CN106943517A - A kind of health products of strengthen immunity and preparation method thereof - Google Patents
A kind of health products of strengthen immunity and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The present invention relates to a kind of health products of strengthen immunity and preparation method thereof, the health products include the raw material of following weight parts：230~250 parts of cervus elaphus linnaeus, 6-18 parts of ginseng ethanol extract, 5-15 parts of ginseng dregs of a decoction water extract, water extract 28-48 parts of the tuber of dwarf lilyturf.Methods described includes：（1）Ginseng is broken into coarse grain, extracted with alcohol reflux, is filtered, filtrate concentration, vacuum drying is crushed standby；（2）By step（1）The dregs of a decoction add water to cook, filter, filtrate concentration, vacuum drying, crush it is standby；（3）The tuber of dwarf lilyturf coarse grain will be broken into, added water pan-fried, filtered, filtrate concentration, vacuum drying is crushed standby；（4）Cervus elaphus linnaeus is burned into floss removing, shaves, is split into fragment, is dried, is then let cool, be ground into fine powder, then is sterilized, it is standby；（5）Above-mentioned raw materials are weighed by weight, after being well mixed, compressing tablet or encapsulated.Health caring product prescription of the present invention is simple, can improve immunity of organisms.
Description
Technical field
The invention belongs to field of health care products, it is related to a kind of traditional Chinese medicine health care product and preparation method thereof, and in particular to one kind enhancing
Traditional Chinese medicine health care product of immunity and preparation method thereof.
Background technology
Immune is a kind of physiological function of human body, human body by this identification of function " oneself " and " non-oneself " composition so that
Destruction and repel the antigenic substance for entering human body, or human body produced damaging cells and tumour cell etc. in itself, to maintain people
The health of body.Human immune system has three kinds of defencive functions：Defense function, stabilization function, immune surveillance function.It is immune usual
It is favourable to body.
With air environmental pollution, the destruction of the ecological balance, various microorganisms are filled with air：Bacterium, disease
Poison, mycoplasma, Chlamydia, fungi etc..In the case where body immunity is not enough, they can turn into the cause of disease of sense mornig shift
Body.Although human body can produce corresponding antibody to different pathogen, to resist subinfection again, antibody have selectivity and when
It is sex-limited, body can only be protected not invaded again in short period of time, other viral infection, hypoimmunity can not be resisted
People can not resist at all virus invasion and attack.If moreover, people's hypoimmunity, not only germ virus is easy to invade people
Body, it is easily ill, while also aggravated the consumption of body, have have a delicate constitution, malnutritive, One's spirits are drooping, fatigue and weak, food
Be intended to reduce, sleep-disorder etc. performance, had a strong impact on the quality of life of people.
At present, it is the most Perfected process for improving human immunological competence to take health products conditioning.Domestic and international health care in the market, increases
The fast sale of strong immunity product also demonstrates this point.The health food for having strengthen immunity function in China can be found everywhere.
For example：Chinese patent CN 103610736B disclose " Chinese medicine preparation and its preparation technology of a kind of strengthen immunity ", from people
Ginseng, shortcake are processed cervus elaphus linnaeus, the Radix Astragali, Radix Angelicae Sinensis, bighead atractylodes rhizome a few herbs and are made.Chinese patent CN 103800661A disclose " one kind enhancing
Immunity, composition for relieving physical fatigue and containing its preparation " from cervus elaphus linnaeus, Fructus lycii P.E, ophiopogon japonicus extract, ganoderma lucidum
Extract, American ginseng extract are made.Chinese patent CN 103396921B disclose a kind of " the ginseng pilose antler of strengthen immunity
Wine and preparation technology " is from cervus elaphus linnaeus, ginseng, barrenwort, the fruit of Chinese wolfberry, cloves, fructus amomi, tortoise plastron, the bark of eucommia, Fructus Corni, the tuber of dwarf lilyturf, Fu
The kinds of traditional Chinese medicines such as Siberian cocklebur, honey-fried licorice root, white granulated sugar, honey are made with more than 50 degree of white wine.Enhancing is can be seen that from above-mentioned formula to exempt from
In the health products of epidemic disease power, ginseng, young pilose antler are necessary selections.
Therefore, how on traditional ginseng and pilose antle health product, suitable Chinese medicine composition is selected, it is both ensured that enhancing is immune
The effect of power, simplifies formula, makes functional component definitely need further to study again.
The content of the invention
The present invention is based on cervus elaphus linnaeus and ginseng, by prolonged research, by constantly being adjusted to Chinese medicine composition
Whole and improvement, has successfully invented a kind of health products of strengthen immunity, and it is formulated simply, and effect is good.
It is an object of the invention to provide a kind of health products of strengthen immunity, the health products include the original of following weight parts
Material：230~250 parts of cervus elaphus linnaeus, 6-18 parts of ginseng ethanol extract, 5-15 parts of ginseng dregs of a decoction water extract, tuber of dwarf lilyturf water extract
28-48 parts.
As the preferred of the present invention, the health products include the raw material of following weight parts：235~245 parts of cervus elaphus linnaeus, ginseng
10-14 parts of ethanol extract, 7.5-12.5 parts of ginseng dregs of a decoction water extract, water extract 33-43 parts of the tuber of dwarf lilyturf.
As the present invention most preferably, the health products include the raw material of following weight parts：240 parts of cervus elaphus linnaeus, ginseng second
12 parts of alcohol extracting thing, 10 parts of ginseng dregs of a decoction water extract, 38 parts of tuber of dwarf lilyturf water extract.
The health-care preparation of strengthen immunity of the present invention is mainly capsule, tablet, powder can also be made, oral
Any formulation in the pharmacies such as liquid preparation, the health products of above-mentioned various formulations can according to health products conventional method system
It is standby.
