CN107041913A - A kind of Chinese medicine composition, spray and the application phlebitis caused for venous transfusion - Google Patents
A kind of Chinese medicine composition, spray and the application phlebitis caused for venous transfusion Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition phlebitis caused for venous transfusion, and raw material includes the component of following parts by weight：25~35 parts of 8~12 parts of frankincense, 8~12 parts of myrrh, 5~15 parts of pseudo-ginseng, 5~15 parts of borneol, 10~20 parts of safflower, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of the dried rhizome of rehmannia, 25~35 parts of Yun Ying and Chinese violet.The present invention provides the spray of the Chinese medicine composition, is counted using Traditional Chinese medicine composition-type spray cumulative volume as 100%, the Chinese medicine composition volume is that 70~80%, film forming agent volume is 4~8% and aerosol propellant volume is 15~25%.The present invention uses medicinal herb componentses, have no toxic side effect, aerosol is when in use, medicine film is evenly affixed to skin surface, and frankincense, Radix Angelicae Sinensis, myrrh, borneol composition are combined penetrating agent, not only the more preferable Transdermal absorption of other medicines in promotion side, and treated in itself with medicine, aerosol focus is administered, with targeting, curative effect enhancing.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese traditional medicine composition phlebitis caused for venous transfusion
Thing, spray and application.
Background technology
Phlebitis is the complication of clinical common infusion treatment caused by venous transfusion, and transfusion nurse association of the U.S. writes
Guide on point out, peripheral phlebitis incidence should be less than 5% or lower, but the incidence clinically counted all considerably beyond
This numeral, the different phlebitis of about 50%~80% patients undergoing chemotherapy occurrence degree.
At present, the phlebitis caused method of prevention venous transfusion has physical method, and chemotherapeutic is reported such as Lv Lanying
When seepage occurs for thing, ice compress or cold compress is selected to inactivate outer sepage as far as possible.Cold compress can make local vasoconstriction, mitigate local edema
And drug diffusion, so as to mitigate local tissue damage；Ice compress can mitigate local waste heat and continue to damage reduction office to living tissue
Portion is metabolized, and makes vessel retraction, reduction is oozed out, while ice compress can reduce the sensitiveness of nerve endings and cell, mitigates pain.But
It is that Cold-compress can only reduce the pain of patient, it is impossible to fundamentally treat venous transfusion phlebitis caused.In addition, doctor trained in Western medicine is controlled
The phlebitis caused magnesium sulfate or Hirudoid ointment external application frequently with mass concentration for 50% of venous transfusion is treated, but curative effect is all not very
It is preferable.
In addition, also having phlebitis caused using the method treatment venous transfusion of Chinese traditional medicine wet compress.Such as king builds rosy clouds report, six god
Ball grinding plus proper honey are tuned into pasty state, and external application for curing chemotherapy-induced phlebitis has unique curative effect.Liu's love celery et al. report by rheum officinale,
Each 250g of saltcake is tuned into pasty state after grinding with mature vinegar, takes and is applied in right amount on sterile gauze, and thickness about 3mm, coverage is more than lesion
Scope 1cm~2cm, is externally applied at phlebitis.Although such scheme is phlebitis caused to venous transfusion certain curative effect,
It is the effect that can not be realized complete anti-inflammatory, subside a swelling, relieve the pain.
The content of the invention
In view of this, it is an object of the invention to provide a kind of Chinese medicine composition phlebitis caused for venous transfusion,
The Chinese medicine composition effect for having anti-inflammatory, subsiding a swelling and relieving the pain phlebitis caused to venous transfusion, and have no toxic side effect, while into
This low, eutherapeutic feature.
It is good, the through affected part of drug effect for quiet caused by venous transfusion it is a further object of the present invention to provide a kind of osmotic absorption
The scorching Traditional Chinese medicine composition-type spray of arteries and veins.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides a kind of Chinese medicine composition phlebitis caused for venous transfusion, raw material includes following parts by weight
Component：8~12 parts of frankincense, 8~12 parts of myrrh, 5~15 parts of pseudo-ginseng, 5~15 parts of borneol, 10~20 parts of safflower, Radix Angelicae Sinensis 10~
25~35 parts of 20 parts, 10~20 parts of the dried rhizome of rehmannia, 25~35 parts of Yun Ying and Chinese violet.
It is preferred that, raw material includes the component of following parts by weight：9~11 parts of frankincense, 9~11 parts of myrrh, 8~12 parts of pseudo-ginseng,
8~12 parts of borneol, 12~18 parts of safflower, 14~17 parts of Radix Angelicae Sinensis, 13~16 parts of the dried rhizome of rehmannia, 27~32 parts of Yun Ying and Chinese violet 28~32
Part.
It is preferred that, raw material includes the component of following parts by weight：10 parts of frankincense, 10 parts of myrrh, 10 parts of pseudo-ginseng, 10 parts of borneol,
30 parts of 15 parts of safflower, 15 parts of Radix Angelicae Sinensis, 15 parts of the dried rhizome of rehmannia, 30 parts of Yun Ying and Chinese violet.
The invention provides the preparation method of described Chinese medicine composition, comprise the following steps：
1) frankincense, myrrh and Radix Angelicae Sinensis are mixed with water, 1.5~2.5h is extracted under the conditions of boiling, obtained frankincense, myrrh and work as
Return extract solution；
2) pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet are mixed with water, 1.5~2.5h is extracted under the conditions of boiling, three are obtained
7th, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet extract solution；
3) by the step 1) obtained frankincense, myrrh and angelica extract and step 2) obtain pseudo-ginseng, safflower, life
Ground, Yun Ying and the mixing of Chinese violet extract solution, obtained mixed liquor is concentrated under reduced pressure, and the comparing to weigh of the mixed liquor reaches 1:
When 1.3~1.5, borneol ethanol solution is mixed with concentrate, Chinese medicine composition is obtained；
The step 1) and step 2) between there is no the limitation of time sequencing.
It is preferred that, the step 2) in pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and the gross mass of Chinese violet and the volume ratio of water be
1mg：(12~15) mL；The step 1) in frankincense, the gross mass of myrrh and Radix Angelicae Sinensis and water volume ratio be 1mg：(12~15)
mL。
It is preferred that, the step 3) in the volume ratio of borneol ethanol solution and concentrate be:1~3：:47~49；The ice
The mass concentration of piece ethanol solution is 0.3~0.8mg/ml.
Present invention also offers a kind of Traditional Chinese medicine composition-type spray phlebitis caused for venous transfusion, with Chinese traditional medicine composition
Composition spray cumulative volume is 100% meter, includes the component of following percentage composition：Claim 4~6 any one methods described system
Standby Chinese medicine composition volume is that 70~80%, film forming agent volume is 4~8% and aerosol propellant volume is 15~25%.
