CN106983821B - A kind of pharmaceutical composition of strengthen immunity and preparation method thereof, preparation and application - Google Patents
A kind of pharmaceutical composition of strengthen immunity and preparation method thereof, preparation and application Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of pharmaceutical composition of strengthen immunity and preparation method thereof, preparation and application.The pharmaceutical composition of the strengthen immunity includes 300 ~ 400 parts of 100 ~ 300 parts of ginseng, the tuber of dwarf lilyturf and 100 ~ 300 parts of the hawthorn of parts by weight of raw materials, is prepared through pre-treatment, extraction, post-processing step.Preparation is prepared into powder, tablet, capsule, granule and pill to add pharmaceutically acceptable auxiliary material in the pharmaceutical composition of the strengthen immunity.The application in improving the immunity of the human body medicine, food and health food is being prepared using the pharmaceutical composition for the strengthen immunity.Each taste material is complementary in terms of effect in compatibility of the present invention, mutually increases, and has the effect of invigorating the spleen and stomach, and full side is by strengthening the body resistance to consolidate the constitution, the effect of supplementing qi and nourishing yin, have received the expection health-care efficacy of enhancing body immunity.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of pharmaceutical composition of strengthen immunity and its preparation side
Method, preparation and application.
Background technology
With the fast development of economic society, people bear while material and the level of cultural life increase substantially
The stress than bigger in the past, there is the problem of more in physically and mentally healthy aspect, and the aged increases considerably in addition,
The influence of many factors such as the destruction of ecological environment, environmental pollution, the people that China has nearly 70% are in sub-health state, particularly
The crowd of hypoimmunity is numerous, and the health care belt to people carrys out high risks.
The invasion and attack of body defenses pathogenic microorganism modern medicine believes that, immune, identification and remove exotic antigen foreign matter with from
Body is denatured material, with a kind of physiological function for maintaining organism balance and stablizing.Human body has complete immune function in itself, perfect
Immune system and sensitive immune response.Immune function is normal, just can identify " non-oneself ", excludes " dissident ", preservation " oneself
Oneself ", human body is in health status.But due to the influence of a variety of undesirable elements, the immune function of human body can be caused to decline, it is all
Such as the aging of older population histoorgan, can immunogenicity decline, and for example nutrient imbalance, chronic disease, mental work load is overweight, the heart
Pressure increase is managed, the factors such as environmental pollution, can make human body immunity degradation, so as to cause various infectious diseases and non-infectious
The incidence of disease, the death rate increase.
In order to strengthen immune function of human body, doctor trained in Western medicine is mainly the various skin test therapies using cell immune response（PHA skins
Examination）And a variety of therapies such as thymosin extrasin, interferon, transfer factor, interleukins；The traditional Chinese medical science is then emphasized to strengthen the body resistance to consolidate the constitution, and benefit defends gas,
Nourish blood gas, the premunition of body, its used dietotherapy, natural materials therapy and the therapy phase of western medicine are transferred from organic conception
Than having the advantages of safe, entirety is nursed one's health, expense is relatively low etc..People are more desirable can be had from the exploitation of TCM Recipe face
Go out the product of strengthen immunity, therefore, develop a kind of product of the strengthen immunity of compound people's demand and be very important.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition of strengthen immunity；Second purpose is to provide institute
The preparation method of the pharmaceutical composition for the strengthen immunity stated；3rd purpose is the medicine group for providing the strengthen immunity
The preparation of compound；4th purpose is the application for providing the pharmaceutical composition of the strengthen immunity.
The first object of the present invention is achieved in that the pharmaceutical composition of the strengthen immunity includes raw material weight
300 ~ 400 parts of 100 ~ 300 parts of the ginseng, the tuber of dwarf lilyturf of part and 100 ~ 300 parts of hawthorn, prepare through pre-treatment, extraction, post-processing step
Obtain.