It is a further object of the present invention to provide a kind of preparation method of the health products of strengthen immunity, methods described include with
Lower step：
(1) ginseng is broken into coarse grain, extracted 2 times with alcohol reflux, merge ethanol extract, filtering；It is in vacuum
73.3~86.6Kpa, under conditions of 60~70 DEG C, to concentrate the filtrate to the medicinal extract that relative density is 1.20, (50 DEG C are surveyed temperature
It is fixed)；Medicinal extract is dried in vacuo again, dry cream is crushed, crosses 150 mesh sieves, obtain ginseng ethanol extracted extract powder, it is standby；
(2) dregs of a decoction after step (1) is filtered are added water to cook 2 times, merge water decoction, filtering；It is 73.3 in vacuum
~86.6Kpa, temperature is 1.20 medicinal extract (50 DEG C of measure) under conditions of 60~70 DEG C, to concentrate the filtrate to relative density；
Medicinal extract is dried in vacuo again, dry cream is crushed, crosses 150 mesh sieves, obtain ginseng dregs of a decoction the water extracted immersing paste powder, it is standby；
(3) tuber of dwarf lilyturf coarse grain will be broken into, added water to cook 2 times, and merge water decoction, filtering；Vacuum be 73.3~
86.6Kpa, temperature is 1.20 medicinal extract (50 DEG C of measure) under conditions of 60~70 DEG C, to concentrate the filtrate to relative density；Again
Medicinal extract is dried in vacuo, dry cream is crushed, crosses 150 mesh sieves, obtain tuber of dwarf lilyturf the water extracted immersing paste powder, it is standby；
(4) cervus elaphus linnaeus is burned into floss removing with without pyrotechnics, is shaved with bamboo knife, be split into fragment, dried, then let cool, be ground into
Fine powder, then sterilized, it is standby；
(5) cervus elaphus linnaeus, ginseng ethanol extract, ginseng dregs of a decoction water extract, tuber of dwarf lilyturf water extract is weighed by weight to enter
Row mixing, after being well mixed, compressing tablet or encapsulated, you can.
Wherein, when step (1) alcohol reflux is extracted, concentration of alcohol is 60-80% (volume ratio), is measured for the first time with 6-10 times
Alcohol reflux extracts 1-3h, measures alcohol reflux with 4-8 times for the second time and extracts 1-2h.
When step (2) decocting is boiled, 1-2h is boiled in the decocting of 6-10 times of the first time medication quantity of slag, measures decocting with 4-8 times for the second time
Boil 0.5-1.5h.
When step (3) decocting is boiled, 1-2h is boiled with the 6-10 times of decocting measured for the first time, decocting is measured with 4-8 times for the second time and boils
0.5-1.5h。
Step (1), (2, (3) vacuum drying when, vacuum be 0.06~0.1Mpa, temperature be 50~60 DEG C.
It is in the range of 80~100 DEG C, to toast 5~6 hours in temperature using far-infrared rays drying case when step (4) is dried
After let cool, fine powder is then ground into ball mill, and sterilize through 60Coradiation.
Effect of heretofore described each raw material is from as follows：
Cervus elaphus linnaeus：Pilose antler have tonify the kidney and support yang, the effect of beneficial to spirit and marrow, kidney yang is sufficient, kidney essense it is exuberant could metaplasia marrow,
Bone must be supported, and bone is strong strong, and the light strength of limb activity is strong.
Ginseng：Ginseng sweet and slightly bitter taste, property disease partial temperature, its work(focuses on the gas of big correction member, Jin Ergu with strong life originally
De-, benefit is damaged, quenched the thirst, calming the nerves.Reinforce vital energy, de- card again is intended to for the deficiency of vital energy.Invigorating the lung and benefiting vital QI, for insufficiency of lung-QI,deficiency of lung-QI, dyspnea with shortness of breath,
Few gas is weak, has a delicate constitution.Hinder Tianjin gas consumption after beneficial Yin and promoting production of body liquid, treatment consumption of both body fluid and QI, pyreticosis sweat.
The tuber of dwarf lilyturf：Tuber of dwarf lilyturf cold nature, sweet and slightly bitter taste.The tuber of dwarf lilyturf contains a variety of steroid saponins, carrotene, mucilaginous substance, carbohydrate, beans steroid
The compositions such as alcohol.Pharmacological evaluation proves that the tuber of dwarf lilyturf has increasing leukocyte, extends the effect of antibody existence time, improves immunologic function
With nucleic acid synthetic ratio, the immune substances such as antibody, complement, interferon, lysozyme are promoted to produce.Therefore there is enhancing healthy tendency the tuber of dwarf lilyturf, added
Strong anti-evil effect, so as to reduce the generation of disease.
Usage and dosage：2 times a day, 2 every time, specification 0.3g/；Or 2 times a day, 2 tablets once, specification 0.3g/ pieces.
Advantages and positive effects of the present invention：The present invention is raw material from cervus elaphus linnaeus, ginseng and the tuber of dwarf lilyturf, from traditional Chinese medical theory
From the perspective of, ginseng and the tuber of dwarf lilyturf all have effects that QI invigorating, can strengthen healthy tendency, strengthen anti-evil effect, so as to reduce disease
Produce.Pilose antler have tonify the kidney and support yang, the effect of beneficial to spirit and marrow.Several material combinations are used, and it is formulated simple, it is possible to improve machine
Body immunity.
The pharmacological property of medicine of the present invention is proved by tests below.
1 materials and methods
1.1 experimental animals
The cleaning grade ICR male mices that preclinical medicine institute of Jilin University animal experimental center is provided, body weight 18-22g, 240
Only, 5 groups are randomly divided into, every group 48, respectively negative control group (only giving distilled water) and medicine of the present invention is basic, normal, high
(0.02,0.2,0.6g/Kg.BW) 3 dosage groups, continuous gavage surveys every immune indexes after 30 days.
1.2 key instruments and reagent
Electronic balance, spiral micrometer, micro syringe, 24 holes and 96 hole level land cells, culture plate, the U-shaped cell in 96 holes
Culture plate, sheep red blood cell (SRBC) (SRBC), physiological saline, Hank ' s (pH7.2-7.4), RPMI1640 nutrient solutions, calf serum, green grass or young crops
Streptomysin, concanavalin A (ConA) etc..
