CN107049879B - A kind of cream containing okra extracting solution - Google Patents

A kind of cream containing okra extracting solution Download PDF

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Publication number
CN107049879B
CN107049879B CN201710442845.XA CN201710442845A CN107049879B CN 107049879 B CN107049879 B CN 107049879B CN 201710442845 A CN201710442845 A CN 201710442845A CN 107049879 B CN107049879 B CN 107049879B
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extracting solution
okra
mixture
hexadeca
filtrate
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CN107049879A (en
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王伟
刘慧敏
刘清雷
魏继文
吴梦
薛文娟
吴健
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Shanghai Institute of Technology
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82Preparation or application process involves sonication or ultrasonication

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of creams containing okra extracting solution, and count by weight percentage, raw material composition and content are as follows: okra extracting solution 0.1~5%;Oily phase 25.0~30.0%;Water phase 68.4~74.65%;Preservative 0.1~0.2%;Essence 0.1~0.2%;Inorganic salts 0.1~1.0%.The present invention is the characteristics of mainly containing the effective components such as okra polysaccharide, flavones Polyphenols using okra extracting solution, with the science collocation such as glycerin monostearate, hexadeca-octadecyl alcohol, isobutyl palmitate, octyl/decyl glyceryl ester, refined wool fat, be made after reasonable formula with anti-inflammatory, whitening, moisturizing, anti-aging cream product.

