CN106963901A - It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof - Google Patents
It is a kind of to treat new medicinal preparation of synovitis and preparation method thereof Download PDFInfo
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Abstract
Present invention offer is a kind of to treat new medicinal preparation of synovitis and preparation method thereof, is related to technical field of pharmaceuticals.New medicinal preparation of the present invention is made up of following raw material：Wheat bran, cactus, moxibustion radix glycyrrhizae, leech, pangolin scale, earthworm, rhizome of chuanxiong, centipede, Radix Angelicae Sinensis, frankincense, honeycomb, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos, gypsum, the new medicinal preparation of present invention treatment synovitis has promoting blood circulation and removing blood stasis, radiating analgesic, warming and activating meridian, dispelling wind and eliminating dampness, the effect of the scattered stasis of blood of promoting circulation of blood, the pharmaceutical preparation takes small to the excitant of human stomach, instant effect, good effect, without obvious adverse reaction and side effect.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and in particular to a kind of new medicinal preparation for treating synovitis and its preparation side
Method.
Background technology
Synovitis is a kind of sterile type inflammation, is that synovial membrane is upset generation inflammation, causes juice to lack of proper care to form hydrops
A kind of arthropathy.Synovitis is mainly because of joint sprain and a variety of intraarticular damages, and the one group of syndrome caused.Synovial membrane
Inflammation easily cause patient temporarily or long term portion disability, to patient and to society harm it is all larger.With life
The quickening that movable joint is played, it is also more and more to obtain synovitis number, occurs that hydrops articuli is red and swollen, become if treatment patient not in time
Shape, heavy tingle, the cold symptom of pain etc. more of limbs, and arthroedema, pain, dysarthrasis are also resulted in, it is even maimed.
In the prior art using doctor trained in Western medicine and process of Chinese patent medicine treatment synovitis, western medicine is such as：It is hormone, drawing liquid, flushing, anti-
The treatments such as raw element, though obtaining the curative effect of some satisfactions, treat not thorough, while the side effect of Western medicine is too many, to the heart, liver, kidney
It is also very big Deng organ damage, the adverse reactions such as gastric ulcer are easily produced, and easily recur.The Chinese medicine used in process of Chinese patent medicine
Material all nature and flavor are worked hard, and have stimulation to stomach, and Time of Administration is long necessarily to injure one's stomach, and synovitis is chronic disease, it is necessary to long-term
Treat, therefore long-term taking can be damaged to stomach.
Up to the present, do not find also a kind of can thoroughly cure the specific medicament of synovitis.
The content of the invention
In view of the shortcomings of the prior art, present invention offer is a kind of to treat new medicinal preparation of synovitis and preparation method thereof,
Solving the medicine for the treatment of synovitis in the prior art has the big technical problem of excitant, drug side-effect.
To realize object above, technical scheme is achieved by the following technical programs：
A kind of new medicinal preparation for treating synovitis, the new medicinal preparation is made up of the raw material of following parts by weight：Wheat bran
Sub- 1-35 parts, 1-40 parts of cactus, 5-10 parts of moxibustion radix glycyrrhizae, 5-12 parts of leech, 8-15 parts of pangolin scale, 8-15 parts of earthworm, river
10-35 parts of vault, 5-12 parts of centipede, 10-35 parts of Radix Angelicae Sinensis, 5-12 parts of frankincense, 6-16 parts of honeycomb, 10-35 parts of burmann cinnamon bark, caulis lonicerae
10-35 parts, 10-35 parts of Pollen Typhae, 10-35 parts of Populus adenopoda, 10-35 parts of rhizoma dioscoreae nipponicae, 10-35 parts of ear water amaranth, 10-35 parts of Poria cocos,
10-55 parts of gypsum.
