CN107050067A - A kind of industrialized process for preparing of Cordyceps militaris water soluble powder - Google Patents
A kind of industrialized process for preparing of Cordyceps militaris water soluble powder Download PDFInfo
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- CN107050067A CN107050067A CN201610946930.5A CN201610946930A CN107050067A CN 107050067 A CN107050067 A CN 107050067A CN 201610946930 A CN201610946930 A CN 201610946930A CN 107050067 A CN107050067 A CN 107050067A
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- cordyceps militaris
- water
- water soluble
- soluble powder
- temperature
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- 241001264174 Cordyceps militaris Species 0.000 title claims abstract description 42
- 239000004552 water soluble powder Substances 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 19
- 238000000605 extraction Methods 0.000 claims abstract description 15
- 239000000706 filtrate Substances 0.000 claims abstract description 13
- 238000001914 filtration Methods 0.000 claims abstract description 13
- 239000008187 granular material Substances 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 11
- 239000000919 ceramic Substances 0.000 claims abstract description 7
- 239000012528 membrane Substances 0.000 claims abstract description 7
- 230000000149 penetrating effect Effects 0.000 claims abstract description 7
- 238000005119 centrifugation Methods 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 239000013078 crystal Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 31
- 230000008569 process Effects 0.000 abstract description 11
- 239000000047 product Substances 0.000 abstract description 8
- 238000005265 energy consumption Methods 0.000 abstract description 6
- 239000006057 Non-nutritive feed additive Substances 0.000 abstract description 2
- 238000010924 continuous production Methods 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000002137 ultrasound extraction Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- 241000235349 Ascomycota Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 2
- 241000190633 Cordyceps Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000221775 Hypocreales Species 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 238000005352 clarification Methods 0.000 description 2
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 2
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 241001529400 Cordycipitaceae Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 241000192128 Gammaproteobacteria Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000257212 Hypocreomycetidae Species 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 241000382353 Pupa Species 0.000 description 1
- 241001326533 Sordariomycetes Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/10—General cosmetic use
Abstract
The present invention relates to a kind of industrialized process for preparing of Cordyceps militaris water soluble powder.This method coarse granule will be made after crushing through dry Cordyceps militaris, using water as solvent, coarse granule is subjected to second extraction under the conditions of low material-water ratio, low temperature, ultrasonic wave added, merging filtrate after centrifugation, filtrate carries out refined filtration by ceramic membrane, it is medicinal extract by gained penetrating fluid concentration after refined filtration, medicinal extract obtains Cordyceps militaris water soluble powder after being dried through cryogenic vacuum continuous band through crushing.Whole process of the inventive method use without any processing aid and auxiliary material than water, it is ensured that the quality safety of product and quality are pure, and whole process carry out at a lower temperature, cost is low, energy consumption is small.It is connected close between each operation designed by this method, technological operation is easy, safe and efficient, is adapted to set up streamline and carries out industrializing continuous production operation.
Description
Technical field
The present invention relates to Cordyceps militaris deep process technology field, and in particular to a kind of preparation of industrialization side of Cordyceps militaris water soluble powder
Method.
Background technology
Cordyceps militaris, also known as northern Chinese caterpillar Fungus (Cordyceps militaris(L.)Link), it is to belong to Eumycota
(Eumycota), Ascomycota (Ascomycota), Ascomycotina (Ascomycotinia), excrement shell Gammaproteobacteria
(Sordariomycetes), meat seat bacterium subclass (Hypocreomycetidae), Hypocreales (Hypocreales), cordyceps sinensis section
(Cordycipitaceae), Cordyceps (Cordyceps) a kind of large-scale medicine food fungi bacteria.Cordyceps militaris has phase with cordyceps sinensis
As pharmacologically active principles, such as contain cordycepin, cordycepic acid, Cordyceps sinensis polysaccharide, ergosterol, amino acid, nucleosides material,
Effect is similar to cordyceps sinensis, with quite varied pharmacotoxicological effect.National health State Family Planning Commission issue in 2014 is announced pupa
Cordyceps sinensis is approved as new raw-food material, causes extensive concern and attention that people utilize to Cordyceps militaris.