1.3 methods
1.3.1 delayed allergy (toes thicken method DTH)
Sheep blood is taken, brine three times, mouse is immune with 2% (V/V) SRBC, after every mouse injection 0.2ml sensitization
4d, measures left back vola pedis thickness, and 20 μ l 20%SRBC then are subcutaneously injected in measuring point, and 24h measures left back vola pedis after injection
Portion's thickness, same position is surveyed 3 times, is averaged.
1.3.2ConA the mouse lymphocyte conversion test induced
Sterile spleen is taken, is placed in and fills appropriate sterile Hank,In the small plate of s liquid, gently spleen is ground with tweezers, list is made
It is individual that individual cells suspension is made.Spleen is ground with 4 pieces of gauzes, is washed with Hank ' s liquid 2 times, 10min (1000r/ is centrifuged every time
min)。
Then cell is suspended in 1ml complete culture solution, adjustment cell concentration is 3 × 106Individual/ml.Cell is hanged
Liquid point holes is added in 24 well culture plates, per hole 1ml, and a hole adds 75 μ l ConA (equivalent to 7.5ug/ml), and another hole is as right
According to putting in 37 DEG C of incubators of 5%CO2 and cultivate 72h.Culture terminates preceding 4h, and supernatant 0.7ml is gently sucked per hole, adds
0.7ml is free of the RPMIl640 cell culture fluids of calf serum, while adding MTT (5mg/ml) 50 μ l/ holes, continues to cultivate 4h.
After culture terminates, 1ml acid isopropyl alcohol is added per hole, piping and druming is uniform, is completely dissolved purple crystal.Then it is lysate is direct
Move into 2ml cuvettes, OD values are surveyed in wavelength 570nm on 722 spectrophotometrics.
1.3.3 antibody-producting cell detection
After every mouse injects the immune 4-5d of 2%SRBC 0.2ml through abdominal cavity, spleen is taken, cell suspension is made.Top layer is cultivated
After base heating for dissolving, with the double Hank of equivalent,S liquid is mixed.Dispense small test tube, every pipe 0.5, then into pipe plus 50ul 10%
SRBC, 10 μ l splenocyte suspensions, mixing are poured on agarose slide, are put into CO2gas incubator and are incubated 1.5h, then
Plus complement, continue to incubate 1.5h, count hemolysis plaque number.
1.3.4 the measure of half hemolytic value
Sheep blood is taken, brine 3 times centrifuges 10min every time, and 2% (V/V) SRBC 0.2ml are injected in every mouse abdominal cavity
After immune 4d, extract eyeball and take blood in centrifuge tube, place about 1h, solidification blood and tube wall are peeled off, serum is fully separated out, is received
Collect serum.With SA buffer solutions by 400 times of serum-dilution.Serum 1ml after dilution is put in test tube, 10% (V/V) is sequentially added
SRBC0.5ml, complement 1ml (presses 1 with SA buffer solutions:8) dilute.Separately the control tube of not increase serum is set (with SA buffer solution generations
For).Put and 15-30min, ice bath terminating reaction are incubated in 37 DEG C of waters bath with thermostatic control.2000r/min centrifuges 10min.Supernatant 1ml is taken, plus
Dou Shi reagents 3ml is in test tube.10%SRBC0.25ml, plus Dou Shi reagents are taken to 4ml simultaneously, is fully mixed, and place 10min
Afterwards, sentence control tube in 540nm and make blank, each pipe OD value is determined respectively.
HC50OD value × extension rate during=sample OD value/SRBC half hemolysis
1.3.5 mouse carbonic clearance is tested
Mouse tail vein injection 1:The india ink of 4 times of dilutions, treats that prepared Chinese ink injects, timing immediately.2 after injection prepared Chinese ink,
10min, takes the μ l of blood 20, and add it to 2ml0.1%Na at once from angular vein clump respectively2CO3In solution, 722 light splitting are used
OD values are surveyed in wavelength 600nm on luminosity, with Na2CO3Solution does negative control.Mouse is put to death, liver and spleen is taken, filter paper is used
Organ surface blood stains are blotted, are weighed respectively.
K=(lgOD1—lgOD2)/(t2-t1)
1.3.6 Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment
Animal is put to death after 20% chicken erythrocyte suspension 1ml, interval 30min are injected per mouse abdominal cavity, takes peritoneal macrophage to wash
Liquid 1ml, drips on slide, is put into the enamel box for being lined with wet gauze, and 37 DEG C of incubators of dislocation incubate 20min.Incubate complete, Yu Yongsheng
Saline rinse is managed, to remove non-paster cell, is dried, fixed, Giemsa dyeing, then dried with distilled water rinsing.Counted under oil mirror
Number, 100 macrophages of every counting, is calculated as follows phagocytic rate and phagocytic index：
Number of macrophages × 100 of number of macrophages/counting of phagocytic rate %=phagocytosis chicken red blood cells
The number of macrophages of the chicken red blood cell sum/counting for phagocytic index=swallowed
1.3.7NK cytoactive detection
24h will target cell YAC-1 progress Secondary Cultures before experiment, be washed 3 times with Hank ' s liquid using preceding, with small containing 10%
The RPMI1640 complete culture solutions adjustment cell concentration of cow's serum is 4 × 103Individual/mL. test mices draw neck to put to death, sterile to take
Spleen, is made splenocyte suspension, uses Hank,S liquid is washed 3 times, 1500r/min centrifugation 10min, then with 2ml containing 10% calf serum
RPMI1640 complete culture solutions it is resuspended, with the blue dyeing counting of platform phenol, adjust cell concentration, it is 50 to make effect target ratio:1. take target thin
Born of the same parents and each 100 μ l of effector cell, are added in the orifice plate of U-shaped 96；Target cell Spontaneous release hole adds target cell and each 100 μ l of nutrient solution,
Target cell maximum release aperture adds target cell and each 100 μ l of 1%NP4O；Above-mentioned two are respectively all provided with three parallel holes, 37 DEG C, 5%CO2
4h is cultivated in incubator, 96 orifice plates are centrifuged into 5min with 1500r/min, the μ l of supernatant 100 are drawn per hole and are put in ELISA Plate, are added
The μ l of LDH matrix liquids 100, react 10min, the 1mol μ l terminating reactions of HCl solution 30 are then added per hole, in ELIASA 490nm
Place surveys OD values, and NK activity is calculated as follows：
NK cytoactives % (reacting hole OD- Spontaneous releases hole OD)/(maximum release aperture OD- Spontaneous releases hole OD) ×
100%
1.4 test datas carry out variance analysis with SPSS10.0 softwares.
