CN106938041A - It is a kind of to treat Chinese medicine preparation of gastric ulcer and preparation method thereof and its medicinal usage - Google Patents
It is a kind of to treat Chinese medicine preparation of gastric ulcer and preparation method thereof and its medicinal usage Download PDFInfo
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- 210000002417 xiphoid bone Anatomy 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention relates to a kind of Chinese medicine preparation for treating gastric ulcer and preparation method thereof and its medicinal usage, belong to pharmaceutical technology field.20 30 parts of the root of large-flowered skullcap, 20 30 parts of the root of herbaceous peony, 20 30 parts of garden burnet, 20 30 parts of Radix Glycyrrhizae, 46 parts of ginger, 20 30 parts of radix bupleuri, 20 30 parts of corydalis tuber, 12 parts of the root of fangji, 12 parts of red ginseng.Advantage is that bulk drug synergy is played and simply acted on rapid-action, determined curative effect, safe and medication, preparation technology is simple, environmentally friendly, the symptom such as abdominal pain caused by gastric ulcer, sour regurgitation, heartburn, Abdeminal pain, Nausea and vomiting, anorexia can effectively be alleviated, there is no toxic and side effect, the various symptoms caused by clinical remission gastric ulcer provide a new selection.
Description
Technical field
It is specifically a kind of to treat Chinese medicine preparation of gastric ulcer and preparation method thereof the present invention relates to medical applications technical field
And purposes.
Background technology
Canker or peptic ulcer are a kind of common disease of digestive tracts, can betide oesophagus, stomach or duodenum,
Stomach-intestinal anastomosis mouthful can be betided nearby or in the Meckel diverticulums containing stomach lining, because gastric ulcer and duodenal ulcer
It is most common, therefore general so-called peptic ulcer refers to gastric ulcer and duodenal ulcer.
Why be referred to as peptic ulcer, be because previously think gastric ulcer and duodenal ulcer be due to hydrochloric acid in gastric juice and
Pepsin is formed to mucous membrane autodigestion, in fact hydrochloric acid in gastric juice and pepsin be ulcer formation main cause it
One, also other reasonses can form peptic ulcer.Because the cause of disease and clinical symptoms of gastric ulcer and duodenal ulcer have
Many similarities, are difficult to differentiate between gastric ulcer or duodenal ulcer sometimes, therefore are often diagnosed as peptic ulcer, or
Taste-blindness rate.If the clear and definite ulcer of energy is in stomach or duodenum, that can directly be diagnosed as gastric ulcer or duodenum
Ulcer.
Clinical manifestation：Upper abdomen pain is this sick cardinal symptom.More be located at upper abdomen, may also appear in left upper abdomen or
After breastbone, xiphoid-process.Often in secret anguish, dull pain, distending pain, burn sample bitterly.The pain of gastric ulcer is more to be occurred in 1 hour after the meal, through 1~
Gradually alleviate after 2 hours, until reappearing the above-mentioned rhythm and pace of moving things again after lower meal feed.Some patientss can be asymptomatic, or with bleeding, perforation etc.
Complication is used as onset symptoms.
The diagnosis of gastric ulcer relies primarily on typical periodicity Upper abdominal pain and x-ray barium meal examination, endoscopy.
Gastric ulcer differentiates with duodenal ulcer：Duodenal ulcer is common in peptic ulcer；Gastric ulcer pain exists more
Ache after meal, duodenal ulcer is more in pain before meals and night pain is also more common.
The cause of disease includes：
1. helicobacter pylori infections：Marshall and Warren successfully turns out helicobacter pylori because of nineteen eighty-three, and proposes
It, which infects, works in peptic ulcer and obtains 2005 annual Nobel Prizes in medicine.Numerous studies are fully proved, are imprisoned
Helicobacter pylori infection is the main cause of peptic ulcer.
2. medicine and dietary factor：The medicines such as long-term taking aspirin, corticosteroid easily cause this disease to occur, this foreign minister
Phase smoking, long-term alcohol and drinks strong tea, coffee like also there is certain relation.
The medicine of easy Ulceration:(1) various Genprins are long-term or large dose oral administration can cause stomachache and uncomfortable,
Severe patient can have spitting blood, melena etc., and gastrocopy can find that stomach lining inflammation, rotten to the corn and ulcer are formed.(2) hormone replacement medicine disappears
Scorching pain and this kind of medicine of phenylbutazone belong to hormone replacement medicine, have direct detrimental effect to stomach lining, can cause acute gastric ulcer.
