CN107029056A - It is a kind of to treat Chinese medicine composition of canker sore and preparation method thereof - Google Patents

It is a kind of to treat Chinese medicine composition of canker sore and preparation method thereof Download PDF

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CN107029056A
CN107029056A CN201710115386.4A CN201710115386A CN107029056A CN 107029056 A CN107029056 A CN 107029056A CN 201710115386 A CN201710115386 A CN 201710115386A CN 107029056 A CN107029056 A CN 107029056A
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powder
chinese
extract
extract powder
glidant
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徐云
赵俞
于艳辉
许艳茹
白冰
徐建
田淋淋
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JILIN XIUZHENG PHARMACEUTICAL NEW MEDICINE DEVELOPMENT Co Ltd
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JILIN XIUZHENG PHARMACEUTICAL NEW MEDICINE DEVELOPMENT Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

A kind of to treat Chinese medicine composition of canker sore and preparation method thereof, Chinese medicine composition is made up of dandelion 10%~30% by weight ratio, Chinese violet 10%~30%, Radix Isatidis 10%~30%, the water extract extract powder of Chinese lobelia 10%~30% and appropriate amount of auxiliary materials；Wherein, the percentage by weight of extract powder and supplementary product consumption is：Medicinal extract powder content 50%~75%, filler accounts for 5%~25%, and binder accounts for 15%~25%, and glidant accounts for 1%~5%.Its preparation method includes：Dandelion, Chinese violet, Chinese lobelia, Radix Isatidis are ground into coarse powder, and decocting is extracted, and prepare water extract extract powder, extract powder and auxiliary material mixed pressuring plate.Advantages of the present invention has：(1) quick acting, the effect for reach detumescence, relieving the pain, and action time is lasting；(2) natural drug, excitant and Small side effects；(3) not only can be for ulcer surface treatment, and ulcer margin tissue is played a protective role, the generation of other mouth diseases can be prevented effectively from.