2 results
Influence of 2.1 medicines of the present invention to mouse cell immunologic function
2.1.1 medicine of the present invention is to Mouse Weight and the influence of delayed allergy (DTH)
The medicine of the present invention of table 1. is to Mouse Weight and the influence of delayed allergy (DTH)
P values：Each experimental group and the ﹡ ﹡ p ＜ 0.01 of negative control group Bi compare ﹡ p ＜ 0.05
From table 1, the medicine of the present invention of orally administration mouse various dose 30 days is statistically analyzed, each dosage group
Mouse weightening compares that there was no significant difference (p ＞ 0.05) between basic, normal, high dosage group and negative control group；Its swelling degree of the paw
Compared that there was no significant difference (p ＞ 0.05) between low dose group and negative control group, compared between middle dose group and negative control group
Relatively there is significant difference (p ＜ 0.05), there are highly significant sex differernce (p ＜ with being compared between negative control group in high dose group
0.01), i.e., the medicine of the present invention of middle and high dosage can strengthen the delayed allergy of mouse.
2.1.2 the influence for the mouse lymphocyte transformation experiment that medicine of the present invention is induced ConA
The influence for the mouse lymphocyte transformation experiment that the medicine of the present invention of table 2 is induced ConA
P values：Each experimental group is compared with negative control group
From table 2, the medicine of the present invention of orally administration mouse various dose 30 days is statistically analyzed, its lymph is thin
The multiplication capacity of born of the same parents in basic, normal, high dosage group with being compared that there was no significant difference (p ＞ 0.05) between negative control group, i.e., it is of the invention
The mouse lymphocyte conversion capability that medicine is induced ConA is without influence.
Influence of 2.2 medicines of the present invention to humoral immunity
2.2.1 influence of the medicine of the present invention to antibody-producting cell number
Influence of the medicine of the present invention of table 3 to mouse antibodies cellulation number
P values：Each experimental group and negative control group Bi compare ﹡ p ＜ 0.05
From table 3, the medicine of the present invention of orally administration mouse various dose 30 days is statistically analyzed, the life of its antibody
Into cell number in basic, normal, high dosage group with being compared that there was no significant difference (p ＞ 0.05) between negative control group；High dose group and the moon
Compare that there were significant differences (p ＜ 0.05) between property control group.I.e. the medicine of the present invention of high dose has to mouse antibodies cellulation number
Obvious influence.
2.2.2 medicine of the present invention is to mouse half hemolytic value (HC50) influence
The medicine of the present invention of table 4. is to mouse half hemolytic value (HC50) influence
P values：Each experimental group and negative control group Bi compare ﹡ p ＜ 0.05
From table 4, the medicine of the present invention of orally administration mouse various dose 30 days is statistically analyzed, its half is molten
Blood value is in basic, normal, high dosage group with being compared that there was no significant difference (p ＞ 0.05) between negative control group；High dose group and feminine gender are right
According to comparing between group, there were significant differences (p ＜ 0.05).That is the medicine of the present invention of high dose can improve mouse half hemolytic value.
Influence of 2.3 medicines of the present invention to mouse monokaryon-macrophage function
2.3.1 influence of the medicine of the present invention to mouse monokaryon-macrophage carbonic clearance function
Influence of the medicine of the present invention of table 5. to mouse monokaryon-macrophage carbonic clearance function
P values：Each experimental group and negative control group Bi compare ﹡ p ＜ 0.05
From table 5, the medicine of the present invention of orally administration mouse various dose 30 days is statistically analyzed, its carbonic clearance
Function in low, middle dose group with being compared no significant difference (p ＞ 0.05) between negative control group, in high dose group and negative control group
Between compare and have significant difference (p ＜ 0.05), i.e. the carbon that the medicine of the present invention of high dose can improve mouse monokaryon-macrophage is wide
Clear ability.
2.3.2 medicine of the present invention swallows the influence of the ability of chicken red blood cell to Mouse Weight and macrophage
The medicine of the present invention of table 6. swallows the influence of the ability of chicken red blood cell to Mouse Weight and macrophage
Phagocytic rate (℅) P1Value：Each experimental group is compared with negative control group
Phagocytic index P2Value：Each experimental group is compared with negative control group
From table 6, the medicine of the present invention of orally administration mouse various dose 30 days is statistically analyzed, each dosage group
Mouse weightening compares that there was no significant difference (p ＞ 0.05) between basic, normal, high dosage group and negative control group；Its phagocytic rate it is low,
Middle and high dosage group and the difference (p ＞ 0.05) that compared that there are no significant between negative control group, its phagocytic index is in basic, normal, high dosage
Difference that there are no significant between group and negative control group (p ＞ 0.05), i.e., it is red thin that medicine of the present invention swallows chicken to mouse macrophage
The ability of born of the same parents is without influence.
Influence of 2.4 medicines of the present invention to NK cells in mice activity
Influence of the medicine of the present invention of table 7 to NK cells in mice activity
P values：Each experimental group is compared with negative control group
From table 7, the medicine of the present invention of orally administration mouse various dose 30 days is statistically analyzed, its NK cell
Activity is in basic, normal, high dosage group with being compared that there was no significant difference (p ＞ 0.05) between negative control group, i.e., medicine of the present invention is to small
The NK cytoactives of mouse are without influence.
From above-mentioned experiment, the medicine of the present invention of orally administration mouse various dose 30 days can improve the half of mouse
Hemolysis value, mouse antibodies cellulation number, the ability of mouse monokaryon-macrophage carbonic clearance, can strengthen mouse delayed become
State is reacted：Body weight increase, the mouse spleen lymphocyte conversion capability of ConA inductions to mouse, Turnover of Mouse Peritoneal Macrophages chicken are red
The ability of cell, NK cytoactives are without influence.Thus prove, health products of the present invention have the function of strengthen immunity.
