CN101053597B - Medicine for treating skin disease and beauty and preparation method thereof - Google Patents
Medicine for treating skin disease and beauty and preparation method thereof Download PDFInfo
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- CN101053597B CN101053597B CN2007100658355A CN200710065835A CN101053597B CN 101053597 B CN101053597 B CN 101053597B CN 2007100658355 A CN2007100658355 A CN 2007100658355A CN 200710065835 A CN200710065835 A CN 200710065835A CN 101053597 B CN101053597 B CN 101053597B
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Abstract
The invention discloses a medicine for treating skin disease and hairdressing. The medicine has the brook anemone as primary material and can combine with the other plants, which selects from one of Blumea balsamifera Dc, Chinese alangium root, delavay ampelopsis root, corn mint or chinarue, or their mixture; in which, the weight ratio of the brook anemone and other plants is 1:100-100:1. The inventive medicine can be used to treat skin moisture and skin disease, such as acne, dermatitis, tetter, flat wart, psora, pityriasis, psoriasis, skin polypus tumor, corporality inductivity skin hypersensitivity and pruritus, dermatophytosis, foot odour, underarm odour, and dander.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly, the present invention relates to the vegetable Chinese herbal medicine is the treatment dermatosis made of primary raw material and the medicine of beauty treatment.Simultaneously, the invention still further relates to the preparation method of described medicine.
Background technology
People's skin bag is by whole body, 16% of the about percentage of liveweight of skin gross weight, and area is 1.5～2 square metres the adult, is the organ of human body maximum.People's skin is owing to outside being exposed to, often be subjected to various x radiation xs, virus infraction, the infection of anaphylaxis material, and skin is the position that is easy to generate inflammation.Treating for skin disease, Western medicine can be seen effect fast, allows the patient be difficult to accept but take for a long time, and the chemical residual that Western medicine is difficult to avoid has seriously injured patient's organs such as stomach, spleen, kidney and heart; The lotion that the patient uses is actually the very big hormonal substance of toxicity, in the course of time, forms hormone and relies on.The price that has is high, and numerous patients' economic capability can not be accepted.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of determined curative effect, applied widely, safe in utilization, treatment common skin diseases that cost is low and the medicine of beauty treatment are provided.
Another object of the present invention provides the preparation method of this medicine.
Purpose of the present invention is achieved by following technical proposals.
* except as otherwise noted, the percent that is adopted among the present invention is percetage by weight.
The invention provides a kind of medicine for the treatment of dermatosis and beauty treatment, the primary raw material that it is characterized in that this medicine is Radix Anemones Rivularis (Anemone rivularis Buch.-ham.), and adopts following method to produce:
(1) get dry medical material of Radix Anemones Rivularis root or bright product, pulverize or section, add 50% ethanol, soaked 48 hours, by weight, the consumption of solvent is 3.5～5 times of medical material weight;
(2) filter, filtering residue soaks with method and extracts twice, merge extractive liquid,, and 65 ℃ of following decompression and solvent recoveries, concentrated solution was placed 65～75 hours, filtered; The water dilution that adds filtrate weight 20%～25%; Be required Radix Anemones Rivularis extracting solution.
In described Radix Anemones Rivularis extracting solution, add 0.5%～1% sodium benzoate, 0.1%～0.2% nipagin ester fully stirs evenly and makes its dissolving, further makes the Radix Anemones Rivularis medicinal liquid.
In order to reach better therapeutic, medicine of the present invention also can make up with other plant, described other plant is a kind of in Herba Blumeae Balsamiferae (Blumea balsamifera DC.), Radix Alangii (Alangium chinense (Lour.) harms), Delavay ampelopsis root (Ampelopsis delavayana (Franch.) Planch.), Herba Menthae (Mentha haplocalyx Briq.) or the Herba Boenninghauseniae (Boenninghausenia sessilicarpaLevl.), or their mixture; Wherein, Radix Anemones Rivularis and other plant weight ratio be 1: 100～100: 1, its preferred weight ratio is 40: 60～60: 40.
