CN107050187A - A kind of Chinese medicine composition for treating impotence, premature ejaculation and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating impotence, premature ejaculation and preparation method thereof Download PDFInfo
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- CN107050187A CN107050187A CN201710316537.2A CN201710316537A CN107050187A CN 107050187 A CN107050187 A CN 107050187A CN 201710316537 A CN201710316537 A CN 201710316537A CN 107050187 A CN107050187 A CN 107050187A
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- 201000001881 impotence Diseases 0.000 title claims abstract description 31
- 206010036596 premature ejaculation Diseases 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 21
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 241000258920 Chilopoda Species 0.000 claims abstract description 11
- 241001016310 Epimedium grandiflorum Species 0.000 claims abstract description 11
- 244000241872 Lycium chinense Species 0.000 claims abstract description 11
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 11
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 11
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 11
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 11
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 11
- 241000405414 Rehmannia Species 0.000 claims abstract description 11
- 229940107666 astragalus root Drugs 0.000 claims abstract description 11
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 11
- 235000018905 epimedium Nutrition 0.000 claims abstract description 11
- 235000008434 ginseng Nutrition 0.000 claims abstract description 11
- 210000000582 semen Anatomy 0.000 claims abstract description 11
- 241000208688 Eucommia Species 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 244000170916 Paeonia officinalis Species 0.000 claims abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 241000208340 Araliaceae Species 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 9
- 239000006228 supernatant Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000007796 conventional method Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010067484 Adverse reaction Diseases 0.000 abstract description 3
- 230000006838 adverse reaction Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 208000008454 Hyperhidrosis Diseases 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 208000013219 diaphoresis Diseases 0.000 abstract description 2
- 230000001939 inductive effect Effects 0.000 abstract description 2
- 210000003734 kidney Anatomy 0.000 abstract description 2
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 241000736199 Paeonia Species 0.000 description 8
- 230000001568 sexual effect Effects 0.000 description 7
- 239000002775 capsule Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 3
- 210000003899 penis Anatomy 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
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- 235000019425 dextrin Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 229960002639 sildenafil citrate Drugs 0.000 description 1
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
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- A61K2236/30—Extraction of the material
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of Chinese medicine composition for treating impotence, premature ejaculation and preparation method thereof.The Chinese medicine composition is by ginseng, Rhizoma Atractylodis Macrocephalae preparata, astragalus root, rattletop, radix bupleuri, dried orange peel, the fruit of Chinese wolfberry, centipede, earthworm, Radix Angelicae Sinensis, the root of herbaceous peony, prepared rhizome of rehmannia, the bark of eucommia, Semen Cuscutae, barrenwort, radix glycyrrhizae is raw material, is prepared from by certain weight, and it can be prepared into any conventional oral formulations.This product has inducing diaphoresis ceases wind, enriching yin and nourishing kidney, enrich blood establishing-Yang the effect of.Clinically it is used to treat impotence, premature ejaculation, it is evident in efficacy, obvious adverse reaction is not found.
Description
Technical field
The present invention is to be related to a kind of Chinese medicine composition, specifically, is related to a kind of Chinese medicine composition for treating impotence, premature ejaculation
And preparation method thereof.
Background technology
Impotence refers to male in sexual life, penis anorthosis or erect it is not hard or hard and soon, it is impossible to complete normal
Sexual life, or penis can not insert vagina and have sexual intercourse at all, and impotence is also known as " impotence " etc., be most common man's property work(
Can obstacle disease, 1-2 sexual intercourse failure once in a while, it is impossible to think exactly to have suffered from impotence.Only in sexual intercourse mortality more than 25%
Shi Caineng is diagnosed as impotence, is counted according to data from abroad, and impotence patient accounts for the 37%- of whole male sexual disfunctions
42%.Domestic relevant investigation shows that impotence occurs for the people that 10% is there are about in adult male.The incidence of impotence with the age increasing
Grow and rise.
