CN106963901A - It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof - Google Patents
It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof Download PDFInfo
- Publication number
- CN106963901A CN106963901A CN201710370536.6A CN201710370536A CN106963901A CN 106963901 A CN106963901 A CN 106963901A CN 201710370536 A CN201710370536 A CN 201710370536A CN 106963901 A CN106963901 A CN 106963901A
- Authority
- CN
- China
- Prior art keywords
- parts
- powder
- medicinal preparation
- new medicinal
- earthworm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 68
- 201000004595 synovitis Diseases 0.000 title claims abstract description 34
- 241000283966 Pholidota <mammal> Species 0.000 claims abstract description 48
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 46
- 241000545744 Hirudinea Species 0.000 claims abstract description 44
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 43
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 43
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 43
- 241000258920 Chilopoda Species 0.000 claims abstract description 43
- 239000004863 Frankincense Substances 0.000 claims abstract description 43
- 241000219357 Cactaceae Species 0.000 claims abstract description 37
- 239000002994 raw material Substances 0.000 claims abstract description 36
- 235000015099 wheat brans Nutrition 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 240000001592 Amaranthus caudatus Species 0.000 claims abstract description 21
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims abstract description 21
- 235000012735 amaranth Nutrition 0.000 claims abstract description 21
- 239000004178 amaranth Substances 0.000 claims abstract description 21
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 21
- 239000010440 gypsum Substances 0.000 claims abstract description 21
- 244000080208 Canella winterana Species 0.000 claims abstract description 20
- 235000008499 Canella winterana Nutrition 0.000 claims abstract description 20
- 244000197580 Poria cocos Species 0.000 claims abstract description 20
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 20
- 229940017545 cinnamon bark Drugs 0.000 claims abstract description 20
- 241001200666 Populus adenopoda Species 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims description 98
- 239000000203 mixture Substances 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 18
- 238000009835 boiling Methods 0.000 claims description 14
- 239000012141 concentrate Substances 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 9
- 241000264877 Hippospongia communis Species 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- 235000019991 rice wine Nutrition 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000000967 suction filtration Methods 0.000 claims description 7
- 239000003860 topical agent Substances 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 241001251949 Xanthium sibiricum Species 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 241000219000 Populus Species 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 31
- 238000011282 treatment Methods 0.000 abstract description 29
- 239000008280 blood Substances 0.000 abstract description 16
- 210000004369 blood Anatomy 0.000 abstract description 16
- 210000002784 stomach Anatomy 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 9
- 230000017531 blood circulation Effects 0.000 abstract description 7
- 206010067484 Adverse reaction Diseases 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 3
- 230000006838 adverse reaction Effects 0.000 abstract description 3
- 230000000202 analgesic effect Effects 0.000 abstract description 3
- 238000010792 warming Methods 0.000 abstract description 2
- 230000004087 circulation Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 34
- 210000000629 knee joint Anatomy 0.000 description 20
- 208000024891 symptom Diseases 0.000 description 11
- 210000000952 spleen Anatomy 0.000 description 8
- 208000006820 Arthralgia Diseases 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 206010023232 Joint swelling Diseases 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 210000003127 knee Anatomy 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 231100000862 numbness Toxicity 0.000 description 5
- 241000521257 Hydrops Species 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 210000002414 leg Anatomy 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 210000001258 synovial membrane Anatomy 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 208000032912 Local swelling Diseases 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 206010071759 Muscle oedema Diseases 0.000 description 2
- 208000006735 Periostitis Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 238000004378 air conditioning Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 201000005917 gastric ulcer Diseases 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 230000003447 ipsilateral effect Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000003460 periosteum Anatomy 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- CVCQAQVBOPNTFI-AAONGDSNSA-N (3r,4r,5s,6r)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol;sulfuric acid Chemical compound OS(O)(=O)=O.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O CVCQAQVBOPNTFI-AAONGDSNSA-N 0.000 description 1
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010065564 Floating patella Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 206010061223 Ligament injury Diseases 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 241000469816 Varus Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000001663 anti-spastic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 241001233061 earthworms Species 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001171 synovial bursa Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Present invention offer is a kind of to treat new medicinal preparation of synovitis and preparation method thereof, is related to technical field of pharmaceuticals.New medicinal preparation of the present invention is made up of following raw material：Wheat bran, cactus, moxibustion radix glycyrrhizae, leech, pangolin scale, earthworm, rhizome of chuanxiong, centipede, Radix Angelicae Sinensis, frankincense, honeycomb, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos, gypsum, the new medicinal preparation of present invention treatment synovitis has promoting blood circulation and removing blood stasis, radiating analgesic, warming and activating meridian, dispelling wind and eliminating dampness, the effect of the scattered stasis of blood of promoting circulation of blood, the pharmaceutical preparation takes small to the excitant of human stomach, instant effect, good effect, without obvious adverse reaction and side effect.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and in particular to a kind of new medicinal preparation for treating synovitis and its preparation side
Method.