Embodiment
Embodiment 1
(1) ginseng 230g (Jian Jia Yuan bio tech ltd) is weighed, ginseng is ground into coarse grain, 60% ethanol is used
Refluxing extraction 2 times, extracts 1h with 6 times of amount alcohol refluxs for the first time, for the second time with 4 times of amount alcohol reflux 1h, merges ethanol extract,
Filtered with flame filter press, filtrate decompression is concentrated into the medicinal extract (50 DEG C of measure) of relative density 1.20, and vacuum is 86.6Kpa,
Temperature is 70 DEG C；Medicinal extract is dried in vacuo, vacuum is 0.06Mpa, temperature is 50 DEG C；Then dry cream is crushed, crosses 150 mesh
Sieve, obtains ginseng ethanol extracted extract powder, standby.
(2) step (1) ethanol is carried into the dregs of a decoction to add water to cook 2 times, 1h is boiled in the decocting of 6 times of amounts of first time dosing slag, second
0.5h is boiled with 4 times of amount decoctings, merges water decoction, is filtered with flame filter press, supernatant is concentrated under reduced pressure into relative density and is
1.20 medicinal extract (50 DEG C of measure), vacuum is 73.3Mpa, and temperature is 60 DEG C；Medicinal extract is dried in vacuo, vacuum is
0.06Mpa, temperature is 50 DEG C；Then dry cream is crushed, crosses 150 mesh sieves, obtain ginseng the water extracted immersing paste powder, it is standby.
(3) tuber of dwarf lilyturf 320g (Anguo City Qi Ao prepared slices of Chinese crude drugs Co., Ltd) is weighed, the tuber of dwarf lilyturf coarse grain will be ground into, and add water to cook
2 times, 1h is boiled with 6 times of amount decoctings for the first time, 0.5h is boiled with 4 times of amount decoctings for the second time, merges water decoction, use flame filter press mistake
Filter, supernatant is concentrated under reduced pressure into the medicinal extract (50 DEG C of measure) that relative density is 1.20, and vacuum is 73.3Mpa, and temperature is 60 DEG C；
Medicinal extract is dried in vacuo, vacuum 0.06Mpa, temperature 50 C, dry cream is crushed, crosses 150 mesh sieves, obtain tuber of dwarf lilyturf the water extracted immersing paste powder, it is standby
With.
(4) cervus elaphus linnaeus 230g (the big clear deer park health care Science and Technology Ltd. in Jilin) is weighed, cervus elaphus linnaeus alcolhol burner is burned
Fine hair, is shaved with bamboo knife, is split into fragment, using far-infrared rays drying case, and when temperature is 80 DEG C, baking is let cool after 5 hours.With
Ball mill is ground into fine powder (150 mesh), and is sterilized through 60Coradiation, standby.
(5) ginseng ethanol extracted extract powder 18g, ginseng dregs of a decoction the water extracted immersing paste powder 5g, tuber of dwarf lilyturf the water extracted immersing paste powder 48g are weighed with matching somebody with somebody
The cervus elaphus linnaeus fine powder 230g of side's amount is well mixed, and mixed powder is filling into capsule with the automatic filler of capsule, and finished product is 0.3g/,
Then capsule subpackage is entered in bottle.
Embodiment 2
(1) ginseng 230g (Jian Jia Yuan bio tech ltd) is weighed, ginseng is ground into coarse grain, 80% ethanol is used
Refluxing extraction 2 times, extracts 3h with 10 times of amount alcohol refluxs for the first time, for the second time with 8 times of amount alcohol reflux 2h, merges ethanol and carries
Liquid, is filtered with flame filter press, and filtrate decompression is concentrated into the medicinal extract (50 DEG C of measure) that relative density is 1.20, and vacuum is
86.6Kpa, temperature is 70 DEG C；Medicinal extract is dried in vacuo, vacuum is 0.1Mpa, temperature is 60 DEG C；Then dry cream is crushed, mistake
150 mesh sieves, obtain ginseng ethanol extracted extract powder, standby.
(2) step (1) ethanol is carried into the dregs of a decoction to add water to cook 2 times, 2h is boiled in the decocting of 10 times of amounts of first time dosing slag, second
1.5h is boiled with 8 times of amount decoctings, merges water decoction, is filtered with flame filter press, supernatant is concentrated under reduced pressure into relative density and is
1.20 medicinal extract (50 DEG C of measure), vacuum is 86.6Mpa, and temperature is 70 DEG C；Medicinal extract is dried in vacuo, vacuum is
0.1Mpa, temperature is 60 DEG C；Then dry cream is crushed, crosses 150 mesh sieves, obtain ginseng the water extracted immersing paste powder, it is standby.
(3) tuber of dwarf lilyturf 190g (Anguo City Qi Ao prepared slices of Chinese crude drugs Co., Ltd) is weighed, the tuber of dwarf lilyturf coarse grain will be ground into, and add water to cook
2 times, 2h is boiled with 10 times of amount decoctings for the first time, 1.5h is boiled with 8 times of amount decoctings for the second time, merges water decoction, use flame filter press
Filtering, supernatant is concentrated under reduced pressure into the medicinal extract (50 DEG C of measure) that relative density is 1.20, and vacuum is 86.6Mpa, and temperature is 70
℃；Medicinal extract is dried in vacuo, vacuum 0.1Mpa, temperature 60 C, dry cream is crushed, crosses 150 mesh sieves, obtain tuber of dwarf lilyturf the water extracted immersing paste powder,
It is standby.
(4) cervus elaphus linnaeus 250g (the big clear deer park health care Science and Technology Ltd. in Jilin) is weighed, cervus elaphus linnaeus alcolhol burner is burned
Fine hair, is shaved with bamboo knife, is split into fragment, using far-infrared rays drying case, and when temperature is 95 DEG C, baking is let cool after 6 hours.With
Ball mill is ground into fine powder (150 mesh), and is sterilized through 60Coradiation, standby.