Description

A kind of cream containing okra extracting solution
Technical field
The invention belongs to cosmetic fields, are related to a kind of creams, specifically a kind of frost containing okra extracting solution Cream.
Background technique
Moisturizing is the key that skin nursing, and it is all skins that moisture-retention function of skin decline, which will lead to a variety of skin problem moisturizings, The basis of skin nursing is just ensuring skin no matter any age, gender, any kind of skin require moisturizing daily It is wet to be to maintain the skin permanent youth, it is not susceptible to suffer from dermopathic important link.
People increasingly pursue now it is pure natural, therefore seek from nature the functions such as natural skin whitening, moisturizing raw material at For people's pursuit new to cosmetics.
Okra is as health-care vegetable of earning foreign exchange, and proteins,vitamins,minerals are more in okra fruit, inorganic salts, vitamin B1, Vc content are above Kidney bean.It is reported that 100g okra edible part dry matter containing cellulose 9.42g, calcium 0.67g, phosphorus 0.56g, iron 0.8mg, Vc 29.95mg and potassium, zinc, manganese etc..Huang Agen etc. determines nutritional ingredient and correlation in okra The content of active constituent contains protein 22.98%, total reducing sugar 19.92%, polysaccharide in dry light yellow gumbo fruit as the result is shown 2.00%, fat 9.40% and flavones 2.56%;In old fruit contain protein 15.78% and total reducing sugar 9.48%, polysaccharide 1.1%, Fat 14.36%, flavones 1.48%.Okra also has quite high medical value.The drug effect of okra is early in " herbal guiding principle Mesh " in have been described, setose abelmoschus root, stem, flower, seed etc. can be used as medicine, have certain antitumaous effect, root inducing diuresis for removing edema, Cough with lung heat is controlled, seed good efficacy to suffering from a deficiency of the kidney controls indigestion etc..Domestic and foreign scholars have done largely its chemical component and pharmacological action Analysis and research, main component have amino acid and protein, microelement, polysaccharide, flavone compound, and Lv Meiyun etc. has found, Edible okra is rich in trace elements zn, Mn, for it there is raising immunity to provide reason with the medical value for reducing injury of lungs By foundation;Wang Junyao, the effect experiment result of Li Jianhua etc. show that okra has antifatigue effect.In addition, okra Antitumaous effect is also gradually revealed.Liu et al. the study found that the sensibility of insulin can be improved in the extract of okra.Okada Y's etc. studies have shown that okra seed can be obviously improved the activity of tnf antibody.Sabitha V etc. is reported To the physiological activity of anti-diabetic and lipidemia, these, which are studied, confirms okra anti-swollen for okra kind skin and seed powder The activity of tumor, hypoglycemic etc. is prominent, has good medical value.
Summary of the invention
For above-mentioned technical problem in the prior art, the present invention provides a kind of creams containing okra extracting solution, This creams containing okra extracting solution will solve cream anti-inflammatory in the prior art, whitening, moisturizing, anti-aging The technical issues of effect cannot be provided simultaneously with.
The present invention provides a kind of creams containing okra extracting solution, count by weight percentage, raw material composition and Content is as follows:
The oil is mutually Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palm The mixture that the different monooctyl ester of acid, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is imidazolidinyl urea, hydantoins, isothiazolinone, any one in methylparaben;
The inorganic salts are sodium chloride, any one or two or more institutes in potassium chloride, magnesium sulfate or magnesium chloride The mixture of composition.
Further, a kind of cream containing okra extracting solution, count by weight percentage, raw material composition And content is as follows:
The oil is mutually Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palm The mixture that the different monooctyl ester of acid, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is imidazolidinyl urea;
The inorganic salts are sodium chloride.
Further, a kind of cream containing okra extracting solution, count by weight percentage, raw material composition And content is as follows:
The oil is mutually Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palm The mixture that the different monooctyl ester of acid, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is hydantoins;
The inorganic salts are magnesium sulfate.
Further, a kind of cream containing okra extracting solution, count by weight percentage, raw material composition And content is as follows:
The oil is mutually Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palm The mixture that the different monooctyl ester of acid, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is that isothiazolinone is one of;
The inorganic salts are potassium chloride.
The present invention also provides a kind of above-mentioned cream containing okra extracting solution, the systems of the okra extracting solution Preparation Method includes the following steps:
1) okra dry powder is taken to be dissolved in the water that addition in extraction vessel is its 10~15 times of quality, at 60~70 DEG C of temperature Under, ultrasonic 30min~60min, extracting solution decompression filters, and filtrate decompression concentration removes 95% water, obtains the first filtrate;
2) filter cake is added in extraction vessel, the ethyl alcohol or mass percent concentration for adding its 5~10 times of quality are 95% ethyl alcohol, ultrasound 30min~60min at 40~50 DEG C of temperature, extracting solution decompression filter, and filtrate decompression steams ethyl alcohol, The second filtrate is obtained, the first filtrate and the second filtrate are merged, mixed liquor is obtained by filtration okra through 400~500 mesh silica gel and extracts Liquid.
Okra extracting solution is mainly contained effective components, the present invention such as okra polysaccharide, flavones Polyphenols and is mentioned using okra Take liquid and glycerin monostearate, hexadeca-octadecyl alcohol, isobutyl palmitate, octyl/decyl glyceryl ester, refined wool fat etc. Science collocation, be made after reasonable formula with anti-inflammatory, whitening, moisturizing, anti-aging cream product.
The present invention is compared with prior art, and technological progress is significant.The present invention utilizes okra anti-inflammatory, whitening, guarantor Wet, anti-aging function provides a kind of cream containing okra extracting solution in conjunction with cosmetics, come meet people to not Congenerous cosmetics demand enriches cosmetics type.
Detailed description of the invention
Fig. 1 subject 1 is different, and test orientation moisturizing value changes with time.
Fig. 2 subject 2 is different, and test orientation moisturizing value changes with time.
Fig. 3 subject 3 is different, and test orientation moisturizing value changes with time.
Specific embodiment
Understand to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that specific embodiment described herein is used merely to explain the present invention, it is not used to Limit the present invention.