It is preferred that, the new medicinal preparation is made up of the raw material of following parts by weight：10-25 parts of wheat bran, cactus 15-
30 parts, 6-8 parts of moxibustion radix glycyrrhizae, 7-11 parts of leech, 10-14 parts of pangolin scale, 9-13 parts of earthworm, 19-28 parts of rhizome of chuanxiong, centipede 7-10
Part, 18-27 parts of Radix Angelicae Sinensis, 7-10 parts of frankincense, 8-14 parts of honeycomb, 20-30 parts of burmann cinnamon bark, 20-30 parts of caulis lonicerae, Pollen Typhae 20-30
Part, 20-30 parts of Populus adenopoda, 19-27 parts of rhizoma dioscoreae nipponicae, 20-30 parts of ear water amaranth, 20-30 parts of Poria cocos, 20-45 parts of gypsum.
It is preferred that, the new medicinal preparation is made up of the raw material of following parts by weight：18 parts of wheat bran, 20 parts of cactus,
8 parts of moxibustion radix glycyrrhizae, 9 parts of leech, 11 parts of pangolin scale, 11 parts of earthworm, 23 parts of rhizome of chuanxiong, 9 parts of centipede, 23 parts of Radix Angelicae Sinensis, 8 parts of frankincense,
11 parts of honeycomb, 24 parts of burmann cinnamon bark, 24 parts of caulis lonicerae, 24 parts of Pollen Typhae, 23 parts of Populus adenopoda, 25 parts of rhizoma dioscoreae nipponicae, 24 parts of ear water amaranth, Fu
23 parts of Siberian cocklebur, 32 parts of gypsum.
It is preferred that, the leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method.
A kind of preparation method of new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.5-6.5h is extracted at 70-75 DEG C of 80% ethanol, suction filtration is received
Collect filtrate, and it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, section dries levigation or infiltrates to take out after 45-50min with yellow rice wine and cuts into slices, and obtains everywhere
Cactus after reason, it is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 120-180min, cool down room temperature, filtering takes decocting liquid, then add
Decocting is boiled to boiling, and then slow fire boils 120-180min, cools down room temperature, and filtering takes decocting liquid, at least 3 times repeatedly, merges and decocts
Liquid, is concentrated into relative density for 1-1.8 by filtered fluid, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Raw material thick paste conventionally, adds customary adjuvant, and the pharmaceutical dosage form of clinical receiving is made.
It is preferred that, the new medicinal preparation is oral medicine or topical agent.
It is preferred that, the formulation of the oral medicine is one kind in granule, capsule, tablet.
It is preferred that, extraction is described in step S2 plus 80% ethanol extracts 6h at 72 DEG C.
It is preferred that, the step S3 is infiltrated to take out after 48min with yellow rice wine and cut into slices for fresh cactus deburring is cleaned.
It is preferred that, slow fire described in step S4 boils 150min.
In the step S5 of above-mentioned preparation method, according to different dosage forms, using corresponding auxiliary material and preparation method.Specifically
Say：
After when preparing granule, thick paste is dried, crushing, ethanol, starch are added, particle is conventionally made.The formulation
The consumption that clinic is recommended is 10-20g/ times, and 3 times/day, detailed directions consumption should follow the doctor's advice.
When preparing capsule, sucrose, dextrin are added into thick paste, pelletizes, dry after mixing, mix again, load capsule
Shell, is conventionally made capsule.The consumption that formulation clinic is recommended is 1-2 tablets/time（0.3-0.5g/）, 3 times/day, tool
Body usage and dosage should follow the doctor's advice.
After when preparing tablet, thick paste is dried, crushing, conventional tablet auxiliary material is added, conventionally extrudes in blocks.Its
In, conventional tablet auxiliary material can select lactose, microcrystalline cellulose or starch.The consumption that formulation clinic is recommended is 1-2 pieces/times
（0.3-0.5g/ pieces）, 3 times/day, detailed directions consumption should follow the doctor's advice.