(3) analgesic-antipyretic such as A.P.C, paracetamol, the cold drug such as somedon and GANMAOTONG.(4) medicine of coronary heart disease is treated such as
PSS (P.S.S), persantine, reserpine, may also lead to gastric ulcer, or even gastrorrhagia.(5) antiphlogistic erythromycin, second
The macrolide antibiotics such as acyl spiramvcin, easily cause the discomfort of stomach.(6) anticarcinogen and other kinds chemotherapeutics be often
Cause gastrointestinal irritation.
3. hydrochloric acid in gastric juice and pepsin：Caused by the ultimately forming of peptic ulcer is due to hydrochloric acid in gastric juice/pepsin autodigestion,
Hydrochloric acid in gastric juice is the deciding factor that ulcer occurs.
4. stress mental element：Acute stress can cause stress ulcer.Stress, anxiety or anxious state of mind for a long time
People is susceptible to suffer from peptic ulcer.
5. inherent cause：In some rare genetic syndromes, such as Multiple Endocrine gland adenoma I types, systematicness fertilizer
Mastocytosis etc., peptic ulcer is its clinical manifestation part.
6. stomach dyskinesia：There is motility disturbances of the stomach in part patients w ith peptic ulcer disease, the gastric acid secretion as caused by gastric emptying increases
Plus the damage with bile caused by Duodenogastric reflux, pancreatic juice and lysolecithin to stomach lining.
7. other factors：I herpes simplex virus types local infection may be relevant.In the patient of kidney transplant or immune deficiency,
Cytomegalovirus infection may also be participated in.
The general principle of reatment medication for pressing peptic ulcer：Application reduces the medicine of damage factor first：Such as antiacid, anti-
Cholinergic drug, H2 receptor antagonists, proglumide, the synthetics of prostaglandin E2 and Omeprazole etc., while giving stomach lining
The medicine of protection：Such as application of ulcerlmin, bismuth agent, 18-BETA-Glycyrrhetinic acid (sanodin) and antibiotic.Thoroughly eradicate helicobacter pylori
(Hp), because it is now recognized that Hp infection with this disease have certain relation, active treatment.
Because peptic ulcer is a kind of chronicity and repeatability very strong disease, clinically as Triple Therapy Hp feels
The popularization of dye, Hp drug resistances are increasingly severe, and Hp therapeutic schemes resistant rate height is eradicated at present, and because of medicine adverse reaction itself
Weight, have impact on the compliance of patient.In order to avoid there is treatment cycle length, the situation of Relapse rate, China expert is total within 2012
Know and recommend Chinese medicine for eradication therapy.Although Chinese medicine works without Western medicine soon, Chinese medicine Small side effects have health care work to body
With, such as improve mucosal blood flow, promote mucous membrane healing, increase Mucosa Barrier, improve patient immune function, suppress Hp breeding etc.,
It just compensate for the deficiency of Western medicine.
The content of the invention
Present invention offer is a kind of to treat Chinese medicine preparation of gastric ulcer and preparation method thereof and its medicinal usage.
The present invention is adopted the technical scheme that, is made up of the raw material of following parts by weight：
20-30 parts of the root of large-flowered skullcap, 20-30 parts of the root of herbaceous peony, 20-30 parts of garden burnet, 20-30 parts of Radix Glycyrrhizae, 4-6 parts of ginger, radix bupleuri 20-30
Part, 20-30 parts of corydalis tuber, 1-2 parts of the root of fangji, 1-2 parts of red ginseng.
Further, the present invention is made up of the crude drug of following parts by weight：25-28 parts of the root of large-flowered skullcap, 23-27 parts of the root of herbaceous peony, garden burnet
22-26 parts, 21-26 parts of Radix Glycyrrhizae, 5-6 parts of ginger, 28-30 parts of radix bupleuri, 22-27 parts of corydalis tuber, 1 part of the root of fangji, 1 part of red ginseng.
Further, the present invention is made up of the crude drug of following parts by weight：21-22 parts of the root of large-flowered skullcap, 26-28 parts of the root of herbaceous peony, garden burnet
20-21 parts, 26-29 parts of Radix Glycyrrhizae, 6 parts of ginger, 22-26 parts of radix bupleuri, 21-23 parts of corydalis tuber, 1.5 parts of the root of fangji, 1.5 parts of red ginseng.