Background technology
Synovitis is a kind of sterile type inflammation, is that synovial membrane is upset generation inflammation, causes juice to lack of proper care to form hydrops
A kind of arthropathy.Synovitis is mainly because of joint sprain and a variety of intraarticular damages, and the one group of syndrome caused.Synovial membrane
Inflammation easily cause patient temporarily or long term portion disability, to patient and to society harm it is all larger.With life
The quickening that movable joint is played, it is also more and more to obtain synovitis number, occurs that hydrops articuli is red and swollen, become if treatment patient not in time
Shape, heavy tingle, the cold symptom of pain etc. more of limbs, and arthroedema, pain, dysarthrasis are also resulted in, it is even maimed.
In the prior art using doctor trained in Western medicine and process of Chinese patent medicine treatment synovitis, western medicine is such as：It is hormone, drawing liquid, flushing, anti-
The treatments such as raw element, though obtaining the curative effect of some satisfactions, treat not thorough, while the side effect of Western medicine is too many, to the heart, liver, kidney
It is also very big Deng organ damage, the adverse reactions such as gastric ulcer are easily produced, and easily recur.The Chinese medicine used in process of Chinese patent medicine
Material all nature and flavor are worked hard, and have stimulation to stomach, and Time of Administration is long necessarily to injure one's stomach, and synovitis is chronic disease, it is necessary to long-term
Treat, therefore long-term taking can be damaged to stomach.
Up to the present, do not find also a kind of can thoroughly cure the specific medicament of synovitis.
The content of the invention
In view of the shortcomings of the prior art, present invention offer is a kind of to treat new medicinal preparation of synovitis and preparation method thereof,
Solving the medicine for the treatment of synovitis in the prior art has the big technical problem of excitant, drug side-effect.
To realize object above, technical scheme is achieved by the following technical programs：
A kind of new medicinal preparation for treating synovitis, the new medicinal preparation is made up of the raw material of following parts by weight：Wheat bran
Sub- 1-35 parts, 1-40 parts of cactus, 5-10 parts of moxibustion radix glycyrrhizae, 5-12 parts of leech, 8-15 parts of pangolin scale, 8-15 parts of earthworm, river
10-35 parts of vault, 5-12 parts of centipede, 10-35 parts of Radix Angelicae Sinensis, 5-12 parts of frankincense, 6-16 parts of honeycomb, 10-35 parts of burmann cinnamon bark, caulis lonicerae
10-35 parts, 10-35 parts of Pollen Typhae, 10-35 parts of Populus adenopoda, 10-35 parts of rhizoma dioscoreae nipponicae, 10-35 parts of ear water amaranth, 10-35 parts of Poria cocos,
10-55 parts of gypsum.
It is preferred that, the new medicinal preparation is made up of the raw material of following parts by weight：10-25 parts of wheat bran, cactus 15-
30 parts, 6-8 parts of moxibustion radix glycyrrhizae, 7-11 parts of leech, 10-14 parts of pangolin scale, 9-13 parts of earthworm, 19-28 parts of rhizome of chuanxiong, centipede 7-10
Part, 18-27 parts of Radix Angelicae Sinensis, 7-10 parts of frankincense, 8-14 parts of honeycomb, 20-30 parts of burmann cinnamon bark, 20-30 parts of caulis lonicerae, Pollen Typhae 20-30
Part, 20-30 parts of Populus adenopoda, 19-27 parts of rhizoma dioscoreae nipponicae, 20-30 parts of ear water amaranth, 20-30 parts of Poria cocos, 20-45 parts of gypsum.
It is preferred that, the new medicinal preparation is made up of the raw material of following parts by weight：18 parts of wheat bran, 20 parts of cactus,
8 parts of moxibustion radix glycyrrhizae, 9 parts of leech, 11 parts of pangolin scale, 11 parts of earthworm, 23 parts of rhizome of chuanxiong, 9 parts of centipede, 23 parts of Radix Angelicae Sinensis, 8 parts of frankincense,
11 parts of honeycomb, 24 parts of burmann cinnamon bark, 24 parts of caulis lonicerae, 24 parts of Pollen Typhae, 23 parts of Populus adenopoda, 25 parts of rhizoma dioscoreae nipponicae, 24 parts of ear water amaranth, Fu
23 parts of Siberian cocklebur, 32 parts of gypsum.
It is preferred that, the leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method.