Part material effect of the present invention and pharmacological action are described below：
Leech：Dissipating blood stasis with potent drugs, Xiao Disorder, salty hardship enters blood system, is apt to dissipating blood stasis with potent drugs；
Frankincense, pungent hardship, slightly warm in nature, thoughts of returning home liver and spleen warp.Effect：Blood-activating and qi-promoting, detumescence and promoting granulation.Cure mainly, trusted subordinate's pain, rheumatism numbness
Bitterly, closed dysmenorrhea, bruise is become silted up bitterly, ulcer pain, acute appendicitis unhealing ulcer, ruptured abscess resistant to healing；
Poria cocos：It is sweet, light, flat.The thoughts of returning home, spleen, kidney channel, can detoxify, dehumidify, easing joint movement, Poria cocos alcohol extracting thing, extracted by ether
Thing, respectively with diuresis, calmness, antitumor, hypoglycemic, increase myocardial contractive power effect.Pachymaran has the immune work(of enhancing
The effect of energy, Poria cocos has liver protection effect, can reduce gastric secretion, have inhibitory action to gastric ulcer；
Gypsum：It is sweet, pungent, in Great Cold, attach to the lung and stomach meridians, it is raw with can clearing heat-fire, relieving restlessness quenches the thirst；Forge with can expelling pus and promoting granulation, hygroscopic,
Hemostasis, can suppress heat-regulating centers, mitigate the excitability of skeletal muscle, reduce vasopermeability, have antipyretic, antispastic, disappear
Scorching, antiviral the effects such as；
Cactus：It is sweet, it is mild-natured, attach to the lung and stomach meridians, the promoting flow of qi and blood circulation is clearing heat and detoxicating, can swelling and pain relieving, the promoting flow of qi and blood circulation, clearing damp moves back
Heat, myogenic；
Honeycomb：It is sweet, flat, return stomach.Detoxicating and destroying parasites, wind-expelling pain-stopping, treatment of ulcer pyogenic infections, acute mastitis, scrofula, stubborn dermatitis itch, cancerous swelling；
Arthralgia pain due to rheumatism, toothache, rubella itch, honeycomb is equal to acute and chronic inflammation to be suppressed, and analgesic activity is then main to chronic ache
Effectively；Also it is depressured, expands blood vessel and cardiotonic；And can anticancer, antibacterial and cooling；
Ear water amaranth：It is sweet, light, flat, returns spleen, bladder warp.Invigorating spleen to remove dampness, scattered stasis, main Spleen deficiency anorexia, full vexed, the acute and chronic of chest diaphragm
Cystitis, women beats the stasis of blood swell and had a pain with；
Moxibustion radix glycyrrhizae：Tonifying spleen and stomach, Yiqi and vein recovery cure mainly weakness of the spleen and the stomach, lassitude hypodynamia, severe palpilation, intermittent pulse；
Radix Angelicae Sinensis：Sweet, pungent, temperature, Return liver, the heart, the spleen channel can enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, cure mainly asthenia cold abdominalgia,
Impotence numbness, numbness, injury from falling down；
Rhizome of chuanxiong：For blood-activating and qi-promoting, wind-expelling pain-stopping, promoting blood circulation, wind-expelling pain-stopping, effectiveness is favourable, can control head wind headache, rheumatism numbness
The diseases such as pain；
Pangolin scale：Pangolin scale is to wind-cold damp pathogen numbness hinders passages through which vital energy circulates, the waist-leg arthralgia caused by qi and blood stagnation is obstructed, wind
Arthritis with fixed pain caused by dampness pain, bends and stretches difficulty, paralysis due to windstroke, traumatic injury, arthroncus, pain over the hypochondriac region etc. has good therapeutic action.