If also add other plant component, the preparation method of medicine of the present invention is:
(1) get Radix Anemones Rivularis and other medical materials, through pulverizing, add water and/or other alcohol then, ketone is done solvent extraction, the weight ratio of Radix Anemones Rivularis and other medical materials is 1: 10～10: 1, is preferably 4: 1; Quantity of solvent is 3: 1～100: 1 of medical material amount; Filter;
(2) according to the dosage form needs, it is 1.01～1.10 extractum that filtrate is condensed into proportion, or drying makes extract;
(3) adopt water, glycerol or other solvent that mixes, as propylene glycol; Perhaps the mixture of these solvents is mixed with various regular dosage forms, for example: emulsion, gel, solid or the aerosol of water formulation, emulsion (Water-In-Oil O/W or oil-in-water W/O) type; The form that described ingredients can powder, allow on wet cloth, washing liquid (liniment), paste or other any beauty treatments and the skin treating medicine exists and uses, and washing liquid, liniment or paste are preferred pharmaceutical dosage form.
Wherein, used extraction solvent is preferably water or 75% ethanol or 40% acetone in the step (1); They are preferably 10: 1 with the ratio of the medical material amount that feeds intake; Extracting mode can be immersion, percolation, reflux; Preferred soak at room temperature, 90 ℃ of reflux.Concentrated mode in the step (2) is heating evaporation, concentrating under reduced pressure, lyophilization, spray drying; Preferably freeze drying or 60 ℃ of concentrating under reduced pressure.
In addition, solvent load requires different with proportion according to prepared dosage form method.Dosage form such as washing liquid, liniment itself is solvent with water, and the water-soluble solvent consumption can be bigger than normal when therefore extracting medical material, or concentrated proportion is less than normal.Need add oiliness carrier when dosage form such as Emulsion, unguentum prepares, therefore must reduce the water-soluble solvent consumption, or concentrated proportion be bigger than normal.
Can add anticorrosion (or antibacterial) agent that cosmetics or skin treating medicine allow to use, acid adjustment (alkali) liquid, aromatic, excipient, dispersion (dilution) agent, toner, stabilizing agent, thickening agent, radiation quencher, surfactant and other in the extract of the present invention and be used to prepare the raw material commonly used of ingredients and external preparation for skin pharmaceutical preparation of improving looks.
Compared with prior art, the present invention has following beneficial effect:
1. determined curative effect, wide accommodation.Pharmaceutical preparation of the present invention can be used for skin moisturizing and treating skin disease for example acne (acne), dermatitis, erythra, verruca plana, tinea, psoriasis, psoriasis, skin sarcoma, materiality (pollen, metal, medicine and other sensitizers) inductivity skin allergy and pruritus, beriberi foot odor, bromhidrosis, the dandruff.
2. product is pure Chinese medicinal preparation, and is non-stimulated to skin, and safety is good.Raw material sources are abundant, and manufacture method is simple, and is with low cost.Determined curative effect, wide accommodation is fit to extensively promote.Through nearly 3 years trying out, total effective rate reaches more than 96%.
Below by testing example beneficial effect of the present invention is set forth, test example comprises the pharmacodynamics test and the clinical observation on the therapeutic effect test of medicine of the present invention.
A. medicine of the present invention is to the irritant test of rabbit skin
Test material:
(1) the Radix Anemones Rivularis extract frost of anthology invention, self-control.Get octadecanol and white vaseline and be heated to 75 ℃ in water-bath, get the Radix Anemones Rivularis extract and be dissolved in the solvent, this solution joins in the oil phase, stirs evenly, and other gets cream base, reaches other raw material, prepares cream by the preparation code requirement, stirs molding promptly.
(2) preparation of depilatory: get sodium sulfide (Na:S9H20) 50g, the distilled water that adds about 300ad is to dissolving, and other gets detergent 10g and adds above-mentioned solution, evenly stirs, and adds appropriate amount of starch again and stirs evenly, and adds distilled water at last to 500ad, makes into scattered paste shape promptly.