A kind of preparation method of new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.5-6.5h is extracted at 70-75 DEG C of 80% ethanol, suction filtration is received
Collect filtrate, and it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, section dries levigation or infiltrates to take out after 45-50min with yellow rice wine and cuts into slices, and obtains everywhere
Cactus after reason, it is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 120-180min, cool down room temperature, filtering takes decocting liquid, then add
Decocting is boiled to boiling, and then slow fire boils 120-180min, cools down room temperature, and filtering takes decocting liquid, at least 3 times repeatedly, merges and decocts
Liquid, is concentrated into relative density for 1-1.8 by filtered fluid, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Raw material thick paste conventionally, adds customary adjuvant, and the pharmaceutical dosage form of clinical receiving is made.
It is preferred that, the new medicinal preparation is oral medicine or topical agent.
It is preferred that, the formulation of the oral medicine is one kind in granule, capsule, tablet.
It is preferred that, extraction is described in step S2 plus 80% ethanol extracts 6h at 72 DEG C.
It is preferred that, the step S3 is infiltrated to take out after 48min with yellow rice wine and cut into slices for fresh cactus deburring is cleaned.
It is preferred that, slow fire described in step S4 boils 150min.
In the step S5 of above-mentioned preparation method, according to different dosage forms, using corresponding auxiliary material and preparation method.Specifically
Say：
After when preparing granule, thick paste is dried, crushing, ethanol, starch are added, particle is conventionally made.The formulation
The consumption that clinic is recommended is 10-20g/ times, and 3 times/day, detailed directions consumption should follow the doctor's advice.
When preparing capsule, sucrose, dextrin are added into thick paste, pelletizes, dry after mixing, mix again, load capsule
Shell, is conventionally made capsule.The consumption that formulation clinic is recommended is 1-2 tablets/time（0.3-0.5g/）, 3 times/day, tool
Body usage and dosage should follow the doctor's advice.
After when preparing tablet, thick paste is dried, crushing, conventional tablet auxiliary material is added, conventionally extrudes in blocks.Its
In, conventional tablet auxiliary material can select lactose, microcrystalline cellulose or starch.The consumption that formulation clinic is recommended is 1-2 pieces/times
（0.3-0.5g/ pieces）, 3 times/day, detailed directions consumption should follow the doctor's advice.
Part material effect of the present invention and pharmacological action are described below：
Leech：Dissipating blood stasis with potent drugs, Xiao Disorder, salty hardship enters blood system, is apt to dissipating blood stasis with potent drugs；
Frankincense, pungent hardship, slightly warm in nature, thoughts of returning home liver and spleen warp.Effect：Blood-activating and qi-promoting, detumescence and promoting granulation.Cure mainly, trusted subordinate's pain, rheumatism numbness
Bitterly, closed dysmenorrhea, bruise is become silted up bitterly, ulcer pain, acute appendicitis unhealing ulcer, ruptured abscess resistant to healing；
Poria cocos：It is sweet, light, flat.The thoughts of returning home, spleen, kidney channel, can detoxify, dehumidify, easing joint movement, Poria cocos alcohol extracting thing, extracted by ether
Thing, respectively with diuresis, calmness, antitumor, hypoglycemic, increase myocardial contractive power effect.Pachymaran has the immune work(of enhancing
The effect of energy, Poria cocos has liver protection effect, can reduce gastric secretion, have inhibitory action to gastric ulcer；
Gypsum：It is sweet, pungent, in Great Cold, attach to the lung and stomach meridians, it is raw with can clearing heat-fire, relieving restlessness quenches the thirst；Forge with can expelling pus and promoting granulation, hygroscopic,
Hemostasis, can suppress heat-regulating centers, mitigate the excitability of skeletal muscle, reduce vasopermeability, have antipyretic, antispastic, disappear
Scorching, antiviral the effects such as；
Cactus：It is sweet, it is mild-natured, attach to the lung and stomach meridians, the promoting flow of qi and blood circulation is clearing heat and detoxicating, can swelling and pain relieving, the promoting flow of qi and blood circulation, clearing damp moves back
Heat, myogenic；
Honeycomb：It is sweet, flat, return stomach.Detoxicating and destroying parasites, wind-expelling pain-stopping, treatment of ulcer pyogenic infections, acute mastitis, scrofula, stubborn dermatitis itch, cancerous swelling；
Arthralgia pain due to rheumatism, toothache, rubella itch, honeycomb is equal to acute and chronic inflammation to be suppressed, and analgesic activity is then main to chronic ache
Effectively；Also it is depressured, expands blood vessel and cardiotonic；And can anticancer, antibacterial and cooling；
Ear water amaranth：It is sweet, light, flat, returns spleen, bladder warp.Invigorating spleen to remove dampness, scattered stasis, main Spleen deficiency anorexia, full vexed, the acute and chronic of chest diaphragm
Cystitis, women beats the stasis of blood swell and had a pain with；
Moxibustion radix glycyrrhizae：Tonifying spleen and stomach, Yiqi and vein recovery cure mainly weakness of the spleen and the stomach, lassitude hypodynamia, severe palpilation, intermittent pulse；
Radix Angelicae Sinensis：Sweet, pungent, temperature, Return liver, the heart, the spleen channel can enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, cure mainly asthenia cold abdominalgia,
Impotence numbness, numbness, injury from falling down；
Rhizome of chuanxiong：For blood-activating and qi-promoting, wind-expelling pain-stopping, promoting blood circulation, wind-expelling pain-stopping, effectiveness is favourable, can control head wind headache, rheumatism numbness
The diseases such as pain；
Pangolin scale：Pangolin scale is to wind-cold damp pathogen numbness hinders passages through which vital energy circulates, the waist-leg arthralgia caused by qi and blood stagnation is obstructed, wind
Arthritis with fixed pain caused by dampness pain, bends and stretches difficulty, paralysis due to windstroke, traumatic injury, arthroncus, pain over the hypochondriac region etc. has good therapeutic action.