The second object of the present invention is achieved in that including pre-treatment, extraction and post-processing step, is specifically included：
A, pre-treatment：By that the raw material ginseng of formulation ratio is sterilized, crushed after being dried sieves to obtain material a is spare, at the same time
By the raw material hawthorn of formulation ratio, the tuber of dwarf lilyturf pulverizes and sieves, to be mixed to get material b spare；
B, extract：60 ~ 80% ethanol solution of concentration expressed in percentage by volume of 4 ~ 8 times of material b weight will be added in material b, in temperature
60 ~ 80 DEG C of refluxing extractions 1 ~ 3 time, 1 ~ 2h, merges extracting solution, concentration, is dried to obtain dry cream c every time；
C, post-process：Material a and dry cream c co-grindings are sieved to obtain material d, formulation ratio is added in material d
Amino acid is uniformly mixed to obtain the pharmaceutical composition of object strengthen immunity.
The third object of the present invention is achieved in that in the pharmaceutical composition of the strengthen immunity and adds pharmaceutically
Acceptable auxiliary material is prepared into powder, tablet, capsule, granule and pill.
The fourth object of the present invention is achieved in that the pharmaceutical composition of the strengthen immunity is preparing raising people
Application in body immunity medicine, food and health food.
The present invention is made of ginseng, the tuber of dwarf lilyturf, hawthorn, 4 taste material of compound amino acid.It is at traditional ancient prescription " Shengmai San "
（《Essential Recipes for Emergent Use Worth A Thousand Gold》）On the basis of add and subtract the formula of composition.
Ginseng in inventive formulation is Araliaceae ginseng panax ginsengC, the drying root and rhizome of A, Mey.
Nature and flavor are sweet, slight bitter, returns spleen, lung, the heart channel of Hang-Shaoyin, ginseng have reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, it is promoting production of body fluid and inducing sedation of the mind the effect of, be
The traditional traditional tonic medicine in China, applicating history more than 4,000 years existing, history tree is on the books,《Dragon Lord book on Chinese herbal medicine warp》By ginseng
It is classified as top grade；《Food book on Chinese herbal medicine》Described in：" ginseng is sweet in flavor to be slightly cold, nontoxic.Main bushing is dirty, soothe the nerves, determines soul, and stop palpitate with fear, is removed
Perverse trend, the happy intelligence development of improving eyesight, long term usage are made light of one's life by commiting suicide macrobiosis." ginseng energy building up healthful vital energy, training tonifying spleen and stomach, the premunition for strengthening human body, therefore
There is strengthen immunity.
The tuber of dwarf lilyturf in inventive formulation is liliaceous plant ophiopogon Ophinopogon japonicus（Thunb.）Ker-
Gawl. dried root.Nature and flavor are sweet, slight bitter, are slightly cold.The thoughts of returning home, lung, stomach.With nourishing Yin and promoting production of body fluid, the effect of moistening lung clears away heart-fire, make
For the product of reinforcing both QI and YIN, clinic is widely used in.《Dragon Lord book on Chinese herbal medicine warp》It is classified as top grade；Song Dynasty《Figure is through book on Chinese herbal medicine》Carry：The tuber of dwarf lilyturf
Decoct, heat wineization takes, has the effect of " bowl spares invigorating heart, beneficial color, QI invigorating of calming the nerves ".The tuber of dwarf lilyturf is not only attached most importance in clinical practice
The tonifying yin medicine wanted, and play the role of tonifying Qi invigorating heart.The effect of helping ginseng qi-tonifying is not only helped with ginseng compatibility, and can be played foster
Cloudy effect." ginseng wheat dissipates " is the classical prescription for treating syndrome of deficiency of both qi and yin, and more clinical reports show, different deficiency of both qi and yin sides
Medicine, from the Analysis on Mechanism of immunity enhancing, shows good auxiliary therapeutic action to the auxiliary treatment of tumour patient." high and level tone sun
Secret, the life activities being normally maintained " tuber of dwarf lilyturf improves the immunity of the human body aspect and plays important work in enriching yin, tonifying Qi, adjustment human body yin-yang balancing
With.
Haw taste rose family large-fruited Chinese hawthorn Crataegus pinnatifida Bge.var.major in inventive formulation
The dry mature fruit of N.E.Br.Nature and flavor are sour, sweet, tepor.Returns spleen, lung, Liver Channel.With food digesting stomach fortifying, promote the production of body fluid to quench thirst, promoting the circulation of qi
The effect of dissipating the stasis of blood,《Food book on Chinese herbal medicine》Record：" hawthorn is sour, cold, nontoxic.Cure mainly dyspepsia, tonifying spleen ".Modern research shows that hawthorn
Have a reducing blood lipid, expand can coronary artery, increase coronary flow and the effect of improve humoral immunity and cellular immunity, hawthorn in formula should
With, the effect of can not only helping ginseng of helping others, the tuber of dwarf lilyturf, but also the effect of hawthorn invigorating the spleen and stomach, can prevent prolonged application tonic from producing
Raw stomach and intestine grow the drawbacks of greasy.