Present invention offer is a kind of to treat new medicinal preparation of synovitis and preparation method thereof, compared with prior art advantage
It is：
The new medicinal preparation of present invention treatment synovitis has promoting blood circulation and removing blood stasis, radiating analgesic, warming and activating meridian, dispelling wind and eliminating dampness, OK
Blood dissipates the effect of the stasis of blood, has significant curative effect to treatment synovitis, and selected raw material are all without any side effects, can be fast
Speed eliminates the symptoms such as the swelling pain of synovitis patient, alleviates the swelling caused by synovial bursa is mechanically damaged, eliminates articular cavity
Hydrops, recovers the normal permeability of knee joint synovial membrane, and new medicinal preparation of the present invention is taken small to the excitant of human stomach, taken effect
Hurry up, good effect, with system with without obvious adverse reaction and side effect；
In the preparation process of the new medicinal preparation of present invention treatment synovitis, raw material are easy to get, and preparation method is simple, takes and controls
Therapeutic effect is good, and cost is low, and then reduces the medical expense of patient, economic and practical, good effect；
Using raw materials such as pangolin scale, earthworms in the new medicinal preparation raw material of present invention treatment synovitis, with work of stimulating the menstrual flow
Network is acted on, and pangolin scale walks whole body partially, nowhere less than earthworm is relatively descending, shares channels and collaterals promoting blood circulation to remove blood stasis above and below current, therefore use
Ache in waist and knee legs and feet, arthrocleisis, contraction person's good effect, instant effect；Use and wear in the new medicinal preparation raw material of the present invention
Naze scale, earthworm and other raw material wheat brans, cactus, moxibustion radix glycyrrhizae, leech, rhizome of chuanxiong, centipede, Radix Angelicae Sinensis, frankincense, honeycomb,
Burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos, the mutual compatibility of gypsum are made and formed, rich in battalion
Support and dampness elimination composition, can infiltrate through rapidly to knee joint and the musculature being connected, wind-dispelling, dehumidifying, anti-inflammation and sterilization, supplement
Nutrition needed for ligament and periosteum, accelerates aqueous metabolism, it is excreted rapidly, make swollen joint recover, Muscle Edema Sections disappear,
No longer pressuring nerve and relieve pain, aqueous metabolic capability strengthen, solve aseptic inflammation.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, with reference to the embodiment of the present invention pair
Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is a part of the invention
Embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making wound
The every other embodiment obtained under the premise of the property made work, belongs to the scope of protection of the invention.
The preparation of the topical agent of embodiment 1：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：35 parts of wheat bran, cactus
40 parts, 10 parts of moxibustion radix glycyrrhizae, 12 parts of leech, 15 parts of pangolin scale, 15 parts of earthworm, 35 parts of rhizome of chuanxiong, 12 parts of centipede, 35 parts of Radix Angelicae Sinensis,
12 parts of frankincense, 16 parts of honeycomb, 35 parts of burmann cinnamon bark, 35 parts of caulis lonicerae, 35 parts of Pollen Typhae, 35 parts of Populus adenopoda, 35 parts of rhizoma dioscoreae nipponicae, ear water
35 parts of amaranth, 35 parts of Poria cocos, 55 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 6.5h extracted at 75 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, section is ground, the cactus after being handled, standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 180min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 180min, cool down room temperature, filtering takes decocting liquid, 5 times repeatedly, collecting decoction is dense by filtered fluid
It is 1.8 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
As topical agent.
The preparation of the granule of embodiment 2：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：1 part of wheat bran, cactus 1
Part, 5 parts of moxibustion radix glycyrrhizae, 5 parts of leech, 8 parts of pangolin scale, 8 parts of earthworm, 10 parts of rhizome of chuanxiong, 5 parts of centipede, 10 parts of Radix Angelicae Sinensis, 5 parts of frankincense,
6 parts of honeycomb, 10 parts of burmann cinnamon bark, 10 parts of caulis lonicerae, 10 parts of Pollen Typhae, 10 parts of Populus adenopoda, 10 parts of rhizoma dioscoreae nipponicae, 10 parts of ear water amaranth, Fu
10 parts of Siberian cocklebur, 10 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.5h extracted at 70 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, infiltrated to take out after 45min with yellow rice wine and cut into slices, the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 120min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 120min, cool down room temperature, filtering takes decocting liquid, 3 times repeatedly, collecting decoction is dense by filtered fluid
It is 1 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
After thick paste is dried, crushing, ethanol 50mL is added as adhesive, starch 20g as filler, wet is made using extrusion molding
Grain, the granule for the synovitis that obtained medical treatment after drying.