(3) experimental animal: big ear is from 16 of rabbit.About body weight 2kg, male and female half and half.
Test method:
(1) animal grouping: random choose male 4 is female 4, and totally 8 rabbit are experimental group.8 rabbit of surplusing are by sex, body weight and experimental group rabbit matched control.
(2) medication: in the test before 24h, with depilatory with tame rabbit back spinal column both sides unhairing (the about 20em2 of every side, no erythema, edema and breakage).Radix Anemones Rivularis extract frost is smeared in depilation district, experimental group rabbit left side, and the right side is contrast, and 0.025% beclometasone frost is smeared in depilation district, matched group rabbit left side.1h behind observation and the recording medicine, 24h, the reaction of 72h skin irritation.
(3) zest evaluation: observe the degree of erythema (comprising eschar) and edema, mark by table 1.
(4) stimulate the score value evaluation:
Stimulate score value=(erythematous response total points+edema reaction total points)/every treated animal number
It is non-stimulated stimulating score value＜0.5;＜2 is slight the stimulation;＜6 are the moderate stimulation;＞6 are the intensity stimulation.
Experimental result shows that Radix Anemones Rivularis extract and reference substance beclometasone frost thereof are respectively 0.125,0 to the stimulation score value of skin, all＜0.5, shows that medicine of the present invention very stimulates invariably to rabbit skin, sees table 1 for details.
Table 1 skin irritation reaction grade form
B. the dermopathic clinical observation of Drug therapy of the present invention
(1) physical data
Accept out-patient's totally 345 examples for medical treatment, wherein male 168 examples, women 177 examples.18～68 years old age,
(2) Therapeutic Method
Adopt preparation to be used for corresponding position outward according to different symptoms.
(3) efficacy assessment standard
Recovery from illness---malaise symptoms disappears, and physical recovery is normal;
Produce effects---cardinal symptom disappears substantially, obviously improves;
Taking a turn for the better---cardinal symptom disappears, and certain improvement is arranged;
Invalid---cardinal symptom does not have improvement.
(4) therapeutic outcome
With Drug therapy 345 examples of the present invention, 276 examples of fully recovering, remarkable 39 examples, 19 examples that take a turn for the better, invalid 11 examples, cure rate 80%, total effective rate is 96.8%, sees table 2 for details.
Table 2.
| Symptom | Total routine number | Recovery from illness (example) | Significantly (example) | Take a turn for the better (example) | Invalid (example) | Total effective rate (%) |
| Acne (acne) | 100 | 80 | 10 | 7 | 3 | 97.0 |
| Dermatitis | 52 | 41 | 7 | 3 | 1 | 98.1 |
| Symptom | Total routine number | Recovery from illness (example) | Significantly (example) | Take a turn for the better (example) | Invalid (example) | Total effective rate (%) |
| Erythra | 20 | 19 | 1 | 0 | 1 | 100.0 |
| Verruca plana | 10 | 8 | 2 | 0 | 0 | 100.0 |
| Tinea | 15 | 11 | 3 | 0 | 1 | 93.3 |
| Psoriasis | 10 | 6 | 2 | 1 | 0 | 90.0 |
| Psoriasis | 12 | 7 | 3 | 1 | 1 | 91.6 |
| Skin sarcoma | 35 | 30 | 3 | 2 | 0 | 100.0 |
| Pollen sensitization | 34 | 30 | 2 | 1 | 1 | 97.1 |
| Metal sensitization | 12 | 11 | 1 | 0 | 0 | 100.0 |
| Medicine sensitization | 16 | 12 | 2 | 1 | 1 | 93.8 |
| The beriberi foot odor | 5 | 3 | 2 | 0 | 0 | 100.0 |
| Bromhidrosis | 10 | 7 | 1 | 1 | 1 | 90.0 |
| The dandruff | 14 | 11 | 0 | 2 | 1 | 92.8 |
The clinical observation patient does not all have the obvious toxic-side effects reaction.All can tolerate for discomfort after the medication, all patients adhere to that all finish medication to the course of treatment.