It is preferred that, counted using Traditional Chinese medicine composition-type spray cumulative volume as 100%, include the component of following percentage composition：It is above-mentioned
Chinese medicine composition volume prepared by method is that 75%, film forming agent volume is 5% and aerosol propellant volume is 20%.
It is preferred that, the film forming agent is polyvinyl alcohol；
The aerosol propellant is dimethyl ether.
The Chinese medicine composition that is prepared present invention also offers described Chinese medicine composition or methods described or it is described in
Application of the drug composition spray in the phlebitis caused medicine for the treatment of venous transfusion is prepared.
The invention provides a kind of Chinese medicine composition phlebitis caused for venous transfusion, raw material includes following parts by weight
Component：8~12 parts of frankincense, 8~12 parts of myrrh, 5~15 parts of pseudo-ginseng, 5~15 parts of borneol, 10~20 parts of safflower, Radix Angelicae Sinensis 10~
25~35 parts of 20 parts, 10~20 parts of the dried rhizome of rehmannia, 25~35 parts of Yun Ying and Chinese violet.The phlebitis caused genesis mechanism of venous transfusion is qi and blood
The stasis of blood is stagnant, and heat toxin is condensed in blood vessels, is that local train of thought QI-blood circulation is not smooth, and treatment is with clearing away damp-heat Removing Blood Stasis, based on eliminating stagnation to stop pain, breast
Fragrant and myrrh is used as primary treatment medicine.Based on frankincense is relieved pain with activating blood circulation and reducing swelling, and myrrh is based on swelling and pain relieving myogenic, frankincense
All there is effect promoting blood circulation and removing blood stasis with myrrh, the two coordinates effect of enhancing blood-activating and qi-promoting analgesic.Pseudo-ginseng, safflower, are auxiliary breasts
Fragrant, myrrh treatment main symptom, while having the medicine for the treatment of accompanying symptoms；Radix Angelicae Sinensis, the dried rhizome of rehmannia, coordinate frankincense, myrrh, pseudo-ginseng, safflower for treating
Accompanying symptoms, while suppressing the toxic side effect of above-mentioned major-minor medicine medicine.Yun Ying, Chinese violet, borneol have main and auxiliary medicine in guiding side very right
Phlebitis diseased region, and the medicine of coordinating the drug actions of a prescription, strengthen the effect of all medicines.The traditional Chinese medicine composite that the present invention is provided is mutual
Mutually cooperate with, with clearing heat and detoxicating, cooling blood and removing stasis, the function of swelling and pain relieving；Radix Angelicae Sinensis, frankincense, myrrh have been mainly itself simultaneously
Therapeutic action, next to that the rush the having effect of oozing is used in combination with borneol, produces synergy, composition is combined penetrating agent, so that
The active ingredient in medicine is set to be easier to pass through body barrier, focus of going directly can be treated and prevented effectively quiet caused by venous transfusion
Arteries and veins is scorching.
Present invention also offers a kind of Traditional Chinese medicine composition-type spray phlebitis caused for venous transfusion, with Chinese traditional medicine composition
Composition spray cumulative volume is 100% meter, includes the component of following percentage composition：The above method prepare Chinese medicine composition volume be
70~80%, film forming agent volume is 4~8% and aerosol propellant volume is 15~25%.By the present invention in that using film forming agent energy
The content of medicine activity component is enough improved, and then promotes the percutaneous rate of medicine to increase by 4~5 times, while skin temperature can also be made
Degree increases to 37 DEG C from 32 DEG C, accelerates local blood circulation, and percutaneous rate is therefore accelerated；Other aerosol propellant has propellant
With the dual-use function of solvent, in diseased region formation medicine film after aerosol spray, there is refrigerant comfort；Again by making from temperature
With medicine can gradually discharge, and play antimicrobial antiphlogistic, antiallergic action, reduce the effect of capillary permeability；Match somebody with somebody again and be fated
Return, frankincense, myrrh and borneol composition compound penetrating agent, make the active ingredient in medicine be easier to pass through body barrier so that
Effectively treat and prevent phlebitis.
The present invention uses medicinal herb componentses, and the property of medicine, which relaxes, not to stimulate, and has no toxic side effect, and decoction is packaged in sealable polyester spraying
It is lucifuge, opaque and do not contacted directly with the oxygen or moisture in air in bottle, add the stability of medicine.When in use,
Decoction is sprayed directly on to injury position, forms uniform medicine film attachment and hinders illing skin, targets focus, safe effect is fast.Conveniently take
Band, it is easy to use.
Embodiment
The invention provides a kind of Chinese medicine composition phlebitis caused for venous transfusion, raw material includes following parts by weight
Component：8~12 parts of frankincense, 8~12 parts of myrrh, 5~15 parts of pseudo-ginseng, 5~15 parts of borneol, 10~20 parts of safflower, Radix Angelicae Sinensis 10~
25~35 parts of 20 parts, 10~20 parts of the dried rhizome of rehmannia, 25~35 parts of Yun Ying and Chinese violet.
In the present invention, the raw material of the Chinese medicine composition includes frankincense.In parts by weight, the frankincense is 8~12 parts, excellent
Elect 9~11 parts, more preferably 10 parts as.The frankincense is the gum resin of olive subject plant Cattell Boswellia carterii, there is regulating qi and activating blood, fixed
Bitterly, the effect chased after poison, controls qi and blood stagnation, trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhoea, postpartum blood stasis stabbing pain, and frankincense is not
But there is more significant analgesic activity, there is stronger bacteriostasis.
In the present invention, the raw material of the Chinese medicine composition includes myrrh.In parts by weight, the myrrh is 8~12 parts, excellent
Elect 9~11 parts, more preferably 10 parts as.The effects such as myrrh has promoting blood circulation and stopping pain, detumescence and promoting granulation, drug for invigorating blood circulation and eliminating stasis, bitter,
It is flat, it is nontoxic." enter liver, spleen, the heart, kidney channel, cure mainly chest and abdomen stasis caused pain, dysmenorrhoea, Amenorrhea, Disorder lumps in the abdomen, traumatic injury, carbuncle swells sore, acute appendicitis,
Red eye, swell pain.
In the present invention, frankincense and myrrh are as primary treatment medicine, based on frankincense is relieved pain with activating blood circulation and reducing swelling, and myrrh is to disappear
Based on swollen analgesic myogenic, frankincense and myrrh all have effect promoting blood circulation and removing blood stasis, and the two coordinates effect of enhancing blood-activating and qi-promoting analgesic.