The preparation of the capsule of embodiment 3：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：25 parts of wheat bran, cactus
30 parts, 8 parts of moxibustion radix glycyrrhizae, 11 parts of leech, 14 parts of pangolin scale, 13 parts of earthworm, 28 parts of rhizome of chuanxiong, 10 parts of centipede, 27 parts of Radix Angelicae Sinensis, breast
Fragrant 10 parts, 14 parts of honeycomb, 30 parts of burmann cinnamon bark, 30 parts of caulis lonicerae, 30 parts of Pollen Typhae, 30 parts of Populus adenopoda, 27 parts of rhizoma dioscoreae nipponicae, ear water amaranth
30 parts, 30 parts of Poria cocos, 45 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 6.3h extracted at 73 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, infiltrated to take out after 49min with yellow rice wine and cut into slices, the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 170min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 170min, cool down room temperature, filtering takes decocting liquid, 4 times repeatedly, collecting decoction is dense by filtered fluid
It is 1.6 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Sucrose 5g, dextrin 10g are added into thick paste, wet granular, drying is mixed evenly to prepare, mixes again, loads capsule shells, treatment is made
The capsule of synovitis.
The preparation of the tablet of embodiment 4：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：10 parts of wheat bran, cactus
15 parts, 6 parts of moxibustion radix glycyrrhizae, 7 parts of leech, 10 parts of pangolin scale, 9 parts of earthworm, 19 parts of rhizome of chuanxiong, 7 parts of centipede, 18 parts of Radix Angelicae Sinensis, frankincense 7
Part, 8 parts of honeycomb, 20 parts of burmann cinnamon bark, 20 parts of caulis lonicerae, 20 parts of Pollen Typhae, 20 parts of Populus adenopoda, 19 parts of rhizoma dioscoreae nipponicae, 20 parts of ear water amaranth,
20 parts of Poria cocos, 20 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.8h extracted at 71 DEG C of 80% ethanol, suction filtration collects filtrate,
And it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, levigation is dried in section, and the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 140min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 140min, cool down room temperature, filtering takes decocting liquid, 4 times repeatedly, collecting decoction is dense by filtered fluid
It is 1.2 to be reduced to relative density, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
After thick paste is dried, crushing, lactose 10g, microcrystalline cellulose 50g are added, the tablet for the treatment of synovitis is pressed into after mixing.
Embodiment 5：
The new medicinal preparation of the present embodiment treatment synovitis is made up of the raw material of following parts by weight：18 parts of wheat bran, cactus
20 parts, 8 parts of moxibustion radix glycyrrhizae, 9 parts of leech, 11 parts of pangolin scale, 11 parts of earthworm, 23 parts of rhizome of chuanxiong, 9 parts of centipede, 23 parts of Radix Angelicae Sinensis, frankincense
8 parts, 11 parts of honeycomb, 24 parts of burmann cinnamon bark, 24 parts of caulis lonicerae, 24 parts of Pollen Typhae, 23 parts of Populus adenopoda, 25 parts of rhizoma dioscoreae nipponicae, ear water amaranth 24
Part, 23 parts of Poria cocos, 32 parts of gypsum；
The preparation method of the present embodiment new medicinal preparation, comprises the following steps：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 6h is extracted at 72 DEG C of 80% ethanol, suction filtration collects filtrate, and
It is concentrated under reduced pressure into paste standby；
S3, fresh cactus deburring cleaned, infiltrated to take out after 48min with yellow rice wine and cut into slices, the cactus after being handled is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 150min, cool down room temperature, filtering takes decocting liquid, added water pan-fried
Boil to boiling, then slow fire boils 150min, cool down room temperature, filtering takes decocting liquid, at least 3 times repeatedly, collecting decoction will be filtered
Liquid is concentrated into relative density for 1-1.8, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Raw material thick paste conventionally, adds customary adjuvant, and the pharmaceutical dosage form of clinical receiving is made.