Compound amino acid in inventive formulation can improve the cellular immunity and humoral immunity of the mouse of immunologic hypofunction
Function, promotes the increase of the weight of immune organ spleen and thymus gland, moreover it is possible to strengthen mouse peripheral blood mononuclear phagocytic cells carbon particle clearance
Ability.The various products of amino acid also serve as the health food extensive use improved the immunity of the human body.
Complete square compatibility 5 in summary, just subtract Schisandra chinensis based on ancient prescription Shengmai San, increase hawthorn and amino acid, formula
In the record of effect existing medical ancient books of each single material to strengthen immunity have clinical and modern pharmacology research base again
Plinth, each taste material is complementary in terms of effect in compound compatibility, mutually increases, and has the effect of invigorating the spleen and stomach, full side by strengthening the body resistance to consolidate the constitution,
The effect of supplementing qi and nourishing yin, have received the expection health-care efficacy of enhancing body immunity.
Brief description of the drawings
Fig. 1 is present invention process flow diagram.
Embodiment
With reference to embodiment and attached drawing, the present invention is further illustrated, but the present invention is not subject in any way
Limitation, based on present invention teach that any conversion or replacement made, belong to protection scope of the present invention.
The pharmaceutical composition of strengthen immunity of the present invention includes 100 ~ 300 parts of ginseng, the Mai Men of parts by weight of raw materials
100 ~ 300 parts of 300 ~ 400 parts of winter and hawthorn, are prepared through pre-treatment, extraction, post-processing step.
The raw material further includes 70 ~ 80 parts of the compound amino acid of parts by weight.
Ginseng 150 ~ 250 part of the pharmaceutical composition of the strengthen immunity including parts by weight of raw materials, the tuber of dwarf lilyturf 300 ~
70 ~ 80 parts of 400 parts, 150 ~ 250 parts of hawthorn and amino acid.
The preparation method of the pharmaceutical composition of strengthen immunity of the present invention, including pre-treatment, extraction and post processing
Step, specifically includes：
A, pre-treatment：By that the raw material ginseng of formulation ratio is sterilized, crushed after being dried sieves to obtain material a is spare, at the same time
By the raw material hawthorn of formulation ratio, the tuber of dwarf lilyturf pulverizes and sieves, to be mixed to get material b spare；
B, extract：60 ~ 80% ethanol solution of concentration expressed in percentage by volume of 4 ~ 8 times of material b weight will be added in material b, in temperature
60 ~ 80 DEG C of refluxing extractions 1 ~ 3 time, 1 ~ 2h, merges extracting solution, concentration, is dried to obtain dry cream c every time；
C, post-process：Material a and dry cream c co-grindings are sieved to obtain material d, formulation ratio is added in material d
Amino acid is uniformly mixed to obtain the pharmaceutical composition of object strengthen immunity.
The broken sieving of raw material ginseng pulverate is to crushed 80 mesh sieves in step A.
It is that crushed 10 mesh sieves that raw material hawthorn, the tuber of dwarf lilyturf, which pulverize and sieve, in step A.
Drying described in step B is microwave drying, and drying temperature is 60 ~ 70 DEG C.
Pulverize and sieve in step C is that crushed 80 mesh sieves.
The preparation of the pharmaceutical composition of strengthen immunity of the present invention is the drug regimen of the strengthen immunity
Pharmaceutically acceptable auxiliary material is added in thing and is prepared into powder, tablet, capsule, granule and pill.
The application of the pharmaceutical composition of strengthen immunity of the present invention is the drug regimen of the strengthen immunity
Thing is preparing the application in improving the immunity of the human body medicine, food and health food.