The preparation method of the Chinese medicine preparation of present invention treatment gastric ulcer, comprises the following steps：
(1) each crude drug is weighed according to parts by weight；
(2) red ginseng and the root of fangji are respectively crushed into impalpable powder；
(3) by the seven flavor medicine material such as remaining root of large-flowered skullcap, clean, be put into container, plus 3 times of amount decoctings are boiled 2 times, 2 hours every time, are decocted
Liquid is filtered, and filtrate merges, and is condensed into relative density for 1.05-1.10 (60 DEG C)；
(4) 5 times of 75% ethanol of amount are added to be sufficiently stirred for, are stood, filtration, filtrate recycling ethanol is concentrated into right amount, obtains thick
Cream；
(5) thick paste is mixed with above-mentioned powder and appropriate dextrin, dry, pulverize, capsule is made.
Auxiliary material of the present invention includes lubricant, disintegrant and wetting agent.
The ratio of the lubricant, disintegrant and wetting agent is 1:6:1.
Lubricant is magnesium stearate, glycerol monostearate vinegar, stearic acid or talcum powder.
Disintegrant is cross-linked cellulose, cornstarch, PVPP, pregelatinized starch, sodium starch or alginic acid.
Wetting agent is poly- sorb vinegar or lauryl sodium sulfate.
Chinese medicine preparation of the present invention is the application in treatment Gastric Ulcer Treatment is prepared.
The method have the advantages that bulk drug synergy plays simple with rapid-action, determined curative effect, safe and medication
Effect, preparation technology is simple, environmentally friendly, can effectively alleviate abdominal pain caused by gastric ulcer, sour regurgitation, it is heartburn, on
The symptoms such as abdomen is glutted, Nausea and vomiting, anorexia, without toxic and side effect, be clinical remission gastric ulcer caused by various symptoms carry
A new selection is supplied.
Embodiment
Embodiment 1
It is made up of the raw material of following parts by weight：20 parts of the root of large-flowered skullcap, 20 parts of the root of herbaceous peony, 20 parts of garden burnet, 20 parts of Radix Glycyrrhizae, 4 parts of ginger, bavin
20 parts recklessly, 20 parts of corydalis tuber, 1 part of the root of fangji, 1 part of red ginseng；
The preparation method of the Chinese medicine preparation of the treatment gastric ulcer, is comprised the following steps that：Each active compound is weighed according to parts by weight
Material；Red ginseng and the root of fangji are respectively crushed into impalpable powder；By the seven flavor medicine material such as remaining root of large-flowered skullcap, clean, be put into container, plus 3 times of amounts
Decocting is boiled 2 times, and 2 hours every time, decocting liquid filtration, filtrate merged, and was condensed into relative density for 1.05-1.10 (60 DEG C)；Add 5 times
Measure 75% ethanol to be sufficiently stirred for, stand, filtration, filtrate recycling ethanol is concentrated into right amount, obtains thick paste.Thick paste and above-mentioned powder and
Appropriate dextrin is mixed, and dry, pulverize, capsule is made.
Usage and dosage：Orally.2-4g, 3 times a day.
Embodiment 2
It is made up of the raw material of following parts by weight：25 parts of the root of large-flowered skullcap, 25 parts of the root of herbaceous peony, 25 parts of garden burnet, 5 parts of Radix Glycyrrhizae, 5 parts of ginger, bavin
25 parts recklessly, 25 parts of corydalis tuber, 1.5 parts of the root of fangji, 1.5 parts of red ginseng；
The preparation method of the Chinese medicine preparation of the treatment gastric ulcer, is comprised the following steps that：Each active compound is weighed according to parts by weight
Material；Red ginseng and the root of fangji are respectively crushed into impalpable powder；By the seven flavor medicine material such as remaining root of large-flowered skullcap, clean, be put into container, plus 3 times of amounts
Decocting is boiled 2 times, and 2 hours every time, decocting liquid filtration, filtrate merged, and was condensed into relative density for 1.05-1.10 (60 DEG C)；Add 5 times
Measure 75% ethanol to be sufficiently stirred for, stand, filtration, filtrate recycling ethanol is concentrated into right amount, obtains thick paste.Thick paste and above-mentioned powder and
Appropriate dextrin is mixed, and dry, pulverize, capsule is made.
Usage and dosage：Orally.2-4g, 3 times a day.