(5) ginseng ethanol extracted extract powder 6g, ginseng dregs of a decoction the water extracted immersing paste powder 15g, tuber of dwarf lilyturf the water extracted immersing paste powder 28g are weighed with matching somebody with somebody
The cervus elaphus linnaeus fine powder 250g of side's amount is well mixed, compressing tablet, and finished product is 0.3g/ pieces, you can.
Embodiment 3
(1) ginseng 150g (Jian Jia Yuan bio tech ltd) is weighed, ginseng is ground into coarse grain, 70% ethanol is used
Refluxing extraction 2 times, extracts 2h with 8 times of amount alcohol refluxs for the first time, for the second time with 6 times of amount alcohol reflux 1.5h, merges ethanol and carries
Liquid, is filtered with flame filter press, and filtrate decompression is concentrated into the medicinal extract (50 DEG C of measure) that relative density is 1.20, and vacuum is
80.0Kpa, temperature is 65 DEG C；Medicinal extract is dried in vacuo, vacuum is 0.08Mpa, temperature is 55 DEG C；Then dry cream is crushed,
150 mesh sieves are crossed, ginseng ethanol extracted extract powder is obtained, it is standby.
(2) step (1) ethanol is carried into the dregs of a decoction to add water to cook 2 times, 1.5h, second are boiled in the decocting of 8 times of amounts of first time dosing slag
It is secondary to boil 1h with 6 times of amount decoctings, merge water decoction, filtered with flame filter press, supernatant is concentrated under reduced pressure into relative density and is
1.20 medicinal extract (50 DEG C of measure), vacuum is 80Mpa, and temperature is 65 DEG C；Medicinal extract is dried in vacuo, vacuum is 0.08Mpa,
Temperature is 55 DEG C；Then dry cream is crushed, crosses 150 mesh sieves, obtain ginseng the water extracted immersing paste powder, it is standby.
(3) tuber of dwarf lilyturf 250g (Anguo City Qi Ao prepared slices of Chinese crude drugs Co., Ltd) is weighed, the tuber of dwarf lilyturf coarse grain will be ground into, and add water to cook
2 times, 1.5h is boiled with 8 times of amount decoctings for the first time, 1h is boiled with 6 times of amount decoctings for the second time, merges water decoction, use flame filter press mistake
Filter, supernatant is concentrated under reduced pressure into the medicinal extract (50 DEG C of measure) that relative density is 1.20, and vacuum is 80.0Mpa, and temperature is 65 DEG C；
Medicinal extract is dried in vacuo, vacuum 0.08Mpa, 55 DEG C of temperature, dry cream is crushed, crosses 150 mesh sieves, obtain tuber of dwarf lilyturf the water extracted immersing paste powder, it is standby
With.
(4) cervus elaphus linnaeus 240g (the big clear deer park health care Science and Technology Ltd. in Jilin) is weighed, cervus elaphus linnaeus alcolhol burner is burned
Fine hair, is shaved with bamboo knife, is split into fragment, using far-infrared rays drying case, and when temperature is 90 DEG C, baking is let cool after 5.5 hours.
Fine powder (150 mesh) is ground into ball mill, and is sterilized through 60Coradiation, it is standby.
(5) ginseng alcohol-extracted extract powder 12g, ginseng dregs of a decoction the water extracted immersing paste powder 10g, tuber of dwarf lilyturf the water extracted immersing paste powder 38g are weighed with matching somebody with somebody
The cervus elaphus linnaeus fine powder 240g of side's amount is well mixed, and mixed powder is filling into capsule with the automatic filler of capsule, and finished product is 0.3g/,
Then capsule subpackage is entered in bottle.
Embodiment 4
(1) ginseng 150g (Jian Jia Yuan bio tech ltd) is weighed, ginseng is ground into coarse grain, 70% ethanol is used
Refluxing extraction 2 times, extracts 2h with 8 times of amount alcohol refluxs for the first time, for the second time with 6 times of amount alcohol reflux 1.5h, merges ethanol and carries
Liquid, is filtered with flame filter press, and filtrate decompression is concentrated into the medicinal extract (50 DEG C measure) of relative density 1.20, vacuum 80.0Kpa,
65 DEG C of temperature；Medicinal extract is dried in vacuo, vacuum is 0.08Mpa, temperature is 55 DEG C；Then dry cream is crushed, crosses 150 mesh sieves,
Ginseng ethanol extracted extract powder is obtained, it is standby.
(2) step (1) ethanol is carried into the dregs of a decoction to add water to cook 2 times, 1h is boiled in the decocting of 6 times of amounts of first time dosing slag, second
0.5h is boiled with 4 times of amount decoctings, merges water decoction, is filtered with flame filter press, supernatant is concentrated under reduced pressure into relative density 1.20
Medicinal extract (50 DEG C measure), vacuum 73.3Mpa, temperature 60 C；Medicinal extract is dried in vacuo, vacuum is 0.06Mpa, temperature is
50℃；Then dry cream is crushed, crosses 150 mesh sieves, obtain ginseng the water extracted immersing paste powder, it is standby.
(3) tuber of dwarf lilyturf 290g (Anguo City Qi Ao prepared slices of Chinese crude drugs Co., Ltd) is weighed, the tuber of dwarf lilyturf coarse grain will be ground into, and add water to cook
2 times, 1.5h is boiled with 8 times of amount decoctings for the first time, 1h is boiled with 6 times of amount decoctings for the second time, merges water decoction, use flame filter press mistake
Filter, supernatant is concentrated under reduced pressure into the medicinal extract (50 DEG C of measure) of relative density 1.20, vacuum 80.0Mpa, 65 DEG C of temperature；By medicinal extract
Vacuum drying, vacuum 0.08Mpa, 55 DEG C of temperature, dry cream is crushed, and is crossed 150 mesh sieves, is obtained tuber of dwarf lilyturf the water extracted immersing paste powder, standby.
(4) cervus elaphus linnaeus 250g (the big clear deer park health care Science and Technology Ltd. in Jilin) is weighed, cervus elaphus linnaeus alcolhol burner is burned
Fine hair, is shaved with bamboo knife, is split into fragment, using far-infrared rays drying case, and when temperature is 80 DEG C, baking is let cool after 5 hours.With
Ball mill is ground into fine powder (150 mesh), and is sterilized through 60Coradiation, standby.