Present invention offer is a kind of to treat new medicinal preparation of synovitis and preparation method thereof, compared with prior art advantage
It is：
The new medicinal preparation of present invention treatment synovitis has promoting blood circulation and removing blood stasis, radiating analgesic, warming and activating meridian, dispelling wind and eliminating dampness, OK
Blood dissipates the effect of the stasis of blood, has significant curative effect to treatment synovitis, and selected raw material are all without any side effects, can be fast
Speed eliminates the symptoms such as the swelling pain of synovitis patient, alleviates the swelling caused by synovial bursa is mechanically damaged, eliminates articular cavity
Hydrops, recovers the normal permeability of knee joint synovial membrane, and new medicinal preparation of the present invention is taken small to the excitant of human stomach, taken effect
Hurry up, good effect, with system with without obvious adverse reaction and side effect；
In the preparation process of the new medicinal preparation of present invention treatment synovitis, raw material are easy to get, and preparation method is simple, takes and controls
Therapeutic effect is good, and cost is low, and then reduces the medical expense of patient, economic and practical, good effect；
Using raw materials such as pangolin scale, earthworms in the new medicinal preparation raw material of present invention treatment synovitis, with work of stimulating the menstrual flow
Network is acted on, and pangolin scale walks whole body partially, nowhere less than earthworm is relatively descending, shares channels and collaterals promoting blood circulation to remove blood stasis above and below current, therefore use
Ache in waist and knee legs and feet, arthrocleisis, contraction person's good effect, instant effect；Use and wear in the new medicinal preparation raw material of the present invention
Naze scale, earthworm and other raw material wheat brans, cactus, moxibustion radix glycyrrhizae, leech, rhizome of chuanxiong, centipede, Radix Angelicae Sinensis, frankincense, honeycomb,
Burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos, the mutual compatibility of gypsum are made and formed, rich in battalion
Support and dampness elimination composition, can infiltrate through rapidly to knee joint and the musculature being connected, wind-dispelling, dehumidifying, anti-inflammation and sterilization, supplement
Nutrition needed for ligament and periosteum, accelerates aqueous metabolism, it is excreted rapidly, make swollen joint recover, Muscle Edema Sections disappear,
No longer pressuring nerve and relieve pain, aqueous metabolic capability strengthen, solve aseptic inflammation.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, with reference to the embodiment of the present invention pair
Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is a part of the invention
Embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making wound
The every other embodiment obtained under the premise of the property made work, belongs to the scope of protection of the invention.
The preparation of the topical agent of embodiment 1：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：35 parts of wheat bran, cactus
40 parts, 10 parts of moxibustion radix glycyrrhizae, 12 parts of leech, 15 parts of pangolin scale, 15 parts of earthworm, 35 parts of rhizome of chuanxiong, 12 parts of centipede, 35 parts of Radix Angelicae Sinensis,
12 parts of frankincense, 16 parts of honeycomb, 35 parts of burmann cinnamon bark, 35 parts of caulis lonicerae, 35 parts of Pollen Typhae, 35 parts of Populus adenopoda, 35 parts of rhizoma dioscoreae nipponicae, ear water
35 parts of amaranth, 35 parts of Poria cocos, 55 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 6.5h extracted at 75 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, section is ground, the cactus after being handled, standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 180min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 180min, cool down room temperature, filtering takes decocting liquid, 5 times repeatedly, collecting decoction is dense by filtered fluid
It is 1.8 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
As topical agent.