Embodiment 3
It is made up of the raw material of following parts by weight：30 parts of the root of large-flowered skullcap, 30 parts of the root of herbaceous peony, 30 parts of garden burnet, 30 parts of Radix Glycyrrhizae, 6 parts of ginger, bavin
30 parts recklessly, 30 parts of corydalis tuber, 2 parts of the root of fangji, 2 parts of red ginseng；
The preparation method of the Chinese medicine preparation of the treatment gastric ulcer, is comprised the following steps that：Each active compound is weighed according to parts by weight
Material；Red ginseng and the root of fangji are respectively crushed into impalpable powder；By the seven flavor medicine material such as remaining root of large-flowered skullcap, clean, be put into container, plus 3 times of amounts
Decocting is boiled 2 times, and 2 hours every time, decocting liquid filtration, filtrate merged, and was condensed into relative density for 1.05-1.10 (60 DEG C)；Add 5 times
Measure 75% ethanol to be sufficiently stirred for, stand, filtration, filtrate recycling ethanol is concentrated into right amount, obtains thick paste.Thick paste and above-mentioned powder and
Appropriate dextrin is mixed, and dry, pulverize, capsule is made, and produces the Chinese medicine preparation for the treatment of gastric ulcer of the present invention.
Usage and dosage：Orally.2-4g, 3 times a day.
The following effect that the present invention is further illustrated by experimental example.
Experimental example 1：Clinical test：
Subjects treat example patient altogether using the present invention, wherein man 20, female 25.The oldest person 60 years old, age
Reckling 18 years old；
Diagnostic criteria：Reference《New Chinese medicine guideline of clinical investigations is tried》New Chinese medicine guideline of clinical investigations is tried
Row is formulated.Western medicine diagnostic criteria：1. there is one or more chronic, rhythmicity of following symptoms, periodic upper abdomen pain
Heating, pantothenic acid, evil of vomitting etc., which are had a stomach upset, the bleedings such as spitting blood, melena performance.2. it is true through gastroscope auxiliary examination related to barium meal etc.
Examine and exclude similar disease.Standards of Chinese Medical Syndrome Differentiation：1. many stomach institute distending pains relevant with feelings will of syndrome of qi stagnation, white and greasy fur, small and wiry pulse.
2. tired blood trouble fixes the stomach headquarters or seat of leading organs of an institute like the Chinese Academy of Sciences acupuncture sample pain do not moved, and more with spitting blood, melena, tongue has addiction point, the thin Huang of tongue, thready and hesitant pulse.③
The hurried scorching hot pain of the stomach headquarters or seat of leading organs of an institute like the Chinese Academy of Sciences of hot and suffocating card, dry and hard excrement helvolus with searching, tongue is red, yellow tongue fur, wiry and frequent pulse.4. asthenia cold syndrome stomachache is twined
Continuous with the passing of time then to be relaxed by it, with the indigestion and loss of appetite just pool, pale tongue, tongue are white, deep thready pulse.5. yin deficiency syndrome stomach institute secret anguish, tongue is red, few tongue, and arteries and veins is thin
Number.
Treatment method：Example patient is equally divided into five groups, every group male 4, and female 5, one group, two groups and three groups is treatment
Group, one group, two groups and three groups is taken embodiment 1 respectively --- in the treatment gastric ulcer of the invention that embodiment 3 is prepared
Medicine preparation, four groups and five groups are respectively positive drug control group and without using medicine group.Method is oral.2-4g, one day 3
It is secondary, it is within one month a course for the treatment of.
Treatment standard:Cure:Clinical symptom disappearance, auxiliary examination shows that ulcer disappears or the paralysed trace tissue of formation；Effectively:It is clinical
Symptom mitigation or partial disappearance, auxiliary examination show that ulcer is obviously reduced；It is invalid:Clinical symptoms are aided in without taking a turn for the better or aggravating earlier above
Inspection shows ulcer without obvious change.
Treatment results:Many after being taken medicine in 27 cases of patient to be taken effect after three weeks, the 1-2 course for the treatment of, which is cured, wherein cures 8,
Effective 14, invalid 5, total effective rate reaches 81.4%.