Premature ejaculation refers to after penis insertion vagina, is not yet come to orgasm in women, and the sex time of male is shorter than 2 points
Clock, the sexual intercourse ejaculated and occurred ahead of time is discord obstacle, and general male 30% has this situation, though problem is small, and making property is given birth to
Work is of low quality, it is also possible to cause other sex dysfunctions such as impotence, and consequence is serious, should draw attention and and early treatment.
At present, impotence drug therapy is mainly Sildenafil citrate tablets, and premature ejaculation drug therapy is mainly serotonin again
Uptake inhibitor, what the country had been listed is that hydrochloric acid Da Paxi stings, and they have certain toxic side effect, and price is somewhat expensive.
Therefore seek safely and effectively to treat impotence, premature ejaculation new Chinese medicine, it has also become vast impotence, Patients with Premature Ejaculation and doctor
Common aspiration.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating impotence, premature ejaculation.
The present invention also aims to provide a kind of Chinese medicine composition for treating impotence, premature ejaculation and preparation method thereof.
The scheme that the present invention is solved is inventor, under the guidance of traditional Chinese medical theory, the machine occurred for impotence, premature ejaculation
Reason, for many years with reference to the clinical experience of oneself, is developed, this product has inducing diaphoresis ceases wind, enriching yin and nourishing kidney, establishing-Yang of enriching blood meticulously
The effect of.Clinically it is used to treat impotence, premature ejaculation, it is evident in efficacy, obvious adverse reaction is not found.
The present invention realizes that medicine of the present invention is mainly the bulk drug system matched by following weight parts by following scheme
Into：
The preferred weight part of the main each raw material of medicine of the present invention is matched：
The optimum weight part of the main each raw material of medicine of the present invention is matched：
15 parts of ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae preparata, 30 parts of astragalus root, 5 parts of rattletop, 10 parts of radix bupleuri, 6 parts of dried orange peel, 15 parts of the fruit of Chinese wolfberry, when
Return 15 parts, 20 parts of centipede, 20 parts of earthworm, 15 parts of the root of herbaceous peony, 15 parts of prepared rhizome of rehmannia, 15 parts of the bark of eucommia, 15 parts of Semen Cuscutae, 15 parts of barrenwort,
6 parts of radix glycyrrhizae.
The preparation method of medicine of the present invention, its method and step is as follows：
(1) by the centipede of weight described in formula, earthworm is ground into fine powder, standby；
(2) remaining ginseng, Rhizoma Atractylodis Macrocephalae preparata, astragalus root, rattletop, radix bupleuri, dried orange peel, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, the root of herbaceous peony, prepared rhizome of rehmannia, Du
Secondary, Semen Cuscutae, barrenwort, radix glycyrrhizae adds water to cook secondary, each plus 6-10 times of water measured, each 1-2 hours, collecting decoction, filter
Cross, filtrate is concentrated into the medicinal extract that relative density is 1.16~1.21 (80 DEG C), and ethanol is added in medicinal extract, it is 50- to make alcohol content
90%, stir evenly, stand 24-48 hours, take supernatant, recovery ethanol is concentrated into the leaching for 1.30~1.35 (60 DEG C) to density
Cream, can add auxiliary material required when preparing different dosage forms, then be prepared into conventional oral agents with conventional method of Chinese medicinal
Type, such as capsule, granule, tablet.
Embodiment
Embodiment 1：A kind of capsule preparation method thereof for treating impotence, premature ejaculation of the present invention, its step is as follows：
15 parts of ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae preparata, 30 parts of astragalus root, 5 parts of rattletop, 10 parts of radix bupleuri, 6 parts of dried orange peel, 15 parts of the fruit of Chinese wolfberry, when
Return 15 parts, 20 parts of centipede, 20 parts of earthworm, 15 parts of the root of herbaceous peony, 15 parts of prepared rhizome of rehmannia, 15 parts of the bark of eucommia, 15 parts of Semen Cuscutae, 15 parts of barrenwort,
6 parts of radix glycyrrhizae.