Description

It is a kind of to treat Chinese medicine composition of canker sore and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating canker sore and its preparation side Method.
Background technology
Canker sore is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, sharp ache during breaking-out, office Substantially, severe patient can also influence diet, speak portion's cusalgia, and very big inconvenience is caused to daily life；Can concurrently halitosis, chronic pharynx The constitutional symptom such as inflammation, constipation, headache, dizziness, nausea, weak, irritated, heating, enlargement of lymph nodes.
The product category for the treatment of canker sore is various in the market, there is paster, spray, toothpaste of drug containing composition etc.. Different product, formulation, have its advantage while also there is its drawback, spray is easily swallowed with saliva, when acting in the oral cavity Between it is short, cure the cycle it is long, the toothpaste of drug containing composition, it is not belonging to medicine, and curative effect is indefinite, and paster is then effectively solved This problem.The patch of most treatment canker sore is all chemicals in the market, although rapid-action but side effect is more, To the injury of body also than larger；Separately there are some products, by anesthesia ulcer surrounding mucosa histocyte when it is acted on, reduction pain Feel and play a role.Cure the symptoms, not the disease.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating canker sore and preparation method thereof, overcome existing Such a disease curative above shortcomings.
The Chinese medicine composition of the present invention is by dandelion, Chinese violet, Radix Isatidis, Chinese lobelia mixture water extract extract powder With auxiliary material filler, binder, glidant composition；
Wherein, the percentage by weight between extract powder is raw materials used is：Dandelion 10%~30%, Chinese violet 10%~ 30%th, Radix Isatidis 10%~30%, Chinese lobelia 10%~30%；
The percentage by weight of extract powder and supplementary product consumption is：Medicinal extract powder content 50%~75%, filler accounts for 5%~ 25%, binder accounts for 15%~25%, and glidant accounts for 1%~5%.
Described binder is EC or CP934P or HPC or HPMC or CMC-Na；Filler is starch or dextrin or lactose； Glidant is talcum powder or taste powder silica gel.
The present invention is to be based on：
The effects such as dandelion has clearing heat and detoxicating, dispersing swelling and dissipating binds, cholagogic diuresis, the acute mastitis that disappears, modern pharmacology research shows Dandelion mainly has antibacterial, anti-inflammatory, anti-oxidant, antitumor, hypoglycemic, reducing blood lipid effect.
Chinese violet sees earliest《Prescriptions worth thousand gold》, its nature and flavor bitter, acrid, cold enters the heart, Liver Channel, disappears with clearing heat and detoxicating, cool blood Swollen the effect of.Ulcer furunculosis, jaundice, dysentery, abscess of throat etc. are cured mainly, fresh goods is mashed can eliminating stasis to subdue swelling, apocenosis myogenic.Chlorogenic acid It is one of active component in Chinese violet, it is golden yellow to Gram-negative bacteria and gram-positive bacteria bacteriostatic activity.
The effect of Radix Isatidis has clearing heat and detoxicating, cool blood relieving sore-throat, is usually used in the infectious diseases such as treatment warm heat disease.
Chinese lobelia first recorded in《The southern regions of the Yunnan Province book on Chinese herbal medicine》Have inducing diuresis to remove edema, it is clearing heat and detoxicating the effect of, clinic be mainly used in treatment, face foot Edema, carbuncle swells furunculosis, snake bite and insect sting, advanced schistosomiasis ascites.
The Chinese medicine composition its preparation method of the present invention comprises the following steps：
(1) dandelion 10%~30%, Chinese violet 10%~30%, Chinese lobelia 10%~30% are taken by weight proportion, Radix Isatidis 10%~30%, is ground into coarse powder；
(2) coarse powder obtained by step (1) is added water 6~8 times of weight, decocts and extract 1~2 time, every time 30~60min, filtering, Merge filtrate twice, filtrate concentration dry, pulverize；
(3) proper auxiliary materials (binder such as EC, CP934P, HPC, HPMC, CMC-Na are taken；Filler such as starch, dextrin, breast Sugar；Glidant such as talcum powder, taste powder silica gel) pulverize and sieve (100 mesh)；
(4) by the auxiliary material after sieving and extract powder extract powder 50%~75% by weight percentage, filler 5%~ 25%, binder 15%~25%, glidant 1%~5% is mixed, and addition punch die is tabletted, produces；
The present invention has advantages below：
(1) quick acting, the effect for reach detumescence, relieving the pain, and action time is lasting；
(2) natural drug, excitant and Small side effects；
(3) not only can be for ulcer surface treatment, and ulcer margin tissue is played a protective role, other mouths can be prevented effectively from The generation of chamber disease.
The present composition is pasted on canker sore affected part, and 2 times a day, every time 1 patch.
Embodiment：With reference to embodiment, the present invention is described in further detail：
Embodiment 1：Dandelion 100g, Chinese violet 300g, Chinese lobelia 300g, Radix Isatidis 300g are ground into coarse powder, added water 8 times of amounts, decoct and extract 2 times, each 60min, filtering, merge filtrate twice, and filtrate concentration dry, pulverize；Take proper auxiliary materials (CP934P、HPMC 1:1 is mixed into binder；Dextrin is filler；Using superfine silica gel powder as glidant) pulverize and sieve (100 mesh)； Auxiliary material after sieving is mixed in proportion with extract powder, addition punch die is tabletted, produces, wherein：Medicinal extract powder content 75%, is filled out Fill agent and account for 15%, binder accounts for 5%, and glidant accounts for 5%.