The outer helicobacter pylori bacteriostatic test of the acceptor of experimental example 2：
1st, pastille agar plate is prepared：Tested material is prepared to the culture medium of different pharmaceutical concentration by doubling dilution, heated, is adjusted
To respective required pH value, 10 pounds of 30min sterilizings are cooled to 45 DEG C.Aseptic flat board (plate d=65mm, 10ml/ plate) is poured into,
The extension rate for finally making stoste containing tested material in culture medium (0.38g/ml) is respectively 1: 2,1: 4 ... 1: 1024.Do simultaneously
Blank control culture medium.
2nd, inoculation takes the young age bacterium that reached for the 3rd generation, by standard opacity tube corrected concentrations is 108cfu/ml not with physiological saline
Bacterium solution to be checked, the respective pastille agar surface of different doubling dilutions is inoculated in respectively, at the same be inoculated with 3 points of parallel point, make every point
Containing 2 μ l bacterium solutions, the liquid-drop diameter of each vaccination is 5~8mm.After point to be seeded is dried, upset flat board is incubated in 36 DEG C
Case culture 72h observes result.Do blank control, criterion simultaneously:The minimum dilution on agar plate to occur without bacterium colony
Tested material concentration is its minimum inhibitory concentration MIC.As a result such as table 1：
The external helicobacter pylori bacteriostatic test result of table 1
The animal model test of experimental example 3：
1st, prepared by model：Rat 70, randomly selects wherein 10 and is only used as Normal group (not infecting, do not treat), its
Remaining animal carries out modeling:After fasting 12h, animal gavage 5%NaHCO is first given3Solution 2ml/ is only.Gavage pylorus spiral shell after 15min
Bacillus bacterium solution 1.5ml/ is only.To food after 30min.Infect 1 time, totally 5 times weekly.In 1 week after last infection, tail blood is taken to carry out serum
Learn and check, look into anti-helicobacter pylori Related Component antibody, antibody positive person is considered as modeling success.
2nd, packet and experimental method:The animal of selection antibody positive totally 40 only enters Experiment on therapy, and modeling animal is random
It is divided into 4 groups, i.e. model control group (10), the preparation of preparation group of embodiment 1 (10), the preparation of preparation group of embodiment 2 (10), reality
Apply the preparation of preparation group of example 3 (10).Treatment group's dosage is respectively 0.3g/kg, 0.3g/kg, 0.3g/kg, is made into respective concentration,
1.0ml/100g gastric infusions are pressed, model control group is with isometric distilled water gavage, and one time a day, common 10d.
3rd, the processing of animal:During experiment, each group animal conventinal breeding, routine observation animal ordinary circumstance, including animal
The state of mind, active situation, hair luster degree and appetite.1 body weight is surveyed weekly.Administration carries out relevant refer to after terminating 1 month
Mark detection.After fasting 24h, the method for de- cervical vertebra is taken to put to death animal, sterile working takes out mouse stomach, gastral cavity is cut off along greater curvature,
Normal saline flushing stomach is used, whole gastric tissue is taken；Half is fixed with 10% formalin, carries out HE dyeing and improvement Giemsa
Dyeing, another hemistich rapid urease test and Hp Bacteria Cultures.And carry out histopathologic examination.
4th, experimental result
4.1 each group animal ordinary circumstances:Rats in normal control group activity is sensitive, by hair gloss, and appetite is larger, body weight increase
Comparatively fast；Model control group rat ordinary circumstance is poor, and activity is slow, and hair color is matt, and appetite is small, and body weight increase is slow, body
It is smaller.Each treatment group is had clear improvement compared with the situation of model control group, and appetite increases earlier above, and body weight is gradually gone up, embodiment 1,2,3
The situation of preparation of preparation group improves more apparent.
4.2 histological observation results
Visually observe:Rats in normal control group stomach lining pinkiness, surfacing is smooth, and coat of the stomach Muscle tensility is stronger.Mould
Type control animals stomach lining color is shallower or kermesinus, and surface lacks gloss, and coat of the stomach Muscle tensility is poor.Each treatment group's stomach lining
In pale red or kermesinus, coat of the stomach Muscle tensility has different degrees of improvement compared with model group.
Om observation stomach lining inflammatory activity:Rats in normal control group gastric epithelial is complete, there is intensive row in lamina propria
The body of gland of row, the lymphocyte that the visible very small amount in mucous membrane bottom in partial rat antrum portion is dispersed in.Model control group Antrum
The degree of inflammation in portion is heavier, visible more lymphocyte, eosinophil and neutrophil infiltration in lamina propria, but not
See that erosion, bleeding and ulcer of mucous membrane etc. change.The antrum portion inflammation of each treatment group animal has mitigated compared with model control group,
Wherein the Ii _ i_iLLci _ i_ almost all of the preparation of preparation group of embodiment 1,2,3 disappears.