The preparation of the granule of embodiment 2：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：1 part of wheat bran, cactus 1
Part, 5 parts of moxibustion radix glycyrrhizae, 5 parts of leech, 8 parts of pangolin scale, 8 parts of earthworm, 10 parts of rhizome of chuanxiong, 5 parts of centipede, 10 parts of Radix Angelicae Sinensis, 5 parts of frankincense,
6 parts of honeycomb, 10 parts of burmann cinnamon bark, 10 parts of caulis lonicerae, 10 parts of Pollen Typhae, 10 parts of Populus adenopoda, 10 parts of rhizoma dioscoreae nipponicae, 10 parts of ear water amaranth, Fu
10 parts of Siberian cocklebur, 10 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.5h extracted at 70 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, infiltrated to take out after 45min with yellow rice wine and cut into slices, the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 120min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 120min, cool down room temperature, filtering takes decocting liquid, 3 times repeatedly, collecting decoction is dense by filtered fluid
It is 1 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
After thick paste is dried, crushing, ethanol 50mL is added as adhesive, starch 20g as filler, wet is made using extrusion molding
Grain, the granule for the synovitis that obtained medical treatment after drying.
The preparation of the capsule of embodiment 3：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：25 parts of wheat bran, cactus
30 parts, 8 parts of moxibustion radix glycyrrhizae, 11 parts of leech, 14 parts of pangolin scale, 13 parts of earthworm, 28 parts of rhizome of chuanxiong, 10 parts of centipede, 27 parts of Radix Angelicae Sinensis, breast
Fragrant 10 parts, 14 parts of honeycomb, 30 parts of burmann cinnamon bark, 30 parts of caulis lonicerae, 30 parts of Pollen Typhae, 30 parts of Populus adenopoda, 27 parts of rhizoma dioscoreae nipponicae, ear water amaranth
30 parts, 30 parts of Poria cocos, 45 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 6.3h extracted at 73 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, infiltrated to take out after 49min with yellow rice wine and cut into slices, the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 170min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 170min, cool down room temperature, filtering takes decocting liquid, 4 times repeatedly, collecting decoction is dense by filtered fluid
It is 1.6 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Sucrose 5g, dextrin 10g are added into thick paste, wet granular, drying is mixed evenly to prepare, mixes again, loads capsule shells, treatment is made
The capsule of synovitis.
The preparation of the tablet of embodiment 4：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：10 parts of wheat bran, cactus
15 parts, 6 parts of moxibustion radix glycyrrhizae, 7 parts of leech, 10 parts of pangolin scale, 9 parts of earthworm, 19 parts of rhizome of chuanxiong, 7 parts of centipede, 18 parts of Radix Angelicae Sinensis, frankincense 7
Part, 8 parts of honeycomb, 20 parts of burmann cinnamon bark, 20 parts of caulis lonicerae, 20 parts of Pollen Typhae, 20 parts of Populus adenopoda, 19 parts of rhizoma dioscoreae nipponicae, 20 parts of ear water amaranth,
20 parts of Poria cocos, 20 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.8h extracted at 71 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, levigation is dried in section, and the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 140min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 140min, cool down room temperature, filtering takes decocting liquid, 4 times repeatedly, collecting decoction is dense by filtered fluid
It is 1.2 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
After thick paste is dried, crushing, lactose 10g, microcrystalline cellulose 50g are added, the tablet for the treatment of synovitis is pressed into after mixing.
Embodiment 5：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：18 parts of wheat bran, cactus
20 parts, 8 parts of moxibustion radix glycyrrhizae, 9 parts of leech, 11 parts of pangolin scale, 11 parts of earthworm, 23 parts of rhizome of chuanxiong, 9 parts of centipede, 23 parts of Radix Angelicae Sinensis, frankincense
8 parts, 11 parts of honeycomb, 24 parts of burmann cinnamon bark, 24 parts of caulis lonicerae, 24 parts of Pollen Typhae, 23 parts of Populus adenopoda, 25 parts of rhizoma dioscoreae nipponicae, ear water amaranth 24
Part, 23 parts of Poria cocos, 32 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 6h is extracted at 72 DEG C of 80% ethanol, suction filtration collects filtrate, and
It is concentrated under reduced pressure into paste standby；
S3, fresh cactus deburring cleaned, infiltrated to take out after 48min with yellow rice wine and cut into slices, the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 150min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 150min, cool down room temperature, filtering takes decocting liquid, at least 3 times repeatedly, collecting decoction will be filtered
Liquid is concentrated into relative density for 1-1.8, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Raw material thick paste conventionally, adds customary adjuvant, and the pharmaceutical dosage form of clinical receiving is made.