At present, the document patent in terms of Cordyceps militaris extract is generally the achievement in laboratory or lab scale or simply applies mechanically it
, there is Feedstock treating complexity, technique fierceness, tedious process, poor continuity, production cost height in the related art method of his extract
Etc. problems.Hair angle is melted from Cordyceps militaris process deeply industry, using efficient low-consume, energy-conserving and environment-protective, safety and sanitation as starting point,
Flow is made by industrialization continuous system, a set of preparation method from Cordyceps militaris pretreatment of raw material to final products is set up,
Have no related specific report.
In addition, when Cordyceps militaris grinding particle size is reached more than 60 mesh, softening can be expanded after being soaked through water, there is certain viscosity,
Good separating effect is difficult to using industrial bag-filter type centrifugal machine, filter residue can form sticky cake layer in filter bag so that
Penetrating fluid can not be filtered out smoothly, needed frequently to stop centrifugation in the industrial production, cleared up cake layer so that filtration stage is operated
Numerous and diverse, inefficiency, penetrating fluid loss are more.Preferably separation effect can be realized using horizontal centrifuge or tube centrifuge
Really, but the two is under identical material handling capacity, cost is high, safeguard and operation be far above bag-filter type centrifugal machine.
Through the Searches of Patent Literature, patent No. CN201310207185.9《A kind of preparation method of Cordyceps militaris instant powder》, it
Main technique be through hot water extraction, homogenate, enzymolysis, soybean dietary fiber, homogeneous, spray drying be made, with this patent method
Compare, there is difference from Feedstock treating, production technology to finished product, its energy consumption in production process is higher, process is more multiple
Miscellaneous and be difficult to serialization, product rehydration clarity is poor, limited using scope.
The content of the invention
The present invention is directed to drawbacks described above, it is therefore intended that provide a kind of quality safety for improving product and the pure one kind of quality
The industrialized process for preparing of Cordyceps militaris water soluble powder.
It is for this technical solution adopted by the present invention：It will be broken first through dry Cordyceps militaris in Particle Breakage equipment
It is broken, the Cordyceps militaris coarse granule that length is 2-5mm is obtained, extraction equipment is put it into, adds the water of 6-10 times of the weight of material, super
Under conditions of acoustic frequency 24-40KHz, 45-55 DEG C of temperature, extract 2-4 hours, then divided filtrate and filter residue using centrifugation apparatus
From filter residue adds 3-5 times of water to carry out second extraction and centrifuge by raw material weight, merges and extracts gained filtrate twice, uses aperture
Refined filtration is carried out to it for 100-1000nm ceramic membrane equipment；Gained penetrating fluid uses vacuum concentration equipment in temperature after refined filtration
60-80 DEG C, the medicinal extract for obtaining that soluble solids concentration is 52%-62% is concentrated under conditions of vacuum -0.07-0.09MPa；Adopt
With cryogenic vacuum continuous band drying equipment, concentrated extract is carried out under conditions of 50-80 DEG C of temperature, vacuum -0.1MPa
Dry, to the crystal that water content is less than 5% is obtained, Cordyceps militaris water soluble powder is obtained after being crushed.