Below in conjunction with specific embodiment, in the present invention technology and application scheme understand and be fully described by.
The preparation of 1 okra extracting solution of embodiment
Okra dry powder 100g is taken to be dissolved in the water that 1000g is added in extraction vessel, at 65 DEG C, ultrasonic 60min, mixed liquor Decompression filters, and filtrate decompression concentration removes 95% or so water, and residual filtrate 60g is spare, and filter cake continuously adds in extraction vessel 200g ethyl alcohol or 95% ethyl alcohol, the ultrasound 60min at 45 DEG C is added, extracting solution decompression filters, and filtrate decompression steams ethyl alcohol, remaining 50g propylene glycol is added in object to be sufficiently stirred to obtain liquor B, merges liquid A, B, mixed liquor is obtained by filtration through 400~500 mesh silica gel Okra extracting solution 110g.
The antioxygenic property of 2 okra extracting solution of embodiment is tested
(1) configuration of DPPH solution: precision weighs the DPPH of 8mg (being accurate to 0.0001g), is dissolved in surely with dehydrated alcohol In 100mL volumetric flask, the DPPH solution that concentration is 2*10-4mol/L is obtained.It is placed in refrigerator and saves with spare.
(2) 5g/L, 10g/L, 15g/L are accurately configured, 20g/L, 25g/L, the okra extracting solution of 30g/L mass concentration,
(3) 2mLDPPH is added into tool plug test tube, distilled water 2mL is protected from light and places 30min at room temperature, surveys at 517nm Its fixed absorbance (A0), the sample solution for separately taking test tube that different quality concentration is added replace the same aforesaid operations of distilled water, and measurement is inhaled Luminosity (A1), with sample solution and the isometric mixed determining absorbance (A2) of distilled water, using VC as positive reference substance, Vc concentration is matched It is made as 0.00025,0.0005,0.0025,0.005,0.025,0.05,0.075,0.10g/L, using distilled water as blank pair According to.
The clearance rate (%) of DPPH are as follows: [1- (A1-A2)/A0] * 100
The Scavenging activity of 1 DPPH free radical of table is tested
As can be seen from the above table okra extracting solution have stronger free radical scavenging ability, okra extracting solution it is dense The Scavenging activity for spending higher DPPH free radical is stronger, but as the Scavenging activity amplification of the increase DPPH free radical of concentration becomes In stabilization.
3 cream of embodiment prepares specific example and performance test
(1) cream prepares specific example
The formula of table 21
The formula of table 32
Continued 5-10
The formula of table 43
Continued 5-11
The formula of table 54
Experimental procedure:
(1) each component in A phase is accurately weighed in 120mL beaker A;
(2) deionized water is accurately weighed in 120mL beaker B, one by one disperses remaining component in B phase in water phase;
(3) load weighted A phase beaker is placed in heating plate and is heated, temperature controls within the scope of 75-80 DEG C;
(4) load weighted water phase is also placed in heating plate and is heated within the scope of 75-80 DEG C, heated while stirring;
(5) reach 80 DEG C (two-phase temperature difference is the smaller the better) to two-phase temperature, A phase is slowly added to B under agitation In phase beaker, homogeneous 2min (just emulsification);
(6) continue to be stirred with blender, speed is slowed down, when temperature is down to 50 DEG C, C phase is added, is adjusted with PH test paper PH;
(7) continue stirring 30 minutes or so, until system is uniform, stops stirring and it is waited to be down to room temperature, complete cream production. (note: the cosmetics of production are the cream systems of 100g)
(2) cream stability is tested
The organoleptic indicator of 6 cream of table, physical and chemical index (being standard with QB/T 1857~2013)
According to 1857~2013 standard of QB/T of table 6-1, the detection of physical and chemical index is carried out to obtained cream, to protect The cream product that card joined okra extracting solution meets professional standard.
Detection method is as follows:
(1) heat resistance is tested.It takes the cream of 30g to be put in beaker, is placed in the drying box that constant temperature is 40 DEG C for 24 hours Afterwards, sample is taken out, is restored to room temperature, observing cream, whether there is or not layerings, precipitation phenomenon.
(2) cold tolerance is tested.The cream of 30g is taken to be put in beaker, being placed on temperature is that constant temperature is for 24 hours in -5 DEG C of refrigerator Afterwards, sample is taken out, warms naturally to room temperature, whether there is or not layerings, precipitation phenomenon for observation cream.
(3) centrifugal test.Cream 5g is weighed, is packed into in graduated centrifuge tube, sets 2000r/ for centrifuge Min takes out, and whether there is or not laminations for observation cream.
Experimental result and analysis:
Four obtained creams of experiment pass through heat-resisting cold-resistant experiment, bright with having no before experiment after spontaneous recovery to room temperature Significant difference is different, finds no layering and precipitation phenomenon.This shows formula effectively, and joined the cream product symbol of okra extracting solution Professional standard is closed, it is also errorless in experimental implementation.
(3) the skin moisture-keeping performance test of cream
Laboratory apparatus and material:
Corneometer825 moisture of skin tester is purchased from German CK company;Dehydrated alcohol;Alcohol cotton;Beaker;
Experimental procedure:
(1) healthy volunteer is selected.Subject is without any dermatopathy, and subject is without any dermatopathy, recipient site Skin is without exception, does not also smear the external preparations such as any external drug and cosmetics.
(2) subject needs unified mild detergent to clean inner forearm face before testing, (the temperature in constant environment Degree is 20-22 DEG C, relative humidity 40%-60%, is sat quietly 30 minutes;Dduring test, subject cannot arbitrarily run and walk about Or leave the environmental field of test, it should which holding is emotionally stable, and mood is gentle, never exciting.
(3) 2*4cm is scratched with ruler2, the sample of phase homogenous quantities is weighed within this range, is averagely applied within the scope of this, Different time is selected, the moisture of skin of each test point is measured respectively, is as a result indicated with humidity measurements;
As shown in Figure 1, 2, 3, it can be seen that by the correlation results of this three groups of experiments after okra extracting solution is added, The blank group that the numeric ratio of moisturizing is not added wants high, and concentration is positively correlated;In addition, be added okra extracting solution after, with when Between increase, the reduction amount of moisturizing numerical value than not plus the blank group of okra extracting solution it is some higher, and okra mentions Take the concentration of liquid higher, moisturizing numerical value is higher.

