CN107029277A - 使用纯化的逆向热敏聚合物的内镜粘膜切除 - Google Patents
使用纯化的逆向热敏聚合物的内镜粘膜切除 Download PDFInfo
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- CN107029277A CN107029277A CN201611014752.9A CN201611014752A CN107029277A CN 107029277 A CN107029277 A CN 107029277A CN 201611014752 A CN201611014752 A CN 201611014752A CN 107029277 A CN107029277 A CN 107029277A
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
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- A61B2017/00269—Type of minimally invasive operation endoscopic mucosal resection EMR
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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| WO (1) | WO2009070793A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4989309B2 (ja) | 2007-05-18 | 2012-08-01 | 株式会社半導体エネルギー研究所 | 液晶表示装置 |
| US9041202B2 (en) | 2008-05-16 | 2015-05-26 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and manufacturing method of the same |
| US8314765B2 (en) | 2008-06-17 | 2012-11-20 | Semiconductor Energy Laboratory Co., Ltd. | Driver circuit, display device, and electronic device |
| KR101762112B1 (ko) | 2008-09-19 | 2017-07-27 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 액정표시장치 |
| TWI574423B (zh) | 2008-11-07 | 2017-03-11 | 半導體能源研究所股份有限公司 | 半導體裝置和其製造方法 |
| US8232947B2 (en) | 2008-11-14 | 2012-07-31 | Semiconductor Energy Laboratory Co., Ltd. | Liquid crystal display device |
| US8461582B2 (en) | 2009-03-05 | 2013-06-11 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and method for manufacturing the same |
| KR101752640B1 (ko) | 2009-03-27 | 2017-06-30 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체장치 |
| WO2011001880A1 (en) | 2009-06-30 | 2011-01-06 | Semiconductor Energy Laboratory Co., Ltd. | Method for manufacturing semiconductor device |
| SG10201403913PA (en) | 2009-07-10 | 2014-10-30 | Semiconductor Energy Lab | Method for manufacturing semiconductor device |
| KR101772639B1 (ko) | 2009-10-16 | 2017-08-29 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 |
| CN104681568B (zh) | 2009-10-21 | 2017-11-21 | 株式会社半导体能源研究所 | 显示装置和包括显示装置的电子设备 |
| KR20190006091A (ko) | 2009-10-29 | 2019-01-16 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 |
| WO2011055631A1 (en) | 2009-11-06 | 2011-05-12 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and manufacturing method thereof |
| KR101871654B1 (ko) | 2009-12-18 | 2018-06-26 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 표시 장치의 구동 방법 및 표시 장치 |
| EP2513893A4 (en) | 2009-12-18 | 2016-09-07 | Semiconductor Energy Lab | Liquid crystal display device and electronic device |
| WO2011089844A1 (en) | 2010-01-24 | 2011-07-28 | Semiconductor Energy Laboratory Co., Ltd. | Display device and manufacturing method thereof |
| DE112011100842T5 (de) | 2010-03-08 | 2013-01-17 | Semiconductor Energy Laboratory Co., Ltd. | Halbleiterbauelement und Verfahren zu dessen Herstellung |
| US8941112B2 (en) | 2010-12-28 | 2015-01-27 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and method for manufacturing the same |
| RU2478344C2 (ru) * | 2011-03-31 | 2013-04-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Иркутский государственный университет | Способ эндоскопической резекции слизистой желудка |
| KR20130043063A (ko) | 2011-10-19 | 2013-04-29 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 및 반도체 장치의 제작 방법 |
| US8962386B2 (en) | 2011-11-25 | 2015-02-24 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and method for manufacturing the same |
| US9312257B2 (en) | 2012-02-29 | 2016-04-12 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device |
| JP2014027263A (ja) | 2012-06-15 | 2014-02-06 | Semiconductor Energy Lab Co Ltd | 半導体装置およびその作製方法 |
| WO2014073585A1 (en) | 2012-11-08 | 2014-05-15 | Semiconductor Energy Laboratory Co., Ltd. | Metal oxide film and method for forming metal oxide film |
| KR102442752B1 (ko) | 2013-05-20 | 2022-09-14 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 |
| US10434215B2 (en) | 2013-06-27 | 2019-10-08 | Regentis Biomaterials Ltd. | Compositions comprising a polymer-protein conjugate and an environmentally-responsive polymer and uses thereof |
| TWI708981B (zh) | 2013-08-28 | 2020-11-01 | 日商半導體能源研究所股份有限公司 | 顯示裝置 |
| ITMI20131924A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| ITMI20131927A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| JP2016001712A (ja) | 2013-11-29 | 2016-01-07 | 株式会社半導体エネルギー研究所 | 半導体装置の作製方法 |