The symptom of synovitis is：Knee joint wound after local swelling pain, in dilatancy pain, knee articulation is unfavorable, lame
OK, skin temperature increases, and has fluctuation by it.
Treatment standard
Recovery from illness：Sings and symptoms disappears, and functional rehabilitation is normal, can participate in normal manual labor.
Take a turn for the better：Symptom, sign disappear substantially, and function is recovered substantially, and work and life have no significant effect.
It is invalid：Sings and symptoms is without too big change.
Treatment results：Clinical testing treatment traumatic synovitis of knee joint patient 100.Through a course of therapy（One
The course for the treatment of is 1 month）Afterwards, fully recover 82, account for 82%, take a turn for the better 14, account for 14%, invalid 4, account for 4%, total effective rate 96%.By controlling
Without any side effects to patient shown in treating, items check no abnormal.
It is exemplified below several model cases：
Case 1：Mr. Li, male, 58 years old.Main suit：Right leg knee joint swelling, pain, limitation of activity 1 year half or so have after rest
Alleviate, nearly month malaise symptoms are aggravated, swollen with back acid, are walked lamely on foot, are taken Glucosamine Sulphate capsule, symptom changes
It is kind that not substantially examination in hospital then, the right slight varus of leg knee joint, floating patella test is positive, and x-ray shows right knee joint degeneration,
Pale tongue, tongue is white, and forceless deep pulse is diagnosed as gonarthromeningitis.
Hair topical agent, which is made, using the embodiment of the present invention 1 coordinates the granule of the preparation of embodiment 2 to take orally, outside topical agent
Xiyan and Weizhong point inside and outside knee joint are affixed on, is changed once daily, 10 days courses for the treatment of.Granule clinic recommend consumption be
10-20g/ times, 3 times/day, 10 days courses for the treatment of, after two courses for the treatment of, knee joint swelling is substantially disappeared, pain relief,
Range of motion of knee joint improves, after 7 courses for the treatment of, and knee joint swelling and pain are disappeared, and other malaise symptoms are wholly absent, knee
Joint substantially can normal activity, consolidate after using one week, knee joint can be freely movable, patient's recovery from illness, follow-up 1 year, patient is without again
Hair.
Case 2：Patient Lv, female, 50 years old, because the right injury of knee joint of cause, local swelling pain, active receiving are fallen down in cycling
Limit, is examined as right traumatic synovitis of knee joint, is fully recovered using after one course for the treatment of of drug therapy of the present invention, and follow-up is not recurred for 1 year.
Case 3：Money so-and-so, man, 30 years old, sportsman, the side in a joint is than more serious during going to a doctor, and previous cross
Ligament injury mistake, opposite side is slightly good；Thigh is thick, be cold and moist unilateral leg the pain increased, it is impossible to carry weight and walk, be afraid of air-conditioning
Blowing.Using the formula of the embodiment of the present invention 5, after two course of therapy, just take effect, there is a pain side, Ipsilateral still without
Take a turn for the better；After four course of therapy, effect substantially, do not ache, Ipsilateral pain relief by side, and be not afraid of air-conditioning and blow, and weight can have been carried
Thing is walked；After five course of therapy, bilateral loses pain, walks normal, leg attenuates.
Case 4：Week certain, man, 45 years old, come when symptom：Both legs are heavy on foot, and double knee joint has swelling, and working can not double knee
Firmly, firmly with regard to pain, pain when downstairs is hydrops articuli through looking into upstairs not bitterly.Use the formula of the embodiment of the present invention 4, warp
After one course of therapy, pin becomes light, feels not swollen；After two course of therapy, both legs sense of heaviness disappears, and dry heavy work also has
Sense of discomfort, pain relief when downstairs；Through six course of therapy, all symptoms disappear, and recover normal.
Case 5：Jia XX, female, 31 years old.Because " left gonalgia, swelling are aggravated 10 days more than half a year " is medical.Patient half
Occur left gonalgia before year after activity uncomfortable, gradually aggravate, tunnel gives oral drug therapy to local clinic,
Specific medication is ominous；Remission, over the past half year left gonalgia occasionally have breaking-out；Before 10 days, occurs left knee joint pain after climbing the mountain
Pain is aggravated, and is gradually aggravated, and difficult with arthroncus, squatting up, and walking pain is aggravated；Left knee joint DR pieces show：Left knee is closed
Save synovitis；With patient diagnosis to our hospital：" left gonarthromeningitis " admits to hospital.