(1) by the centipede of weight described in formula, earthworm is ground into fine powder, standby；
(2) remaining ginseng, Rhizoma Atractylodis Macrocephalae preparata, astragalus root, rattletop, radix bupleuri, dried orange peel, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, the root of herbaceous peony, prepared rhizome of rehmannia, Du
Secondary, Semen Cuscutae, barrenwort, radix glycyrrhizae adds water to cook secondary, each plus 8 times of amounts water, and 1.5 hours every time, collecting decoction was filtered,
Filtrate is concentrated into the medicinal extract that relative density is 1.16~1.21 (80 DEG C), and ethanol is added in medicinal extract, and it is 90% to make alcohol content, is stirred
It is even, 36 hours are stood, supernatant is taken, ethanol is reclaimed and is concentrated into the medicinal extract that density is 1.30~1.35 (60 DEG C), add above-mentioned
Fine powder, microcrystalline cellulose is mixed, and dry, pulverize into fine powder, is loaded capsule, is produced capsule.
Embodiment 2：A kind of process for producing granula for treating impotence, premature ejaculation of the present invention, its step is as follows：
15 parts of ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae preparata, 30 parts of astragalus root, 5 parts of rattletop, 10 parts of radix bupleuri, 6 parts of dried orange peel, 15 parts of the fruit of Chinese wolfberry, when
Return 15 parts, 20 parts of centipede, 20 parts of earthworm, 15 parts of the root of herbaceous peony, 15 parts of prepared rhizome of rehmannia, 15 parts of the bark of eucommia, 15 parts of Semen Cuscutae, 15 parts of barrenwort,
6 parts of radix glycyrrhizae.
(1) by the centipede of weight described in formula, earthworm is ground into fine powder, standby；
(2) remaining ginseng, Rhizoma Atractylodis Macrocephalae preparata, astragalus root, rattletop, radix bupleuri, dried orange peel, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, the root of herbaceous peony, prepared rhizome of rehmannia, Du
Secondary, Semen Cuscutae, barrenwort, radix glycyrrhizae adds water to cook secondary, each plus 6 times of amounts water, and 2 hours every time, collecting decoction was filtered, filter
Liquid is concentrated into the medicinal extract that relative density is 1.16~1.21 (80 DEG C), and ethanol is added in medicinal extract, and it is 50% to make alcohol content, is stirred evenly,
48 hours are stood, supernatant is taken, ethanol is reclaimed and is concentrated into the medicinal extract that density is 1.30~1.35 (60 DEG C), is added above-mentioned thin
Powder, dextrin, Steviosin, mixing are pelletized, and dry, that is, granule is made.
Embodiment 3：A kind of method for preparing tablet thereof for treating impotence, premature ejaculation of the present invention, its step is as follows：
15 parts of ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae preparata, 30 parts of astragalus root, 5 parts of rattletop, 10 parts of radix bupleuri, 6 parts of dried orange peel, 15 parts of the fruit of Chinese wolfberry, when
Return 15 parts, 20 parts of centipede, 20 parts of earthworm, 15 parts of the root of herbaceous peony, 15 parts of prepared rhizome of rehmannia, 15 parts of the bark of eucommia, 15 parts of Semen Cuscutae, 15 parts of barrenwort,
6 parts of radix glycyrrhizae.
(1) by the centipede of weight described in formula, earthworm is ground into fine powder, standby；
(2) remaining ginseng, Rhizoma Atractylodis Macrocephalae preparata, astragalus root, rattletop, radix bupleuri, dried orange peel, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, the root of herbaceous peony, prepared rhizome of rehmannia, Du
Secondary, Semen Cuscutae, barrenwort, radix glycyrrhizae adds water to cook secondary, each plus 10 times of amounts water, and 1 hour every time, collecting decoction was filtered, filter
Liquid is concentrated into the medicinal extract that relative density is 1.16~1.21 (80 DEG C), and ethanol is added in medicinal extract, and it is 70% to make alcohol content, is stirred evenly,
24 hours are stood, supernatant is taken, ethanol is reclaimed and is concentrated into the medicinal extract that density is 1.30~1.35 (60 DEG C), is added above-mentioned thin
Powder, adds microcrystalline cellulose, magnesium stearate, and particle is made in mixing, and tabletting is coated, produces tablet.
