CN107050007B - 涉及类视黄醇受体选择性通路的方法和组合物 - Google Patents

涉及类视黄醇受体选择性通路的方法和组合物 Download PDF

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CN107050007B
CN107050007B CN201611020419.9A CN201611020419A CN107050007B CN 107050007 B CN107050007 B CN 107050007B CN 201611020419 A CN201611020419 A CN 201611020419A CN 107050007 B CN107050007 B CN 107050007B
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rxrα
sulindac
cells
analog
tnfα
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CN107050007A (zh
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张晓坤
苏迎
周虎
刘�文
黄培强
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Xiamen University
Sanford Burnham Prebys Medical Discovery Institute
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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CN201611020419.9A 2010-05-06 2011-05-06 涉及类视黄醇受体选择性通路的方法和组合物 Expired - Fee Related CN107050007B (zh)

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JP2013533212A (ja) 2010-05-06 2013-08-22 サンフォード−バーナム メディカル リサーチ インスティテュート レチノイド受容体に選択的な経路に関する方法および組成物
JP2014517813A (ja) * 2011-04-01 2014-07-24 サザン リサーチ インスティテュート スリンダク誘導体、その使用及びその調製
WO2015100267A1 (en) * 2013-12-23 2015-07-02 Sanford-Burnham Medical Research Institute Methods and compositions for treating cancer
WO2017193086A1 (en) * 2016-05-06 2017-11-09 Tarrex Biopharma Inc. Therapeutic compounds and methods
US20230234909A1 (en) * 2020-06-12 2023-07-27 Nucmito Pharmaceuticals Co. Ltd. Indene compounds, pharmaceutical compositions thereof, and their therapeutic applications
CN117916215A (zh) * 2021-05-15 2024-04-19 藤济(厦门)生物医药科技有限公司 茚化合物、其药物组合物及其治疗应用
CN120513226A (zh) * 2022-11-16 2025-08-19 藤济(厦门)生物医药科技有限公司 茚化合物、其药物组合物及其治疗应用

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DE10163426A1 (de) * 2001-12-21 2003-07-03 Max Planck Gesellschaft Pharmakologisch wirksame Inden-Derivate

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AU6909000A (en) 1999-08-16 2001-03-13 Johns Hopkins University, The Ppardelta links apc to chemopreventive drugs
AU2003298020A1 (en) * 2002-11-26 2004-06-18 Florida Atlantic University Catalytic antioxidants and methods of use
WO2005037189A2 (en) 2003-08-13 2005-04-28 The Burnham Institute Cytoplasmic activity of retinoid x receptor and its regulation by ligands and dimerization
JP2005247807A (ja) * 2004-03-08 2005-09-15 Japan Science & Technology Agency Ｎｓａｉｄを利用した癌治療用組成物
EP1865972B1 (en) 2005-03-23 2013-11-06 CHS Pharma, Inc. Treatment or prevention of cancer and precancerous disorders
AU2007205208B2 (en) * 2006-01-04 2012-11-01 Southern Research Institute Derivatives of sulindac, use thereof and preparation thereof
WO2010070379A1 (en) 2008-12-17 2010-06-24 Centre National De La Recherche Scientifique Rxr-ppargamma agonist/growth factor inhibitor combination therapy for inducing apoptosis and the treatment of cancer
JP2013533212A (ja) 2010-05-06 2013-08-22 サンフォード−バーナム メディカル リサーチ インスティテュート レチノイド受容体に選択的な経路に関する方法および組成物
CN102030642A (zh) 2010-12-03 2011-04-27 厦门大学 舒林酸类似物的中间体的合成方法与应用
WO2015100267A1 (en) 2013-12-23 2015-07-02 Sanford-Burnham Medical Research Institute Methods and compositions for treating cancer
WO2017193086A1 (en) 2016-05-06 2017-11-09 Tarrex Biopharma Inc. Therapeutic compounds and methods

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DE10163426A1 (de) * 2001-12-21 2003-07-03 Max Planck Gesellschaft Pharmakologisch wirksame Inden-Derivate

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CA2798692A1 (en) 2011-11-10
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ES2702532T3 (es) 2019-03-01
EP2571497B1 (en) 2018-09-19
EP2571497A2 (en) 2013-03-27
WO2011140525A2 (en) 2011-11-10
KR20130113932A (ko) 2013-10-16
US20170313668A1 (en) 2017-11-02
CN103002887B (zh) 2016-12-21
US10087156B2 (en) 2018-10-02
AU2011249857A1 (en) 2012-12-06
JP2013533212A (ja) 2013-08-22
US20150266842A1 (en) 2015-09-24
AU2011249857B2 (en) 2015-03-12
JP2017008050A (ja) 2017-01-12
CN107050007A (zh) 2017-08-18
JP6375340B2 (ja) 2018-08-15
CN103002887A (zh) 2013-03-27
WO2011140525A3 (en) 2012-03-22
KR101889290B1 (ko) 2018-08-20
EP2571497A4 (en) 2013-12-04

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