Embodiment 2：Dandelion 200g, Chinese violet 300g, Chinese lobelia 200g, Radix Isatidis 300g are ground into coarse powder, added water 8 times of amounts, decoct and extract 2 times, each 60min, filtering, merge filtrate twice, and filtrate concentration dry, pulverize；Take proper auxiliary materials (CP934P、HPMC 1:1 is mixed into binder；Dextrin is filler；Using superfine silica gel powder as glidant) pulverize and sieve (100 mesh)； Auxiliary material after sieving is mixed in proportion with extract powder, addition punch die is tabletted, produces, wherein：Medicinal extract powder content 50%, is filled out Fill agent and account for 25%, binder accounts for 20%, and glidant accounts for 5%.
Embodiment 3：Dandelion 300g, Chinese violet 200g, Chinese lobelia 300g, Radix Isatidis 200g are ground into coarse powder, added water 8 times of amounts, decoct and extract 2 times, each 60min, filtering, merge filtrate twice, and filtrate concentration dry, pulverize；Take proper auxiliary materials (CP934P、HPMC 1:1 is mixed into binder；Dextrin is filler；Using superfine silica gel powder as glidant) pulverize and sieve (100 mesh)； Auxiliary material after sieving is mixed in proportion with extract powder, addition punch die is tabletted, produces, wherein：Medicinal extract powder content 60%, Filler accounts for 15%, and binder accounts for 20%, and glidant accounts for 5%.
Embodiment 4：Dandelion 300g, Chinese violet 100g, Chinese lobelia 300g, Radix Isatidis 300g are ground into coarse powder, added water 8 times of amounts, decoct and extract 2 times, each 60min, filtering, merge filtrate twice, and filtrate concentration dry, pulverize；Take proper auxiliary materials (CP934P、HPMC 1:1 is mixed into binder；Dextrin is filler；Using superfine silica gel powder as glidant) pulverize and sieve (100 mesh)； Auxiliary material after sieving is mixed in proportion with extract powder, addition punch die is tabletted, produces, wherein：Medicinal extract powder content 50%, is filled out Fill agent and account for 25%, binder accounts for 15%, and glidant accounts for 5%.
Embodiment 5：Dandelion 300g, Chinese violet 300g, Chinese lobelia 300g, Radix Isatidis 100g are ground into coarse powder, added water 8 times of amounts, decoct and extract 2 times, each 60min, filtering, merge filtrate twice, and filtrate concentration dry, pulverize；Take proper auxiliary materials (CP934P、HPMC 1:1 is mixed into binder；Dextrin is filler；Using superfine silica gel powder as glidant) pulverize and sieve (100 mesh)； Auxiliary material after sieving is mixed in proportion with extract powder, addition punch die is tabletted, produces, wherein：Medicinal extract powder content 65%, is filled out Fill agent and account for 20%, binder accounts for 14%, and glidant accounts for 1%.
Embodiment 6：Dandelion 300g, Chinese violet 300g, Chinese lobelia 100g, Radix Isatidis 300g are ground into coarse powder, added water 8 times of amounts, decoct and extract 2 times, each 60min, filtering, merge filtrate twice, and filtrate concentration dry, pulverize；Take proper auxiliary materials (CP934P、HPMC 1:1 is mixed into binder；Dextrin is filler；Using superfine silica gel powder as glidant) pulverize and sieve (100 mesh)； Auxiliary material after sieving is mixed in proportion with extract powder, addition punch die is tabletted, produces, wherein：Medicinal extract powder content extract powder Content 75%, filler accounts for 12%, and binder accounts for 10%, and glidant accounts for 3%.
Embodiment 7：Dandelion 250g, Chinese violet 250g, Chinese lobelia 250g, Radix Isatidis 250g are ground into coarse powder, added water 8 times of amounts, decoct and extract 1~2 time, each 60min, filtering, merge filtrate twice, and filtrate concentration dry, pulverize；Take suitable auxiliary Expect (CP934P, HPMC 1:1 is mixed into binder；Dextrin is filler；Using superfine silica gel powder as glidant) pulverize and sieve (100 Mesh)；Auxiliary material after sieving is mixed in proportion with extract powder, addition punch die is tabletted, produces, wherein：Medicinal extract powder content 75%, filler accounts for 15%, and binder accounts for 5%, and glidant accounts for 5%.
In order to further evaluate the curative effect and its safety of Chinese medicine composition of the present invention, applicant carries out pharmacodynamics examination to it Test, be now reported as follows result：
1. experiment material
1.1 experimental animal Wistar rats, 180~220g of body weight, male and female half and half；New zealand rabbit, 2.5 ± 0.5kg, Male.Purchased from preclinical medicine institute of Jilin University Experimental Animal Center, quality certification number：SCXK (Ji) 2014-0003.
1.2 instruments and reagent Chinese medicine composition of the present invention；Bingpeng San：Ling Yuan pharmaceutcal corporation, Ltds of Quanzhou City；Glacial acetic acid： Beijing Chemical Plant；Formaldehyde：Tianjin Yong Sheng Fine Chemical Co., Ltd；Yellow Jackets：Sigma is dispensed；Complete Freund's adjuvant is Beijing Ding Guo Bioisystech Co., Ltd product；Interleukin-6 (IL-6), TNF (TNF-α) ELISA kit, on Hai Langdun bio tech ltd；SMP500-18272-LSIO ELIASAs：Manufactured in China Designed in California USA；LD5-2A type low speed centrifuges：Beijing Medical Centrifugal Machine Factory；Portable high speed disperser：Ningbo is new Sesame biotech inc.
2. experimental method
2.1 rabbit canker sore are tested
2.1.1 remaining White Rabbit is randomly divided into model control group, ice by packet with modeling in addition to 3 left blanks are compareed Boron dissipates group, Chinese medicine composition group of the present invention, and all animals are after 3% yellow Jackets auricular vein injecting anesthetic, with prefabricated straight Footpath is 5mm, thickness about 1mm filter paper (glacial acetic acid for being impregnated with 40%), is placed in rabbit upper lip both sides, and 60s takes out and sets up the white of 4-5mm Color ulcer surface；There is the ulcer surface that diameter is about 5.5mm in 48h, marks ulcer diameter.
2.1.2 after medication modeling success, Chinese medicine composition of the present invention is affixed on 2 times/d at ulcer, Bingpeng San group and uses cotton 2 times/d of rod coating, model control group is not processed.
