CN106955736A - 酶催化反应精馏中生物催化涂层的原位涂覆和更新的方法 - Google Patents
酶催化反应精馏中生物催化涂层的原位涂覆和更新的方法 Download PDFInfo
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- CN106955736A CN106955736A CN201710288199.6A CN201710288199A CN106955736A CN 106955736 A CN106955736 A CN 106955736A CN 201710288199 A CN201710288199 A CN 201710288199A CN 106955736 A CN106955736 A CN 106955736A
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- 238000006555 catalytic reaction Methods 0.000 title claims abstract description 52
- 238000000576 coating method Methods 0.000 title claims abstract description 45
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- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000011065 in-situ storage Methods 0.000 title claims abstract description 23
- 108090000790 Enzymes Proteins 0.000 claims abstract description 39
- 102000004190 Enzymes Human genes 0.000 claims abstract description 39
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 30
- 239000000243 solution Substances 0.000 claims description 40
- 238000006243 chemical reaction Methods 0.000 claims description 39
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 33
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 22
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 238000010438 heat treatment Methods 0.000 claims description 14
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 230000003197 catalytic effect Effects 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 12
- 229910021641 deionized water Inorganic materials 0.000 claims description 12
- 239000005457 ice water Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 102100021851 Calbindin Human genes 0.000 claims description 10
- 101000898082 Homo sapiens Calbindin Proteins 0.000 claims description 10
- 101001021643 Pseudozyma antarctica Lipase B Proteins 0.000 claims description 10
- LFQCEHFDDXELDD-UHFFFAOYSA-N tetramethyl orthosilicate Chemical compound CO[Si](OC)(OC)OC LFQCEHFDDXELDD-UHFFFAOYSA-N 0.000 claims description 10
- 229940053652 fluorinse Drugs 0.000 claims description 9
- 150000002148 esters Chemical group 0.000 claims description 8
- BDKKLAMRIATMPA-UHFFFAOYSA-N C[SiH3].[O] Chemical compound C[SiH3].[O] BDKKLAMRIATMPA-UHFFFAOYSA-N 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- 238000004821 distillation Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000010422 painting Methods 0.000 claims description 4
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- 239000000203 mixture Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 239000000945 filler Substances 0.000 abstract description 22
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 230000002779 inactivation Effects 0.000 abstract description 6
- 238000012856 packing Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000005587 bubbling Effects 0.000 abstract description 2
- 239000003054 catalyst Substances 0.000 description 17
- 239000000499 gel Substances 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 238000000066 reactive distillation Methods 0.000 description 6
- 238000009434 installation Methods 0.000 description 5
- 238000010992 reflux Methods 0.000 description 4
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- 238000002474 experimental method Methods 0.000 description 3
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- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 229960001866 silicon dioxide Drugs 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
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- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011942 biocatalyst Substances 0.000 description 1
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- 230000009849 deactivation Effects 0.000 description 1
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- 239000003292 glue Substances 0.000 description 1
- 238000007210 heterogeneous catalysis Methods 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/02—Impregnation, coating or precipitation
- B01J37/0215—Coating
- B01J37/0217—Pretreatment of the substrate before coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/003—Catalysts comprising hydrides, coordination complexes or organic compounds containing enzymes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/02—Impregnation, coating or precipitation
- B01J37/0215—Coating
- B01J37/0219—Coating the coating containing organic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/02—Impregnation, coating or precipitation
- B01J37/0215—Coating
- B01J37/0228—Coating in several steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/02—Impregnation, coating or precipitation
- B01J37/0236—Drying, e.g. preparing a suspension, adding a soluble salt and drying
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Catalysts (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201710288199.6A CN106955736B (zh) | 2017-04-27 | 2017-04-27 | 酶催化反应精馏中生物催化涂层的原位涂覆和更新的方法 |
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CN201710288199.6A CN106955736B (zh) | 2017-04-27 | 2017-04-27 | 酶催化反应精馏中生物催化涂层的原位涂覆和更新的方法 |
Publications (2)
Publication Number | Publication Date |
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CN106955736A true CN106955736A (zh) | 2017-07-18 |
CN106955736B CN106955736B (zh) | 2018-01-02 |
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CN201710288199.6A Active CN106955736B (zh) | 2017-04-27 | 2017-04-27 | 酶催化反应精馏中生物催化涂层的原位涂覆和更新的方法 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109837271A (zh) * | 2018-12-29 | 2019-06-04 | 河北工业大学 | 一种载酶填料及其制备方法和用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070125998A1 (en) * | 2003-10-15 | 2007-06-07 | Bunce Timothy R | Manufacture of resins |
CN102020284A (zh) * | 2011-01-12 | 2011-04-20 | 厦门大学 | 一种二氧化硅的制备方法 |
-
2017
- 2017-04-27 CN CN201710288199.6A patent/CN106955736B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070125998A1 (en) * | 2003-10-15 | 2007-06-07 | Bunce Timothy R | Manufacture of resins |
CN102020284A (zh) * | 2011-01-12 | 2011-04-20 | 厦门大学 | 一种二氧化硅的制备方法 |
Non-Patent Citations (3)
Title |
---|
MANFRED T. REETZ ET AL.: "Efficient Immobilization of Lipases by Entrapment in Hydrophobic Sol-Gel Materials", 《BIOTECHNOLOGY AND BIOENGINEERING》 * |
RENE HEILS ET AL.: "Enzymatic Reactive Distillation: Kinetic Resolution of rac-2-Pentanol with Biocatalytic Coatings on Structured Packings", 《INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH》 * |
RENE HEILS ET AL.: "Integration of Enzymatic Catalysts in a Reactive Distillation Column with Structured Packings", 《INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109837271A (zh) * | 2018-12-29 | 2019-06-04 | 河北工业大学 | 一种载酶填料及其制备方法和用途 |
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Effective date of registration: 20240219 Address after: No. 1-7-101, 301, Hegong Science and Technology Innovation Park, north side of Jinyong Road, Shuangkou Town, Beichen District, Tianjin, 300401 Patentee after: Tianjin Mass Spectrometry Biotechnology Co.,Ltd. Country or region after: China Address before: 300130 No. 8, Hebei University of Technology, Tianjin, Hongqiao No. 330 Patentee before: Hebei University of Technology Country or region before: China |
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