Give embodiment 1 to prepare during in hospital and be dealt into topical agent and the local needle-knife solution art of knee joint, coordinate Chinese and Western medicine to live
Blood stagnation resolvation, filling liver kidney, strengthening the bones and muscles, anti symptom treatment of removing obstruction in channels to relieve pain.Appropriate functional training.Pay a return visit result：One month later institute of patient
Check is normal；Pay a return visit and do not recur after half a year.
In summary, pangolin scale, earthworm are used in the new medicinal preparation raw material of present invention treatment synovitis, both
There is clearing and activating the channels and collaterals effect, pangolin scale walks whole body partially, nowhere less than earthworm is relatively descending, shares channels and collaterals above and below current and lives
Blood dissipates the stasis of blood, therefore aches for waist and knee legs and feet, arthrocleisis, contraction person's good effect, instant effect；The new medicinal preparation of the present invention is rich
Containing nutrition and dampness elimination composition, it can infiltrate through rapidly to knee joint inside and the musculature being connected, wind-dispelling, dehumidifying, anti-inflammation and sterilization,
Nutrition needed for ligament and periosteum is supplemented, accelerates aqueous metabolism, it is excreted rapidly, make swollen joint recover, Muscle Edema Sections
Disappear, no longer pressuring nerve and relieve pain, aqueous metabolic capability strengthen, solve aseptic inflammation.
It should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although ginseng
The present invention is described in detail according to previous embodiment, it will be understood by those within the art that：It still can be with
Technical scheme described in foregoing embodiments is modified, or equivalent substitution is carried out to which part technical characteristic；And
These modifications are replaced, and the essence of appropriate technical solution is departed from the spirit and model of various embodiments of the present invention technical scheme
Enclose.
Claims (10)
1. a kind of new medicinal preparation for treating synovitis, it is characterised in that the new medicinal preparation is by following parts by weight
Raw material is made：1-35 parts of wheat bran, 1-40 parts of cactus, 5-10 parts of moxibustion radix glycyrrhizae, 5-12 parts of leech, 8-15 parts of pangolin scale,
8-15 parts of earthworm, 10-35 parts of rhizome of chuanxiong, 5-12 parts of centipede, 10-35 parts of Radix Angelicae Sinensis, 5-12 parts of frankincense, 6-16 parts of honeycomb, burmann cinnamon bark 10-
35 parts, 10-35 parts of caulis lonicerae, 10-35 parts of Pollen Typhae, 10-35 parts of Populus adenopoda, 10-35 parts of rhizoma dioscoreae nipponicae, 10-35 parts of ear water amaranth, Fu
10-35 parts of Siberian cocklebur, 10-55 parts of gypsum.
2. new medicinal preparation according to claim 1, it is characterised in that：The new medicinal preparation is by following parts by weight
Raw material be made：10-25 parts of wheat bran, 15-30 parts of cactus, 6-8 parts of moxibustion radix glycyrrhizae, 7-11 parts of leech, pangolin scale 10-14
Part, 9-13 parts of earthworm, 19-28 parts of rhizome of chuanxiong, 7-10 parts of centipede, 18-27 parts of Radix Angelicae Sinensis, 7-10 parts of frankincense, 8-14 parts of honeycomb, burmann cinnamon bark
20-30 parts, 20-30 parts of caulis lonicerae, 20-30 parts of Pollen Typhae, 20-30 parts of Populus adenopoda, 19-27 parts of rhizoma dioscoreae nipponicae, ear water amaranth 20-30
Part, 20-30 parts of Poria cocos, 20-45 parts of gypsum.
3. new medicinal preparation according to claim 1, it is characterised in that：The new medicinal preparation is by following parts by weight
Raw material be made：18 parts of wheat bran, 20 parts of cactus, 8 parts of moxibustion radix glycyrrhizae, 9 parts of leech, 11 parts of pangolin scale, 11 parts of earthworm, river
23 parts of vault, 9 parts of centipede, 23 parts of Radix Angelicae Sinensis, 8 parts of frankincense, 11 parts of honeycomb, 24 parts of burmann cinnamon bark, 24 parts of caulis lonicerae, 24 parts of Pollen Typhae, sound
23 parts of leaf poplar, 25 parts of rhizoma dioscoreae nipponicae, 24 parts of ear water amaranth, 23 parts of Poria cocos, 32 parts of gypsum.
4. new medicinal preparation according to claim 1, it is characterised in that：The leech, pangolin scale, earthworm, Wu
Centipede, frankincense are obtained using concocted method.
