radix glycyrrhizae are added 5
75% ethanol of amount soaks 6 days again, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；Filter residue adds the water heating of 7 times of amounts
Decoct 3 times, 2 hours every time, filtering, filtrate concentration dry, pulverize into fine powder, standby；
3) vinegar that fructus viticis is added into 2 times of amounts soaks 15 hours, and filtering, filtrate concentrates, dry, pulverize into fine powder, standby；
4) above-mentioned standby fine powder is well mixed, adds auxiliary material, pharmaceutically acceptable formulation is made.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112518A (en) * | 2007-08-29 | 2008-01-30 | 北京艺信堂医药研究所 | Chinese traditional medicine preparations for treating postpartum blood deficiency and fever |
| CN104399050A (en) * | 2014-12-11 | 2015-03-11 | 刘桐言 | Traditional Chinese medicine for treating postpartum hemorrhage |
| CN105362987A (en) * | 2015-11-18 | 2016-03-02 | 王广梅 | Traditional Chinese medicine preparation for postpartum care |
| CN105709077A (en) * | 2016-03-20 | 2016-06-29 | 赵中美 | Traditional Chinese medicine composition for treating puerperal disease and preparation method thereof |
| CN105853920A (en) * | 2016-04-25 | 2016-08-17 | 闫密桃 | Chinese herbal medicine composition for treating puerperal diseases and preparation method of Chinese herbal medicine |
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2016
- 2016-11-10 CN CN201611007454.7A patent/CN107050199A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112518A (en) * | 2007-08-29 | 2008-01-30 | 北京艺信堂医药研究所 | Chinese traditional medicine preparations for treating postpartum blood deficiency and fever |
| CN104399050A (en) * | 2014-12-11 | 2015-03-11 | 刘桐言 | Traditional Chinese medicine for treating postpartum hemorrhage |
| CN105362987A (en) * | 2015-11-18 | 2016-03-02 | 王广梅 | Traditional Chinese medicine preparation for postpartum care |
| CN105709077A (en) * | 2016-03-20 | 2016-06-29 | 赵中美 | Traditional Chinese medicine composition for treating puerperal disease and preparation method thereof |
| CN105853920A (en) * | 2016-04-25 | 2016-08-17 | 闫密桃 | Chinese herbal medicine composition for treating puerperal diseases and preparation method of Chinese herbal medicine |
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Address after: 266000 Qingdao city women and children's Hospital, Tongfu Road, Qingdao, Shandong 6 Applicant after: Lv Hongjuan Address before: No. 14, Silver Beach, Silver Beach, Rushan, Shandong Applicant before: Diao Yuanyuan |
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Application publication date: 20170818 |