Case is embodied, the present invention will be further described below：
Embodiment 1
Ginseng 100g, tuber of dwarf lilyturf 300g, hawthorn 100g are weighed, ginseng be crushed into 80 mesh sieves spare, the wheat that obtains ginseng pulverate
Door winter and hawthorn crushed 10 mesh sieves, add the ethanol solution of the concentration expressed in percentage by volume 60% of 4 times of the tuber of dwarf lilyturf and hawthorn weight, in
60 ~ 80 DEG C of temperature refluxing extraction 3 times, each 1h, merges extracting solution, and concentration, 60 DEG C of microwave dryings, crushed 80 mesh sieves, with
Ginseng pulverate mixes, and the composite aminophenol powder for adding 70g is uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 2
Ginseng 300g, tuber of dwarf lilyturf 400g, hawthorn 300g are weighed, ginseng be crushed into 80 mesh sieves spare, the wheat that obtains ginseng pulverate
Door winter and hawthorn crushed 10 mesh sieves, add the ethanol solution of the concentration expressed in percentage by volume 80% of 4 ~ 8 times of the tuber of dwarf lilyturf and hawthorn weight,
In 60 ~ 80 DEG C of temperature refluxing extraction 1 time, time 2h, extracting solution concentration, 70 DEG C of microwave dryings, crushed 80 mesh sieves, with
Ginseng pulverate mixes, and the composite aminophenol powder for adding 80g is uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 3
Ginseng 200g, tuber of dwarf lilyturf 350g, hawthorn 200g are weighed, ginseng be crushed into 80 mesh sieves spare, the wheat that obtains ginseng pulverate
Door winter and hawthorn crushed 10 mesh sieves, add the ethanol solution of the concentration expressed in percentage by volume 70% of 4 ~ 8 times of the tuber of dwarf lilyturf and hawthorn weight,
In 60 ~ 80 DEG C of temperature refluxing extraction 2 times, each 1.5h, merges extracting solution, concentration, 65 DEG C of microwave dryings, crushed 80 mesh
Sieve, mixes with ginseng pulverate, and the composite aminophenol powder for adding 75g is uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 4
Ginseng 100g, tuber of dwarf lilyturf 400g, hawthorn 200g are weighed, ginseng be crushed into 80 mesh sieves spare, the wheat that obtains ginseng pulverate
Door winter and hawthorn crushed 10 mesh sieves, add the ethanol solution of the concentration expressed in percentage by volume 70% of 4 ~ 8 times of the tuber of dwarf lilyturf and hawthorn weight,
In 60 ~ 80 DEG C of temperature refluxing extraction 2 times, each 2h, merges extracting solution, concentration, 70 DEG C of microwave dryings, crushed 80 mesh
Sieve, mixes with ginseng pulverate, and the composite aminophenol powder for adding 80g is uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 5
Ginseng 250g, tuber of dwarf lilyturf 300g, hawthorn 300g are weighed, ginseng be crushed into 80 mesh sieves spare, the wheat that obtains ginseng pulverate
Door winter and hawthorn crushed 10 mesh sieves, add the ethanol solution of the concentration expressed in percentage by volume 80% of 8 times of the tuber of dwarf lilyturf and hawthorn weight, in
60 ~ 80 DEG C of temperature refluxing extraction 3 times, each 1h, merges extracting solution, and concentration, 68 DEG C of microwave dryings, crushed 80 mesh sieves, with
Ginseng pulverate mixes, and the composite aminophenol powder for adding 77g is uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 6
Ginseng 300g, tuber of dwarf lilyturf 300g, 100 ~ g of hawthorn are weighed, ginseng be crushed into 80 mesh sieves spare, the wheat that obtains ginseng pulverate
Door winter and hawthorn crushed 10 mesh sieves, add the ethanol solution of the concentration expressed in percentage by volume 65% of 7 times of the tuber of dwarf lilyturf and hawthorn weight, in
60 ~ 80 DEG C of temperature refluxing extraction 3 times, each 1.5h, merges extracting solution, and concentration, 65 DEG C of microwave dryings, crushed 80 mesh sieves,
Mixed with ginseng pulverate, the composite aminophenol powder for adding 75g is uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 7
Ginseng 100g, tuber of dwarf lilyturf 300g, hawthorn 300g are weighed, propylhomoserin medicinal extract 20g is glued, respectively by ginseng and viscous propylhomoserin medicinal extract
It crushed that 80 mesh sieves obtain ginseng pulverate and viscous propylhomoserin powder is spare, the tuber of dwarf lilyturf and hawthorn crushed 10 mesh sieves, add the tuber of dwarf lilyturf and mountain
The ethanol solution for the concentration expressed in percentage by volume 70% that 6 times of short, bristly hair or beard weight, in 60 ~ 80 DEG C of temperature refluxing extraction 3 times, each 1.5h, merges