5. the preparation method of a kind of new medicinal preparation as described in claim 1-4 is any, it is characterised in that including following step
Suddenly：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.5-6.5h is extracted at 70-75 DEG C of 80% ethanol, suction filtration is received
Collect filtrate, and it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, section dries levigation or infiltrates to take out after 45-50min with yellow rice wine and cuts into slices, and obtains everywhere
Cactus after reason, it is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 120-180min, cool down room temperature, filtering takes decocting liquid, then add
Decocting is boiled to boiling, and then slow fire boils 120-180min, cools down room temperature, and filtering takes decocting liquid, at least 3 times repeatedly, merges and decocts
Liquid, is concentrated into relative density for 1-1.8 by filtered fluid, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Raw material thick paste conventionally, adds customary adjuvant, and the pharmaceutical dosage form of clinical receiving is made.
6. new medicinal preparation prepared by new medicinal preparation according to claim 1 or claim 5, its feature exists
In：The new medicinal preparation is oral medicine or topical agent.
7. new medicinal preparation according to claim 6, it is characterised in that：The formulation of the oral medicine be granule,
One kind in capsule, tablet.
8. preparation method according to claim 5, it is characterised in that：Extraction is described in step S2 plus 80% ethanol is at 72 DEG C
Lower extraction 6h.
9. preparation method according to claim 5, it is characterised in that：The step S3 is to clean fresh cactus deburring,
Cut into slices with being taken out after yellow rice wine infiltration 48min.
10. preparation method according to claim 5, it is characterised in that：Slow fire described in step S4 boils 150min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710370536.6A CN106963901A (en) | 2017-05-23 | 2017-05-23 | It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710370536.6A CN106963901A (en) | 2017-05-23 | 2017-05-23 | It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106963901A true CN106963901A (en) | 2017-07-21 |
Family
ID=59326684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710370536.6A Pending CN106963901A (en) | 2017-05-23 | 2017-05-23 | It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106963901A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398910A (en) * | 2014-11-20 | 2015-03-11 | 界首骨科医院 | Traditional Chinese medicine preparation for treating synovitis |
-
2017
- 2017-05-23 CN CN201710370536.6A patent/CN106963901A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398910A (en) * | 2014-11-20 | 2015-03-11 | 界首骨科医院 | Traditional Chinese medicine preparation for treating synovitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101874867B (en) | Chinese medicinal preparation for treating psoriasis | |
| CN102614422A (en) | Traditional Chinese medical decoction for treatment of acute gouty arthritis | |
| CN103536858B (en) | Medicine for treating rheumatoid arthritis | |
| CN100586460C (en) | Oral Chinese medicine composition for treating gout | |
| CN102908391B (en) | Chinese medicinal composition for treating dermatosis and preparation method and application thereof | |
| CN102716334B (en) | Chinese medicinal composition for dispelling the cold and removing stasis | |
| CN104758743A (en) | Traditional Chinese medicine foot fumigating powder for treating rheumatism as well as preparation method and using method thereof | |
| CN101912567B (en) | Chinese medicinal prescription for treating chronic myocarditis | |
| CN105832947A (en) | Health-care foot-soaking Chinese herbal medicine powder | |
| CN103446502A (en) | Traditional Chinese medicine for treating solar dermatitis | |
| CN103230457B (en) | A kind of Chinese medicine composition treating viral myocarditis and preparation method thereof and purposes | |
| CN105012833A (en) | Traditional Chinese medicine for treating polyneuropathy | |
| CN104491642A (en) | Foot bath powder for preventing and treating gout | |
| CN101690797B (en) | Traditional Chinese medicine for treating rheumatism and rheumatoid diseases | |
| CN101085247A (en) | Medicine for treating nephritis and uremia and its preparation method | |
| CN106963901A (en) | It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof | |
| CN104873911A (en) | Traditional Chinese medicine for oral administration for adjunctively treating sepsis | |
| CN103948763A (en) | Traditional Chinese medicinal composition for treating hepatosis | |
| CN103638259A (en) | Traditional Chinese medicine pill for treating liver stagnation type irregular menstrual period | |
| CN103520569B (en) | Traditional Chinese medicine for treatment of lumbago of syndrome of yin deficiency of liver and kidney | |
| CN117224624B (en) | Traditional Chinese medicine composition for preventing and/or treating renal edema and preparation method thereof | |
| CN102846772B (en) | Navel-applied plaster for treating senile constipation and preparation method thereof | |
| CN102961540A (en) | Medicine for treating coronary heart disease and preparation method for same | |
| CN103520693B (en) | Traditional Chinese medicine for treating heart-lung qi-deficiency syndrome type angina pectoris | |
| CN107233489A (en) | A kind of Chinese medicine composition for treating stomach trouble |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170721 |
|
| RJ01 | Rejection of invention patent application after publication |