In the present invention, the raw material of the Chinese medicine composition includes pseudo-ginseng.In parts by weight, the pseudo-ginseng is 5~15 parts, excellent
Elect 8~12 parts, more preferably 10 parts as.The pseudo-ginseng is the rhizome of plant pseudo-ginseng, warm-natured, sweet and slightly bitter taste, enter liver, stomach, large intestine
Through pseudo-ginseng has hemostasis, dissipates the effect of stasis of blood, detumescence, analgesic therapy.Haematemesis is cured mainly, hemoptysis, bleeding from five sense organs or subcutaneous tissue is had blood in stool, bloody flux, uterine bleeding , Disorder lumps in the abdomen,
Postpartum anemic fainting, lochia not under, fall and flutter hemostasis, traumatism and bleeding, carbuncle swells pain.《Detailed outline》：Hemostasis, dissipates blood, analgesic therapy.《Jade seizes medicine
Solution》：New blood is held back with hemostasis, the row stasis of blood of promoting blood circulation, row hemostasis is sought.All postpartum, menstrual period, bruise, carbuncle swells, all hemostasis are all broken；It is all to tell
Nosebleed, uterine bleeding, knife wound, arrow are penetrated, and all new blood all stop.Pseudo-ginseng has expansion blood vessel, reduced blood pressure, and improves microcirculation, increases blood flow
Amount, prevention and treatment heart and brain tissues ischemic, air hunger；Protein, ribonucleic acid (RNA), DNA (DNA) is promoted to close
Into physical fitness；Promote blood cell metabolism, balance adjustment blood cell；Bidirectional modulation nervous centralis, improves mental,
Strengthen learning and memory ability；Strengthen body's immunity, it is antitumor；Hemostasis, it is promoting blood circulation and removing blood stasis；Liver protection, anti-inflammatory；Anti-aging；
Bidirectional modulation blood glucose, reduction blood fat, cholesterol, suppression artery sclerosis effect.
In the present invention, the raw material of the Chinese medicine composition includes safflower.In parts by weight, the safflower is 10~20 parts,
Preferably 12~18 parts, more preferably 15 parts.The safflower is the flower of feverfew safflower, and safflower contains carthamin yellow and safflower
Glucoside.Carthamin is hydrolyzed through hydrochloric acid, obtains glucose and carthamin.Also contain 15 α, 20 beta-dihydroxies-Δ 4- pregnene -3- ketone.Separately still contain
Fat oil claims safflower oil, is the glyceride type of palmitic acid, stearic acid, arachidic acid, oleic acid, linoleic acid, leukotrienes etc..Leaf contains sweet-scented osmanthus
Careless element -7- glycosides, safflower has invigorate blood circulation, stasis eliminatings analgesic.Controlling through closing , Disorder lumps in the abdomen, disease that postpartum lochia can't go, hemostasis are had a pain,
Carbuncle swells, effect of injury from falling down.《Detailed outline》：Promoting blood circulation, moisturizes, and relieves pain, and dissipates swollen, stimulates the menstrual flow.《Book on Chinese herbal medicine is just》：Go out up to variola blood-head difficulty,
Speckle rash stasis does not disappear.Safflower, which has, is applicable various varication, and peripheral neuritis improves blood circulation, mitigates, lower limb numbness
Or the congestion such as livid purple.
In the present invention, the pseudo-ginseng and safflower are auxiliary frankincense, myrrh treatment main symptom, while having the medicine for the treatment of accompanying symptoms
Thing.
In the present invention, the raw material of the Chinese medicine composition includes borneol.In parts by weight, the borneol is 5~15 parts, excellent
Elect 8~12 parts, more preferably 10 parts as.The borneol is worked hard, temperature, poisonous.Enter the heart, lung channel.Its effect leads to all keys, dissipates stagnated fire,
Go screen improving eyesight, swelling and pain relieving.Control apoplexy lockjaw, pyreticosis coma, frightened epilepsy phlegm fan, deafness with qi stagnation, larynx numbness, aphtha, tympanitis, carbuncle
It is swollen, hemorrhoid, mesh also screen film, enterobiasis.
In the present invention, the raw material of the Chinese medicine composition includes Radix Angelicae Sinensis.It is in parts by weight, described to be classified as 10~20 parts,
Preferably 14~17 parts, more preferably 15 parts.The Radix Angelicae Sinensis has warm-natured, sweet, pungent, Return liver, the heart, the spleen channel, and replenishing and activating blood is adjusted
Through relieving the pain, the characteristics of relaxing bowel, effect and the effect of Radix Angelicae Sinensis have a lot, and especially suitable women is used, and motherland's medical science thinks, when
Return sweet and weigh, therefore can specially enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, bowl spares has, has benefit in row, is the key medicine in blood.Cause
And, it can enrich blood, and can invigorate blood circulation, and can both stimulate the menstrual flow, and can be active.
In the present invention, the raw material of the Chinese medicine composition includes the dried rhizome of rehmannia.In parts by weight, the dried rhizome of rehmannia is 10~20 parts,
Preferably 13~16 parts, more preferably 15 parts.Institute's dried rhizome of rehmannia has sweet, cold, the thoughts of returning home, liver and kidney channel, yin-nourishing life, with clearing heat and cooling blood
Effect.It is dried rhizome of rehmannia sweet-bitter flavor, cold in nature and enter blood system, can clear ying blood point heat and cool blood.Hyperpyrexia, heat for warm heat disease enter ying blood,
Mouth parched and tongue scorched, night fever abating at dawn person, in addition, the dried rhizome of rehmannia still has the effect of hemostasis by cool blood, the various haemorrhages available for blood-head.It is raw
Ground also has effects that nourishing Yin and promoting production of body fluid, and dried rhizome of rehmannia quality moistens many liquid energy yin-nourishing, it is sweet it is cold in nature can promote the production of body fluid, there is nourishing yin to moisten dryness to promote the production of body fluid work
With.For injury thirst, Heat Diabetes.Control warm disease impairment of yin, dry constipation of intestines.
In the present invention, Radix Angelicae Sinensis and the dried rhizome of rehmannia coordinate frankincense, myrrh, pseudo-ginseng, safflower for treating accompanying symptoms, while suppressing above-mentioned major-minor medicine
The toxic side effect of thing medicine.