2.1.3 observation index observation ulcerative lesions degree, the change of measurement ulcer area, the time of record ulcer healing, take Lower ulcerated mucosa, 10% neutral formalin is fixed, HE dyeing, observation by light microscope pathological change.
2.2 rat canker sore are tested
2.2.1 the preparation of antigen emulsion：20 SD rats take off neck and put to death, and oral cavity mucous membrane tissue is stripped under aseptic condition, Shred, tissue homogenizer homogenate adds 0.1mol/L, pH=7.4 .-70 DEG C of refrigerator of PBS is standby.It is immune dynamic every time During thing, equivalent complete Freund's adjuvant is added, antigen emulsion is prepared into.
2.2.2 the foundation of Oral ulcer model：40 intracutaneous common notes in SD rats (in addition to normal group 10) backbone both sides Penetrate 2~3 antigen emulsions, every 0.1ml, every 1 week 1 time, co-injection 5 times.1 week after the 3rd injections of antigens emulsion There is canker sore in all rat models.1 week, Chinese medicine composition of the present invention after the 3rd injections of antigens emulsion of medication 2 times/d at ulcer, Bingpeng San group swab stick 2 times/d of coating are affixed on, model control group is not processed, continuous 14d.After the completion for the treatment of Abdominal aortic blood is anaesthetized from each group experimental rat respectively, supernatant is taken after 3000r/min centrifugations, ELISA is determined in serum IL-6, TNF-α, and record the change of ulcer number.
2.3 statistical analysis using the statistical softwares of SPSS 17.0 analyze, data withRepresent, t is carried out between two groups Examine.p<0.05 is difference, statistically significant.
3. experimental result
3.1 rabbit canker sore are tested
3.1.1 to the comparison of redness degree around each group rabbit canker sore
Redness degree around deliberated index ulcer：Ⅰ：Congested diameter ＜ 1mm；Ⅱ：Congested 1~2mm of diameter；Ⅲ：It is congested straight 2~4mm of footpath；Ⅳ：Congested diameter ＞ 4mm.
Redness degree around each group rabbit canker sore of table 1
3.1.2 the comparison of each group different time points canker sore area (maximum transverse diameter × maximum indulges footpath)
The influence that table 2 changes to each group different time points canker sore area
Compared * * p with model control group<0.01, * * * p<0.001
3.1.3 each group rabbit canker sore healing time compares
Influence of the table 3 to each group rabbit healing
Compared * p with model control group<0.05, * * p<0.01
3.1.4 visually observe and Pathologic changes
3.1.4.1 visually observe
Ulcer Models the 1st day：Mucosa ulcer is circular, 5~6mm of diameter, neat in edge, surrounding congestion and edema, and center is in recessed Shape defect is fallen into, above there is the covering of yellow pseudomembrane；After drug-treated 3d, Bingpeng San group and Chinese medicine composition group ulcer area of the present invention become Small, about 4~5mm or so, pseudomembrane is thinning；After drug-treated 5d, Bingpeng San group and Chinese medicine composition group ulcer area of the present invention It is obviously reduced, about 3~4mm or so pseudomembranes come off, congestion and edema mitigates around ulcer；After drug-treated 7d, Bingpeng San group and Chinese medicine composition group ulcer of the present invention has healing；Non- healing person's ulcer diameter is about 1~2mm.
3.1.4.2 histological observation
Normal mucosa：Epithelium is complete, and lower section is loose connective tissue；Ulcer Models：Mucosal epithelium ulceration comes off, under mucous membrane A large amount of cell infiltrations, mostly lymphocyte and neutrophil leucocyte.Bingpeng San group and Chinese medicine composition group of the present invention have into fiber Scaly epithelium is complete, thicken after cell and scaly epithelium generation, ulcer healing, is loose connective tissue under mucous membrane.
3.2 rat canker sore are tested
3.2.1 there is canker sore after 1 week in the 3rd injections of antigens emulsifying agent in rat.Ulcer mostly occurs above and below
Lip, circular or ellipse, edge is more neat, the covering of yellow-white pseudomembrane.Diameter about 2~5mm, 3~5
D heals, rear to recur again.
3.2.2 the change of ulcer number
Compared with model group, Bingpeng San group and Chinese medicine composition group ulcer number of the present invention significantly reduce (p ＜ 0.05), hold The continuous time also substantially shortens (p ＜ 0.05), the relative extension (p ＜ 0.05, p ＜ 0.01) of recurrence time, and there were significant differences, is shown in Table 4.
The each group rat ulcer of table 4 changes
Compared * p with model control group<0.05, * * p<0.01
3.2.3 to IL-6 in rat blood serum, the influence of TNF-α change
Model group IL-6 and TNF-α level are significantly raised compared with normal group, Bingpeng San group and Chinese medicine composition group two of the present invention Person's level is remarkably decreased, and is compared that there were significant differences (p ＜ 0.05, p ＜ 0.01) with model control group, the results are shown in Table 5.
The each group rat ulcer of table 5 changes
Compared * p with model control group<0.05, * * p<0.01
4. conclusion
(1) Chinese medicine composition of the present invention can significantly reduce ulcer area and mitigate the effect of redness degree around ulcer, this May, swelling and pain relieving promoting blood circulation and removing blood stasis with it, vasodilator, improve the local sanguimotor effect of ulcer relevant.
(2) immunologic dysfunction, viral infection, microcirculation disorder, hypovitaminosis, endocrine disturbance, psychologic factors Deng the pathogenic factor for being likely to be canker sore.IL-6 and TNF-α are all the important inflammatory cells for participating in immune response The factor, plays an important role during cell function regulation, immune and inflammatory reaction of body etc..Chinese traditional medicine composition of the present invention Thing accelerates the healing of canker sore by adjusting body IL-6 and the change of TNF-α level.