Experimental example
In June 1 year July in 2013,39 impotence patients, 22 Patients with Premature Ejaculation are clinically selected, in one month not
Once treatment was received.Receive a kind of capsule for treating impotence, premature ejaculation of the present embodiment 1, it is orally, twice a day, 5 every time, before meals
With a course for the treatment of is 15 days, and the 1-2 course for the treatment of is as a result as follows：
This product therapeutic effect is good, and treatment impotence effective percentage is 100%, and treatment premature ejaculation effective percentage is 95.5%.Treating
Cheng Zhong, patient has no obvious adverse reaction.
Although being above described in detail with a general description of the specific embodiments to the present invention,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (4)
1. a kind of Chinese medicine composition for treating impotence, premature ejaculation, it is characterised in that it is mainly by the raw material of following weight
Medicine is made：
2. a kind of Chinese medicine composition for treating impotence, premature ejaculation according to claim 1, it is characterised in that it is mainly under
The bulk drug of the preferred weight of row is made：
3. a kind of Chinese medicine composition for treating impotence, premature ejaculation according to claim 1, it is characterised in that it is mainly under
The bulk drug of row optimum weight part proportioning is made：
15 parts of ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae preparata, 30 parts of astragalus root, 5 parts of rattletop, 10 parts of radix bupleuri, 6 parts of dried orange peel, 15 parts of the fruit of Chinese wolfberry, Radix Angelicae Sinensis 15
Part, 20 parts of centipede, 20 parts of earthworm, 15 parts of the root of herbaceous peony, 15 parts of prepared rhizome of rehmannia, 15 parts of the bark of eucommia, 15 parts of Semen Cuscutae, 15 parts of barrenwort, radix glycyrrhizae 6
Part.
4. a kind of impotence, premature ejaculation process for preparing medicine according to claim 1 or 2 or 3, it is characterised in that it includes following
Step：
(1) by the centipede of weight described in formula, earthworm is ground into fine powder, standby；
(2) remaining ginseng, Rhizoma Atractylodis Macrocephalae preparata, astragalus root, rattletop, radix bupleuri, dried orange peel, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, the root of herbaceous peony, prepared rhizome of rehmannia, the bark of eucommia,
Semen Cuscutae, barrenwort, radix glycyrrhizae adds water to cook secondary, each plus the 6-10 times of water measured, each 1-2 hours, collecting decoction, filters,
Filtrate is concentrated into the medicinal extract that relative density is 1.16~1.21 (80 DEG C), and ethanol is added in medicinal extract, and it is 50-90% to make alcohol content,
Stir evenly, stand 24-48 hour, take supernatant, reclaim ethanol and be concentrated into medicinal extract to density for 1.30~1.35 (60 DEG C), can be with
Addition prepares auxiliary material required during different dosage forms, then is prepared into conventional peroral dosage form, such as glue with conventional method of Chinese medicinal
Wafer, granule, tablet etc..
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114272222A (en) * | 2021-12-23 | 2022-04-05 | 安徽悦博生物制药有限公司 | Shenhuwenshen capsule preparation and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114272222A (en) * | 2021-12-23 | 2022-04-05 | 安徽悦博生物制药有限公司 | Shenhuwenshen capsule preparation and its preparing method |
| CN114272222B (en) * | 2021-12-23 | 2023-06-30 | 安徽悦博生物制药有限公司 | Ginseng kidney-warming capsule preparation and preparation method thereof |
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Application publication date: 20170818 |