(5) weigh ginseng ethanol extracted extract powder 10g, ginseng dregs of a decoction the water extracted immersing paste powder 7.5g, tuber of dwarf lilyturf the water extracted immersing paste powder 43g with
The cervus elaphus linnaeus fine powder 245g of formula ratio is well mixed, the mixed powder filling capsule of the automatic filler of capsule, and finished product is 0.3g/,
Then capsule subpackage is entered in bottle.
Embodiment 5
(1) ginseng 195g (Jian Jia Yuan bio tech ltd) is weighed, ginseng is ground into coarse grain, 80% ethanol is used
Refluxing extraction 2 times, extracts 3h with 10 times of amount alcohol refluxs for the first time, for the second time with 8 times of amount alcohol reflux 2h, merges ethanol and carries
Liquid, is filtered with flame filter press, and filtrate decompression is concentrated into the medicinal extract (50 DEG C measure) of relative density 1.20, vacuum 86.6Kpa,
Temperature 70 C；Medicinal extract is dried in vacuo, vacuum is 0.1Mpa, temperature is 60 DEG C；Then dry cream is crushed, crosses 150 mesh sieves, obtain
Ginseng ethanol extracted extract powder, it is standby.
(2) step (1) ethanol is carried into the dregs of a decoction to add water to cook 2 times, 2h is boiled in the decocting of 10 times of amounts of first time dosing slag, second
1.5h is boiled with 8 times of amount decoctings, merges water decoction, is filtered with flame filter press, supernatant is concentrated under reduced pressure into relative density 1.20
Medicinal extract (50 DEG C measure), vacuum 86.6Mpa, temperature 70 C；Medicinal extract is dried in vacuo, vacuum is 0.1Mpa, temperature is
60℃；Then dry cream is crushed, crosses 150 mesh sieves, obtain ginseng the water extracted immersing paste powder, it is standby.
(3) tuber of dwarf lilyturf 230g (Anguo City Qi Ao prepared slices of Chinese crude drugs Co., Ltd) is weighed, the tuber of dwarf lilyturf coarse grain will be ground into, and add water to cook
2 times, 1.5h is boiled with 8 times of amount decoctings for the first time, 1h is boiled with 6 times of amount decoctings for the second time, merges water decoction, use flame filter press mistake
Filter, supernatant is concentrated under reduced pressure into the medicinal extract (50 DEG C of measure) of relative density 1.20, vacuum 80.0Mpa, 65 DEG C of temperature；By medicinal extract
Vacuum drying, vacuum 0.08Mpa, 55 DEG C of temperature, dry cream is crushed, and is crossed 150 mesh sieves, is obtained tuber of dwarf lilyturf the water extracted immersing paste powder, standby.
(4) cervus elaphus linnaeus 235g (the big clear deer park health care Science and Technology Ltd. in Jilin) is weighed, cervus elaphus linnaeus alcolhol burner is burned
Fine hair, is shaved with bamboo knife, is split into fragment, using far-infrared rays drying case, and when temperature is 95 DEG C, baking is let cool after 6 hours.With
Ball mill is ground into fine powder (150 mesh), and is sterilized through 60Coradiation, standby.
(5) ginseng ethanol extracted extract powder 14g, ginseng dregs of a decoction the water extracted immersing paste powder 12.5g, tuber of dwarf lilyturf the water extracted immersing paste powder 33g are weighed
It is well mixed with the cervus elaphus linnaeus fine powder 235g of formula ratio, compressing tablet, finished product is 0.3g/ pieces, you can.
Embodiment 6
(1) ginseng 150g (Jian Jia Yuan bio tech ltd) is weighed, ginseng is ground into coarse grain, 80% ethanol is used
Refluxing extraction 2 times, extracts 3h with 10 times of amount alcohol refluxs for the first time, for the second time with 8 times of amount alcohol reflux 2h, merges ethanol and carries
Liquid, is filtered with flame filter press, and filtrate decompression is concentrated into the medicinal extract (50 DEG C measure) of relative density 1.20, vacuum 86.6Kpa,
Temperature 70 C；Medicinal extract is dried in vacuo, vacuum is 0.1Mpa, temperature is 60 DEG C；Then dry cream is crushed, crosses 150 mesh sieves, obtain
Ginseng ethanol extracted extract powder, it is standby.
(2) step (1) ethanol is carried into the dregs of a decoction to add water to cook 2 times, 2h is boiled in the decocting of 10 times of amounts of first time dosing slag, second
1.5h is boiled with 8 times of amount decoctings, merges water decoction, is filtered with flame filter press, supernatant is concentrated under reduced pressure into relative density 1.20
Medicinal extract (50 DEG C measure), vacuum 86.6Mpa, temperature 70 C；Medicinal extract is dried in vacuo, vacuum is 0.1Mpa, temperature is
60℃；Then dry cream is crushed, crosses 150 mesh sieves, obtain ginseng the water extracted immersing paste powder, it is standby.
(3) tuber of dwarf lilyturf 230g (Anguo City Qi Ao prepared slices of Chinese crude drugs Co., Ltd) is weighed, the tuber of dwarf lilyturf coarse grain will be ground into, and add water to cook
2 times, 1.5h is boiled with 8 times of amount decoctings for the first time, 1h is boiled with 6 times of amount decoctings for the second time, merges water decoction, use flame filter press mistake
Filter, supernatant is concentrated under reduced pressure into the medicinal extract (50 DEG C of measure) of relative density 1.20, vacuum 80.0Mpa, 65 DEG C of temperature；By medicinal extract
Vacuum drying, vacuum 0.08Mpa, 55 DEG C of temperature, dry cream is crushed, and is crossed 150 mesh sieves, is obtained tuber of dwarf lilyturf the water extracted immersing paste powder, standby.
(4) cervus elaphus linnaeus 250g (the big clear deer park health care Science and Technology Ltd. in Jilin) is weighed, cervus elaphus linnaeus alcolhol burner is burned
Fine hair, is shaved with bamboo knife, is split into fragment, using far-infrared rays drying case, and when temperature is 95 DEG C, baking is let cool after 6 hours.With
Ball mill is ground into fine powder (150 mesh), and is sterilized through 60Coradiation, standby.