It is an advantage of the invention that：
1st, the material treatment process of the inventive method is simple, without Cordyceps militaris is crushed, is only broken for coarse granule, should
Technique is easily achieved, processing cost is low and does not influence extraction efficiency, and solves made because grinding particle size is too small well
It is the effect that good initial gross separation can be achieved using the bag-filter type centrifugal machine of low cost, it is not necessary to adopt into the situation for being difficult to separate
With the costs such as horizontal centrifuge or tube centrifuge height, operation and the equipment for safeguarding complexity；
2nd, in the extraction process of the inventive method, material-water ratio example is relatively low（It is aided with ultrasonic extraction and can guarantee that extraction efficiency）, same
Under conditions of feed throughput, the technique requires low to the model of extraction equipment, can save its energy consumption and equipment investment, and by
In the reduction of extract solution, in downstream centrifugation, enrichment process, it can also mitigate the treating capacity and energy consumption of material significantly so that comprehensive
Production cost is greatly reduced, production efficiency and resource utilization are greatly improved；
3rd, the filtering technique of the inventive method uses ceramic membrane technology, and it can filter out water-insoluble minute solid particles, ceramic membrane
Aperture through overtesting and checking, the aperture that selection clarity is high, the rate of filtration is fast and active principle retention degree is small so that worm
The small molecule active component damages such as careless element are few, and can at utmost ensure the complete reservation of water-soluble active ingredient in Cordyceps militaris,
Directly make it that the clarity after product rehydration is splendid；
4th, the drying process of the inventive method uses vacuum belt type drying technology, compared to entering for 160 DEG C conventional of spray drying
Air temperature, and the drying aids such as addition soluble starch, maltodextrin are needed, vacuum belt type drying temperature is substantially reduced, material
Loss is small, and energy consumption is low, and need not add auxiliary agent, ensures product safety and pure, and it is in loose porous to dry resulting material, and is contained
Water is less than 5%, beneficial to storage；
5th, whole process of the inventive method use without any processing aid and auxiliary material than water, it is ensured that product
Quality safety is pure with quality, and whole process is carried out at a lower temperature, and cost is low, energy consumption is small；
6th, in the integrated artistic of the inventive method, Extracting temperature, thickening temperature, drying temperature are gentle, and whole technological process all exists
Carried out at relatively low temperature, reduce influence of the high temperature to Active Components in Various Cordyceps militaris Strains, can at utmost retain Cordyceps militaris and be extracted into
The activity divided；
7th, it is connected close between each operation designed by the inventive method, technological operation is easy, safe and efficient, is adapted to set up flowing water
Line carries out industrializing continuous production operation；
8th, Cordyceps militaris water soluble powder made from the inventive method is in loose porous, and water-soluble fabulous, hot and cold water is quickly dissolving, and it is multiple
Clarity is high after water, limpid transparent, without any precipitation；
9th, Cordyceps militaris water soluble powder made from the inventive method is suitable to rich in various bioactivators such as cordycepin, adenosine, polysaccharide
Apply in the fields such as functional food, beverage, oral liquid, lozenge, daily use chemicals, beauty.
Brief description of the drawings
The state diagram of Fig. 1 Cordyceps militaris water soluble powders.
Fig. 2 is that Cordyceps militaris water soluble powder redissolves figure (in figure from left to right) with 50/100/200/300 part of water.
Embodiment
Embodiment（One）：
（1）Crush：By Cordyceps militaris through being crushed, 5mm coarse granules are obtained；
（2）Once extract：Cordyceps militaris coarse granule is put into extractor, and the water of 8 times of quality is added thereto, 45 DEG C is heated to, makes
With 28KHz ultrasound assisted extraction 2h；
（3）Separation：Feed liquid is separated using centrifuge, obtains and once extracts filtrate and filter residue；
（4）Second extraction：Filter residue is put into extractor, the water of 4 times of former Cordyceps militaris coarse granule quality is added thereto, is heated to
45 DEG C, use 28KHz ultrasound assisted extraction 2h；
（5）Separation：Feed liquid is separated using centrifuge, second extraction filtrate and filter residue is obtained；
（6）Refined filtration：Merge and once extract and second extraction filtrate, carry out refined filtration using the ceramic membrane equipment in 500nm apertures, obtain
The penetrating fluid of clarification.
（7）Concentration：Concentrated using single-effect external circulation inspissator, 60 DEG C of thickening temperature, vacuum -0.078MPa is dense
It is reduced to 55% solids level concentration.
（8）Dry：Dried using cryogenic vacuum continuous band drying equipment, 60 DEG C of drying condition, vacuum -0.1MPa,
Dry crystal is obtained, Cordyceps militaris water soluble powder is obtained after being crushed.