In the present invention, the raw material of the Chinese medicine composition includes cloud English.In parts by weight, the cloud English is 25~35 parts,
Preferably 27~32 parts, more preferably 30 parts.The cloud English is pungent, flat, nontoxic, there is dispelling pathogenic wind for improving eyesight, strengthening the spleen and replenishing qi, analgesic of detoxifying
Effect；Herb：For acute conjunctivitis, neuralgia, herpes zoster, boil carbuncle swells, hemorrhoid blood-breaking, hemostasia and promoting granulation.Yun Ying has profit
The five internal organs are supported, bright knowledge, hot blast of dispelling makes us spry and light, food is not minded long, mend people, only hot malaria, flat stomach of invigorating blood circulation.
In the present invention, the raw material of the Chinese medicine composition includes Chinese violet.In parts by weight, the Chinese violet is 25~35 parts,
Preferably 28~32 parts, more preferably 30 parts.The Chinese violet contains more than 10 kinds of alkaloid.Corydlis bungeana A prime, second are obtained therefrom
Element, 4 kinds of different alkaloids of C prime and D prime (temporary name).Another lactone containing Coumarins, steroid saponin, phenolic substance, neutral tree
Fat and volatile oil etc., with clearing heat and detoxicating effect, can control warm disease hyperpyrexia agitation, influenza, catarrhal jaundice, ephritis, scrofula, the cheek
Adenositis, furunculosis and other pyogenic infections.《Detailed outline》：Cure mainly all ulcer carbuncle on the back, malignant boil swells scrofula, nameless sores or boils, malignant sore.《This
Grass asks former》：Cool blood, detumescence poison.Blood-head muscle impotence is controlled, sore is applied wonderful.
In the present invention, Yun Ying, Chinese violet and borneol have guiding side in main and auxiliary medicine very to phlebitis diseased region, and
The medicine of coordinating the drug actions of a prescription, strengthens the effect of all medicines.
In the present invention, 9 kinds of raw materials are cooperateed with mutually, with clearing heat and detoxicating, cooling blood and removing stasis, effect of swelling and pain relieving.
In the present invention, frankincense, myrrh, Radix Angelicae Sinensis and borneol also constitute compound penetrating agent.Frankincense, bdellium aromatics, and
Aromatics medicine mostly has volatility, and frankincense and myrrh are mainly all made up of resin, natural gum and volatile oil etc..Waved contained by frankincense
Hair oil mainly has firpene, limonene and phellandrene etc., also some unknown fragrance ingredients.Volatile oil mainly has cloves contained by myrrh
Oily phenol, firpene, limonene and cinnaldehydrum etc., the research of modern Chinese herbal medicine penetrating agent also indicate that the volatile oil in aromatics medicine has been
The major pharmaceutical component of effect is oozed to rush.The volatile oil of Radix Angelicae Sinensis has the rush effect of oozing.Borneol is main ingredient in the compound penetrating agent,
Borneol can be in itself a kind of good penetrating agent again as transdermal drug.Radix Angelicae Sinensis, frankincense, myrrh have been mainly the treatment of itself
Effect, next to that the rush the having effect of oozing is used in combination with borneol, produces synergy, the compound penetrating agent of composition, so that medicine
Active ingredient in thing is easier to pass through body barrier.
The invention provides the preparation method of described Chinese medicine composition, comprise the following steps：
1) frankincense, myrrh and Radix Angelicae Sinensis are mixed with water, 1.5~2.5h is extracted under the conditions of boiling, obtained frankincense, myrrh and work as
Return extract solution；
2) pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet are mixed with water, 1.5~2.5h is extracted under the conditions of boiling, three are obtained
7th, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet extract solution；
3) by the step 1) obtained frankincense, myrrh and angelica extract and step 2) obtain pseudo-ginseng, safflower, life
Ground, Yun Ying and the mixing of Chinese violet extract solution, obtained mixed liquor is concentrated under reduced pressure, and the comparing to weigh of the mixed liquor reaches 1:
When 1.3~1.5, borneol ethanol solution is mixed with concentrate, Chinese medicine composition is obtained；
The step 1) and step 2) between there is no the limitation of time sequencing.
The present invention mixes frankincense, myrrh and Radix Angelicae Sinensis with water, and 1.5~2.5h is extracted under the conditions of boiling, frankincense, myrrh is obtained
And angelica extract.
In the present invention, the volume ratio of the frankincense, the gross mass of myrrh and Radix Angelicae Sinensis and water is preferably 1mg：(12~15) mL,
More preferably 1mg：14mL.
In the present invention, the frankincense, myrrh and Radix Angelicae Sinensis are preferably broken before being mixed with water.The broken method is not special
Limitation, using broken technical scheme well-known to those skilled in the art.It is described it is broken after fragment be preferably sized to
0.2~1cm, more preferably 0.5~0.8cm.
In the present invention, the method for the boiling is preferred to use the method holding fluidized state for being passed through steam.
In the present invention, separation of solid and liquid is preferably included after the extraction.The method of the separation of solid and liquid, which is not particularly limited, adopts
With scheme well-known to those skilled in the art.The solid drugs residue that separation of solid and liquid is obtained preferably is extracted again.It is described
The method of extraction is preferably to mix medicine residue with 12 times of water, and 1.5~2.5h is extracted under the conditions of boiling, and separation of solid and liquid is obtained
Secondary drug extract.It drug extract will merge twice, and obtain frankincense, myrrh and angelica medicament extract solution.
The present invention mixes pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet with water, and 1.5~2.5h is extracted under the conditions of boiling, is obtained
To pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet extract solution.
In the present invention, the pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and the gross mass of Chinese violet and the volume ratio of water are preferably 1mg：
(12~15) mL, more preferably 1mg：14mL.
In the present invention, the frankincense, myrrh and Radix Angelicae Sinensis are preferably broken before being mixed with water.The broken method is not special
Limitation, using broken technical scheme well-known to those skilled in the art.It is described it is broken after fragment be preferably sized to
0.2~1cm, more preferably 0.5~0.8cm.
In the present invention, the method for the boiling is preferred to use the method holding fluidized state for being passed through steam.
In the present invention, separation of solid and liquid is preferably included after the extraction.The method of the separation of solid and liquid, which is not particularly limited, adopts
With scheme well-known to those skilled in the art.The solid drugs residue that separation of solid and liquid is obtained preferably is extracted again.It is described
The method extracted again is preferably to mix medicine residue with 12 times of water, and 1.5~2.5h, separation of solid and liquid are extracted under the conditions of boiling
Obtain secondary drug extract.It drug extract will merge twice, and obtain pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet medicine and extract
Liquid.
In the present invention, by the frankincense, myrrh and angelica extract and pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet extract solution
Mixing, obtained mixed liquor is concentrated under reduced pressure, and the comparing to weigh of the mixed liquor reaches 1:When 1.3~1.5, by borneol second
Alcoholic solution is mixed with concentrate, obtains Chinese medicine composition.