Claims (3)

1. a kind of Chinese medicine composition for treating canker sore, it is characterized in that：Mixed by dandelion, Chinese violet, Radix Isatidis, Chinese lobelia Compound water extract extract powder and auxiliary material filler, binder, glidant composition；
Wherein, the percentage by weight between extract powder is raw materials used is：Dandelion 10%~30%, Chinese violet 10%~ 30%th, Radix Isatidis 10%~30%, Chinese lobelia 10%~30%；
The percentage by weight of extract powder and supplementary product consumption is：Extract powder 50%~75%, filler 5%~25%, binder 15%~25%, glidant 1%~5%.
2. a kind of Chinese medicine composition for treating canker sore according to claim 1, it is characterized in that：Described binder be EC or CP934P or HPC or HPMC or CMC-Na；Filler is starch or dextrin or lactose；Glidant is talcum powder or taste powder silica gel.
3. the preparation method of the Chinese medicine composition for the treatment of canker sore, comprises the following steps as claimed in claim 1：
(1) dandelion 10%~30%, Chinese violet 10%~30%, Chinese lobelia 10%~30%, plate are taken by weight percentage Blue root 10%~30%, is ground into coarse powder；
(2) coarse powder obtained by step (1) is added water 6~8 times of weight, decocts and extract 1~2 time, 30~60min, is filtered every time, is merged Filtrate twice, filtrate is concentrated to give medicinal extract, dry, pulverize, extract powder；
(3) take：EC or CP934P or HPC or HPMC or CMC-Na as binder, starch or dextrin or lactose as filler, Talcum powder or taste powder silica gel crush foregoing auxiliary material as glidant respectively, cross 100 mesh sieves；
(4) auxiliary material after sieving and extract powder are pressed into extract powder 50%~75%, filler 5%~25%, binder 15%~ 25%, the weight percent of glidant 1%~5% is mixed, and addition punch die is tabletted, produces.
CN201710115386.4A 2017-02-28 2017-02-28 It is a kind of to treat Chinese medicine composition of canker sore and preparation method thereof Pending CN107029056A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109044916A (en) * 2018-10-10 2018-12-21 广东心宝药业科技有限公司 A kind of Pudilan toothpaste and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1634383A (en) * 2004-11-29 2005-07-06 崔翼 Chinese violet containing capsule and its preparing process
CN102784245A (en) * 2012-08-01 2012-11-21 李虹霖 Erding granule and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1634383A (en) * 2004-11-29 2005-07-06 崔翼 Chinese violet containing capsule and its preparing process
CN102784245A (en) * 2012-08-01 2012-11-21 李虹霖 Erding granule and preparation method thereof

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CN109044916A (en) * 2018-10-10 2018-12-21 广东心宝药业科技有限公司 A kind of Pudilan toothpaste and preparation method thereof

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