Extracting solution, concentration, 60 ~ 70 DEG C of microwave dryings, crushed 80 mesh sieves, are mixed with ginseng pulverate and viscous propylhomoserin extract powder, add 60g
Composite aminophenol powder be uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 8
Ginseng 300g, tuber of dwarf lilyturf 350g, hawthorn 200g are weighed, propylhomoserin medicinal extract 40g is glued, respectively by ginseng and viscous propylhomoserin medicinal extract
It crushed that 80 mesh sieves obtain ginseng pulverate and viscous propylhomoserin powder is spare, the tuber of dwarf lilyturf and hawthorn crushed 10 mesh sieves, add the tuber of dwarf lilyturf and mountain
The ethanol solution for the concentration expressed in percentage by volume 70% that 4 ~ 8 times of short, bristly hair or beard weight, in 60 ~ 80 DEG C of temperature refluxing extraction 2 times, each 2h, merges
Extracting solution, concentration, 65 DEG C of microwave dryings, crushed 80 mesh sieves, are mixed with ginseng pulverate and viscous propylhomoserin extract powder, add 35g's
Composite aminophenol powder is uniformly mixed so as to obtain the pharmaceutical composition of object strengthen immunity.
Embodiment 9
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition for the strengthen immunity that embodiment 2 is prepared to prepare
Into powder.
Embodiment 10
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition for the strengthen immunity that embodiment 3 is prepared to prepare
Piece agent.
Embodiment 11
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition for the strengthen immunity that embodiment 5 is prepared to prepare
Into capsule.
Embodiment 12
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition for the strengthen immunity that embodiment 6 is prepared to prepare
Into granule.
Embodiment 13
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition for the strengthen immunity that embodiment 8 is prepared to prepare
Into pill.
Embodiment 14
The pharmaceutical composition for the strengthen immunity being prepared with embodiment 3 carries out the following test of pesticide effectiveness：
Experimental animal：Kunming mouse（2 monthly ages）, 20 ± 2g of weight, half male and half female, is carried by animal section of unming Medical College
For.
Experiment equipment：XSB211 types microscope, incubator, mouse fixed plate, tool lid enamel tray etc..
Sample and reagent：The pharmaceutical composition for the strengthen immunity that embodiment 3 is prepared, 6% is made into by it with distilled water
Suspension it is spare.5% chicken red blood cell suspension, physiological saline, 4%（V/V）Ji's nurse Sa-auspicious special Albert'stain Albert liquid.
Experimental method：Mouse is taken to be randomly divided into 2 groups：That is sample sets and control group, every group each 20.The daily gavage of sample sets
Only, control group gives isometric(al) physiological saline to 0.5ml/, totally 10 days.5% chicken red blood cell liquid is injected intraperitoneally per mouse when 1 is small after drug withdrawal
0.4ml, 10 it is small when after animal cervical dislocation is put to death, face upward position and be fixed on mouse plate.Belly is sterilized, skin is cut off, is given birth to through Intraperitoneal injection
Manage brine 2.5ml.Fixed plate 1 minute is rotated, then extracts abdominal cavity washing lotion 1ml, drop coating is on clean slide, every 0.2ml,
Totally 2, it is placed in the enamel box for being lined with wet gauze, is placed in 37 DEG C of incubators and incubates 30 minutes, take out slide, puts into physiological saline
Middle rinsing, to remove the cell of non-patch.Dry, with one methanol solution of acetone（1:1）5 minutes are fixed, then with 4% Ji's nurse Sa-auspicious
Te Shi liquid dyes 3-5 minutes, is rinsed, dried with distilled water.Every meter number of macrophages 200, are calculated as follows under oil mirror
Its phagocytic index and phagocytic percentage：
Phagocytic index=
Phagocytic percentage=× 100%
As a result with conclusion：
It the results are shown in Table 1
The pharmaceutical composition for the strengthen immunity that 1 embodiment 3 of table is prepared swallows work(to Turnover of Mouse Peritoneal Macrophages
The influence of energy
*P<0.05
Test result indicates that the difference that sample sets compared with the control group, are statistically analyzed two groups of phagocytic index has significantly
Property, the phagocytosis work of Turnover of Mouse Peritoneal Macrophages can be improved by showing the pharmaceutical composition for the strengthen immunity that embodiment 3 is prepared
With.