In the present invention, the method for the mixing is not particularly limited using hybrid plan well-known to those skilled in the art
.
In the present invention, the method being concentrated under reduced pressure is not particularly limited, use it is well-known to those skilled in the art, with
Water is the scheme being concentrated under reduced pressure of solvent extraction decoction.The pressure being concentrated under reduced pressure is preferably 0.1~0.2MPa, more excellent
Elect 0.15MPa as.Reciprocal of duty cycle is preferably -0.06~-0.1MPa, more preferably -0.08MPa.The time being concentrated under reduced pressure is preferred
For 60min~120min, more preferably 90min.
In the present invention, the volume ratio of the borneol extract solution and concentrate is 1~3:47~49, more preferably 2:48.Institute
The mass concentration for stating borneol ethanol solution is 0.4~0.8mg/ml, more preferably 0.5mg/ml.The system of the borneol ethanol solution
Preparation Method is preferably to mix borneol and volumetric concentration for 95% ethanol, is ground, until all dissolvings, obtain borneol ethanol molten
Liquid.
In the present invention, the method for the mixing of the borneol ethanol solution and concentrate preferably by borneol ethanol solution with it is dense
Contracting liquid is mixed, and is placed, and ethanol is evaporated into naturally to the greatest extent.
Present invention also offers a kind of Traditional Chinese medicine composition-type spray phlebitis caused for venous transfusion, with Chinese traditional medicine composition
Composition spray cumulative volume is 100% meter, includes the component of following percentage composition：The volume of Chinese medicine composition prepared by the above method
For 70~80%, film forming agent volume be 4~8% and aerosol propellant volume is 15~25%.
Prepared provided by the present invention for the phlebitis caused Traditional Chinese medicine composition-type spray of venous transfusion including the above method
Chinese medicine composition.The volume of the Chinese medicine composition is preferably 75%.
Include film forming agent provided by the present invention for the phlebitis caused Traditional Chinese medicine composition-type spray of venous transfusion.It is described into
The volume of film is preferably 5%.The film forming agent is preferably polyvinyl alcohol.
Include aerosol propellant provided by the present invention for the phlebitis caused Traditional Chinese medicine composition-type spray of venous transfusion.Institute
The volume for stating aerosol propellant is preferably 20%.The aerosol propellant is preferably dimethyl ether.
The present invention does not have special restriction to the preparation method of the Traditional Chinese medicine composition-type spray, and such scheme is prepared into
The Chinese medicine composition arrived is mixed with film forming agent and aerosol propellant.
The Chinese medicine composition that is prepared present invention also offers described Chinese medicine composition or methods described or it is described in
Application of the drug composition spray in the phlebitis caused medicine for the treatment of venous transfusion is prepared.
In the present invention, sprayed using the phlebitis caused Chinese medicine external aerosol of the phlebitis caused venous transfusion of venous transfusion
At blood vessel redness, spray range is more than 3~4cm of lesion, thickness≤1mm.Due to the phlebitis caused Chinese medicine of venous transfusion
Contain in aerosol for external use and cover layer is formed after film forming agent, spraying, 2~4 times/d, treat 4~5d.
With reference to embodiment to a kind of Chinese medicine composition phlebitis caused for venous transfusion of the invention provided, spray
Mist agent and application are described in detail, but they can not be interpreted as limiting the scope of the present invention.
Embodiment 1
It is a kind of for the phlebitis caused Chinese medicine composition of venous transfusion, the active ingredient of the Chinese medicine external aerosol by
The bulk drug of following weight parts is prepared from：Frankincense 8g, myrrh 12g, pseudo-ginseng 5g, borneol 15g, safflower 10g, Radix Angelicae Sinensis 20g, the dried rhizome of rehmannia
10g, Yun Ying 35g and Chinese violet 25g.
Frankincense, myrrh, Radix Angelicae Sinensis disintegrating machine are broken and spit into 0.2 centimetre of big fragment, input stainless steel is extracted in pot, is added
The deionized water that 14 times of drug weight, steam is passed through into the bottom of a pan back-shaped pipe, is made boiling water and is kept 2 hours extraction volatile oil standby
With, and medicine residue is added into 12 times of amount deionized waters again, continue to decoct 2 hours, release decocting liquid, input hopper static 24 is small
When, suction clear liquid is taken, bottom land slurry is discarded.
Prescription pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying, Chinese violet are first spitted into 0.2 centimetre of big fragment with disintegrating machine is broken, input is not
The steel that becomes rusty is extracted in pot, adds the deionized water of 14 times of drug weight.Steam is passed through into the bottom of a pan back-shaped pipe, makes boiling water and keeps
2 hours, decocting liquid is released, residue is still stayed in pot, then add 12 times of amount deionized waters, decocted and equally decoct 2 hours with first, release second
Secondary decocting liquid, decocting liquid will merge twice, and static 24 hours of input hopper takes suction clear liquid, discards bottom land slurry.
The clear liquid of above two decocting liquid is merged, then is concentrated under reduced pressure, making to compare weighs 1:When 1.36, borneol solution is added
Enter in above-mentioned concentrate, dispersed with stirring is uniform, it is qualified that decoction is examined, and finally dispenses into 50ML medical packaging polyester spray bottles,
Chinese medicine composition volume prepared by the above method accounts for the 77% of aerosol cumulative volume, film forming agent polyvinyl alcohol volume for 8% and
Aerosol propellant dimethyl ether volume is mixed for 15%, and a kind of phlebitis caused Chinese medicine external aerosol of venous transfusion is made
Agent.
Embodiment 2
It is a kind of for the phlebitis caused Chinese medicine composition of venous transfusion, the active ingredient of the Chinese medicine external aerosol by
The bulk drug of following weight parts is prepared from：Frankincense 12g, myrrh 8g, pseudo-ginseng 15g, borneol 5g, safflower 20g, Radix Angelicae Sinensis 10g, the dried rhizome of rehmannia
20g, Yun Ying 25g and Chinese violet 35g.
Frankincense, myrrh, Radix Angelicae Sinensis disintegrating machine are broken and spit into 1.0 centimetres of big fragments, input stainless steel is extracted in pot, is added
The deionized water that 12 times of drug weight, steam is passed through into the bottom of a pan back-shaped pipe, is made boiling water and is kept 2 hours extraction volatile oil standby
With, and medicine residue is added into 12 times of amount deionized waters again, continue to decoct 2 hours, release decocting liquid, input hopper static 24 is small
When, suction clear liquid is taken, bottom land slurry is discarded.