The symptom of synovitis is：Knee joint wound after local swelling pain, in dilatancy pain, knee articulation is unfavorable, lame
OK, skin temperature increases, and has fluctuation by it.
Treatment standard
Recovery from illness：Sings and symptoms disappears, and functional rehabilitation is normal, can participate in normal manual labor.
Take a turn for the better：Symptom, sign disappear substantially, and function is recovered substantially, and work and life have no significant effect.
It is invalid：Sings and symptoms is without too big change.
Treatment results：Clinical testing treatment traumatic synovitis of knee joint patient 100.Through a course of therapy（One
The course for the treatment of is 1 month）Afterwards, fully recover 82, account for 82%, take a turn for the better 14, account for 14%, invalid 4, account for 4%, total effective rate 96%.By controlling
Without any side effects to patient shown in treating, items check no abnormal.
It is exemplified below several model cases：
Case 1：Mr. Li, male, 58 years old.Main suit：Right leg knee joint swelling, pain, limitation of activity 1 year half or so have after rest
Alleviate, nearly month malaise symptoms are aggravated, swollen with back acid, are walked lamely on foot, are taken Glucosamine Sulphate capsule, symptom changes
It is kind that not substantially examination in hospital then, the right slight varus of leg knee joint, floating patella test is positive, and x-ray shows right knee joint degeneration,
Pale tongue, tongue is white, and forceless deep pulse is diagnosed as gonarthromeningitis.
Hair topical agent, which is made, using the embodiment of the present invention 1 coordinates the granule of the preparation of embodiment 2 to take orally, outside topical agent
Xiyan and Weizhong point inside and outside knee joint are affixed on, is changed once daily, 10 days courses for the treatment of.Granule clinic recommend consumption be
10-20g/ times, 3 times/day, 10 days courses for the treatment of, after two courses for the treatment of, knee joint swelling is substantially disappeared, pain relief,
Range of motion of knee joint improves, after 7 courses for the treatment of, and knee joint swelling and pain are disappeared, and other malaise symptoms are wholly absent, knee
Joint substantially can normal activity, consolidate after using one week, knee joint can be freely movable, patient's recovery from illness, follow-up 1 year, patient is without again
Hair.
Case 2：Patient Lv, female, 50 years old, because the right injury of knee joint of cause, local swelling pain, active receiving are fallen down in cycling
Limit, is examined as right traumatic synovitis of knee joint, is fully recovered using after one course for the treatment of of drug therapy of the present invention, and follow-up is not recurred for 1 year.
Case 3：Money so-and-so, man, 30 years old, sportsman, the side in a joint is than more serious during going to a doctor, and previous cross
Ligament injury mistake, opposite side is slightly good；Thigh is thick, be cold and moist unilateral leg the pain increased, it is impossible to carry weight and walk, be afraid of air-conditioning
Blowing.Using the formula of the embodiment of the present invention 5, after two course of therapy, just take effect, there is a pain side, Ipsilateral still without
Take a turn for the better；After four course of therapy, effect substantially, do not ache, Ipsilateral pain relief by side, and be not afraid of air-conditioning and blow, and weight can have been carried
Thing is walked；After five course of therapy, bilateral loses pain, walks normal, leg attenuates.
Case 4：Week certain, man, 45 years old, come when symptom：Both legs are heavy on foot, and double knee joint has swelling, and working can not double knee
Firmly, firmly with regard to pain, pain when downstairs is hydrops articuli through looking into upstairs not bitterly.Use the formula of the embodiment of the present invention 4, warp
After one course of therapy, pin becomes light, feels not swollen；After two course of therapy, both legs sense of heaviness disappears, and dry heavy work also has
Sense of discomfort, pain relief when downstairs；Through six course of therapy, all symptoms disappear, and recover normal.