Claims (4)

1. a kind of cream containing okra extracting solution, it is characterised in that count by weight percentage, raw material composition and content It is as follows:
The preparation method of the okra extracting solution includes the following steps:
1) it takes okra dry powder to be dissolved in the water that addition in extraction vessel is its 10~15 times of quality to surpass at 60~70 DEG C of temperature Sound 30min~60min, extracting solution decompression filter, and filtrate decompression concentration removes 95% water, obtain the first filtrate;
2) filter cake is added in extraction vessel, the ethyl alcohol or mass percent concentration for adding its 5~10 times of quality are 95% Ethyl alcohol, ultrasound 30min~60min at 40~50 DEG C of temperature, extracting solution decompression filter, and filtrate decompression steams ethyl alcohol, obtain the Two filtrates, merge the first filtrate and okra extracting solution is obtained by filtration through 400~500 mesh silica gel in the second filtrate, mixed liquor;
The described oil is mutually that Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palmitinic acid are different The mixture that monooctyl ester, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is imidazolidinyl urea, hydantoins, isothiazolinone, any one in methylparaben;
The inorganic salts are by any one in sodium chloride, potassium chloride, magnesium sulfate or magnesium chloride or two or more form Mixture.
2. a kind of cream containing okra extracting solution as described in claim 1, it is characterised in that count by weight percentage, Its raw material composition and content are as follows:
The described oil is mutually that Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palmitinic acid are different The mixture that monooctyl ester, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is imidazolidinyl urea;
The inorganic salts are sodium chloride.
3. a kind of cream containing okra extracting solution as described in claim 1, it is characterised in that count by weight percentage, Its raw material composition and content are as follows:
The described oil is mutually that Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palmitinic acid are different The mixture that monooctyl ester, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is hydantoins;
The inorganic salts are magnesium sulfate.
4. a kind of cream containing okra extracting solution as described in claim 1, it is characterised in that count by weight percentage, Its raw material composition and content are as follows:
The described oil is mutually that Brij72, Brij721, glycerin monostearate, hexadeca-octadecyl alcohol, dimethicone, palmitinic acid are different The mixture that monooctyl ester, octyl/decyl glyceryl ester, white oil, lanolin and BHT are formed;
The water phase is the mixture that propylene glycol, glycerol, xanthan gum and ionized water form;
The preservative is that isothiazolinone is one of;
The inorganic salts are potassium chloride.
CN201710442845.XA 2017-06-13 2017-06-13 A kind of cream containing okra extracting solution Active CN107049879B (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
KR102539398B1 (en) 2021-03-31 2023-06-02 숙명여자대학교산학협력단 Composition for Inhibiting Inflammation containing Sous Vide-treated Okra

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CN109718259B (en) * 2017-10-30 2021-08-06 马晓萍 Okra mite removing agent, okra mite removing patch and preparation method thereof
CN110538110A (en) * 2019-09-20 2019-12-06 杭州美库生物医药有限公司 Method for extracting okra colloid by spray drying method and application of okra colloid in cosmetics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103054041A (en) * 2013-01-20 2013-04-24 湖南奇异生物科技有限公司 Preparation process of okra extractive dry powder

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103054041A (en) * 2013-01-20 2013-04-24 湖南奇异生物科技有限公司 Preparation process of okra extractive dry powder

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Title
FANCL(芳凯尔)锁水活肤乳霜;无;《COSDNA》;20070730;第1页 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102539398B1 (en) 2021-03-31 2023-06-02 숙명여자대학교산학협력단 Composition for Inhibiting Inflammation containing Sous Vide-treated Okra

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