CN106999439B - 用于生产包含活益生菌的软胶囊和包含具有长有效期的活益生菌的软胶囊的改进方法 - Google Patents

用于生产包含活益生菌的软胶囊和包含具有长有效期的活益生菌的软胶囊的改进方法 Download PDF

Info

Publication number
CN106999439B
CN106999439B CN201580048082.XA CN201580048082A CN106999439B CN 106999439 B CN106999439 B CN 106999439B CN 201580048082 A CN201580048082 A CN 201580048082A CN 106999439 B CN106999439 B CN 106999439B
Authority
CN
China
Prior art keywords
oil
soft gel
capsule
probiotic bacteria
capsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580048082.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN106999439A (zh
Inventor
J·菲利普
L·库尔特曼
梅特·温宁
J·M·卡佩尔戈德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asia Pacific Ltd
Original Assignee
Asia Pacific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asia Pacific Ltd filed Critical Asia Pacific Ltd
Publication of CN106999439A publication Critical patent/CN106999439A/zh
Application granted granted Critical
Publication of CN106999439B publication Critical patent/CN106999439B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Insects & Arthropods (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580048082.XA 2014-09-08 2015-09-08 用于生产包含活益生菌的软胶囊和包含具有长有效期的活益生菌的软胶囊的改进方法 Active CN106999439B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1415862.0A GB201415862D0 (en) 2014-09-08 2014-09-08 Process
GB1415862.0 2014-09-08
PCT/GB2015/052594 WO2016038355A1 (en) 2014-09-08 2015-09-08 An improved process for producing a soft gel capsule comprising viable probiotic bacteria and a soft gel capsule comprising viable probiotic bacteria having a long shelf life

Publications (2)

Publication Number Publication Date
CN106999439A CN106999439A (zh) 2017-08-01
CN106999439B true CN106999439B (zh) 2021-01-08

Family

ID=51796364

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580048082.XA Active CN106999439B (zh) 2014-09-08 2015-09-08 用于生产包含活益生菌的软胶囊和包含具有长有效期的活益生菌的软胶囊的改进方法

Country Status (10)

Country Link
US (1) US20170258857A1 (da)
EP (2) EP3446695B1 (da)
JP (1) JP2017529099A (da)
CN (1) CN106999439B (da)
DK (2) DK3446695T3 (da)
ES (2) ES2769302T3 (da)
GB (1) GB201415862D0 (da)
PL (2) PL3446695T3 (da)
TR (1) TR201908675T4 (da)
WO (1) WO2016038355A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018165563A1 (en) * 2017-03-09 2018-09-13 The Clorox Company Probiotic capsule and methods of preparing the same
US11896720B2 (en) * 2017-09-26 2024-02-13 Captek Softgel International Orally available articles containing at least one stabilized supplement therein
CN107594538B (zh) * 2017-10-20 2020-10-16 青岛伸东矿液有限公司 一种分子筛生物制剂及其制备方法
CA3142389A1 (en) * 2019-06-13 2020-12-17 Lactobio A/S A gel composition comprising viable microorganisms
GR1010228B (el) * 2020-12-09 2022-05-05 UNI-PHARMA ΚΛΕΩΝ ΤΣΕΤΗΣ ΦΑΡΜΑΚΕΥΤΙΚΑ ΕΡΓΑΣΤΗΡΙΑ ΑΒΕΕ με δ.τ. "UNI-PHARMA ABEE", Διατροφικο συμπληρωμα για την απο του στοματος χορηγηση συνδυασμου βιταμινων, μεταλλων, φυσικων εκχυλισματων, προβιοτικων για την ενισχυση του ανοσοποιητικου συστηματος
BE1030385B1 (fr) * 2022-03-24 2023-10-23 Bellavie Capsules à usage par voie orale comprenant une formulation à base de probiotiques, conditionnées en dose unitaire dans un emballage-coque stratifié

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120107395A1 (en) * 2010-11-01 2012-05-03 Viva Pharmaceutical Inc. Probiotic Soft Gel Compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2127392C (en) * 1993-07-08 2008-05-27 Hideki Sunohara Process for producing capsule and capsule obtained thereby
US7214370B2 (en) * 2000-12-18 2007-05-08 Probiohealth, Llc Prebiotic and preservative uses of oil-emulsified probiotic encapsulations
US20030138483A1 (en) * 2001-05-25 2003-07-24 Sergio Petriconi Soft elastic capsules and compositions thereof
WO2008046625A2 (en) * 2006-10-18 2008-04-24 Dsm Ip Assets B.V. Encapsulation of heat and moisture sensitive substances
JP2010516308A (ja) * 2007-01-20 2010-05-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ソフトカプセルを含むパック
GB0801643D0 (en) * 2008-01-29 2008-03-05 Probio Nutraceuticals As Product
CA3065589C (en) * 2010-06-03 2022-04-26 Catalent Ontario Limited Multi phase soft gel capsules, apparatus and method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120107395A1 (en) * 2010-11-01 2012-05-03 Viva Pharmaceutical Inc. Probiotic Soft Gel Compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
明胶在胶囊中的应用;李承献;《明胶科学与技术》;20120315;第32卷(第1期);第40-46页 *

Also Published As

Publication number Publication date
EP3177301B1 (en) 2019-03-20
EP3446695A1 (en) 2019-02-27
GB201415862D0 (en) 2014-10-22
DK3177301T3 (da) 2019-06-17
PL3446695T3 (pl) 2020-05-18
ES2769302T3 (es) 2020-06-25
ES2731816T3 (es) 2019-11-19
TR201908675T4 (tr) 2019-07-22
JP2017529099A (ja) 2017-10-05
CN106999439A (zh) 2017-08-01
EP3446695B1 (en) 2019-10-30
US20170258857A1 (en) 2017-09-14
WO2016038355A1 (en) 2016-03-17
PL3177301T3 (pl) 2019-10-31
EP3177301A1 (en) 2017-06-14
DK3446695T3 (da) 2020-02-03

Similar Documents

Publication Publication Date Title
CN106999439B (zh) 用于生产包含活益生菌的软胶囊和包含具有长有效期的活益生菌的软胶囊的改进方法
RU2593788C2 (ru) Способ изготовления стабильной мягкой гелевой капсулы, содержащей микроинкапсулированные пробиотические бактерии
US20100055083A1 (en) Encapsulation of heat and moisture sensitive substances
Chan et al. Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium
JP6468633B2 (ja) 三層構造シームレスカプセル
KR20230129965A (ko) 장용성 연질캡슐제용 유산균 복합제, 이의 제조방법 및 이를 포함하는 복합 기능성 장용성 연질캡슐제
JP2021521249A (ja) 耐湿性プロバイオティック顆粒およびその製造方法
JP6640966B2 (ja) 三層構造シームレスカプセル
Bollom Development and characterization of a novel, edible bigel system with the potential to protect probiotics during in vitro digestion
CN114874935A (zh) 一种高活性的益生菌制剂组合物及其制备方法
KR20220142402A (ko) 유산균 슬러리를 포함하는 장용성 연질 캡슐제
WO2024076586A2 (en) Lipid encapsulated probiotic compositions
CN117256859A (zh) 包含活益生菌的饮料和使用的多层滴丸
CN117257845A (zh) 靶向投递活益生菌的方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1241276

Country of ref document: HK

CB02 Change of applicant information
CB02 Change of applicant information

Address after: German Liz Walker

Applicant after: Asia Pacific Limited

Address before: German Liz Walker

Applicant before: Ayanda GmbH & Co. KG

GR01 Patent grant
GR01 Patent grant