Case 5：Jia XX, female, 31 years old.Because " left gonalgia, swelling are aggravated 10 days more than half a year " is medical.Patient half
Occur left gonalgia before year after activity uncomfortable, gradually aggravate, tunnel gives oral drug therapy to local clinic,
Specific medication is ominous；Remission, over the past half year left gonalgia occasionally have breaking-out；Before 10 days, occurs left knee joint pain after climbing the mountain
Pain is aggravated, and is gradually aggravated, and difficult with arthroncus, squatting up, and walking pain is aggravated；Left knee joint DR pieces show：Left knee is closed
Save synovitis；With patient diagnosis to our hospital：" left gonarthromeningitis " admits to hospital.
Give embodiment 1 to prepare during in hospital and be dealt into topical agent and the local needle-knife solution art of knee joint, coordinate Chinese and Western medicine to live
Blood stagnation resolvation, filling liver kidney, strengthening the bones and muscles, anti symptom treatment of removing obstruction in channels to relieve pain.Appropriate functional training.Pay a return visit result：One month later institute of patient
Check is normal；Pay a return visit and do not recur after half a year.
In summary, pangolin scale, earthworm are used in the new medicinal preparation raw material of present invention treatment synovitis, both
There is clearing and activating the channels and collaterals effect, pangolin scale walks whole body partially, nowhere less than earthworm is relatively descending, shares channels and collaterals above and below current and lives
Blood dissipates the stasis of blood, therefore aches for waist and knee legs and feet, arthrocleisis, contraction person's good effect, instant effect；The new medicinal preparation of the present invention is rich
Containing nutrition and dampness elimination composition, it can infiltrate through rapidly to knee joint inside and the musculature being connected, wind-dispelling, dehumidifying, anti-inflammation and sterilization,
Nutrition needed for ligament and periosteum is supplemented, accelerates aqueous metabolism, it is excreted rapidly, make swollen joint recover, Muscle Edema Sections
Disappear, no longer pressuring nerve and relieve pain, aqueous metabolic capability strengthen, solve aseptic inflammation.
It should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although ginseng
The present invention is described in detail according to previous embodiment, it will be understood by those within the art that：It still can be with
Technical scheme described in foregoing embodiments is modified, or equivalent substitution is carried out to which part technical characteristic；And
These modifications are replaced, and the essence of appropriate technical solution is departed from the spirit and model of various embodiments of the present invention technical scheme
Enclose.
Claims (10)
1. a kind of new medicinal preparation for treating synovitis, it is characterised in that the new medicinal preparation is by following parts by weight
Raw material is made：1-35 parts of wheat bran, 1-40 parts of cactus, 5-10 parts of moxibustion radix glycyrrhizae, 5-12 parts of leech, 8-15 parts of pangolin scale,
8-15 parts of earthworm, 10-35 parts of rhizome of chuanxiong, 5-12 parts of centipede, 10-35 parts of Radix Angelicae Sinensis, 5-12 parts of frankincense, 6-16 parts of honeycomb, burmann cinnamon bark 10-
35 parts, 10-35 parts of caulis lonicerae, 10-35 parts of Pollen Typhae, 10-35 parts of Populus adenopoda, 10-35 parts of rhizoma dioscoreae nipponicae, 10-35 parts of ear water amaranth, Fu
10-35 parts of Siberian cocklebur, 10-55 parts of gypsum.
2. new medicinal preparation according to claim 1, it is characterised in that：The new medicinal preparation is by following parts by weight
Raw material be made：10-25 parts of wheat bran, 15-30 parts of cactus, 6-8 parts of moxibustion radix glycyrrhizae, 7-11 parts of leech, pangolin scale 10-14
Part, 9-13 parts of earthworm, 19-28 parts of rhizome of chuanxiong, 7-10 parts of centipede, 18-27 parts of Radix Angelicae Sinensis, 7-10 parts of frankincense, 8-14 parts of honeycomb, burmann cinnamon bark
20-30 parts, 20-30 parts of caulis lonicerae, 20-30 parts of Pollen Typhae, 20-30 parts of Populus adenopoda, 19-27 parts of rhizoma dioscoreae nipponicae, ear water amaranth 20-30
Part, 20-30 parts of Poria cocos, 20-45 parts of gypsum.