Prescription pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying, Chinese violet are first spitted into 1 centimetre of big fragment with disintegrating machine is broken, put into stainless
Steel is extracted in pot, adds the deionized water of 12 times of drug weight.Steam is passed through into the bottom of a pan back-shaped pipe, makes boiling water and holding 2
Hour, decocting liquid is released, residue is still stayed in pot, then add 12 times of amount deionized waters, decoct and equally decoct 2 hours with first, release second
Secondary decocting liquid, decocting liquid will merge twice, and static 24 hours of input hopper takes suction clear liquid, discards bottom land slurry.
The clear liquid of above two decocting liquid is merged, then is concentrated under reduced pressure, making to compare weighs 1:When 1.3, borneol solution is added
Enter in above-mentioned concentrate, dispersed with stirring is uniform, it is qualified that decoction is examined, and finally dispenses into 50ML medical packaging polyester spray bottles,
Chinese medicine composition volume prepared by the above method accounts for the 78% of aerosol cumulative volume, film forming agent polyvinyl alcohol volume for 3% and
Aerosol propellant dimethyl ether volume is mixed for 25%, and a kind of phlebitis caused Chinese medicine external aerosol of venous transfusion is made
Agent.
Embodiment 3
It is a kind of for the phlebitis caused Chinese medicine composition of venous transfusion, the active ingredient of the Chinese medicine external aerosol by
The bulk drug of following weight parts is prepared from：Frankincense 9g, myrrh 11g, pseudo-ginseng 8g, borneol 18g, safflower 12g, Radix Angelicae Sinensis 17g, the dried rhizome of rehmannia
13g, Yun Ying 32g and Chinese violet 28g.
Frankincense, myrrh, Radix Angelicae Sinensis disintegrating machine are broken and spit into 0.8 centimetre of big fragment, input stainless steel is extracted in pot, is added
The deionized water that 15 times of drug weight, steam is passed through into the bottom of a pan back-shaped pipe, is made boiling water and is kept 2 hours extraction volatile oil standby
With, and medicine residue is added into 12 times of amount deionized waters again, continue to decoct 2 hours, release decocting liquid, input hopper static 24 is small
When, suction clear liquid is taken, bottom land slurry is discarded.
Prescription pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying, Chinese violet are first spitted into 0.8 centimetre of big fragment with disintegrating machine is broken, input is not
The steel that becomes rusty is extracted in pot, adds the deionized water of 15 times of drug weight.Steam is passed through into the bottom of a pan back-shaped pipe, makes boiling water and keeps
2 hours, decocting liquid is released, residue is still stayed in pot, then add 12 times of amount deionized waters, decocted and equally decoct 2 hours with first, release second
Secondary decocting liquid, decocting liquid will merge twice, and static 24 hours of input hopper takes suction clear liquid, discards bottom land slurry.
The clear liquid of above two decocting liquid is merged, then is concentrated under reduced pressure, making to compare weighs 1:When 1.3, borneol solution is added
Enter in above-mentioned concentrate, dispersed with stirring is uniform, it is qualified that decoction is examined, and finally dispenses into 50ML medical packaging polyester spray bottles,
Chinese medicine composition volume prepared by the above method accounts for the 80% of aerosol cumulative volume, film forming agent polyvinyl alcohol volume for 4% and
Aerosol propellant dimethyl ether volume is mixed for 16%, and a kind of phlebitis caused Chinese medicine external aerosol of venous transfusion is made
Agent.
Embodiment 4
It is a kind of for the phlebitis caused Chinese medicine composition of venous transfusion, the active ingredient of the Chinese medicine external aerosol by
The bulk drug of following weight parts is prepared from：Frankincense 11g, myrrh 9g, pseudo-ginseng 12g, borneol 8g, safflower 18g, Radix Angelicae Sinensis 14g, the dried rhizome of rehmannia
16g, Yun Ying 27g and Chinese violet 32g.
Frankincense, myrrh, Radix Angelicae Sinensis disintegrating machine are broken and spit into 0.5 centimetre of big fragment, input stainless steel is extracted in pot, is added
The deionized water that 15 times of drug weight, steam is passed through into the bottom of a pan back-shaped pipe, is made boiling water and is kept 2 hours extraction volatile oil standby
With, and medicine residue is added into 12 times of amount deionized waters again, continue to decoct 2 hours, release decocting liquid, input hopper static 24 is small
When, suction clear liquid is taken, bottom land slurry is discarded.
Prescription pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying, Chinese violet are first spitted into 0.5 centimetre of big fragment with disintegrating machine is broken, input is not
The steel that becomes rusty is extracted in pot, adds the deionized water of 14 times of drug weight.Steam is passed through into the bottom of a pan back-shaped pipe, makes boiling water and keeps
2 hours, decocting liquid is released, residue is still stayed in pot, then add 12 times of amount deionized waters, decocted and equally decoct 2 hours with first, release second
Secondary decocting liquid, decocting liquid will merge twice, and static 24 hours of input hopper takes suction clear liquid, discards bottom land slurry.
The clear liquid of above two decocting liquid is merged, then is concentrated under reduced pressure, making to compare weighs 1:When 1.3, borneol solution is added
Enter in above-mentioned concentrate, dispersed with stirring is uniform, it is qualified that decoction is examined, and finally dispenses into 50ML medical packaging polyester spray bottles,
Chinese medicine composition volume prepared by the above method accounts for the 70% of aerosol cumulative volume, film forming agent polyvinyl alcohol volume for 8% and
Aerosol propellant dimethyl ether volume is mixed for 22%, and a kind of phlebitis caused Chinese medicine external aerosol of venous transfusion is made
Agent.
Embodiment 5
It is a kind of for the phlebitis caused Chinese medicine composition of venous transfusion, the active ingredient of the Chinese medicine external aerosol by
The bulk drug of following weight parts is prepared from：Frankincense 10g, myrrh 10g, pseudo-ginseng 10g, borneol 10g, safflower 15g, Radix Angelicae Sinensis 15g, life
Ground 15g, Yun Ying 30g and Chinese violet 30g.
Frankincense, myrrh, Radix Angelicae Sinensis disintegrating machine are broken and spit into 0.8 centimetre of big fragment, input stainless steel is extracted in pot, is added
The deionized water that 13 times of drug weight, steam is passed through into the bottom of a pan back-shaped pipe, is made boiling water and is kept extracting volatile oil in 1.5 hours
It is standby, and medicine residue is added into 12 times of amount deionized waters again, continue to decoct 2 hours, release decocting liquid, input hopper static 24 is small
When, suction clear liquid is taken, bottom land slurry is discarded.
