CN106999498B - 用于治疗淋巴瘤的ezh2抑制剂 - Google Patents

用于治疗淋巴瘤的ezh2抑制剂 Download PDF

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Publication number
CN106999498B
CN106999498B CN201580036258.XA CN201580036258A CN106999498B CN 106999498 B CN106999498 B CN 106999498B CN 201580036258 A CN201580036258 A CN 201580036258A CN 106999498 B CN106999498 B CN 106999498B
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ezh2
subject
acid
lymphoma
treatment
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Chinese (zh)
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CN106999498A (zh
Inventor
海克·凯尔哈克
L·奥特森
L·瑞德曼
萨拉·K·克努森
L·丹尼尔·约翰斯顿
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Sanitary Material R&d Management Co ltd
Epizyme Inc
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Sanitary Material R&d Management Co ltd
Epizyme Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580036258.XA 2014-06-17 2015-06-17 用于治疗淋巴瘤的ezh2抑制剂 Active CN106999498B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110532717.0A CN113289022A (zh) 2014-06-17 2015-06-17 用于治疗淋巴瘤的ezh2抑制剂

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US201462013522P 2014-06-17 2014-06-17
US62/013,522 2014-06-17
US201462036265P 2014-08-12 2014-08-12
US62/036,265 2014-08-12
PCT/US2015/036310 WO2015195848A1 (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma

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CN106999498B true CN106999498B (zh) 2021-06-08

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BR112016029492A2 (pt) 2017-10-17
EP3157527A1 (en) 2017-04-26
SG10201811128RA (en) 2019-01-30
MX2016016744A (es) 2017-11-30
EP3157527A4 (en) 2018-05-23
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WO2015195848A1 (en) 2015-12-23
US20190175604A1 (en) 2019-06-13
WO2015195848A8 (en) 2016-07-07
US20200323866A1 (en) 2020-10-15
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AU2020244382B2 (en) 2022-08-04
US20200022987A1 (en) 2020-01-23
AU2020244382A1 (en) 2020-10-29
JP2017518334A (ja) 2017-07-06
IL285201B2 (en) 2024-05-01
CA2952074C (en) 2022-08-30
SI3157527T1 (sl) 2023-09-29
EA038337B1 (ru) 2021-08-11
MX2021007651A (es) 2021-08-11
IL309539A (en) 2024-02-01
SG11201610273VA (en) 2017-01-27
KR20230031963A (ko) 2023-03-07
US20170216300A1 (en) 2017-08-03
AU2015277139A1 (en) 2016-12-22
HUE062158T2 (hu) 2023-10-28
CA2952074A1 (en) 2015-12-23
KR20170052558A (ko) 2017-05-12
PL3157527T3 (pl) 2023-08-07
US20240058348A1 (en) 2024-02-22
DK3157527T3 (da) 2023-07-03
EP4252851A3 (en) 2023-11-22
IL249438A0 (en) 2017-02-28
US10166238B2 (en) 2019-01-01
EA201692285A1 (ru) 2017-06-30
IL285201A (en) 2021-08-31
ES2948442T3 (es) 2023-09-12
EP4252851A2 (en) 2023-10-04
CN106999498A (zh) 2017-08-01
CN113289022A (zh) 2021-08-24
US11642347B2 (en) 2023-05-09
MX383866B (es) 2025-03-14
PT3157527T (pt) 2023-06-30
AU2022263523A1 (en) 2022-12-08
JP6779793B2 (ja) 2020-11-04

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