The result of 4.3 rapid urease tests, Gimsa dyeing and gastric mucosa tissue Bacteria Culture, is shown in Table 2.With 3 inspections
Feminine gender is used as helicobacter pylori eradication standard.Normal group animal, which is not looked into, sees helicobacter pylori infections, model group all infection (0/
10), the preparation of preparation group helicobacter pylori infections animals showing positive number of embodiment 1,2,3 is reduced in various degree compared with model group.
The each group stomach lining helicobacter pylori testing result of table 2 compares
The each group helicobacter pylori eradicating rate of table 3 compares
| Group | HP number positives | HP feminine gender numbers | HP radical rates/% |
| Normal group | 0 | 10 | |
| Model group | 10 | 0 | 0 |
| The preparation of preparation of embodiment 1 | 7 | 3 | 70 |
| The preparation of preparation of embodiment 2 | 4 | 6 | 68 |
| The preparation of preparation of embodiment 3 | 2 | 8 | 72 |
As shown in Table 3, model group animal is without elimination, and 3 groups of Hp eradication rates of this Chinese medicine preparation are respectively 70%, 68%, 72%,
Illustrate that there is the Chinese medicine preparation certain elimination to act on to Hp.
Claims (5)
1. a kind of Chinese medicine preparation for treating gastric ulcer, it is characterised in that be made up of the raw material of following parts by weight：
20-30 parts of the root of large-flowered skullcap, 20-30 parts of the root of herbaceous peony, 20-30 parts of garden burnet, 20-30 parts of Radix Glycyrrhizae, 4-6 parts of ginger, 20-30 parts of radix bupleuri, prolong
20-30 parts of Hu rope, 1-2 parts of the root of fangji, 1-2 parts of red ginseng.
2. a kind of Chinese medicine preparation for treating gastric ulcer according to claim 1, it is characterised in that by the original of following parts by weight
Medicinal material is made：25-28 parts of the root of large-flowered skullcap, 23-27 parts of the root of herbaceous peony, 22-26 parts of garden burnet, 21-26 parts of Radix Glycyrrhizae, 5-6 parts of ginger, radix bupleuri 28-30
Part, 22-27 parts of corydalis tuber, 1 part of the root of fangji, 1 part of red ginseng.
3. a kind of Chinese medicine preparation for treating gastric ulcer according to claim 1, it is characterised in that by the original of following parts by weight
Medicinal material is made：21-22 parts of the root of large-flowered skullcap, 26-28 parts of the root of herbaceous peony, 20-21 parts of garden burnet, 26-29 parts of Radix Glycyrrhizae, 6 parts of ginger, 22-26 parts of radix bupleuri,
21-23 parts of corydalis tuber, 1.5 parts of the root of fangji, 1.5 parts of red ginseng.
4. a kind of preparation method for the Chinese medicine preparation for treating gastric ulcer as claimed in claim 1, it is characterised in that including following
Step：
(1) each crude drug is weighed according to parts by weight；
(2) red ginseng and the root of fangji are respectively crushed into impalpable powder；
(3) by the seven flavor medicine material such as remaining root of large-flowered skullcap, clean, be put into container, plus 3 times of amount decoctings are boiled 2 times, 2 hours every time, decocting liquid filter
Cross, filtrate merges, be condensed into relative density for 1.05-1.10 (60 DEG C)；
(4) 5 times of 75% ethanol of amount are added to be sufficiently stirred for, are stood, filtration, filtrate recycling ethanol is concentrated into right amount, obtains thick paste；
(5) thick paste is mixed with above-mentioned powder and appropriate dextrin, dry, pulverize, capsule is made.
5. a kind of Chinese medicine preparation for treating gastric ulcer answering in treatment Gastric Ulcer Treatment is prepared as described in claims 1 to 3
With.
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| CN107496692A (en) * | 2017-09-14 | 2017-12-22 | 天津易德晟科技发展有限公司 | A kind of original Chinese traditional medicine composition agent for treating all diseases of stomach and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107496692A (en) * | 2017-09-14 | 2017-12-22 | 天津易德晟科技发展有限公司 | A kind of original Chinese traditional medicine composition agent for treating all diseases of stomach and preparation method |
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Application publication date: 20170711 |