3. new medicinal preparation according to claim 1, it is characterised in that：The new medicinal preparation is by following parts by weight
Raw material be made：18 parts of wheat bran, 20 parts of cactus, 8 parts of moxibustion radix glycyrrhizae, 9 parts of leech, 11 parts of pangolin scale, 11 parts of earthworm, river
23 parts of vault, 9 parts of centipede, 23 parts of Radix Angelicae Sinensis, 8 parts of frankincense, 11 parts of honeycomb, 24 parts of burmann cinnamon bark, 24 parts of caulis lonicerae, 24 parts of Pollen Typhae, sound
23 parts of leaf poplar, 25 parts of rhizoma dioscoreae nipponicae, 24 parts of ear water amaranth, 23 parts of Poria cocos, 32 parts of gypsum.
4. new medicinal preparation according to claim 1, it is characterised in that：The leech, pangolin scale, earthworm, Wu
Centipede, frankincense are obtained using concocted method.
5. the preparation method of a kind of new medicinal preparation as described in claim 1-4 is any, it is characterised in that including following step
Suddenly：
S1, leech, pangolin scale, earthworm, centipede, frankincense are obtained using concocted method, each is weighed according still further to parts by weight of raw materials
Raw material, leech, pangolin scale, earthworm, centipede, frankincense, honeycomb, wheat bran are ground respectively, obtain leech powder, pangolin squama
Piece powder, earthworm powder, centipede powder, frankincense powder, honeycomb powder, wheat bran powder, it is standby；
S2, centipede powder, pangolin scale powder be well mixed, plus 5.5-6.5h is extracted at 70-75 DEG C of 80% ethanol, suction filtration is received
Collect filtrate, and it is standby to be concentrated under reduced pressure into paste；
S3, fresh cactus deburring cleaned, section dries levigation or infiltrates to take out after 45-50min with yellow rice wine and cuts into slices, and obtains everywhere
Cactus after reason, it is standby；
S4, by moxibustion radix glycyrrhizae, rhizome of chuanxiong, Radix Angelicae Sinensis, burmann cinnamon bark, caulis lonicerae, Pollen Typhae, Populus adenopoda, rhizoma dioscoreae nipponicae, ear water amaranth, Poria cocos mix
Insert in decoction kettle, add water to cook to boiling, then slow fire boils 120-180min, cool down room temperature, filtering takes decocting liquid, then add
Decocting is boiled to boiling, and then slow fire boils 120-180min, cools down room temperature, and filtering takes decocting liquid, at least 3 times repeatedly, merges and decocts
Liquid, is concentrated into relative density for 1-1.8 by filtered fluid, obtains concentrate；
S5, leech powder prepared by step S1, earthworm powder, frankincense powder, honeycomb powder, wheat bran powder are well mixed, addition gypsum,
Cactus, the obtained concentrates of step S4 after paste prepared by step S2, step S3 processing, stir and evenly mix and obtain thick paste,
Raw material thick paste conventionally, adds customary adjuvant, and the pharmaceutical dosage form of clinical receiving is made.
6. new medicinal preparation prepared by new medicinal preparation according to claim 1 or claim 5, its feature exists
In：The new medicinal preparation is oral medicine or topical agent.
7. new medicinal preparation according to claim 6, it is characterised in that：The formulation of the oral medicine be granule,
One kind in capsule, tablet.
8. preparation method according to claim 5, it is characterised in that：Extraction is described in step S2 plus 80% ethanol is at 72 DEG C
Lower extraction 6h.
9. preparation method according to claim 5, it is characterised in that：The step S3 is to clean fresh cactus deburring,
Cut into slices with being taken out after yellow rice wine infiltration 48min.
10. preparation method according to claim 5, it is characterised in that：Slow fire described in step S4 boils 150min.
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Application publication date: 20170721 |