Embodiment（Two）：
（1）Crush：By Cordyceps militaris through being crushed, 3mm coarse granules are obtained；
（2）Once carry：Cordyceps militaris coarse granule is put into extractor, and the water of 7 times of quality is added thereto, 55 DEG C are heated to,
Using 28KHz ultrasound assisted extraction 2h, extract 2 times；
（3）Separation：Feed liquid is separated using centrifuge, obtains and once extracts filtrate and filter residue；
（4）Second extraction：Filter residue is put into extractor, the water of 3.5 times of former Cordyceps militaris coarse granule quality, heating are added thereto
To 55 DEG C, 28KHz ultrasound assisted extraction 2h is used；
（5）Separation：Feed liquid is separated using centrifuge, second extraction filtrate and filter residue is obtained；
（6）Refined filtration：Merge and once extract and second extraction filtrate, carry out refined filtration using the ceramic membrane equipment in 800nm apertures, obtain
The penetrating fluid of clarification.
（7）Concentration：Concentrated using single-effect external circulation inspissator, 60 DEG C of thickening temperature, vacuum -0.078MPa is dense
It is reduced to 62% solids level concentration.
（8）Dry：Dried using cryogenic vacuum continuous band drying equipment, 60 DEG C of drying condition, vacuum -0.1MPa,
Dry crystal is obtained, Cordyceps militaris water soluble powder is obtained after being crushed.
Claims (2)
1. a kind of industrialized process for preparing of Cordyceps militaris water soluble powder, it is characterised in that comprise the following steps：
（1）Crushed through dry Cordyceps militaris in Particle Breakage equipment, obtain the Cordyceps militaris coarse granule that length is 2-5mm；
（2）Cordyceps militaris coarse granule is put into extraction equipment, the water of 6-10 times of weight of material is added, supersonic frequency 24-40KHz,
Under conditions of 45-55 DEG C of temperature, filtrate is separated with filter residue using centrifugation apparatus after extracting 2-4 hours；
（3）Gained penetrating fluid after refined filtration, refined filtration is carried out to filtrate using aperture for 100-1000nm ceramic membrane equipment to use very
Empty concentrator is concentrated into acquisition soluble solids concentration under conditions of 60-80 DEG C of temperature, vacuum -0.07-0.09MPa
For 52%-62% medicinal extract；
（4）Using cryogenic vacuum continuous band drying equipment, by concentrated extract in 50-80 DEG C of temperature, vacuum -0.1MPa bar
It is dried under part, to the crystal that water content is less than 5% is obtained, Cordyceps militaris water soluble powder is obtained after being crushed.
2. the industrialized process for preparing of a kind of Cordyceps militaris water soluble powder according to claim 1, it is characterised in that described 2）Step
In rapid, once extract after centrifugation, add 3-5 times of water to carry out second extraction and centrifuge, supersonic frequency by raw material weight filter residue
45-55 DEG C of 24-40KHz, temperature, merges and extracts gained filtrate twice.
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| CN113952902A (en) * | 2021-11-19 | 2022-01-21 | 广东容大生物股份有限公司 | Method for extracting water-soluble cordycepin serving as antibacterial growth promoter |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104473977A (en) * | 2014-11-18 | 2015-04-01 | 广东省微生物研究所 | Cordyceps militaris water extract as well as preparation method and application thereof |
| CN105294796A (en) * | 2015-11-11 | 2016-02-03 | 湖南炎帝生物工程有限公司 | Method for extracting cordycepin and cordyceps from cordyceps militaris solid medium residues |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104473977A (en) * | 2014-11-18 | 2015-04-01 | 广东省微生物研究所 | Cordyceps militaris water extract as well as preparation method and application thereof |
| CN105294796A (en) * | 2015-11-11 | 2016-02-03 | 湖南炎帝生物工程有限公司 | Method for extracting cordycepin and cordyceps from cordyceps militaris solid medium residues |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113952902A (en) * | 2021-11-19 | 2022-01-21 | 广东容大生物股份有限公司 | Method for extracting water-soluble cordycepin serving as antibacterial growth promoter |
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