Prescription pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying, Chinese violet are first spitted into 0.8 centimetre of big fragment with disintegrating machine is broken, input is not
The steel that becomes rusty is extracted in pot, adds the deionized water of 13 times of drug weight.Steam is passed through into the bottom of a pan back-shaped pipe, makes boiling water and keeps
1.5 hours, decocting liquid is released, residue still stayed in pot, then add 12 times of amount deionized waters, decocted and equally decoct 2 hours with first, release the
Secondary decocting liquid, decocting liquid will merge twice, and static 24 hours of input hopper takes suction clear liquid, discards bottom land slurry.
The clear liquid of above two decocting liquid is merged, then is concentrated under reduced pressure, making to compare weighs 1:When 1.3, borneol solution is added
Enter in above-mentioned concentrate, dispersed with stirring is uniform, it is qualified that decoction is examined, and finally dispenses into 50ML medical packaging polyester spray bottles,
Chinese medicine composition volume prepared by the above method accounts for the 75% of aerosol cumulative volume, film forming agent polyvinyl alcohol volume for 5% and
Aerosol propellant dimethyl ether volume is mixed for 20%, and vein caused by a kind of phlebitis caused venous transfusion of venous transfusion is made
Scorching Chinese medicine external aerosol.
Embodiment 6
In March, 2014 to my section of in December, the 2016 vein PICC during chemotherapy that is in hospital is chosen to put and infuse phlebitis caused after pipe
Patient 60, male 21 in observation group, women 9,26~78 years old age, phlebitis 1 grade 18,2 grades 9,3 grades 3.It is right
According to male in group 22, women 8,29~81 years old age, phlebitis 1 grade 18,2 grades 8,3 grades 4.
Method：60 patients select the three-dimensional valve vein PICC conduits (model 4Fr) of The Budd Co. of the U.S..Implement
Vein PICC conduits put Guan Zhewei, and there is vein PICC conduits to puncture qualification and possess the abundant clinical nurse specialism for putting pipe experience, selected
Select evaluated without red and swollen heat pain, breakage, scleroma, ecchymosis, scar etc. before venipuncture, do not carried out venipuncture in 5d.
Control group：Periphery vein blood vessel puncture insert vein PICC conduits after, using 50% magnesium sulfate gauze soak in
Soak scope is more than above 3-4cm of lesion, gauze with covered rearing with plastic film at blood vessel redness, to prevent moisture evaporation, wet every time
30m in are applied, 3 times/d, 5d are treated.
Observation group：After periphery vein blood vessel punctures and inserts vein PICC conduits, prepared using embodiment 1~5
Chinese medicine external aerosol is sprayed at blood vessel redness, and spray range is more than 3~4cm of lesion, thickness≤1mm, because vein is defeated
Contain in the phlebitis caused quiet Chinese medicine external aerosol of liquid and cover layer is formed after film forming agent, spraying, 3 times/d, treat 5d.
Criterion：By transfusion nursing association of the U.S. (IN S) phlebitis criterion：
I grades：Transfusion part is rubescent, companion or not companion's pain；
II grade：Transfusion part pain is with rubescent and (or) oedema；
II1 grades：Transfusion part pain is formed with rubescent and (or) oedema, bar rope sample thing, tangible to streak quiet
Arteries and veins；
IV grades：Transfusion part pain is formed with rubescent and (or) oedema, bar rope sample thing, tangible to arrive streak vein
>2.5cm, has fester to ooze out.
Observation of curative effect：Observe two groups of patient medication number of times, local skin color, temperature, touch a tender spot sense, it is streak change and
The satisfaction of patient's Chinese medicine external aerosol phlebitis caused to such as venous transfusion.
It is effective：Pain relief or disappearance in 30min after being sprayed with the phlebitis caused Chinese medicine external aerosol of venous transfusion,
2~3d local skins are red, swollen, disappear bitterly and along the streak red line that vein is moved towards；
Effectively：Substantially mitigated with pain in 30min after the phlebitis caused Chinese medicine external aerosol spraying of venous transfusion,
The streak red lines of 3-5d soften, and are not wholly absent；
It is invalid：It is not improved with symptom after 6~7d after the phlebitis caused Chinese medicine external aerosol spraying of venous transfusion.
As a result Tables 1 and 2 is seen below：
1 two groups of patient's phlebitis therapeutic effects of table compare
Note：(example, %)
2 two groups of patient's phlebitis treatment number of days of table compare：
30 phlebitis patients can be seen that by above-mentioned experimental result, fully recover within 3~5 days.Total effective rate 93.4%~
96.7%, rapid-action, therapeutic effect is good, and can effectively mitigate local pain, using simple to operate, has no toxic side effect, and suffers from
Person's activity is unaffected, and comfort level is high, is easily accepted by patients.
Comparative example
The compound composition compatibility of ruyi jinhuang powder, ruyi jinhuang san is as follows：Root of Chinese trichosanthes 500g, each 250g of golden cypress, rheum officinale, turmeric, the root of Dahurain angelica are thick
Piao, dried orange peel, radix glycyrrhizae, each 100g compositions of rhizoma atractylodis, rhizoma arisaematis, they are shredded and dried, and superfine end is ground altogether.Can from side
Going out it mainly has 3 groups of medicines：1st group be bitter cold removing toxic substances rheum officinale, golden cypress be monarch drug in a prescription；2nd group is eliminating dampness and eliminating phlegm qi-activating drug, Ru Tiannan
Star, dried orange peel, the bark of official magnolia, blood-breaking medicine, such as turmeric are ministerial drug；3rd group be pungent-warm dispel pathogenic wind and remove dampness, swelling and pain relieving medicine, it is such as white
The root of Dahurian angelica, to make medicine.Rheum officinale has anti-infective, regulating lipid metabolism, protection vascular endothelial cell, suppresses vascular smooth muscle cells increasing
Grow, anti-oxidant, antithrombotic effect, have suppression to a variety of gram positive bacterias such as staphylococcus aureus and some gram-negative bacterias
Effect；The extract curcumin of turmeric has effects that anti-infective, antitumor, anti-oxidant and cytoprotection；Rhizoma arisaematis then has
Anti-infective, analgesia, anticoagulant effect, but it has certain toxicity, so JINHUANG SAN is not orally available；Rhizoma atractylodis, bark of official magnolia etc. other
Composition also has anti-infective, spasmolysis, analgesia and cytoprotection.Ruyi jinhuang powder, ruyi jinhuang san has the phagocytosis work(of enhancing macrophage
Can, serum lysozyme content is improved, promotes lymphocyte transformation, the effect of capillary permeability is reduced, so that invasion machine
The microorganism of body is removed, and makes inflammation and infection be able to alleviate rapidly.In summary, ruyi jinhuang powder, ruyi jinhuang san has antibacterial, anti-sense
Dye, analgesia, spasmolysis, promote microcirculation, adjust local immunity, mitigate that local pain, oedema, exudate be excessive and secondary infection
Deng effect.