| EP3099336B1 (en) * | 2014-01-29 | 2023-04-26 | Cosmo Technologies Ltd. | Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum |
| KR20210039507A (ko) | 2014-11-28 | 2021-04-09 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치, 모듈, 및 전자 기기 |
| JP6736321B2 (ja) | 2015-03-27 | 2020-08-05 | 株式会社半導体エネルギー研究所 | 半導体装置の製造方法 |
| TWI777164B (zh) | 2015-03-30 | 2022-09-11 | 日商半導體能源研究所股份有限公司 | 半導體裝置的製造方法 |
| JP2017022377A (ja) | 2015-07-14 | 2017-01-26 | 株式会社半導体エネルギー研究所 | 半導体装置 |
| KR20170084020A (ko) | 2015-10-23 | 2017-07-19 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 및 전자 기기 |
| KR102296809B1 (ko) | 2016-06-03 | 2021-08-31 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 금속 산화물 및 전계 효과 트랜지스터 |
| KR101884467B1 (ko) * | 2017-06-12 | 2018-08-02 | 한국맥널티 주식회사 | 알긴산 또는 그 약학적으로 허용되는 염과 콜로이드성 다당류를 함유하는 액상 조성물 |
| WO2020132514A1 (en) | 2018-12-21 | 2020-06-25 | Qmark Medical Inc. | Hydrogel composition for mucosal lifting procedures within lumenal anatomical structures |
| EP3928767A4 (en) | 2019-02-22 | 2022-12-14 | Seikagaku Corporation | METHOD OF IMPROVING STORAGE STABILITY |
| EP4154865A1 (en) * | 2021-09-23 | 2023-03-29 | Ovesco Endoscopy AG | Process for manufacturing an injection agent and injection agent obtainable by this process |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005046438A2 (en) * | 2003-11-06 | 2005-05-26 | Pluromed, Inc. | Internal clamp for surgical procedures |
| US20060070631A1 (en) * | 2004-09-27 | 2006-04-06 | Boston Scientific Scimed, Inc. | Devices and methods for agent-assisted medical procedures |
| CN1794980A (zh) * | 2003-03-24 | 2006-06-28 | 生物领域医疗公司 | 利用逆向热敏聚合物的暂时栓塞 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188373A (en) | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| US4478822A (en) | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US4474751A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
| US5567859A (en) * | 1991-03-19 | 1996-10-22 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| ES2140408T3 (es) | 1991-03-19 | 2000-03-01 | Cytrx Corp | Copolimeros de polioxipropileno/polioxietileno con actividad biologica mejorada. |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US5800711A (en) * | 1996-10-18 | 1998-09-01 | Mdv Technologies, Inc. | Process for the fractionation of polyoxyalkylene block copolymers |
| AU2001241958A1 (en) * | 2000-03-03 | 2001-09-17 | Valentis, Inc. | Improved poloxamer and poloxamine compositions for nucleic acid delivery |
| GB2362100B (en) * | 2000-05-08 | 2002-05-08 | Maelor Pharmaceuticals Ltd | Wound gels |
| US6761824B2 (en) * | 2000-08-17 | 2004-07-13 | Reeve Lorraine E | Process for the fractionation of polymers |
| TW200307011A (en) * | 2002-04-18 | 2003-12-01 | Chugai Pharmaceutical Co Ltd | Hyaluronic acid modifier |
| US20050079147A1 (en) * | 2003-10-14 | 2005-04-14 | Bernard Delaey | Wound healing compositions and uses |
| US20050143678A1 (en) * | 2003-10-14 | 2005-06-30 | Pluromed, Inc. | Confinement of kidney-stone fragments during lithotripsy |
| AU2005289520A1 (en) * | 2004-09-27 | 2006-04-06 | Vical Incorporated | Formulations and methods for treatment of inflammatory diseases |
| CA2599219C (en) * | 2005-02-25 | 2011-09-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and preventing cardiomyopathy and heart disease |
| DK2601972T3 (en) * | 2005-05-02 | 2015-02-16 | Genzyme Corp | Kidney stone treatment without lithotripsy |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1794980A (zh) * | 2003-03-24 | 2006-06-28 | 生物领域医疗公司 | 利用逆向热敏聚合物的暂时栓塞 |
| WO2005046438A2 (en) * | 2003-11-06 | 2005-05-26 | Pluromed, Inc. | Internal clamp for surgical procedures |
| US20060070631A1 (en) * | 2004-09-27 | 2006-04-06 | Boston Scientific Scimed, Inc. | Devices and methods for agent-assisted medical procedures |
Also Published As
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|---|---|
| US20160317701A1 (en) | 2016-11-03 |
| US20110052490A1 (en) | 2011-03-03 |
| JP2011505377A (ja) | 2011-02-24 |
| EP2219546A1 (en) | 2010-08-25 |
| JP2014221205A (ja) | 2014-11-27 |
| EP2219546B1 (en) | 2017-02-01 |
| CN101932287A (zh) | 2010-12-29 |
| EP2219546A4 (en) | 2012-01-18 |
| JP6049658B2 (ja) | 2016-12-21 |
| WO2009070793A1 (en) | 2009-06-04 |
| JP5613567B2 (ja) | 2014-10-22 |
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