The specific embodiment
By specific embodiment given below and typical Application Example, can further be well understood to the present invention.But they are not the qualification to protection domain of the present invention.
Preparation embodiment 1
Get the dry medical material 2.5kg of Radix Anemones Rivularis root (or bright product 9.0kg), pulverize (or section), add 50% ethanol 40L, soaked 48 hours, and filtered, filtering residue soaks with method and extracts twice, the about 100L of merge extractive liquid,, 65 ℃ of decompression and solvent recoveries are to about 40L (contain amount of alcohol below 10% this moment), and concentrated solution was placed 72 hours, filter, the filtrate thin up adds sodium benzoate 250g, nipagin ester 50g to 50L, and fully mixing makes dissolving, placed 72 hours, and filtered.Get filtrate 10L, use the cillin bottle packing, every bottle of 10ml.
Preparation embodiment 2
Get the dry medical material 1kg of Radix Anemones Rivularis root, pulverize, add entry 8L, reflux 3 hours is filtered, and filtering residue extracts twice with method again, merge extractive liquid; Other gets 1 kilogram of Herba Blumeae Balsamiferae medical material, Herba Menthae 0.5kg, uses steam distillation, collects distillate 10L; Merge two kinds of extracting solution, mix homogeneously was placed 48 hours, filtered, and filtrate can be as carrying out packing or preparation among the embodiment 1.
Preparation embodiment 3
Get the dry medical material 1kg of Radix Anemones Rivularis root, Delavay ampelopsis root 1kg, Radix Alangii 1kg, pulverize, add 20% ethanol 15L, 50 ℃ of warm macerating twice, each 12 hours, merge extractive liquid, was placed 24 hours; Filter filtrate for later use; Other gets 2 kilograms of Herba Blumeae Balsamiferae medical materials, uses steam distillation, collect distillate and add in the aforementioned filtrate, to mixeding liquid volume to 40L till.Mix homogeneously was placed 24 hours, filtered filtrate for later use.Get this filtrate, add in system fancy soap preparation technology, every fancy soap weighs 100g, wherein amounts to contain described extracting solution 12ml.
Preparation embodiment 4
Get the bright product medical material of Radix Anemones Rivularis Herb 5kg, Herba Boenninghauseniae medical material 3kg, add 75% ethanol, soaks three times, each liquid feeding 20L soaked 48 hours, filtration, and the filtrate merging, 75 ℃ of decompression and solvent recoveries get density and are 1.10～1.25 extractum.Add entry 40L in this extractum, transfer PH=5.0～5.5, fully stir evenly, placed 48 hours, filter filtrate for later use with 10% hydrochloric acid.
Get above-mentioned filtrate 10L, lyophilization gets medicated powder 113g, gets this medicated powder 20g, adds vaseline 200g, lanoline 100g, glycerol 50g, liquid paraffin 30g, abundant mixing, packing, every bottle of 5g.
Get above-mentioned filtrate 5L, spray drying gets medicated powder 51g, with the dissolving of the Herba Blumeae Balsamiferae distillate 5L among the embodiment two, uses the cillin bottle packing, every bottle of 10ml.
Application Example 1
The woman, 23 years old, people from Qujing, Yunnan.Nearly 1 year of facial trouble acne.Facial skin is comparatively greasy under the jaw, and forehead and two cheeks have more kermesinus pimple, and total focus number has 37,6 of pustule, new and old being mingled with.With dry mouth and throat, constipation, the red partially yellow and greasy fur of body of the tongue, the sliding number of pulse condition.Diagnosis: acne vulgaris.
Application Example 2
The woman, 23 years old, people from Chengdu, Sichuan.Local skin lesion is from the beginning of erubescence, glad heat, mild swelling, and miliaria is in blocks then, companion's pruritus.Diagnosis: acute eczema dermatitis.