16 patients for causing drug extravasation to occur phlebitis through peripheral vein application adriamycin class medication infusion are used
Ruyi jinhuang powder, ruyi jinhuang san mixture external application, is as a result shown, swelling pain after pain relief after 4d, 7d~9d is smeared for 12 in 16 patients
Etc. symptom mitigation and basic disappearance, always effectively control as 75%.
By the scheme disclosed in comparative example compared with the present invention, cure mechanism is all according to promoting blood circulation and removing blood stasis, swelling and pain relieving
Effect carrys out combination drug, but effect but has bigger difference, and the Chinese medicine composition that the present invention is provided always has in treatment phlebitis
Efficiency reaches 93.4~96.7%, and uses ruyi jinhuang powder, ruyi jinhuang san to treat phlebitis, always effectively controls only 75%.This shows the application
The effect of collaboration enhancing drug effect is provided between 9 kinds of Chinese medicines of Chinese medicine composition of offer.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition phlebitis caused for venous transfusion, it is characterised in that raw material includes following parts by weight
Component：8~12 parts of frankincense, 8~12 parts of myrrh, 5~15 parts of pseudo-ginseng, 5~15 parts of borneol, 10~20 parts of safflower, Radix Angelicae Sinensis 10~20
Part, 10~20 parts of the dried rhizome of rehmannia, 25~35 parts of Yun Ying and 25~35 parts of Chinese violet.
2. Chinese medicine composition according to claim 1, it is characterised in that raw material includes the component of following parts by weight：Frankincense 9
~11 parts, 9~11 parts of myrrh, 8~12 parts of pseudo-ginseng, 8~12 parts of borneol, 12~18 parts of safflower, 14~17 parts of Radix Angelicae Sinensis, the dried rhizome of rehmannia 13~
28~32 parts of 16 parts, 27~32 parts of Yun Ying and Chinese violet.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that raw material includes the component of following parts by weight：Breast
Fragrant 10 parts, 10 parts of myrrh, 10 parts of pseudo-ginseng, 10 parts of borneol, 15 parts of safflower, 15 parts of Radix Angelicae Sinensis, 15 parts of the dried rhizome of rehmannia, 30 parts of Yun Ying and Chinese violet 30
Part.
4. the preparation method of the Chinese medicine composition described in claims 1 to 3 any one, it is characterised in that comprise the following steps：
1) frankincense, myrrh and Radix Angelicae Sinensis are mixed with water, 1.5~2.5h is extracted under the conditions of boiling, frankincense, myrrh and Radix Angelicae Sinensis is obtained and carries
Take liquid；
2) pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying and Chinese violet are mixed with water, 1.5~2.5h is extracted under the conditions of boiling, pseudo-ginseng is obtained, red
Flower, the dried rhizome of rehmannia, Yun Ying and Chinese violet extract solution；
3) by the step 1) obtained frankincense, myrrh and angelica extract and step 2) obtain pseudo-ginseng, safflower, the dried rhizome of rehmannia, cloud
English and the mixing of Chinese violet extract solution, obtained mixed liquor are concentrated under reduced pressure, and comparing for the mixed liquor weighs to 1:1.3~
When 1.5, borneol ethanol solution is mixed with concentrate, Chinese medicine composition is obtained；
The step 1) and step 2) between there is no the limitation of time sequencing.
5. preparation method according to claim 4, it is characterised in that the step 2) in pseudo-ginseng, safflower, the dried rhizome of rehmannia, Yun Ying
It is 1mg with the gross mass of Chinese violet and the volume ratio of water：(12~15) mL；The step 1) in frankincense, myrrh and Radix Angelicae Sinensis total matter
Amount and the volume ratio of water are 1mg：(12~15) mL.
6. the preparation method according to claim 4 or 5, it is characterised in that the step 3) in borneol ethanol solution with it is dense
The volume ratio of contracting liquid is 1~3：47~49；The mass concentration of the borneol ethanol solution is 0.3~0.8mg/ml.
7. a kind of Traditional Chinese medicine composition-type spray phlebitis caused for venous transfusion, it is characterised in that sprayed with Chinese medicine composition
Mist agent cumulative volume is 100% meter, includes the component of following percentage composition：Prepared by claim 4~6 any one methods described
Chinese medicine composition volume is that 70~80%, film forming agent volume is 4~8% and the volume of aerosol propellant is 15~25%.
8. Traditional Chinese medicine composition-type spray according to claim 7, it is characterised in that with Traditional Chinese medicine composition-type spray cumulative volume
For 100% meter, include the component of following percentage composition：Chinese medicine composition prepared by claim 4~6 any one methods described
Volume be that the volume of 75%, film forming agent is 5% and the volume of aerosol propellant is 20%.
9. the Traditional Chinese medicine composition-type spray according to claim 7 or 8, it is characterised in that the film forming agent is polyvinyl alcohol；
The aerosol propellant is dimethyl ether.
10. Chinese medicine composition or claim 4~6 any one methods described system described in claims 1 to 3 any one
Application of the standby Chinese medicine composition in the phlebitis caused medicine for the treatment of venous transfusion is prepared.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488790A (en) * | 2011-12-11 | 2012-06-13 | 孙爱莲 | External Chinese traditional medicine transfusion plaster for preventing and treating phlebitis |
| CN102961729A (en) * | 2012-12-18 | 2013-03-13 | 王涛 | Externally-used traditional Chinese medicine for treating varicosity, thromboangiitis obliterans and phlebitis |
| CN105434545A (en) * | 2015-12-16 | 2016-03-30 | 高燕飞 | Preparation and application of drug percutaneous absorbent |
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2017
- 2017-03-28 CN CN201710190763.0A patent/CN107041913B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488790A (en) * | 2011-12-11 | 2012-06-13 | 孙爱莲 | External Chinese traditional medicine transfusion plaster for preventing and treating phlebitis |
| CN102961729A (en) * | 2012-12-18 | 2013-03-13 | 王涛 | Externally-used traditional Chinese medicine for treating varicosity, thromboangiitis obliterans and phlebitis |
| CN105434545A (en) * | 2015-12-16 | 2016-03-30 | 高燕飞 | Preparation and application of drug percutaneous absorbent |
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| Title |
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| 邱映堂: "《跌打大全》", 31 December 2015, 中国中医药出版社 * |
| 马新生: "《外敷活络止痛膏治疗输液性静脉炎121例》", 《甘肃中医》 * |
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