(5) weigh ginseng ethanol extracted extract powder 10g, ginseng dregs of a decoction the water extracted immersing paste powder 7.5g, tuber of dwarf lilyturf the water extracted immersing paste powder 33g with
The cervus elaphus linnaeus fine powder 245g of formula ratio is well mixed, compressing tablet, and finished product is 0.3g/ pieces, you can.
Claims (7)
1. a kind of health products of strengthen immunity, it is characterised in that：The health products include the raw material of following weight parts：Cervus elaphus linnaeus
230~250 parts, 6-18 parts of ginseng ethanol extract, 5-15 parts of ginseng dregs of a decoction water extract, water extract 28-48 parts of the tuber of dwarf lilyturf.
2. a kind of health products of strengthen immunity according to claim 1, it is characterised in that：The health products are comprising following
The raw material of parts by weight：235~245 parts of cervus elaphus linnaeus, 10-14 parts of ginseng ethanol extract, ginseng dregs of a decoction water extract 7.5-12.5
Part, water extract 33-43 parts of the tuber of dwarf lilyturf.
3. a kind of health products of strengthen immunity according to claim 1, it is characterised in that：The health products are comprising following
The raw material of parts by weight：240 parts of cervus elaphus linnaeus, 12 parts of ginseng ethanol extract, 10 parts of ginseng dregs of a decoction water extract, tuber of dwarf lilyturf water extract
38 parts.
4. a kind of preparation method of the health products of strengthen immunity according to claim 1,2 or 3, it is characterised in that：Bag
Include following steps：
（1）Ginseng is broken into coarse grain, extracted 2 times with alcohol reflux, merges ethanol extract, filtering；It is 73.3 in vacuum
~86.6Kpa, temperature is 1.20 medicinal extract under conditions of 60~70 DEG C, to concentrate the filtrate to relative density；It is again that medicinal extract is true
Sky is dried, and dry cream is crushed, and is crossed 150 mesh sieves, is obtained ginseng ethanol extracted extract powder, standby；
（2）By step（1）The dregs of a decoction after filtering are added water to cook 2 times, merge water decoction, filtering；Vacuum be 73.3~
86.6Kpa, temperature is 1.20 medicinal extract under conditions of 60~70 DEG C, to concentrate the filtrate to relative density；Again by medicinal extract vacuum
Dry, dry cream is crushed, cross 150 mesh sieves, obtain ginseng dregs of a decoction the water extracted immersing paste powder, it is standby；
（3）The tuber of dwarf lilyturf coarse grain will be broken into, added water to cook 2 times, and merge water decoction, filtering；Vacuum be 73.3~
86.6Kpa, temperature is 1.20 medicinal extract under conditions of 60~70 DEG C, to concentrate the filtrate to relative density；Again by medicinal extract vacuum
Dry, dry cream is crushed, cross 150 mesh sieves, obtain tuber of dwarf lilyturf the water extracted immersing paste powder, it is standby；
（4）Cervus elaphus linnaeus is burned into floss removing with without pyrotechnics, is shaved with bamboo knife, is split into fragment, is dried, is then let cool, be ground into fine powder
End, then sterilized, it is standby；
（5）Cervus elaphus linnaeus, ginseng ethanol extract, ginseng dregs of a decoction water extract, tuber of dwarf lilyturf water extract is weighed by weight to be mixed
Close, after being well mixed, compressing tablet or encapsulated, you can.
5. a kind of preparation method of the health products of strengthen immunity according to claim 4, it is characterised in that：
Step（1）When the alcohol reflux is extracted, concentration of alcohol is 60-80%（Volume ratio）, measure ethanol with 6-10 times for the first time and return
Stream extracts 1-3h, measures alcohol reflux with 4-8 times for the second time and extracts 1-2h；
Step（2）When the decocting is boiled, 1-2h is boiled in the decocting of 6-10 times of the first time medication quantity of slag, measures decocting with 4-8 times for the second time
Boil 0.5-1.5h；
Step（3）When the decocting is boiled, 1-2h is boiled with the 6-10 times of decocting measured for the first time, decocting is measured with 4-8 times for the second time and boils
0.5-1.5h；
Step（1）、（2）、（3）The vacuum drying, vacuum is 0.06~0.1Mpa, and temperature is 50~60 DEG C.
6. a kind of preparation method of the health products of strengthen immunity according to claim 4, it is characterised in that：Step（4）
It is that in the range of 80~100 DEG C, baking is let cool after 5~6 hours, then uses ball mill powder in temperature using far-infrared rays drying case
Fine powder is broken into, and is sterilized through 60Coradiation.
7. a kind of health products of strengthen immunity according to claim 1,2 or 3, it is characterised in that：The health products are
Capsule or tablet.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610005021.1A CN106943517A (en) | 2016-01-06 | 2016-01-06 | A kind of health products of strengthen immunity and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610005021.1A CN106943517A (en) | 2016-01-06 | 2016-01-06 | A kind of health products of strengthen immunity and preparation method thereof |
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| CN110140962A (en) * | 2019-06-06 | 2019-08-20 | 河北鲜合药业科技有限公司 | A kind of capsule of strengthen immunity and preparation method thereof |
| CN112617195A (en) * | 2021-01-07 | 2021-04-09 | 北京善养健康科技有限公司 | Medicinal and edible composition and preparation method thereof |
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| CN110025011A (en) * | 2019-04-30 | 2019-07-19 | 浙江麦斯康莱医药有限公司 | A kind of Radix Ophiopogonis ginseng lozenge of strengthen immunity |
| CN110140962A (en) * | 2019-06-06 | 2019-08-20 | 河北鲜合药业科技有限公司 | A kind of capsule of strengthen immunity and preparation method thereof |
| CN112617195A (en) * | 2021-01-07 | 2021-04-09 | 北京善养健康科技有限公司 | Medicinal and edible composition and preparation method thereof |
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Application publication date: 20170714 |