Embodiment 15
It is prepared into respectively with embodiment 1, embodiment 2, embodiment 4, embodiment 5, embodiment 6, embodiment 7 and embodiment 8
To the pharmaceutical composition of strengthen immunity tested, as a result method shows, enhancing of the present invention with embodiment 14
The pharmaceutical composition of immunity can improve the phagocytosis of Turnover of Mouse Peritoneal Macrophages.
Claims (6)
1. a kind of pharmaceutical composition of strengthen immunity, it is characterised in that the raw material of the pharmaceutical composition of the strengthen immunity is
Ginseng, 300 ~ 400 parts of the tuber of dwarf lilyturf, 100 ~ 300 parts of hawthorn and 70 ~ 80 parts of the compound amino acid that 100 ~ 300 parts of parts by weight,
Preparation method includes pre-treatment, extraction and post-processing step, specifically includes：
A, pre-treatment：By the raw material ginseng of formulation ratio is sterilized, crushed after being dried crosses 80 mesh sieves to obtain material a spare, at the same time
By the raw material hawthorn of formulation ratio, the tuber of dwarf lilyturf crushed 10 mesh sieves, to be mixed to get material b spare；
B, extract：60 ~ 80% ethanol solution of concentration expressed in percentage by volume of 4 ~ 8 times of material b weight will be added in material b, in temperature 60 ~
80 DEG C of refluxing extractions 1 ~ 3 time, 1 ~ 2h, merges extracting solution, concentration, is dried to obtain dry cream c every time；
C, post-process：Material a and dry cream c co-grindings are sieved to obtain material d, the amino of formulation ratio is added in material d
Acid is uniformly mixed and obtains the pharmaceutical composition of object strengthen immunity.
2. the pharmaceutical composition of strengthen immunity according to claim 1, it is characterised in that raw material is 150 ~ 250 parts of parts by weight
Ginseng, 300 ~ 400 parts of the tuber of dwarf lilyturf, 150 ~ 250 parts of hawthorn and 70 ~ 80 parts of compound amino acid.
3. the pharmaceutical composition of strengthen immunity according to claim 1, it is characterised in that drying is microwave described in step B
Dry, drying temperature is 60 ~ 70 DEG C.
4. the pharmaceutical composition of strengthen immunity according to claim 1, it is characterised in that it is to crush to pulverize and sieve in step C
Cross 80 mesh sieves.
5. a kind of preparation of the pharmaceutical composition of the strengthen immunity of claim 1 or 2, it is characterised in that the enhancing is immune
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition of power and is prepared into powder, tablet, capsule, granule or pill.
6. a kind of pharmaceutical composition of the strengthen immunity of claim 1 or 2 is improved the immunity of the human body in preparation in medicine
Using.
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| CN109247536A (en) * | 2018-09-25 | 2019-01-22 | 武汉万密斋养生堂科技发展股份有限公司 | A kind of food granule of strengthen immunity and preparation method thereof |
| CN111686238A (en) * | 2020-07-17 | 2020-09-22 | 杜振晓 | Traditional Chinese medicine formula for conditioning human body and improving immunity |
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| CN1283500A (en) * | 1999-08-04 | 2001-02-14 | 成都迪康药物研究所 | Freeze-dried 'Shenmai' powder for injection and its preparing process |
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| CN1283500A (en) * | 1999-08-04 | 2001-02-14 | 成都迪康药物研究所 | Freeze-dried 'Shenmai' powder for injection and its preparing process |
Non-Patent Citations (2)
| Title |
|---|
| 复合氨基酸胶囊改善外科患儿免疫功能的临床研究;吕金星等;《苏州医学院学报》;19961231(第06期);第1077页，左栏第1段 * |
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