Application Example 3
The woman, 25 years old, people from Liuzhou.Erythra is the hatpin head to Semen Glycines size smooth flat pimple, and is rounded, the normal colour of skin, and face, the back of the hand, forearm idol have little itching, and after scratching, are beading along scratch and arrange.Diagnosis: verruca plana.
Application Example 4
The man, 50 years old, red pimple appearred on one's body in people from Qingdao, the silvery white squama of skin lesion surface coverage, the squama of scratching gently is promptly tear-away, diagnosis: psoriasis (psoriasis).
Application Example 5
The woman, 28 years old, people from Mengzi, Yunnan, behind the belt of contacting metal, belt contact position skin just plays red packet, itches the stream yellow fluid.Diagnosis: Metal Contact dermatitis.
Application Example 6
The woman, 30 years old, people from Baoshan, Yunnan.After the contact Fructus Mangifera Indicae, originally lip has pruritus, scorching hot, and then edematous erythema appears in lip, mouthful week, cheeks and other position, and there is intensive pimple and the papulovesicle of needle point size on the surface.Diagnosis: Fructus Mangifera Indicae allergic dermatitis.
Application Example 7
The man, 10 years old, people from Jinan, Shandong.Due to illness the toxicity encephalitis slowly instils with Rhizoma Belamcandae antiviral injection adding grape glucose injection angular vein.After the medication the 4th day, red grouper pimple and vesicle that differing in size appears in cervical region, skin of back.Through drug withdrawal and give this product antianaphylactic treatment, diagnosis: drug-induced property skin allergy.
Application Example 8
The man, 35 years old, people from Taizhou, Zhejiang.Scalp has diffusivity, canescence, slightly oily pityrosporum shape squama, and often with pruritus, standby hands one is grabbed when many, and the dandruff is just numerous and confused and descend as snowflake.Diagnosis: and seborrhea sicca goes out disease.
Application Example 9
The man, 21 years old, people from Kaifeng.There is brown stricture of vagina thread hole the oxter, and the glutinous greasy as cream of sweating is like fat, and flavor is as if wild Vulpes.Diagnosis: bromhidrosis.
Application Example 10
The woman, 38 years old, people from Zhaotong, Yunnan, sole is felt very to itch unbearably often, but also can follow vesicle, and decortication is chapped, and oozes out symptoms such as foot odor, diagnosis: beriberi foot odor.
* above-mentioned each case all adopts the Radix Anemones Rivularis extract formulation to be used for corresponding position outward, and symptom is eased in a short time, and the skin abnormality situation disappears automatically, follows up a case by regular visits to and does not see recurrence.
Claims (2)
1. the application of the extracting solution of a Radix Anemones Rivularis in the external used medicine of preparation treatment dermatosis and beauty treatment, wherein, described Radix Anemones Rivularis extracting solution is to adopt following method to produce: (1) gets dry medical material of Radix Anemones Rivularis root or bright product, pulverize or section, add 50% ethanol, soaked 48 hours, by weight, the consumption of solvent is 3.5～5 times of medical material weight; (2) filter, filtering residue soaks with method and extracts twice, merge extractive liquid,, and 65 ℃ of following decompression and solvent recoveries, concentrated solution was placed 65～75 hours, filtered; Add the water dilution of filtrate weight 20%～25%, be required Radix Anemones Rivularis extracting solution.
2. application according to claim 1 is characterized in that further adding 0.5%～1% sodium benzoate in described Radix Anemones Rivularis extracting solution, and 0.1%～0.2% nipagin ester fully stirs evenly and makes its dissolving.
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| CN2007100658355A CN101053597B (en) | 2007-04-25 | 2007-04-25 | Medicine for treating skin disease and beauty and preparation method thereof |
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| CN2007100658355A CN101053597B (en) | 2007-04-25 | 2007-04-25 | Medicine for treating skin disease and beauty and preparation method thereof |
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| CN101053597B true CN101053597B (en) | 2010-11-10 |
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| CN103989949A (en) * | 2014-05-30 | 2014-08-20 | 刘湘春 | Medicine for treating dental ulcer and preparation method thereof |
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